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Journal Articles

Final Results of Phase 1, Dose Escalation Study Evaluating ARQ 531 in Patients with Relapsed or Refractory B-Cell Lymphoid Malignancies

Jennifer Woyach, MD, Deborah M. Stephens, DO, Ian W. Flinn, MD PhD, Seema A. Bhat, MD, Ronald E. Savage, Feng Chai, MD, Sudharshan Eathiraj, PhD, Lindsey Granlund, Lyndsey A. Szuszkiewicz, Brian Schwartz, MD, John C. Byrd, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4298.
https://doi.org/10.1182/blood-2019-127260
Published: 2019
Journal Articles

Specific Inhibition of AKT with ARQ 092, an Orally-Available Selective AKT Inhibitor, Attenuates Acute Vaso-Occlusive Events in Sickle Cell Disease

Jing Li, PhD, Kyungho Kim, PhD, Alan Tseng, Andrew Barazia, PhD, Seock-Won Youn, Giovanni Abbadessa, MD, Yi Yu, PhD, Brian Schwartz, MD, Robert K Andrews, PhD, Victor R. Gordeuk, MD, Jaehyung Cho, PhD
Journal: Blood
Blood (2016) 128 (22): 160.
https://doi.org/10.1182/blood.V128.22.160.160
Published: 2016
Journal Articles

The Bruton's Tyrosine Kinase (BTK) Inhibitor ARQ 531 Effectively Inhibits Wild Type and C481S Mutant BTK and Is Superior to Ibrutinib in a Mouse Model of Chronic Lymphocytic Leukemia

Sean D. Reiff, Rose Mantel, Lisa L. Smith, MS, Samantha McWhorter, Virginia M. Goettl, DVM , PhD, Amy J. Johnson, PhD, Sudharsan Eathiraj, Giovanni Abbadessa, MD, Brian Schwartz, MD, John C. Byrd, MD, Jennifer A. Woyach, MD
Journal: Blood
Blood (2016) 128 (22): 3232.
https://doi.org/10.1182/blood.V128.22.3232.3232
Published: 2016
Journal Articles

Clinical Trial Results from the Subgroup of Lymphoma/CLL in a Phase 1 Study of ARQ 092, a Novel Pan AKT-Inhibitor

Wael Harb, Mansoor N. Saleh, MD, Kyriakos P Papadopoulos, MD, Feng Chai, MD, Maria Larmar, Giovanni Abbadessa, MD, Brian Schwartz, MD, Anthony Tolcher, MD
Journal: Blood
Blood (2015) 126 (23): 5116.
https://doi.org/10.1182/blood.V126.23.5116.5116
Published: 2015