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Journal Articles

The Lysine-Specific Demethylase 1 (LSD1) Inhibitor Tranylcypromine (TCP) in Combination with ATRA Is Tolerable and Has Anti-Leukemic Activity in Adult Patients with Relapsed/Refractory AML and MDS

Justin M Watts, MD, Terrence J Bradley, MD, Amber Thomassen, MA, MSN, Yvonne Trang Dinh, BS, Dalissa Tejera, MSN, Kristen Englund, Sorab Boga, MPH, Randy Astaiza, BS, Charles J Chen, MPH, Malika Abdur-Rahman, BS, MSED, Marinescu Ion, CCRC, FMG, Aymee Perez, PhD, Masoumeh Tayari, PhD, Lluis Morey, PhD, Maria E. Figueroa, MD, Ramin Shiekhattar, PhD, Arthur Zelent, PhD, Ronan Swords, MD PhD

Blood (2018) 132 (Supplement 1): 2721.

https://doi.org/10.1182/blood-2018-99-115411

Published: 2018

Journal Articles

The Novel Translocation t(4;15)(q31;q22) in AML Is Associated with a Proliferative Phenotype in the Presence of All-Trans Retinoic Acid (ATRA)

Justin M Watts, MD, Aymee Perez, PhD, Fernando Vargas, MD, Yao-Shan Fan, MD PhD, Alejandra Weisman, Ana Rodriguez, Omar Lopez, Francisco Vega, MD PhD, Ronan T Swords, MD PhD FRCPI, FRCPath, Arthur Zelent, PhD

Blood (2016) 128 (22): 1526.

https://doi.org/10.1182/blood.V128.22.1526.1526

Published: 2016

Journal Articles

The BET Bromodomain Inhibitors EP11313 and EP11336 Have Potent Anti-Leukemic Activity in Acute Myeloid Leukemia (AML) and Augment the Effects of All-Trans-Retinoic Acid (AtRA) in Vitro

Ronan T. Swords, MDPhDFRCPI FRCPath, Shaun Brothers, PhD, Nagi Ayad, PhD, Aymee Perez, PhD, Justin M. Watts, MD, Fernando Vargas, MD, Roy Elias, Ana Rodriguez, Shawn Johnstone, PhD, Jeffrey Albert, Joseph Collard, Arthur Zelent, PhD, Claes Wahlestedt, PhD

Blood (2015) 126 (23): 2552.

https://doi.org/10.1182/blood.V126.23.2552.2552

Published: 2015

Journal Articles

A Patient-Specific Ex Vivo Screening Platform for Personalized Acute Myeloid Leukemia (AML) Therapy

Diana Azzam, PhD, Claude-Henry Volmar, PhD, Al-Ali Hassan, PhD, Aymee Perez, PhD, Justin M. Watts, MD, Fernando Vargas, MD, Roy Elias, Francisco Vega, MD PhD, Arthur Zelent, PhD, Christopher R. Cogle, MD, Claes Wahlestedt, PhD, Ronan T. Swords, MDPhDFRCPI FRCPath

Blood (2015) 126 (23): 1352.

https://doi.org/10.1182/blood.V126.23.1352.1352

Published: 2015

Journal Articles

Inhibition of the PI3K/AKT/mTOR Pathway Leads to Down-Regulation of c-Myc and Overcomes Resistance to ATRA in Acute Myeloid Leukemia

Ronan T. Swords, MDPhDFRCPI FRCPath, Tino Schenk, PhD, Sven Stengel, PhD, Veronica Sylvina Gil, PhD, Kevin R. Petrie, PhD, Aymee Perez, PhD, Rodriguez Ana, Justin M. Watts, MD, Fernando Vargas, MD, Roy Elias, Arthur Zelent, PhD

Blood (2015) 126 (23): 1363.

https://doi.org/10.1182/blood.V126.23.1363.1363

Published: 2015

Journal Articles

The Small Molecule Img-98, a Potent and Selective Inhibitor of the Lysine Demethylase Lsd-1, Effectively Augments the Pro-Differentiation Effects of ATRA in a Pre-Clinical Model of AML

Ronan T. Swords, MDPhDFRCPI FRCPath, Aymee Perez, PhD, Ana Rodriguez, Justin M. Watts, MD, Fernando Vargas, MD, Roy Elias, Hugh Y. Rienhoff, Jr., MD, Arthur Zelent, PhD

Blood (2015) 126 (23): 460.

https://doi.org/10.1182/blood.V126.23.460.460

Published: 2015

Journal Articles

In Acute Myeloid Leukemia (AML), Targeting the Histone Methyltransferase EZH2 Promotes Differentiation, Impairs Clonogenic Survival and Augments the Anti-Leukemic Effects of the Retinoid, All-Trans-Retinoic Acid (ATRA)

Ronan T. Swords, MDPhDFRCPI FRCPath, Aymee Perez, PhD, Ana Rodriguez, Justin M. Watts, MD, Tino Schenk, PhD, Fernando Vargas, MD, Roy Elias, Arthur Zelent, PhD

Blood (2015) 126 (23): 3786.

https://doi.org/10.1182/blood.V126.23.3786.3786

Published: 2015

Journal Articles

Sodium Salicylate Has a Priming Effect When Combined with Azacitidine in Pre-Clinical Models of AML

Yehuda E. Deutsch, MD, Aymee Perez, PhD, Ana Rodrigues, BS, Ezra S. Blumenthal, Elena Cubedo, PhD, Justin M. Watts, MD, Ronan T Swords, MD PhD FRCPI, FRCPath, Arthur Zelent, PhD

Blood (2014) 124 (21): 2300.

https://doi.org/10.1182/blood.V124.21.2300.2300

Published: 2014

Journal Articles

HDAC9 Expression Is Deregulated in Malignant B-Cell Lymphomas in Particular in Diffuse Large B Cell Lymphoma and Mantle Cell Lymphoma

Elena Cubedo, PhD, Veronica Sylvina Gil, PhD, Chae Hwa Kim, German Campuzano-Zuluaga, MD, Nitin Kumar Agarwal, PhD, Louise Howell, BSc, Kevin R. Petrie, PhD, Francisco Vega, MD PhD, Arthur Zelent, PhD

Blood (2014) 124 (21): 5374.

https://doi.org/10.1182/blood.V124.21.5374.5374

Published: 2014

Journal Articles

Loss Of H3K27 Trimethylation (H3K27me3) Associates With a Multi Drug Resistance Phenotype In Acute Myeloid Leukemia (AML)

Stefanie Göllner, PhD, Tino Schenk, PhD, Sven Stengel, PhD, Christian Rohde, PhD, Tim Sauer, MD, Arthur Zelent, PhD, Sigal Tavor, MD, Friedrich Stölzel, MD, Gerhard Ehninger, MD, Gabriele Köhler, MD, Wolfgang E. Berdel, MD, Christian Thiede, MD, Carsten Müller-Tidow, MD

Blood (2013) 122 (21): 1253.

https://doi.org/10.1182/blood.V122.21.1253.1253

Published: 2013

Journal Articles

Deregulated Expression of HDAC9 in B-Cells Leads to Lymphoproliferative Disorders As Well As Germinal Center and Post-Germinal Center Derived Lymphomas

Veronica Sylvina Gil, PhD, Sven Stengel, PhD, Govind Bhagat, MD, Louise Howell, BSc, Daniel Catovsky, MD, Laura Pasqualucci, MD, Kevin Petrie, PhD, Arthur Zelent, PhD

Blood (2012) 120 (21): 3505.

https://doi.org/10.1182/blood.V120.21.3505.3505

Published: 2012

Journal Articles

Loss of EZH2 and Aberrant DNA Methylation Account for PKC412 Drug Resistance in the FLT3-ITD Positive Acute Myeloid Leukemia (AML) Cell Line MV4-11,

Stefanie Göllner, PhD, Tino Schenk, PhD, Christian Rohde, PhD, Arthur Zelent, PhD, Friedrich Stölzel, MD, Christian Thiede, MD, Wolfgang E. Berdel, Carsten Müller-Tidow, MD

Blood (2011) 118 (21): 3468.

https://doi.org/10.1182/blood.V118.21.3468.3468

Published: 2011

Journal Articles

Histone H3 Methylation Mediates All- Trans -Retinoic Acid Responsiveness in Acute Myeloid Leukemia

Tino Schenk, PhD, Stefanie Göllner, PhD, Weihsu Claire Chen, PhD, Louise Howell, BSc, Liqing Jin, MD, Katja Hebestreit, Hans-Ulrich Klein, PhD, Alan K Burnett, MD, Ken I. Mills, PhD, FRCPath, Laurence Marton, MD, Robert Casero, Jr., PhD, Patrick Woster, PhD, Martin Dugas, MD, Jean C.Y. Wang, MD, PhD, John E. Dick, PhD, Carsten Müller-Tidow, MD, Kevin Petrie, PhD, Arthur Zelent, PhD

Blood (2011) 118 (21): 224.

https://doi.org/10.1182/blood.V118.21.224.224

Published: 2011

Journal Articles

Modulation of Histone H3K4 and H3K27 Methylation Levels Via Pharmacological Inhibition of LSD1 and Degradation of the EZH2-Containing Polycomb Repressive Complex 2 Stimulates ATRA-Mediated Differentiation of AML Cells.

Kevin R. Petrie, PhD, Tino Schenk, PhD, Manuel Boix Chornet, PhD, Louise Howell, John E Dick, PhD, Victor E Marquez, PhD, Laurence J Marton, MD, Patrick M Woster, PhD, Robert A Casero, Jr., PhD, Arthur Zelent, PhD

Blood (2009) 114 (22): 1046.

https://doi.org/10.1182/blood.V114.22.1046.1046

Published: 2009

Journal Articles

PLZF-RARα Utilizes the Histone Methyl Transferase G9a/GLP and the Histone Demethylase LSD1 to Repress RARα Target Genes and Block Myeloid Differentiation

Itsaso Hormaeche, PhD, Kim L. Rice, Ph.D., Arthur Zelent, PhD, Melanie J. McConnell, Ph.D., Jonathan D. Licht, MD

Blood (2008) 112 (11): 198.

https://doi.org/10.1182/blood.V112.11.198.198

Published: 2008

Journal Articles

Ectopic Expression of HDAC9 in Murine Lymphoid System Leads to Altered Lymphocyte Numbers and Proliferation as Well as Predisposition to Tumorigenesis.

Veronica S. Gil, BSc, Louise M.C. Howell, BSc, Jenny Yeung, PhD, Kevin R. Petrie, PhD, Adrian Smith, PhD, Neil Sebire, MD, Estela Matutes, MD, PhD, Andy Wotherspoon, MD, Tariq Enver, PhD, Eric So, PhD, Arthur Zelent, PhD

Blood (2007) 110 (11): 376.

https://doi.org/10.1182/blood.V110.11.376.376

Published: 2007

Journal Articles

Deregulation of RARγ and RARγ-Specific miRNAs in AML.

Angela N. Barrett, PhD, Rajeev Gupta, MD, Annegret Glasow, PhD, David Grimwade, PhD, Marieke von Lindern, PhD, Samuel Waxman, MD, Ken Mills, PhD, FRCPath, Alan Burnett, PhD, Tariq Enver, PhD, Arthur Zelent, PhD

Blood (2007) 110 (11): 3182.

https://doi.org/10.1182/blood.V110.11.3182.3182

Published: 2007

Journal Articles

Recruitment of RXRα by Homo-Oligomeric RARα Is a Key for RARα-Mediated Transformation.

Bernd B. Zeisig, PhD, Colin Kwok, PhD, Amanda J. Wilson, BSc, Arthur Zelent, PhD, Hinrich Gronemeyer, PhD, Shuo Dong, MD PhD, Chi Wai Eric So, PhD

Blood (2006) 108 (11): 360.

https://doi.org/10.1182/blood.V108.11.360.360

Published: 2006

Journal Articles

LRF/Pokemon Plays a Pivotal Role in B Versus T Lymphoid Lineage Fate Decision at the Early Lymphoid Progenitor Stage by Opposing Notch1 Signaling.

Takahiro Maeda, MD, PhD, Taha Merghoub, PhD, Lin Dong, MD, Manami Maeda, MD.PhD., Robin Hobbs, PhD, Johannes Zakrzewski, MD, Marcel van den Brink, MD.PhD., Hirokazu Shigematsu, MD.PhD., Koichi Akashi, MD.PhD., Arthur Zelent, PhD, Julie Teruya-Feldstein, MD, Giorgio Cattoretti, MD, Pier Paolo Pandolfi, MD.PhD.

Blood (2006) 108 (11): 778.

https://doi.org/10.1182/blood.V108.11.778.778

Published: 2006

Journal Articles

Mice Overexpressing Histone Deacetylase 9 Display Abnormal B Cell Development and Proliferation.

Veronica S. Gil, MPhil, Kevin Petrie, PhD, Manuel Boix Chornet, PhD, Louise Howell, BSc, Neil J. Sebire, MD, Arthur Zelent, PhD

Blood (2006) 108 (11): 1433.

https://doi.org/10.1182/blood.V108.11.1433.1433

Published: 2006

NARROW

The Lysine-Specific Demethylase 1 (LSD1) Inhibitor Tranylcypromine (TCP) in Combination with ATRA Is Tolerable and Has Anti-Leukemic Activity in Adult Patients with Relapsed/Refractory AML and MDS

The Novel Translocation t(4;15)(q31;q22) in AML Is Associated with a Proliferative Phenotype in the Presence of All-Trans Retinoic Acid (ATRA)

The BET Bromodomain Inhibitors EP11313 and EP11336 Have Potent Anti-Leukemic Activity in Acute Myeloid Leukemia (AML) and Augment the Effects of All-Trans-Retinoic Acid (AtRA) in Vitro

A Patient-Specific Ex Vivo Screening Platform for Personalized Acute Myeloid Leukemia (AML) Therapy

Inhibition of the PI3K/AKT/mTOR Pathway Leads to Down-Regulation of c-Myc and Overcomes Resistance to ATRA in Acute Myeloid Leukemia

The Small Molecule Img-98, a Potent and Selective Inhibitor of the Lysine Demethylase Lsd-1, Effectively Augments the Pro-Differentiation Effects of ATRA in a Pre-Clinical Model of AML

In Acute Myeloid Leukemia (AML), Targeting the Histone Methyltransferase EZH2 Promotes Differentiation, Impairs Clonogenic Survival and Augments the Anti-Leukemic Effects of the Retinoid, All-Trans-Retinoic Acid (ATRA)

Sodium Salicylate Has a Priming Effect When Combined with Azacitidine in Pre-Clinical Models of AML

HDAC9 Expression Is Deregulated in Malignant B-Cell Lymphomas in Particular in Diffuse Large B Cell Lymphoma and Mantle Cell Lymphoma

Loss Of H3K27 Trimethylation (H3K27me3) Associates With a Multi Drug Resistance Phenotype In Acute Myeloid Leukemia (AML)

Deregulated Expression of HDAC9 in B-Cells Leads to Lymphoproliferative Disorders As Well As Germinal Center and Post-Germinal Center Derived Lymphomas

Loss of EZH2 and Aberrant DNA Methylation Account for PKC412 Drug Resistance in the FLT3-ITD Positive Acute Myeloid Leukemia (AML) Cell Line MV4-11,

Histone H3 Methylation Mediates All- Trans -Retinoic Acid Responsiveness in Acute Myeloid Leukemia

Modulation of Histone H3K4 and H3K27 Methylation Levels Via Pharmacological Inhibition of LSD1 and Degradation of the EZH2-Containing Polycomb Repressive Complex 2 Stimulates ATRA-Mediated Differentiation of AML Cells.

PLZF-RARα Utilizes the Histone Methyl Transferase G9a/GLP and the Histone Demethylase LSD1 to Repress RARα Target Genes and Block Myeloid Differentiation

Ectopic Expression of HDAC9 in Murine Lymphoid System Leads to Altered Lymphocyte Numbers and Proliferation as Well as Predisposition to Tumorigenesis.

Deregulation of RARγ and RARγ-Specific miRNAs in AML.

Recruitment of RXRα by Homo-Oligomeric RARα Is a Key for RARα-Mediated Transformation.

LRF/Pokemon Plays a Pivotal Role in B Versus T Lymphoid Lineage Fate Decision at the Early Lymphoid Progenitor Stage by Opposing Notch1 Signaling.

Mice Overexpressing Histone Deacetylase 9 Display Abnormal B Cell Development and Proliferation.

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American Society of Hematology

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American Society of Hematology

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