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Journal Articles

Clinical ALK5 Inhibitor, Vactosertib, Reverses TGFβ-1 Stimulated Smad-2 Driven Ineffective Hematopoiesis in MDS

Srinivas Aluri, Kimo Bachiashvili, MD, Anjali Budhathoki, MD, Tushar D Bhagat, PhD, Gaurav S Choudhary, PhD, Shanisha Gordon, Nandini Ramachandra, Kith Pradhan, PhD, Shahina Maqbool, Aditi Shastri, MD, Jung Im Huh, Sunjin Hwang, Kim Seong-Jin, PhD, Hui Zhang, Britta Will, PhD, Amittha Wickrema, PhD, Ulrich G. Steidl, MD PhD, Amit Verma, MBBS

Blood (2019) 134 (Supplement_1): 2990.

https://doi.org/10.1182/blood-2019-127561

Published: 2019

Journal Articles

SF3B1 Mutations Induce Oncogenic IRAK4 Isoforms and Activate Targetable Innate Immune Pathways in MDS and AML

Blood (2019) 134 (Supplement_1): 4224.

https://doi.org/10.1182/blood-2019-124458

Published: 2019

Journal Articles

Reduced Expression of DOCK4 Leads to Increased Protein Phosphorylation and Migration of Hematopoietic Stem/Progenitor Cells

Sriram Sundaravel, MS, Wen Liang-Kuo, PhD, Hui Liu, MS, Jong Jeong, PhD, Gaurav Choudhary, PhD, Tushar Damodar Bhagat, PhD, Shanisha Gordon, Amit Verma, MD, Amittha Wickrema, PhD

Blood (2018) 132 (Supplement 1): 2563.

https://doi.org/10.1182/blood-2018-99-114320

Published: 2018

Journal Articles

Identifying Inherited and Acquired Genetic Factors Involved in Poor Stem Cell Mobilization and Donor-Derived Malignancy

Katarzyna Rojek, BS, Eric Nickels, Barbara Niestadt, Rafael Marquez, Amittha Wickrema, PhD, Andrew Artz, MD MS, Koen van Besien, MD, Ming K Lee, Jeremy P. Segal, MD PhD, Mary-Claire King, Tom Walsh, Akiko Shimamura, MD PhD, Sioban Keel, MD, Jane E Churpek, MD, Lucy A Godley, MD PhD

Blood (2015) 126 (23): 3163.

https://doi.org/10.1182/blood.V126.23.3163.3163

Published: 2015

Journal Articles

Myelodysplastic Syndrome Marrow Stroma Shows Widespread Aberrant Hypermethylation That Is Abrogated By Treatment with Dnmt Inhibitors

Tushar D Bhagat, PhD, Matthias Bartenstein, MD, Yiting Yu, PhD, A. Mario Q. Marcondes, MD PhD, Britta Will, PhD, Orsolya Giricz, PhD, Davendra P. Sohal, MD MPH, Ioannis Mantzaris, MD, Amittha Wickrema, PhD, Christine Mcmahon, MD, Yeung Cecilia, MD, John Greally, MB, PhD, Siddhartha Mukherjee, MD PhD, Ulrich Steidl, MD PhD, H. Joachim Deeg, MD, Amit Verma, MD

Blood (2014) 124 (21): 4379.

https://doi.org/10.1182/blood.V124.21.4379.4379

Published: 2014

Journal Articles

Haplo-Cord UCB SCT with Low Cell Dose, Well Matched UCB Units. a Prospective Multicenter Study

Koen van Besien, MD PhD, Hongtao Liu, MD PhD, Usama Gergis, MD, Melissa M. Cushing, MD, Stephanie Tsai, MD, Sebastian Mayer, MD, Amittha Wickrema, PhD, Wendy Stock, MD, Richard A. Larson, Tsiporah B. Shore, MD, Olatoyosi Odenike, MD, Roger N Pearse, MD PhD, Lucy A Godley, MD PhD, Tomer M Mark, MD MSc, Justin Kline, MD, John M Cunningham, MD, James LaBelle, MD PhD, Michael R Bishop, MD, Andrew S. Artz, MD MS

Blood (2014) 124 (21): 1093.

https://doi.org/10.1182/blood.V124.21.1093.1093

Published: 2014

Journal Articles

Frequency and Risk Factors of Cord Graft Failure (CGF) Following Reduced Intensity Conditioning Haplo-Cord Hematopoietic Stem Cell Transplantation

Stephanie B. Tsai, MD MA, Hongtao Liu, MD PhD, Tsiporah B. Shore, MD, Michael R Bishop, MD, Melissa M. Cushing, MD, Yun Fan, MD, Usama Gergis, MD, Lucy A Godley, MD PhD, Justin Kline, MD, Richard A. Larson, Guadalupe G. Martinez, BS, Sebastian Mayer, MD, Olatoyosi Odenike, MD, Wendy Stock, MD, Amittha Wickrema, PhD, Koen van Besien, MD PhD, Andrew S. Artz, MD MS

Blood (2014) 124 (21): 2463.

https://doi.org/10.1182/blood.V124.21.2463.2463

Published: 2014

Journal Articles

Characterization of Tcra and Tcrb Repertoires in Acute Myeloid Leukemia Patients before and after Combined Haploidentical and Umbilical Cord Blood Transplant

Houda Alachkar, PharmD, PhD, Poh-Yin Yew, PhD, Rui Yamaguch, Kazuma Kiyotani, Hongtao Liu, MDPhD, Andrew S. Artz, MD MS, Amittha Wickrema, PhD, Koen van Besien, MD, Michael R Bishop, MD, Satoru Miyano, PhD, Wendy Stock, MD, Yusuke Nakamura, MD PhD

Blood (2014) 124 (21): 2503.

https://doi.org/10.1182/blood.V124.21.2503.2503

Published: 2014

Journal Articles

Unexplained Anemia In The Elderly Is Due To An Intrinsic Defect In Hematopoietic Stem Cells

Wendy W. Pang, M.D., Ph.D., John V. Pluvinage, Yasuo Mori, M.D., Ph.D., Elizabeth Price, MD, MPH, Amittha Wickrema, PhD, Oyebimpe Adensina, M.D., Andrew Artz, MD, Irving L. Weissman, MD, Stanley L. Schrier, MD

Blood (2013) 122 (21): 2187.

https://doi.org/10.1182/blood.V122.21.2187.2187

Published: 2013

Journal Articles

Pilot Study Of Regulatory T Cell Depletion In The Setting Of Autologous Stem Cell Transplantation For Multiple Myeloma

Gottfried von Keudell, MD, PhD, Cara A Rosenbaum, MD, Todd M. Zimmerman, MD, Michael Bishop, MD, Koen van Besien, MD, Rebecca Malloy, RN, BSN, Amittha Wickrema, PhD, Andrzej Jakubowiak, MD, PhD, Justin Paul Kline, MD

Blood (2013) 122 (21): 4607.

https://doi.org/10.1182/blood.V122.21.4607.4607

Published: 2013

Journal Articles

Aberrant Expression of DOCK4 Leads to Disruption of the F-Actin Skeleton and Altered Membrane Stability in MDS Erythroblasts and Mature Erythrocytes

Sriram Sundaravel, MS, Tushar D. Bhagat, MS, Carolina Schinke, M.D., David Ebenezer, Hui Liu, MS, Yiting Yu, PhD, Andrea Pellagatti, PhD, Jacqueline Boultwood, MD, Vijay Yajnik, MD, Ph.D, Andrew Artz, MD MS, Amit Verma, Amittha Wickrema, PhD

Blood (2012) 120 (21): 924.

https://doi.org/10.1182/blood.V120.21.924.924

Published: 2012

Journal Articles

Mir-21 Mediates Hematopoietic Suppression in MDS by Activating TGF-b Signaling,

Tushar D. Bhagat, M.S., Li Zhou, PhD, Lubomir Sokol, MD, PhD, Ioannis Mantzaris, MD, Krishna Gundabolu, MD, Shanisha A. K. Gordon, Yiting Yu, PhD, Sangeeta Nischal, Ph.D., Rahul Polineni, MD, Carolina Schinke, M.D., Grigorios Chrysofakis, M.D., Amittha Wickrema, PhD, Andrea Pellagatti, Jacqueline Boultwood, PhD, Ulrich G Steidl, MD, PhD, Gang Liu, MD., Ph.D., Alan F List, MD, Markus Bitzer, M.D., Amit Verma, MD

Blood (2011) 118 (21): 3813.

https://doi.org/10.1182/blood.V118.21.3813.3813

Published: 2011

Journal Articles

Vacuolin-1 Promotes Enucleation of Cultured Human and Murine Erythroblasts

Ganesan Keerthivasan, MBBS, MD, Barbara Ghinassi, PhD, John S. Wilmes, Amittha Wickrema, PhD, Anna Rita F Migliaccio, PhD, Mark-Eugene Duban, John Crispino, PhD

Blood (2011) 118 (21): 2321.

https://doi.org/10.1182/blood.V118.21.2321.2321

Published: 2011

Journal Articles

Reduced Intensity Conditioning with Combined Haploidentical and Cord Blood Transplantation Results in Rapid Engraftment and Durable Remissions in Hematological Malignancies

Hongtao Liu, MD, PhD, Elizabeth Shima Rich, MD, PhD, Lucy Godley, MD, PhD, Olatoyosi Odenike, MD, Loren Joseph, M.D., Susana Marino, M.D., Justin Kline, MD, Vu H. Nguyen, MD, John M Cunningham, MD, Richard A. Larson, MD, Paula Del Cerro, RN, Linda Schroeder, RN, Lisa Pape, RN, Wendy Stock, MD, Amittha Wickrema, PhD, Andrew Artz, MD MS, Koen M. Van Besien, MD

Blood (2011) 118 (21): 830.

https://doi.org/10.1182/blood.V118.21.830.830

Published: 2011

Journal Articles

Mimetic Peptide to CDK Inhibitor p16 INK4a Induces Cell Death In Mantle Cell Lymphoma Cells: A New Strategy to Eradicate Minimal Residual Disease

Hongtao Liu, MD, PhD, Greg Koval, MS, Greg Malnassy, MS, Pamela Ihonor, MS, Hui Liu, MS, Roger Luo, PhD, Amittha Wickrema, PhD, Steven Dowdy, PhD, Michael Thirman, MD, Koen van Besien, MD, Wendy Stock, MD

Blood (2010) 116 (21): 3921.

https://doi.org/10.1182/blood.V116.21.3921.3921

Published: 2010

Journal Articles

Phase I-II Study of Clofarabine-Melphalan-Alemtuzumab (CMA) Conditioning for Allogeneic Hematopoietic Cell Transplantation (HCT) in Patients with Advanced Hematologic Malignancies: Determination of MTD and Outcomes.

Koen van Besien, MD, Justin Kline, Lucy A Godley, MD, PhD, Richard A. Larson, MD, Vu H. Nguyen, MD, Olatoyosi Odenike, MD, Elizabeth Shima Rich, MD, PhD, Wendy Stock, MD, Amittha Wickrema, PhD, Scott Allen, BA, Paula del Cerro, Sarah Horowitz, Lisa Pape, RN, Linda Schroeder, RN, Andrew Artz, MD, MS

Blood (2009) 114 (22): 197.

https://doi.org/10.1182/blood.V114.22.197.197

Published: 2009

Journal Articles

Dysregulation of TGF-Beta Stimulated Smad Signaling Is Seen in Myelodysplasia and Points to the Potential Therapeutic Efficacy of TGF-Beta Receptor I Kinase Inhibition in Low Grade Disease.

Blood (2009) 114 (22): 737.

https://doi.org/10.1182/blood.V114.22.737.737

Published: 2009

Journal Articles

Allogeneic Hematopoietic Cell Transplantation From Combined Haploidentical Family Members and Unrelated Cord Blood (CB) Can Benefit High Risk Patients Lacking HLA-Identical Donors.

Elizabeth Shima Rich, MD, PhD, Andrew Artz, MD, MS, Theodore Karrison, Ph.D., Lucy A Godley, MD, PhD, Olatoyosi Odenike, MD, Loren Joseph, MD, Justin Kline, MD, Vu H. Nguyen, MD, Guadalupe Martinez, BS, Paula del Cerro, RN, Lisa Pape, RN, Linda Schroeder, RN, Scott Allen, BA, Sarah Horowitz, BA, John Cunningham, MD, Richard A. Larson, MD, Wendy Stock, MD, Amittha Wickrema, PhD, Koen van Besien, MD

Blood (2009) 114 (22): 3378.

https://doi.org/10.1182/blood.V114.22.3378.3378

Published: 2009

Journal Articles

Preliminary Results of Combined Haploidentical-Cord Blood Transplantation for Patients Lacking HLA Identical Donors

Elizabeth Shima Rich, MD, PhD, Andrew Artz, MD, MS, Theodore Karrison, PhD, Amittha Wickrema, PhD, Loren Joseph, PhD, Lucy Godley, MD, PhD, Olatoyosi Odenike, MD, Justin Kline, MD, Paula del Cerro, RN, John M Cunningham, MD, Richard A. Larson, MD, Wendy Stock, MD, Koen van Besien, MD

Blood (2008) 112 (11): 3015.

https://doi.org/10.1182/blood.V112.11.3015.3015

Published: 2008

Journal Articles

Clofarabine-Melphalan-Alemtuzumab Conditioning for Allogeneic Hematopoietic Cell Transplantation (Hct) in Patients with Advanced Hematologic Malignancies: A Phase I–II Study

Koen Van Besien, Frederick Locke, MD, Justin Kline, Lucy Godley, MD, PhD, Richard A. Larson, MD, Olatoyosi Odenike, MD, Elizabeth Shima Rich, MD, PhD, Wendy Stock, MD, Amittha Wickrema, PhD, Andrew Artz, MD, MS

Blood (2008) 112 (11): 4381.

https://doi.org/10.1182/blood.V112.11.4381.4381

Published: 2008

NARROW

Clinical ALK5 Inhibitor, Vactosertib, Reverses TGFβ-1 Stimulated Smad-2 Driven Ineffective Hematopoiesis in MDS

SF3B1 Mutations Induce Oncogenic IRAK4 Isoforms and Activate Targetable Innate Immune Pathways in MDS and AML

Reduced Expression of DOCK4 Leads to Increased Protein Phosphorylation and Migration of Hematopoietic Stem/Progenitor Cells

Identifying Inherited and Acquired Genetic Factors Involved in Poor Stem Cell Mobilization and Donor-Derived Malignancy

Myelodysplastic Syndrome Marrow Stroma Shows Widespread Aberrant Hypermethylation That Is Abrogated By Treatment with Dnmt Inhibitors

Haplo-Cord UCB SCT with Low Cell Dose, Well Matched UCB Units. a Prospective Multicenter Study

Frequency and Risk Factors of Cord Graft Failure (CGF) Following Reduced Intensity Conditioning Haplo-Cord Hematopoietic Stem Cell Transplantation

Characterization of Tcra and Tcrb Repertoires in Acute Myeloid Leukemia Patients before and after Combined Haploidentical and Umbilical Cord Blood Transplant

Unexplained Anemia In The Elderly Is Due To An Intrinsic Defect In Hematopoietic Stem Cells

Pilot Study Of Regulatory T Cell Depletion In The Setting Of Autologous Stem Cell Transplantation For Multiple Myeloma

Aberrant Expression of DOCK4 Leads to Disruption of the F-Actin Skeleton and Altered Membrane Stability in MDS Erythroblasts and Mature Erythrocytes

Mir-21 Mediates Hematopoietic Suppression in MDS by Activating TGF-b Signaling,

Vacuolin-1 Promotes Enucleation of Cultured Human and Murine Erythroblasts

Reduced Intensity Conditioning with Combined Haploidentical and Cord Blood Transplantation Results in Rapid Engraftment and Durable Remissions in Hematological Malignancies

Mimetic Peptide to CDK Inhibitor p16 INK4a Induces Cell Death In Mantle Cell Lymphoma Cells: A New Strategy to Eradicate Minimal Residual Disease

Phase I-II Study of Clofarabine-Melphalan-Alemtuzumab (CMA) Conditioning for Allogeneic Hematopoietic Cell Transplantation (HCT) in Patients with Advanced Hematologic Malignancies: Determination of MTD and Outcomes.

Dysregulation of TGF-Beta Stimulated Smad Signaling Is Seen in Myelodysplasia and Points to the Potential Therapeutic Efficacy of TGF-Beta Receptor I Kinase Inhibition in Low Grade Disease.

Allogeneic Hematopoietic Cell Transplantation From Combined Haploidentical Family Members and Unrelated Cord Blood (CB) Can Benefit High Risk Patients Lacking HLA-Identical Donors.

Preliminary Results of Combined Haploidentical-Cord Blood Transplantation for Patients Lacking HLA Identical Donors

Clofarabine-Melphalan-Alemtuzumab Conditioning for Allogeneic Hematopoietic Cell Transplantation (Hct) in Patients with Advanced Hematologic Malignancies: A Phase I–II Study

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American Society of Hematology

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American Society of Hematology

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