Chronic Acquired Hemolytic Anemia Associated with Hemoglobinuria and Raynaud's Phenomena

The clinical history and serological findings in a patient suffering from chronic hemolytic anemia with Raynaud's phenomena and hemoglobinuria are briefly reported. The patient's serum contained a cold antibody in very high concentration, which was active up to a temperature of at least 33.5 C. Its activity in vitro differed from that of the sera of previously reported cases in that the hemolysis of normal red cells was diminished rather than increased by lowering the pH. It is thought probable that the patient's frequent attacks of hemoglobinuria may be correlated with the ease with which hemolysis took place in vitro at the physiological pH.