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Journal Articles

Preclinical Rationale for the Use of Crizanlizumab (SEG101) in Myelofibrosis

Paola Verachi, Fabrizio Martelli, PhD, Maria Zingariello, PhD, Shalini Chaturvedi, Celine Wilke, MD, Valerie Campello-Iddison, MD, Anna Rita Migliaccio, PhD

Blood (2020) 136 (Supplement 1): 26–27.

https://doi.org/10.1182/blood-2020-133896

Published: 2020

Journal Articles

Inhibition of P-Selectin Rescues the Phenotype of a Novel Genetic Animal Model for Idiopathic Pulmonary Fibrosis

Francesca Gobbo, Paola Verachi, Barbara Bacci, PhD, Maria Zingariello, PhD, Angelo Peli, PhD, Carolyn Mead-Harvey, MS, Amylou C. Dueck, PhD, Giuseppe Sarli, PhD, Anna Rita Migliaccio, PhD

Blood (2020) 136 (Supplement 1): 29.

https://doi.org/10.1182/blood-2020-133898

Published: 2020

Journal Articles

Rationale for and Results of a Phase I Study of the TGF-β 1/3 Inhibitor AVID200 in Subjects with Myelofibrosis: MPN-RC 118 Trial

John Mascarenhas, MD, Heidi E. Kosiorek, MS, Lilian Varricchio, PhD, Rupali Bhave, MD, Andrew T. Kuykendall, MD, Rami Komrokji, MD, Aaron T. Gerds, MDMS, Jeanne M. Palmer, MD, Amelia R. Gabler, Lonette Sandy, Anna Rita Migliaccio, PhD, Mohamed E Salama, MD, Rona Singer Weinberg, PhD, Maureen O'Connor-McCourt, PhD, Gilles Tremblay, PhD, Paul I. Nadler, MD, Amylou C. Dueck, PhD, Ruben A. Mesa, MD FACP, Ronald Hoffman, MD

Blood (2020) 136 (Supplement 1): 6–8.

https://doi.org/10.1182/blood-2020-140830

Published: 2020

Journal Articles

Altered Megakaryocytes Are Associated with Development of Pulmonary Fibrosis in Mice Carrying the Hypomorphic Gata1 low Mutation

Barbara Bacci, PhD, Francesca Gobbo, Mariana Roccaro, Angelo Peli, PhD, Maria Zingariello, PhD, Fabrizio Martelli, PhD, Paola Verachi, Claudio Bardelli, PhD, Maria Mazzarini, Giuseppe Sarli, PhD, Anna Rita Migliaccio, PhD

Blood (2019) 134 (Supplement_1): 2336.

https://doi.org/10.1182/blood-2019-123994

Published: 2019

Journal Articles

Human GATA1 Driven By the Human Μicro LCR/β-Globin Promoter Rescues the Erythroid but Not the Megakaryocytic Phenotype Induced in Mice By the Gata1 low Mutation

Maria Zingariello, Laura Sancillo, Fabrizio Martelli, Rosa Alba Rana, Laura Calabresi, PhD BSc, Niccolò Bartalucci, PhDBSc, Alessandro M. Vannucchi, MD, George Stamatoyannopoulos, Anna Rita Migliaccio, PhD

Blood (2018) 132 (Supplement 1): 1042.

https://doi.org/10.1182/blood-2018-99-115970

Published: 2018

Journal Articles

The Hypomorphic Gata1 low Mutation Induces Fibrosis in Multiple Organs

Maria Zingariello, Laura Sancillo, Fabrizio Martelli, Paola Verachi, Claudio Bardelli, Mauro Valeri, Yujin Hoshida, Fiorella Ciaffoni, Manuela Marra, Rosa Alba Rana, Anna Rita Migliaccio, PhD

Blood (2018) 132 (Supplement 1): 3059.

https://doi.org/10.1182/blood-2018-99-110927

Published: 2018

Journal Articles

AVID200, a Potent Trap for TGF-β Ligands Inhibits TGF-β1 Signaling in Human Myelofibrosis

Lilian Varricchio, PhD, John Mascarenhas, MD, Anna Rita Migliaccio, PhD, Maureen O'Connor-McCourt, PhD, Gilles Tremblay, Jean-François Denis, Camelia Iancu-Rubin, PhD, Ronald Hoffman, MD

Blood (2018) 132 (Supplement 1): 1791.

https://doi.org/10.1182/blood-2018-99-116474

Published: 2018

Journal Articles

Systematic Analyses of Clinically Relevant Single Nucleotide Polymorphisms (SNPs) of NR3C1 in Patients from the Italian Registry of Diamond Blackfan Anemia

Jiawen Li, Mayte Suarez-Farinas, Stuart Scott, PhD, Lilian Varricchio, Carolyn F. Whitsett, MD, Ugo Ramenghi, MD, Irma Dianzani, Anna Rita Migliaccio, PhD

Blood (2017) 130 (Supplement 1): 2200.

https://doi.org/10.1182/blood.V130.Suppl_1.2200.2200

Published: 2017

Journal Articles

Shared and Tissue-Specific Genetic Features of Primary Myelofibrosis, Hepatic Fibrosis, Idiopathic Pulmonary Fibrosis and Kidney Fibrosis

Anders B Dohlman, MS, Rosa S Kim, Hadassa Hirschfield, Lilian Varricchio, Fiorella Ciaffoni, Massimiliano Dall'ora, Yujin Hoshida, Naftali Kaminski, Giovanni Barosi, MD, Vittorio Rosti, MD, Scott Friedman, Ronald Hoffman, MD, Anna Rita Migliaccio, PhD

Blood (2017) 130 (Supplement 1): 4196.

https://doi.org/10.1182/blood.V130.Suppl_1.4196.4196

Published: 2017

Journal Articles

Phosphoproteomic Landscaping Unveils Constitutive cKIT Activation in Human Erythroblasts from Polycythemia Vera (PV) Patients

Lilian Varricchio, PhD, Giulia Federici, PhD, Francesca Masiello, MS, Fabrizio Martelli, PhD, Mario Falchi, PhD, Orietta Picconi, Gabriella Girelli, MD, Agostino Tafuri, MD, Emanuel Petricoin III, PhD, Ann Zeuner, PhD, Anna Rita Migliaccio, PhD

Blood (2016) 128 (22): 399.

https://doi.org/10.1182/blood.V128.22.399.399

Published: 2016

Journal Articles

The Carboxy-Terminal Domain of Calreticulin (CALR) Exports the Glucocorticoid Receptor (GR) from the Nucleus to the Cytoplasm of Human Erythroid Cells Resetting Their Stress Response

Anna Rita Migliaccio, PhD, Mario Falchi, PhD, Lilian Varricchio, PhD, Fabrizio Martelli, PhD, Francesca Masiello, MS, Manuela Marra, PhD, Orietta Picconi, Agostino Tafuri, MD, Gabriella Girelli, MD, Carolyn F. Whitsett, MD

Blood (2016) 128 (22): 545.

https://doi.org/10.1182/blood.V128.22.545.545

Published: 2016

Journal Articles

Glucocorticoid Regulation of Erythropoiesis in Humans: A Study of Patients with Cushing's Disease

Eliza B Geer, MD, Lilian Varricchio, PhD, Fabrizio Martelli, PhD, Wu He, PhD, Lizette Couto, Yelena Lazar, Vanessa Cohen, Anna Rita Migliaccio, PhD

Blood (2015) 126 (23): 2135.

https://doi.org/10.1182/blood.V126.23.2135.2135

Published: 2015

Journal Articles

The JAK2 V617F Mutation Disrupts the Regulatory Activity Exerted By Calreticulin on the Glucocorticoid Receptor in Erythroid Cells

Mario Falchi, PhD, Lilian Varricchio, PhD, Fabrizio Martelli, PhD, Francesca Masiello, Orietta Piccioni, Agostino Tafuri, MD, Gabriella Girelli, Camelia Iancu-Rubin, PhD, Ronald Hoffman, MD, Anna Rita Migliaccio, PhD

Blood (2015) 126 (23): 5216.

https://doi.org/10.1182/blood.V126.23.5216.5216

Published: 2015

Journal Articles

An Inhibitor of TGF-β Promotes Proliferation of Normal but Not MPN Hematopoietic Cells and Is a Candidate Therapeutic Agent for the Treatment of MPN Patients Carrying JAK2 V617F or Calr pQ365fs Mutations

Anna Rita Migliaccio, PhD, Camelia Iancu-Rubin, PhD, Rona Singer Weinberg, PhD, Ronald Hoffman, MD, Amylou Constance Dueck, PhD, John O. Mascarenhas, MD MS

Blood (2015) 126 (23): 4089.

https://doi.org/10.1182/blood.V126.23.4089.4089

Published: 2015

Journal Articles

The Making Of “Erythroid Islands” In HEMA Culture

Mario Falchi, PhD, Valentina Tirelli, MS, Francesca Masiello, MS, Carolyn Whitsett, Ann Zeuner, PhD, Anna Rita Migliaccio, PhD

Blood (2013) 122 (21): 939.

https://doi.org/10.1182/blood.V122.21.939.939

Published: 2013

Journal Articles

Human Erythroblasts Generated in Vitro Remain Functional with a Normal Karyotype 8 Years after Cryopreservation: Implications for Ex Vivo Generated Erythroid Transfusion Products.

Massimo Sanchez, PhD, Amanda Leblanc, Annalisa Mancini, PhD, Francesca Masiello, PhD, Valentina Tirelli, PhD, Giovanni Migliaccio, PhD, Anna Rita Migliaccio, PhD, Vesna Najfeld, PhD, Carolyn Whitsett, MD

Blood (2008) 112 (11): 2303.

https://doi.org/10.1182/blood.V112.11.2303.2303

Published: 2008

Journal Articles

Pericyte Coverage of Abnormal Blood Vessels in Myelofibrosis Bone Marrows.

Eva Zetterberg, MD, PhD, Alessandro M. Vannucchi, MD, Anna Rita Migliaccio, PhD, William Vainchenker, MD, PhD, Micheline Tulliez, MD, Renee Dickie, PhD, Rick Rogers, PhD, Jan Palmblad, MD, PhD

Blood (2005) 106 (11): 4936.

https://doi.org/10.1182/blood.V106.11.4936.4936

Published: 2005

Journal Articles

Increased and Pathological Emperipolesis of Neutrophils within Megakaryocytes Associated with Myelofibrosis in GATA-1 Low Mice.

Anna Rita Migliaccio, PhD, Lucia Centurione, MD, Angela Di Baldassarre, MD, Maria Zingariello, MD, Domenico Bosco, Valentina Gatta, PhD, Rosa Alba Rana, MD, Antonio Di Virgilio, Alessandro M. Vannucchi, MD

Blood (2004) 104 (11): 2430.

https://doi.org/10.1182/blood.V104.11.2430.2430

Published: 2004

Journal Articles

Effects of the Genetic Background on the Myelofibrosis Induced by the GATA-1 Low Mutation.

Anna Rita Migliaccio, PhD, Fabrizio Martelli, PhD, Barbara Panetta, PhD, Elena Alfani, PhD, Giovanni Migliaccio, PhD, Valentina Gatta, PhD, Angela Di Baldassarre, MD, Alessandro Pancrazi, PhD, Costanza Bogani, PhD, Francesco Paoletti, MD, Alessandro M. Vannucchi, MD

Blood (2004) 104 (11): 2433.

https://doi.org/10.1182/blood.V104.11.2433.2433

Published: 2004

Journal Articles

Aroyl-Pyrrolyl-Hydroxy-Amides (APHAs), a Novel Family of Synthetic Histone Deacetylases Inhibitors, Are Potent Inducers of Human g-Globin Gene Expression.

Antonello Mai, PhD, Silvio Massa, PhD, Antonella Di Noia, Katija Jelicic, PhD, Elena Alfani, PhD, Cristina Di Rico, PhD, Angela Di Baldassarre, MD, Anna Rita Migliaccio, PhD, Giovanni Migliaccio, PhD

Blood (2004) 104 (11): 1216.

https://doi.org/10.1182/blood.V104.11.1216.1216

Published: 2004

NARROW

Preclinical Rationale for the Use of Crizanlizumab (SEG101) in Myelofibrosis

Inhibition of P-Selectin Rescues the Phenotype of a Novel Genetic Animal Model for Idiopathic Pulmonary Fibrosis

Rationale for and Results of a Phase I Study of the TGF-β 1/3 Inhibitor AVID200 in Subjects with Myelofibrosis: MPN-RC 118 Trial

Altered Megakaryocytes Are Associated with Development of Pulmonary Fibrosis in Mice Carrying the Hypomorphic Gata1 low Mutation

Human GATA1 Driven By the Human Μicro LCR/β-Globin Promoter Rescues the Erythroid but Not the Megakaryocytic Phenotype Induced in Mice By the Gata1 low Mutation

The Hypomorphic Gata1 low Mutation Induces Fibrosis in Multiple Organs

AVID200, a Potent Trap for TGF-β Ligands Inhibits TGF-β1 Signaling in Human Myelofibrosis

Systematic Analyses of Clinically Relevant Single Nucleotide Polymorphisms (SNPs) of NR3C1 in Patients from the Italian Registry of Diamond Blackfan Anemia

Shared and Tissue-Specific Genetic Features of Primary Myelofibrosis, Hepatic Fibrosis, Idiopathic Pulmonary Fibrosis and Kidney Fibrosis

Phosphoproteomic Landscaping Unveils Constitutive cKIT Activation in Human Erythroblasts from Polycythemia Vera (PV) Patients

The Carboxy-Terminal Domain of Calreticulin (CALR) Exports the Glucocorticoid Receptor (GR) from the Nucleus to the Cytoplasm of Human Erythroid Cells Resetting Their Stress Response

Glucocorticoid Regulation of Erythropoiesis in Humans: A Study of Patients with Cushing's Disease

The JAK2 V617F Mutation Disrupts the Regulatory Activity Exerted By Calreticulin on the Glucocorticoid Receptor in Erythroid Cells

An Inhibitor of TGF-β Promotes Proliferation of Normal but Not MPN Hematopoietic Cells and Is a Candidate Therapeutic Agent for the Treatment of MPN Patients Carrying JAK2 V617F or Calr pQ365fs Mutations

The Making Of “Erythroid Islands” In HEMA Culture

Human Erythroblasts Generated in Vitro Remain Functional with a Normal Karyotype 8 Years after Cryopreservation: Implications for Ex Vivo Generated Erythroid Transfusion Products.

Pericyte Coverage of Abnormal Blood Vessels in Myelofibrosis Bone Marrows.

Increased and Pathological Emperipolesis of Neutrophils within Megakaryocytes Associated with Myelofibrosis in GATA-1 Low Mice.

Effects of the Genetic Background on the Myelofibrosis Induced by the GATA-1 Low Mutation.

Aroyl-Pyrrolyl-Hydroxy-Amides (APHAs), a Novel Family of Synthetic Histone Deacetylases Inhibitors, Are Potent Inducers of Human g-Globin Gene Expression.

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American Society of Hematology

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American Society of Hematology

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