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Journal Articles

Synergistic Platelet Inhibitory Effects of Riociguat and Nitric Oxide Are Decreased By Protein Binding

Yifeng WU, MD, Alan D Michelson, MD, Andrew L Frelinger, III, PhD

Blood (2018) 132 (Supplement 1): 4971.

https://doi.org/10.1182/blood-2018-99-117070

Published: 2018

Journal Articles

Elipsis: A Longitudinal Study of Electronic Patient-Reported Outcomes, Actigraphy and Biomarkers to Identify and Assess at-Home Vaso-Occlusive Crises in Adults and Adolescents with Sickle Cell Disease

Michael U. Callaghan, Patrick C. Hines, MD PhD, Debra D Pittman, MS, David Beidler, PhD, Denis Rybin, PhD, Ahmar Urooj Zaidi, MD BSc, Jennell White, PhD, Ke Liu, PhD, Bryan Hannan, MS, Xiufeng Gao, MD, Andreas M Pleil, PhD, Alexandra Barsdorf, PhD, Martin David, Pharm D, Melanie Simmons, PMP, PSM, Andrew L Frelinger, III, PhD, Alan D Michelson, MD, Nick Clarke, PhD, Robert J Charnigo, MS

Blood (2017) 130 (Supplement 1): 973.

https://doi.org/10.1182/blood.V130.Suppl_1.973.973

Published: 2017

Journal Articles

A Phase 1b, Randomized, Double-Blind, Placebo-Controlled Study of PF-04447943 in Patients with Stable Sickle Cell Disease: Changes in Exploratory Biomarkers

Robert J Charnigo, MS, Jo Howard, MBBCh, David Beidler, PhD, Denis Rybin, PhD, Beesan Tan, PhD, Alan D Michelson, MD, Andrew L Frelinger, III, PhD, Nicholas Clarke, PhD

Blood (2017) 130 (Supplement 1): 974.

https://doi.org/10.1182/blood.V130.Suppl_1.974.974

Published: 2017

Journal Articles

Mass Cytometry of Platelets: Simultaneous Functional and Phenotypic Analysis of Multiple Surface Markers in Healthy Subjects and Patients with Inherited Platelet Disorders Reveals Novel Platelet Sub-Populations

Thomas A. Blair, PhD, Alan D Michelson, MD, Andrew L Frelinger, III, PhD

Blood (2017) 130 (Supplement 1): 2311.

https://doi.org/10.1182/blood.V130.Suppl_1.2311.2311

Published: 2017

Journal Articles

Platelet Function in Thrombocytopenic Patients with Chronic Liver Disease

Elena Smolensky Koganov, PhD, Sabrina L Carmichael, BS, Emma E Forde, BS, Andrew L Frelinger, III, PhD, Alan D Michelson, MD

Blood (2017) 130 (Supplement 1): 2314.

https://doi.org/10.1182/blood.V130.Suppl_1.2314.2314

Published: 2017

Journal Articles

Avatrombopag, a Novel Thrombopoietin Receptor Agonist, Increases Platelet Counts without Increasing Platelet Activation in Patients with Thrombocytopenia Due to Chronic Liver Disease

Andrew L Frelinger, III, PhD, Elena Smolensky Koganov, PhD, Emma E Forde, BS, Sabrina L Carmichael, BS, Alan D Michelson, MD

Blood (2017) 130 (Supplement 1): 290.

https://doi.org/10.1182/blood.V130.Suppl_1.290.290

Published: 2017

Journal Articles

GLS-409, a Synergistic Inhibitor of Both P2Y 1 and P2Y 12 : Efficacy in a Canine Model of Recurrent Coronary Thrombosis and Reversibility of Human Platelet Inhibition

Elena Smolensky Koganov, PhD, Alan D Michelson, MD, Ivan B Yanachkov, PhD, Milka I Yanachkova, PhD, George E Wright, PhD, Karin Przyklenk, PhD, Andrew L Frelinger, III, PhD

Blood (2017) 130 (Supplement 1): 630.

https://doi.org/10.1182/blood.V130.Suppl_1.630.630

Published: 2017

Journal Articles

The Platelet Phenotype of Children with ITP Is Consistent over Time and Is Associated with Both Concurrent and Subsequent Bleeding Severity

Andrew L. Frelinger, III, PhD, Rachael F Grace, MD, Anja J. Gerrits, PhD, Sabrina L Carmichael, BS, Emma E Forde, BS, Alan D. Michelson, MD

Blood (2016) 128 (22): 2550.

https://doi.org/10.1182/blood.V128.22.2550.2550

Published: 2016

Journal Articles

Hypoxia Reoxygenation Treatment Induces Platelet Hyperactivity and Relieves Calpain-1-Mediated Inhibition of Platelet Aggregation in a Mouse Model of Severe Sickle Cell Disease

Jennifer O. Nwankwo, BS, Rod R. Warburton, BA, Thomas Gremmel, MD, Anja J. Gerrits, PhD, Lauren J. Richey, DVM, PhD, Nicholas S. Hill, MD, Alicia Rivera, Joseph A. Jakubowski, PhD, Andrew L. Frelinger, III, PhD, Athar H. Chishti, PhD

Blood (2015) 126 (23): 413.

https://doi.org/10.1182/blood.V126.23.413.413

Published: 2015

Journal Articles

Effects Of Eltrombopag On Thrombocytopenia, Platelet Function and Bleeding In Patients With Wiskott-Aldrich Syndrome/X-Linked Thrombocytopenia

Anja J Gerrits, PhD, Emily Leven, Andrew L. Frelinger, III, PhD, Michelle A. Berny-Lang, PhD, Hannah Tamary, MD, Shoshana Revel-Vilk, MD, MSc, Sabrina L. Carmichael, BS, W. Beau Mitchell, MD, Alan D. Michelson, MD, James B Bussel, MD

Blood (2013) 122 (21): 3536.

https://doi.org/10.1182/blood.V122.21.3536.3536

Published: 2013

Journal Articles

Association Of Platelet Function Markers, Independent Of Platelet Count, With Bleeding Score In Patients With Immune Thrombocytopenia

Andrew L. Frelinger, III, PhD, Anja J Gerrits, PhD, Michelle A. Berny-Lang, PhD, Travis Brown, Sabrina L. Carmichael, BS, Ellis J. Neufeld, MD, PhD, Alan D. Michelson, MD, Rachael F. Grace, MD

Blood (2013) 122 (21): 3534.

https://doi.org/10.1182/blood.V122.21.3534.3534

Published: 2013

Journal Articles

Platelet Activation and Inhibition in Sickle Cell Disease (PAINS) Study

Andrew L. Frelinger, III, PhD, Joseph A. Jakubowski, PhD, Julie K. Brooks, MS, Sabrina L. Zayas, BS, Michelle A. Berny-Lang, PhD, Marc R. Barnard, MS, Matthew M. Heeney, MD, Alan D. Michelson, MD

Blood (2012) 120 (21): 5147.

https://doi.org/10.1182/blood.V120.21.5147.5147

Published: 2012

Journal Articles

Clopidogrel Pharmacokinetics and Pharmacodynamics Vary Widely Despite Exclusion or Control of Polymorphisms ( CYP2C19 , ABCB1 , PON1 ), Non-Compliance, Diet, Smoking, Co-Medications (including Proton Pump Inhibitors), and Pre-Existent Variability in Platelet Function

Andrew L. Frelinger, III, PhD, Deepak L. Bhatt, MD, MPH, Ronald D. Lee, PhD, Darcy J. Mulford, PhD, Jingtao Wu, PhD, Sai Nudurupati, PhD, Anu Nigam, MS, Michael Lampa, BS, Julie K. Brooks, MS, Marc R. Barnard, MS, Alan D. Michelson, MD

Blood (2012) 120 (21): 4356.

https://doi.org/10.1182/blood.V120.21.4356.4356

Published: 2012

Journal Articles

A Phase 1 Study of Prasugrel in Subjects with Sickle Cell Disease: Impact on Ex Vivo Platelet Reactivity

Joseph A. Jakubowski, PhD, Chunmei Zhou, MS, David S. Small, PhD, Kenneth J. Winters, MD, D. Richard Lachno, DPhil, Andrew L. Frelinger, III, PhD, Jo Howard, MB, BChir, MRCP, FRCPath, Stipo Jurcevic, MD, Christopher D. Payne, MSc

Blood (2011) 118 (21): 1053.

https://doi.org/10.1182/blood.V118.21.1053.1053

Published: 2011

Journal Articles

A Phase 1 Study of Prasugrel in Subjects with Sickle Cell Disease: Effects on In Vivo Markers of Platelet Activation and of Coagulation

Blood (2011) 118 (21): 1049.

https://doi.org/10.1182/blood.V118.21.1049.1049

Published: 2011

Journal Articles

In Vivo Platelet Activation and Its In Vitro Inhibition by Prasugrel's Active Metabolite In Adolescents with Sickle Cell Disease

Andrew L. Frelinger, III, PhD, Joseph A. Jakubowski, PhD, Julie K. Brooks, MS, Anu Nigam, MS, Michelle A. Berny-Lang, Ph.D., Marc R. Barnard, MS, Matthew M. Heeney, MD, Alan D. Michelson, MD

Blood (2011) 118 (21): 2141.

https://doi.org/10.1182/blood.V118.21.2141.2141

Published: 2011

Journal Articles

Platelet Function and Response to Thrombopoietin Mimetics In Wiskott-Aldrich Syndrome/X-Linked Thrombocytopenia.

James B. Bussel, MD, Andrew L Frelinger, III, PhD, William B Mitchell, MD, Mariana P Pinheiro, MD, Marc R Barnard, MS, Michael Lampa, BS, Bethan Psaila, MD, PhD, Nayla Boulad, BA, Hannah Tamary, MD, Alan D. Michelson, MD

Blood (2010) 116 (21): 1429.

https://doi.org/10.1182/blood.V116.21.1429.1429

Published: 2010

NARROW

Synergistic Platelet Inhibitory Effects of Riociguat and Nitric Oxide Are Decreased By Protein Binding

Elipsis: A Longitudinal Study of Electronic Patient-Reported Outcomes, Actigraphy and Biomarkers to Identify and Assess at-Home Vaso-Occlusive Crises in Adults and Adolescents with Sickle Cell Disease

A Phase 1b, Randomized, Double-Blind, Placebo-Controlled Study of PF-04447943 in Patients with Stable Sickle Cell Disease: Changes in Exploratory Biomarkers

Mass Cytometry of Platelets: Simultaneous Functional and Phenotypic Analysis of Multiple Surface Markers in Healthy Subjects and Patients with Inherited Platelet Disorders Reveals Novel Platelet Sub-Populations

Platelet Function in Thrombocytopenic Patients with Chronic Liver Disease

Avatrombopag, a Novel Thrombopoietin Receptor Agonist, Increases Platelet Counts without Increasing Platelet Activation in Patients with Thrombocytopenia Due to Chronic Liver Disease

GLS-409, a Synergistic Inhibitor of Both P2Y 1 and P2Y 12 : Efficacy in a Canine Model of Recurrent Coronary Thrombosis and Reversibility of Human Platelet Inhibition

The Platelet Phenotype of Children with ITP Is Consistent over Time and Is Associated with Both Concurrent and Subsequent Bleeding Severity

Hypoxia Reoxygenation Treatment Induces Platelet Hyperactivity and Relieves Calpain-1-Mediated Inhibition of Platelet Aggregation in a Mouse Model of Severe Sickle Cell Disease

Effects Of Eltrombopag On Thrombocytopenia, Platelet Function and Bleeding In Patients With Wiskott-Aldrich Syndrome/X-Linked Thrombocytopenia

Association Of Platelet Function Markers, Independent Of Platelet Count, With Bleeding Score In Patients With Immune Thrombocytopenia

Platelet Activation and Inhibition in Sickle Cell Disease (PAINS) Study

Clopidogrel Pharmacokinetics and Pharmacodynamics Vary Widely Despite Exclusion or Control of Polymorphisms ( CYP2C19 , ABCB1 , PON1 ), Non-Compliance, Diet, Smoking, Co-Medications (including Proton Pump Inhibitors), and Pre-Existent Variability in Platelet Function

A Phase 1 Study of Prasugrel in Subjects with Sickle Cell Disease: Impact on Ex Vivo Platelet Reactivity

A Phase 1 Study of Prasugrel in Subjects with Sickle Cell Disease: Effects on In Vivo Markers of Platelet Activation and of Coagulation

In Vivo Platelet Activation and Its In Vitro Inhibition by Prasugrel's Active Metabolite In Adolescents with Sickle Cell Disease

Platelet Function and Response to Thrombopoietin Mimetics In Wiskott-Aldrich Syndrome/X-Linked Thrombocytopenia.

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American Society of Hematology

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American Society of Hematology

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