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Carla Heise, PhD
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Journal Articles

Target Engagement, Pathway Inhibition, and Efficacy Of The Bruton’s Tyrosine Kinase (Btk) Inhibitor CC-292

Daniel W Pierce, Sabine Ponader, PhD, Kumudha Balakrishnan, Varsha Gandhi, PhD, William G. Wierda, MD, Susan O'Brien, MD, Carla Heise, PhD, Mariana Nacht, PhD, Sharon Aslanian, Xiping Liu, Sean Hong, Shijuan Wu, Marianna Zavodovskaya, MS, Jeffrey Marine, Evelyn Barnett, Pilar Nava-Parada, Jay Mei, MD, Rajesh Chopra, MD, Jan A. Burger, MD, PhD, Juswinder Singh
Journal: Blood
Blood (2013) 122 (21): 4169.
https://doi.org/10.1182/blood.V122.21.4169.4169
Published: 2013
Journal Articles

Updated Efficacy and Safety, and Exploratory Ki-67 Results For The MCL-001 Study Of Lenalidomide In Mantle Cell Lymphoma Patients Who Relapsed Or Were Refractory To Bortezomib

Andre Goy, MD, Michael E. Williams, MD, ScM, Sevgi Kalayoglu Besisik, MD, Johannes Drach, Radhakrishnan Ramchandren, MD, Michael J. Robertson, MD, Irit Avivi, MD, Jacob M Rowe, MD, Raoul Herbrecht, MD, Achiel Van Hoof, Miklos Egyed, Lei Zhang, Sherri Cicero, Tommy Fu, Carla Heise, PhD, Thomas E Witzig, MD
Journal: Blood
Blood (2013) 122 (21): 3057.
https://doi.org/10.1182/blood.V122.21.3057.3057
Published: 2013
Journal Articles

Sotatercept, An Activin Receptor-2a Ligand Trap, Modulates Hepcidin Levels In Primary Human Hepatocytes

Mehnaz Malek, Carla Heise, PhD, Rajesh Chopra, PhD, Tom O Daniel, MD, PhD, Victoria Sung, PhD
Journal: Blood
Blood (2013) 122 (21): 3441.
https://doi.org/10.1182/blood.V122.21.3441.3441
Published: 2013
Journal Articles

Novel Intracranial Xenografts Of CNS Lymphoma Implicate a Role For Cereblon As a Mediator Of Lenalidomide Efficacy

Hua-Xin Gao, Ph.D., Shawn Anderson, Cigall Kadoch, Ph.D., Mekhala Maiti, Ph.D., Lingjing Chen, Ph.D., Dong-Han Yao, Gerd Melkus, Ph.D., Maria Wang, Ph.D., Yan Ren, Ph.D., Michael Breider, Ph.D., Carla Heise, PhD, Clifford A. Lowell, MD, PhD, Colin Collins, Ph.D., James L. Rubenstein, M.D., Ph.D.
Journal: Blood
Blood (2013) 122 (21): 374.
https://doi.org/10.1182/blood.V122.21.374.374
Published: 2013
Journal Articles

Sotatercept Promotes Differentiation and Survival Of Erythroid Progenitors By Blocking Inhibitory Effects Of TGFβ Superfamily Members

Soraya Carrancio, PhD, Jennifer A. Markovics, PhD, Piu Wong, PhD, Carla Heise, PhD, Tom O. Daniel, MD, PhD, Rajesh Chopra, MD, Victoria Sung, PhD
Journal: Blood
Blood (2013) 122 (21): 944.
https://doi.org/10.1182/blood.V122.21.944.944
Published: 2013
Journal Articles

Lenalidomide Efficacy in Activated B-Cell-Like Subtype Diffuse Large B-Cell Lymphoma Is Dependent Upon IRF4 and Cereblon Expression

Ling-Hua Zhang, PhD, Jolanta Kosek, BA, Maria Wang, Ph.D., Carla Heise, PhD, Peter H Schafer, PhD, Rajesh Chopra, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 3287.
https://doi.org/10.1182/blood.V120.21.3287.3287
Published: 2012
Journal Articles

Sotatercept, an Activin Receptor IIa Ligand Trap, Acts Through Bone Marrow Accessory Cells to Promote Late-Stage Erythropoiesis and a Rapid Induction of Red Blood Cell Number and Hemoglobin

Soraya Carrancio, PhD, Jennifer A Markovics, PhD, Piu Wong, PhD, Jim Leisten, Matthew C Groza, Heather K Raymon, Carla Heise, PhD, Rajesh Chopra, MD, PhD, Tom O Daniel, MD, PhD, Victoria Sung, PhD
Journal: Blood
Blood (2012) 120 (21): 372.
https://doi.org/10.1182/blood.V120.21.372.372
Published: 2012
Journal Articles

Activation of T and NK Cells Following Lenalidomide Therapy in Patients with Follicular Lymphoma.

Seema Rawal, PhD, Nathan Fowler, MD, Min Zhang, Ph.D., Zhiqiang Wang, Ph.D., Tariq Muzzafar, MBBS, Nusrat Harun, MS, Veerabhadran Baladandayuthapani, Ph.D., Rakesh Sharma, Ph.D, David Delgado, Michael Wallace, MD, Carla Heise, PhD, Linda Catherine Lacerte, RN, Felipe Samaniego, M.D., R Eric Davis, M.D, Sattva S. Neelapu, MD
Journal: Blood
Blood (2012) 120 (21): 2766.
https://doi.org/10.1182/blood.V120.21.2766.2766
Published: 2012
Journal Articles

Lenalidomide Induces Capping of CD20 and Cytoskeleton Proteins to Enhance Rituximab Immune Recognition of Malignant B-Cells

Svetlana Gaidarova, Derek Mendy, Carla Heise, PhD, Sharon Lea Aukerman, PhD, Tom Daniel, Rajesh Chopra, Antonia Lopez-Girona
Journal: Blood
Blood (2010) 116 (21): 2845.
https://doi.org/10.1182/blood.V116.21.2845.2845
Published: 2010
Journal Articles

Human Antagonistic Anti-CD40 Antibody, CHIR-12.12, Inhibits CD40-Mediated Survival of Chronic Lymphocytic Leukemia B Cells Leading to Cellular Apoptosis.

Anu Cherukuri, PhD, Edward Kadel, BS, Sang H. Lee, PhD, Cheryl Goldbeck, BS, Carla Heise, PhD, Mohammad Luqman, PhD, Sharon L. Aukerman, PhD, Natasha Aziz, PhD, Susan O’Brien, MD, William G. Wierda, MD, PhD, Bahija Jallal, PhD
Journal: Blood
Blood (2005) 106 (11): 2965.
https://doi.org/10.1182/blood.V106.11.2965.2965
Published: 2005
Journal Articles

CHIR-258 Efficacy in a Newly Developed Preclinical Bone Marrow Model of t(4;14) Multiple Myeloma.

Xiaohua Xin, PhD, Yan Tang, MD, Yoko Oei, BA, Helen Ye, BS, Daniel Menezes, PhD, Katherine Rendahl, PhD, Paul Hollenbach, MS, Nancy Pryer, PhD, Suzanne Trudel, MD, Dirk Mendel, PhD, Bahija Jallal, PhD, Carla Heise, PhD
Journal: Blood
Blood (2005) 106 (11): 3449.
https://doi.org/10.1182/blood.V106.11.3449.3449
Published: 2005
Journal Articles

CHIR258: A Multitargeted Growth Factor Receptor Tyrosine Kinase (RTK) Inhibitor Induces Significant Apoptosis of Human FLT3 ITD Acute Myelogenous Leukemia Cells In Vitro and in Vivo.

Daniel L. Menezes, PhD, Marion Wiesmann, PhD, Sang Hoon Lee, PhD, Isabelle Lee, BS, Jing Peng, MS, Yan Tang, MD, Helen Ye, BS, Yoko Oei, BA, Cheryl Goldbeck, BS, Evelyn N. Garrett, MA, Carla Heise, PhD
Journal: Blood
Blood (2004) 104 (11): 1789.
https://doi.org/10.1182/blood.V104.11.1789.1789
Published: 2004