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Journal Articles

Functional Profiling of Patient AML Stem Cells Reveals Mechanisms of Epigenetic Plasticity Controlling Therapy Resistance

Sumiko Takao, MD PhD, Richard Koche, PhD, Paolo Cifani, PhD, Zheng Ser, Alex Kentsis, MD PhD

Blood (2018) 132 (Supplement 1): 1318.

https://doi.org/10.1182/blood-2018-99-114433

Published: 2018

Journal Articles

Rational Targeting of a NuRD Sub-Complex for Fetal Hemoglobin Induction Following Comprehensive in Situ Mutagenesis

Mir Hossain, PhD, Falak Sher, PhD, Davide Seruggia, PhD, Vivien Schoonenberg, BS, Mitchel A. Cole, BS, Paolo Cifani, PhD, Laura Dassama, PhD, Claudio Macias-Trevino, BS, Matthew C. Canver, MD PhD, Ryo Kurita, PhD, Yukio Nakamura, MD PhD, Luca Pinello, PhD, Takahiro Maeda, MD PhD, Alex Kentsis, MD PhD, Stuart H. Orkin, MD, Daniel E. Bauer, MD PhD

Blood (2018) 132 (Supplement 1): 2342.

https://doi.org/10.1182/blood-2018-99-117043

Published: 2018

Journal Articles

Therapeutic Disassembly of Leukemogenic Enhancer Complexes

Lauren Forbes, BS, MS, Krasnopolsky Isaac, BA, Gerard Minuesa Dinares, PhD, Michael G. Kharas, PhD, Alex Kentsis, MD PhD

Blood (2018) 132 (Supplement 1): 1352.

https://doi.org/10.1182/blood-2018-99-118807

Published: 2018

Journal Articles

High-Resolution CRISPR Functional Genomics Reveals Critical Vulnerabilities of the NuRD Complex for Fetal Hemoglobin Control

Falak Sher, PhD, Vivien Schoonenberg, BS, Mitchel A. Cole, BS, Claudio Macias-Trevino, BS, Paolo Cifani, PhD, Patrick G Schupp, BS, Matthew C. Canver, BS, Ryo Kurita, PhD, Yukio Nakamura, MD PhD, Stuart Orkin, Alex Kentsis, MD PhD, Luca Pinello, PhD, Takahiro Maeda, MDPhD, Daniel E. Bauer, MD PhD

Blood (2017) 130 (Supplement 1): 286.

https://doi.org/10.1182/blood.V130.Suppl_1.286.286

Published: 2017

Journal Articles

Peptidomimetic Blockade of MYB in Acute Myeloid Leukemia

Kavitha Ramaswamy, MD, Lauren Forbes, Fiona C Brown, PhD, Richard Koche, PhD, Tatyana Gindin, MDPhD, Gerard Minuesa, PhD, Michael G. Kharas, PhD, Andrei Krivtsov, PhD, Scott A. Armstrong, MD PhD, Eric Still, Elisa de Stanchina, PhD, Randi Isenhart, Guangwu Guo, Birgit Knoechel, MDPhD, Alex Kentsis, MD PhD

Blood (2016) 128 (22): 3945.

https://doi.org/10.1182/blood.V128.22.3945.3945

Published: 2016

Journal Articles

Non-Catalytic Role of SETD1A Regulates DNA Repair in Leukemia

Takayuki Hoshii, PhD, Paolo Cifani, PhD, Tomoyoshi Nakadai, PhD, Zhaohui Feng, BM, BS, Chun-Hao Huang, PhD, Richard Koche, PhD, Christopher D Delaney, Chun-Wei David Chen, PhD, Scott W. Lowe, PhD, Robert Roeder, PhD, Alex Kentsis, MD PhD, Scott A. Armstrong, MD PhD

Blood (2016) 128 (22): 434.

https://doi.org/10.1182/blood.V128.22.434.434

Published: 2016

Journal Articles

Comprehensive Genomic Profiling for Improved Diagnosis and Therapy of Pediatric Acute Leukemias

Blood (2016) 128 (22): 1605.

https://doi.org/10.1182/blood.V128.22.1605.1605

Published: 2016

Journal Articles

Aberrant Phosphorylation of MEF2C Is Dispensable for Hematopoiesis, and Induces Chemotherapy Resistance and Susceptibility to MARK Kinase Inhibition Therapy in Acute Myeloid Leukemia

Fiona C Brown, PhD, Eric Still, Paolo Cifani, PhD, Casie Reed, Scott Ficarro, PhD, Jie He, PhD, Richard Koche, PhD, Patrick Bhola, PhD, Peter Romanienko, PhD, Willie Mark, PhD, Andrei V. Krivtsov, PhD, Anthony Letai, MD PhD, Nathanael Gray, PhD, Jarrod Marto, PhD, Scott A. Armstrong, MD PhD, Alex Kentsis, MD PhD

Blood (2016) 128 (22): 436.

https://doi.org/10.1182/blood.V128.22.436.436

Published: 2016

Journal Articles

Ribosomal Protein Rpl22 Regulates Development and Transformation Via Altering RNA Processing

Minshi Wang, PhD, Zheng Ser, Shuyun Rao, PhD, Shawn Fahl, Yong Zhang, Suraj Peri, PhD, Alex Kentsis, MD PhD, David L Wiest, PhD

Blood (2016) 128 (22): 3878.

https://doi.org/10.1182/blood.V128.22.3878.3878

Published: 2016

Journal Articles

High Expression of Myocyte Enhancer Factor 2C ( MEF2C ) Is Associated with Adverse Risk Features and Poor Outcome in Pediatric Acute Myeloid Leukemia: A Report from the Children's Oncology Group

George S. Laszlo, PhD, Todd A. Alonzo, PhD, Chelsea J. Gudgeon, BS, Kimberly H. Harrington, BS, Alex Kentsis, MD PhD, Robert B. Gerbing, MA, Yi-Cheng Wang, MS, Rhonda E. Ries, MA, Susana C. Raimondi, PhD, Betsy A. Hirsch, PhD, Alan S. Gamis, MD MPH, Soheil Meshinchi, MD PhD, Roland B. Walter, MD PhD MS

Blood (2015) 126 (23): 2570.

https://doi.org/10.1182/blood.V126.23.2570.2570

Published: 2015

Journal Articles

Functional Proteomics of Regulatory and Epigenetic Signaling in Normal and Malignant Hematopoiesis

Paolo Cifani, PhD, Mojdeh Shakiba, Fiona Brown, PhD, Avantika Dhabaria, PhD, Daniel E. Bauer, MD, PhD, Alex Kentsis, MD PhD

Blood (2015) 126 (23): 4972.

https://doi.org/10.1182/blood.V126.23.4972.4972

Published: 2015

Journal Articles

Genomic and Proteomic Analysis of Primary Chemoresistance and Induction Failure in Acute Myeloid Leukemia

Blood (2015) 126 (23): 88.

https://doi.org/10.1182/blood.V126.23.88.88

Published: 2015

Journal Articles

Selective Inhibitor of Nuclear Export (SINE), Selinexor (KPT-330), Shows Remarkable Activity Against AML Leukemia-Initiating Cells

Julia Etchin, PhD, Bonnie Thi Le, M.S., Alex Kentsis, MD PhD, Marc R Mansour, MDPhD, Alla Berezovskaya, B.S., Richard M. Stone, MD, Ilene Galinsky, RNP, Daniel J. DeAngelo, MDPhD, Dilara McCauley, PhD, Michael Kauffman, MD PhD, Sharon Shacham, PhDMBA, Jean C.Y. Wang, MDPhD, Andrew L Kung, MD PhD, A. Thomas Look, MD

Blood (2014) 124 (21): 995.

https://doi.org/10.1182/blood.V124.21.995.995

Published: 2014

Journal Articles

Novel Inhibitors Of CRM1/XPO1 Nuclear Exporter Exhibit Striking Activity Against AML “primagrafts,” Including AML Leukemia Initiating Cells, While Sparing Normal Hematopoietic Cells

Julia Etchin, PhD, Bonnie Thi Le, M.S., Alex Kentsis, MD, PhD, Richard M. Stone, MD, Dilara McCauley, PhD, Michael Kauffman, MD, PhD, Sharon Shacham, PhD, MBA, Jean C.Y. Wang, MD PhD, Andrew L Kung, MD, PhD, A. Thomas Look, MD

Blood (2013) 122 (21): 3932.

https://doi.org/10.1182/blood.V122.21.3932.3932

Published: 2013

Journal Articles

Targeting Oncogenic Interleukein-7 Receptor Signaling With N-Acetylcysteine In T-Cell Acute Lymphoblastic Leukemia

Marc R. Mansour, MD PhD FRCPath, Casie Reed, Amy Eisenberg, Jen-Chieh Tseng, PhD, Akinori Yoda, PhD, Scott J Rodig, MD, PhD, Daniel J. DeAngelo, MD, Ph.D, Stephen E. Sallan, MD, David M. Weinstock, MD, Shai Izraeli, MD, Andrew L Kung, MD, PhD, Alex Kentsis, MD, PhD, Thomas Look, MD

Blood (2013) 122 (21): 2535.

https://doi.org/10.1182/blood.V122.21.2535.2535

Published: 2013

Journal Articles

Phenothiazines Induce Apoptosis in T-Cell Acute Lymphoblastic Leukemia by Activating the Phosphatase Activity of the PP2A Tumor Suppressor

Blood (2012) 120 (21): 3558.

https://doi.org/10.1182/blood.V120.21.3558.3558

Published: 2012

Journal Articles

KPT-SINE, a Potent, Small Molecule Inhibitor of CRM1-Dependent Nuclear-Cytoplasmic Shuttling, with Potent Activity Against T-ALL and AML

Julia Etchin, PhD, Alex Kentsis, MD, PhD, Takaomi Sanda, MD, PhD, Andrew L. Kung, MD, PhD, Richard M. Stone, MD, Dilara McCauley, Michael Kauffman, MD, Ph.D., Sharon Shacham, PhD, Thomas Look, MD

Blood (2011) 118 (21): 2622.

https://doi.org/10.1182/blood.V118.21.2622.2622

Published: 2011

Journal Articles

Combined Targeting of the MET and FGF Receptor Tyrosine Kinases Induces Sustained AML Cell Death by Preventing Compensatory Upregulation of HGF in Response to MET Kinase Inhibition

Alex Kentsis, MD, PhD, Takaomi Sanda, MD, PhD, Casie Reed, BS, Scott J. Rodig, MD, PhD, Eleni Tholouli, PhD, MRCPath, Vu Ngo, PhD, Jeffery Lorne Kutok, MD, PhD, Suzanne E. Dahlberg, PhD, Lisa A Moreau, PhD, George Vande Woude, PhD, James Christensen, MD, Richard Byers, PhD, MBChB, FRCPath, Andrew L. Kung, MD, PhD, Louis M. Staudt, MD., Ph.D., Thomas Look, MD

Blood (2011) 118 (21): 1405.

https://doi.org/10.1182/blood.V118.21.1405.1405

Published: 2011

Journal Articles

The BCL11B Tumor Suppressor Is Mutated In Human T-Cell Acute Lymphoblastic Leukemia

Alejandro Gutierrez, MD, Alex Kentsis, MD, PhD, Takaomi Sanda, MD, PhD, Julia Etchin, PhD, Alexei Protopopov, PhD, Jianhua Zhang, PhD, Lynda Chin, MD, Lewis B. Silverman, MD, Stuart Winter, MD, Stephen Hunger, MD, Stephen E. Sallan, MD, Shan Zha, PhD, Frederick Alt, PhD, A. Thomas Look, MD

Blood (2010) 116 (21): 4177.

https://doi.org/10.1182/blood.V116.21.4177.4177

Published: 2010

Journal Articles

Aberrant Expression of Hepatocyte Growth Factor Induces Autocrine MET Activation Providing a Novel Therapeutic Target In Acute Myeloid Leukemia.

Alex Kentsis, MD, PhD, Takaomi Sanda, MD, PhD, Vu Ngo, PhD, Scott J. Rodig, MD, PhD, Jeffery Kutok, MD, PhD, Eleni Tholouli, PhD, MRCPath, Richard Byers, PhD, MBChB, FRCPath, George Vande Woude, PhD, Andrew L. Kung, MD, PhD, Louis M. Staudt, MD, PhD, A. Thomas Look, MD

Blood (2010) 116 (21): 1042.

https://doi.org/10.1182/blood.V116.21.1042.1042

Published: 2010

NARROW

Functional Profiling of Patient AML Stem Cells Reveals Mechanisms of Epigenetic Plasticity Controlling Therapy Resistance

Rational Targeting of a NuRD Sub-Complex for Fetal Hemoglobin Induction Following Comprehensive in Situ Mutagenesis

Therapeutic Disassembly of Leukemogenic Enhancer Complexes

High-Resolution CRISPR Functional Genomics Reveals Critical Vulnerabilities of the NuRD Complex for Fetal Hemoglobin Control

Peptidomimetic Blockade of MYB in Acute Myeloid Leukemia

Non-Catalytic Role of SETD1A Regulates DNA Repair in Leukemia

Comprehensive Genomic Profiling for Improved Diagnosis and Therapy of Pediatric Acute Leukemias

Aberrant Phosphorylation of MEF2C Is Dispensable for Hematopoiesis, and Induces Chemotherapy Resistance and Susceptibility to MARK Kinase Inhibition Therapy in Acute Myeloid Leukemia

Ribosomal Protein Rpl22 Regulates Development and Transformation Via Altering RNA Processing

High Expression of Myocyte Enhancer Factor 2C ( MEF2C ) Is Associated with Adverse Risk Features and Poor Outcome in Pediatric Acute Myeloid Leukemia: A Report from the Children's Oncology Group

Functional Proteomics of Regulatory and Epigenetic Signaling in Normal and Malignant Hematopoiesis

Genomic and Proteomic Analysis of Primary Chemoresistance and Induction Failure in Acute Myeloid Leukemia

Selective Inhibitor of Nuclear Export (SINE), Selinexor (KPT-330), Shows Remarkable Activity Against AML Leukemia-Initiating Cells

Novel Inhibitors Of CRM1/XPO1 Nuclear Exporter Exhibit Striking Activity Against AML “primagrafts,” Including AML Leukemia Initiating Cells, While Sparing Normal Hematopoietic Cells

Targeting Oncogenic Interleukein-7 Receptor Signaling With N-Acetylcysteine In T-Cell Acute Lymphoblastic Leukemia

Phenothiazines Induce Apoptosis in T-Cell Acute Lymphoblastic Leukemia by Activating the Phosphatase Activity of the PP2A Tumor Suppressor

KPT-SINE, a Potent, Small Molecule Inhibitor of CRM1-Dependent Nuclear-Cytoplasmic Shuttling, with Potent Activity Against T-ALL and AML

Combined Targeting of the MET and FGF Receptor Tyrosine Kinases Induces Sustained AML Cell Death by Preventing Compensatory Upregulation of HGF in Response to MET Kinase Inhibition

The BCL11B Tumor Suppressor Is Mutated In Human T-Cell Acute Lymphoblastic Leukemia

Aberrant Expression of Hepatocyte Growth Factor Induces Autocrine MET Activation Providing a Novel Therapeutic Target In Acute Myeloid Leukemia.

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American Society of Hematology

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American Society of Hematology

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