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Journal Articles

BCL-2, a Therapeutic Target for High Risk Hypodiploid B-Cell Acute Lymphoblastic Leukemia

Ernesto Diaz-Flores, PhD, Evan Q. Comeaux, PhD, Kailyn Kim, Kyle Beckman, BS, Kara L. Davis, DO, Kevin Wu, Jon Akutagawa, Linda Holmfeldt, PhD, Benjamin S. Braun, MD PhD, Charles Mullighan, MBBS, MSc, MD, Mignon L. Loh, MD

Blood (2016) 128 (22): 280.

https://doi.org/10.1182/blood.V128.22.280.280

Published: 2016

Journal Articles

Negative Feedback By Dusp6 Modulates Myeloproliferation Induced By Oncogenic Nras

Charisa Cottonham, PhD, Jon Akutagawa, Inbal Epstein, Lana Bogdanova, Benjamin S. Braun, MD PhD

Blood (2015) 126 (23): 1256.

https://doi.org/10.1182/blood.V126.23.1256.1256

Published: 2015

Journal Articles

Inhibition of Akt Signaling Alleviates MDS/MPN Driven By Kras D12 or Nf1 Loss

Tannie Huang, MD, Jon Akutagawa, Inbal Epstein, Charisa Cottonham, PhD, Maricel Quirindongo-Crespo, Benjamin S. Braun, MD PhD

Blood (2015) 126 (23): 360.

https://doi.org/10.1182/blood.V126.23.360.360

Published: 2015

Journal Articles

Subclonal Mutations in SETBP1 Predict Relapse in Juvenile Myelomonocytic Leukemia

Elliot Stieglitz, MD, Camille B Troup, PhD, Laura C Gelston, ScM, Eric D Chow, PhD, Kristie B Yu, Jon Akutagawa, BS, Amaro N Taylor-Weiner, BS, Y. Lucy Liu, MD PhD, Peter D Emanuel, MD, Benjamin S Braun, MD PhD, Robert B. Gerbing, MA, Todd A. Alonzo, PhD, Mignon L. Loh, MD

Blood (2014) 124 (21): 410.

https://doi.org/10.1182/blood.V124.21.410.410

Published: 2014

Journal Articles

Feedback Through Dusp6 Modulates Ineffective Erythropoiesis Caused By Mutant Kras

Charisa Cottonham, Ph.D., Roeltje R. Maas, Benjamin S. Braun, MD, PhD

Blood (2013) 122 (21): 750.

https://doi.org/10.1182/blood.V122.21.750.750

Published: 2013

Journal Articles

The PI3K Inhibitor GDC-0941 Attenuates Disease in a Kras G12D Mouse Model of CMML and JMML.

Jon Akutagawa, B.S., Monique Dail, PhD, Lori S Friedman, PhD, Kevin M. Shannon, MD, Deepak Sampath, PhD, Benjamin S. Braun, MD, PhD

Blood (2012) 120 (21): 2862.

https://doi.org/10.1182/blood.V120.21.2862.2862

Published: 2012

Journal Articles

An In Vitro Library Screen to Rapidly Determine Activity Against Normal and Mutant Bone Marrow Progenitor Cells

Wan Xing Hong, M.S., B.A., Steven Chen, B.S., Jon Akutagawa, B.S., Michelle Arkin, PhD, Benjamin S. Braun, MD, PhD

Blood (2012) 120 (21): 4916.

https://doi.org/10.1182/blood.V120.21.4916.4916

Published: 2012

Journal Articles

MEK Inhibition Modulates the Growth of Nf1 mutant Hematopoietic Cells and Induces Clinical Improvement in a Murine Model of Juvenile Myelomonocytic Leukemia (JMML)

Tiffany Y. Chang, MD, Kimberly Krisman, BA, Emily Rose Harding-Theobald, BA, Benjamin S. Braun, MD, PhD, Kevin M. Shannon, MD

Blood (2011) 118 (21): 797.

https://doi.org/10.1182/blood.V118.21.797.797

Published: 2011

Journal Articles

Treatment with a MEK Inhibitor Improves Myeloproliferation, Anemia and Survival in a Mouse Model of CMML and JMML.

Natalya Lyubynska, Jennifer Lauchle, MD, Kevin Shannon, MD, Benjamin S. Braun, MD, PhD

Blood (2009) 114 (22): 966.

https://doi.org/10.1182/blood.V114.22.966.966

Published: 2009

Journal Articles

PI3 Kinase, Phospholipase C (PLC)-γ, and RasGRPs Act Cooperatively to Activate the Ras-Extracellular-Related Kinase (ERK) Pathway in Response to Cytokines in Normal and Kras Mutant Myeloid Cells.

Ernesto Diaz-Flores, PhD, Hana Leah Goldschmidt, BA, Philippe Depeille, Ph.D, Victor Ng, BA, Jeroen Roose, Assistant, Professor, Kevan Shokat, Ph.D., Benjamin S. Braun, MD, PhD, Kevin Shannon, MD

Blood (2009) 114 (22): 2512.

https://doi.org/10.1182/blood.V114.22.2512.2512

Published: 2009

Journal Articles

Germline Mutations in CBL Cause a Predisposition to Juvenile Myelomonocytic Leukemia.

Blood (2009) 114 (22): 310.

https://doi.org/10.1182/blood.V114.22.310.310

Published: 2009

Journal Articles

A Noncatalytic, Ras-Independent Function of SHP-2 Is Essential in Hematopoietic Progenitors.

Benjamin S. Braun, MD, PhD, Laurene S. Cheung, Gordon G. Chan, PhD, Wentian A. Yang, PhD, Joehleen A. Archard, Benjamin G. Neel, MD, PhD, Kevin Shannon, MD

Blood (2007) 110 (11): 85.

https://doi.org/10.1182/blood.V110.11.85.85

Published: 2007

Journal Articles

Leukemogenic K-Ras G12D Induces Cell Cycle Entry and Clonal Dominance in Hematopoietic Stem Cells.

Amit J. Sabnis, MS, Laurene S. Cheung, BA, Kevin Shannon, MD, Benjamin S. Braun, MD, PhD

Blood (2007) 110 (11): 778.

https://doi.org/10.1182/blood.V110.11.778.778

Published: 2007

Journal Articles

Myelopoiesis Requires a Noncatalytic, Ras-Independent Function of SHP-2.

Benjamin S. Braun, MD, PhD, Joehleen A. Archard, Wentian Yang, PhD, Gordon Chan, PhD, Benjamin G. Neel, MD, PhD, Kevin Shannon, MD

Blood (2006) 108 (11): 635.

https://doi.org/10.1182/blood.V108.11.635.635

Published: 2006

Journal Articles

Oncogenic Ras Requires SHP-2 To Induce Myeloproliferative Disease (MPD).

Benjamin S. Braun, MD, PhD, Joehleen Archard, Wentian Yang, PhD, Gordon Chan, PhD, Benjamin G. Neel, MD, PhD, Kevin M. Shannon, MD

Blood (2005) 106 (11): 3517.

https://doi.org/10.1182/blood.V106.11.3517.3517

Published: 2005

Journal Articles

Multiparameter Flow Cytometric Analysis Reveals Aberrant Phosphorylation of a Network of Effector Molecules in Defined Populations of Kras Mutant Bone Marrow.

Margaret E.M. Van Meter, BA, Ernesto Diaz-Flores, PhD, Joehleen A. Archard, BS, Nikesh Kotecha, BS, Amit J. Sabnis, BS, Jonathan M. Irish, PhD, Garry P. Nolan, PhD, Kevin M. Shannon, MD, Benjamin S. Braun, MD, PhD

Blood (2005) 106 (11): 239.

https://doi.org/10.1182/blood.V106.11.239.239

Published: 2005

Journal Articles

In Vitro Analysis of Myeloid Proliferation Caused by Oncogenic Kras.

Benjamin S. Braun, MD, PhD, Joehleen Gavin, David A. Tuveson, MD, PhD, Tyler E. Jacks, PhD

Blood (2004) 104 (11): 795.

https://doi.org/10.1182/blood.V104.11.795.795

Published: 2004

Journal Articles

Anemia and Ineffective Erythropoiesis Caused by Somatic RAS Mutation.

Benjamin S. Braun, MD, PhD, Jessica van Ziffle, Joehleen Gavin, David A. Tuveson, MD, PhD, Tyler Jacks, PhD, Kevin Shannon, MD

Blood (2004) 104 (11): 3419.

https://doi.org/10.1182/blood.V104.11.3419.3419

Published: 2004

NARROW

BCL-2, a Therapeutic Target for High Risk Hypodiploid B-Cell Acute Lymphoblastic Leukemia

Negative Feedback By Dusp6 Modulates Myeloproliferation Induced By Oncogenic Nras

Inhibition of Akt Signaling Alleviates MDS/MPN Driven By Kras D12 or Nf1 Loss

Subclonal Mutations in SETBP1 Predict Relapse in Juvenile Myelomonocytic Leukemia

Feedback Through Dusp6 Modulates Ineffective Erythropoiesis Caused By Mutant Kras

The PI3K Inhibitor GDC-0941 Attenuates Disease in a Kras G12D Mouse Model of CMML and JMML.

An In Vitro Library Screen to Rapidly Determine Activity Against Normal and Mutant Bone Marrow Progenitor Cells

MEK Inhibition Modulates the Growth of Nf1 mutant Hematopoietic Cells and Induces Clinical Improvement in a Murine Model of Juvenile Myelomonocytic Leukemia (JMML)

Treatment with a MEK Inhibitor Improves Myeloproliferation, Anemia and Survival in a Mouse Model of CMML and JMML.

PI3 Kinase, Phospholipase C (PLC)-γ, and RasGRPs Act Cooperatively to Activate the Ras-Extracellular-Related Kinase (ERK) Pathway in Response to Cytokines in Normal and Kras Mutant Myeloid Cells.

Germline Mutations in CBL Cause a Predisposition to Juvenile Myelomonocytic Leukemia.

A Noncatalytic, Ras-Independent Function of SHP-2 Is Essential in Hematopoietic Progenitors.

Leukemogenic K-Ras G12D Induces Cell Cycle Entry and Clonal Dominance in Hematopoietic Stem Cells.

Myelopoiesis Requires a Noncatalytic, Ras-Independent Function of SHP-2.

Oncogenic Ras Requires SHP-2 To Induce Myeloproliferative Disease (MPD).

Multiparameter Flow Cytometric Analysis Reveals Aberrant Phosphorylation of a Network of Effector Molecules in Defined Populations of Kras Mutant Bone Marrow.

In Vitro Analysis of Myeloid Proliferation Caused by Oncogenic Kras.

Anemia and Ineffective Erythropoiesis Caused by Somatic RAS Mutation.

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American Society of Hematology

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American Society of Hematology

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