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Charles Prussak, PhD
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Journal Articles

Immunotherapeutic Targeting of ROR1-Dependent, Non-Canonical Wnt5a-Signaling By Cirmtuzumab: A First-in-Human Phase I Trial for Patients with Intractable Chronic Lymphocytic Leukemia

Michael Y. Choi, MD, George F. Widhopf, II, PhD, Jian Yu, PhD, Reilly L Kidwell, BS, BA, CCRC, Laura Z. Rassenti, PhD, Charlene Gutierrez, Susette Gorak, Tiffany Juarez, PhD, Emily Pittman, PhD, Hongying Li, PhD, Karen Messer, PhD, Charles Prussak, PhD, Januario E. Castro, MD, Catriona Jamieson, MD PhD, Thomas J. Kipps, MD, PhD
Journal: Blood
Blood (2016) 128 (22): 3224.
https://doi.org/10.1182/blood.V128.22.3224.3224
Published: 2016
Journal Articles

Cirmtuzumab (UC-961), a First-in-Class Anti-ROR1 Monoclonal Antibody: Planned Interim Analysis of Initial Phase 1 Cohorts

Michael Y. Choi, MD, George F. Widhopf, II, PhD, Januario Castro, MD, Hongying Li, PhD, Reilly L Kidwell, BS, BA, CCRC, Sam C Zhang, B.A., Tiffany Juarez, PhD, Susette Gorak, Laura Z. Rassenti, PhD, Karen Messer, PhD, Charles Prussak, PhD, Catriona HM Jamieson, MD PhD, Thomas J. Kipps, MD PhD
Journal: Blood
Blood (2015) 126 (23): 1736.
https://doi.org/10.1182/blood.V126.23.1736.1736
Published: 2015
Journal Articles

Targeting Of Chronic Lymphocytic Leukemia B Cells With a Humanized Monoclonal Antibody Specific For ROR1

George F. Widhopf, II, PhD, Bing Cui, Ph.D., Christina C.N. Wu, PhD, Jian Yu, PhD, Fitzgerald Lao, Rommel Tawatao, Rongrong Wu, Esther Avery, B.S., Anil Sadarangani, PhD, Charles Prussak, PhD, Catriona HM Jamieson, MD, PhD, Dennis A. Carson, M.D., Thomas J. Kipps, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 2873.
https://doi.org/10.1182/blood.V122.21.2873.2873
Published: 2013
Journal Articles

A Highly Selective Anti-ROR1 Monoclonal Antibody Inhibits Human Acute Myeloid Leukemia CD34+ Cell Survival and Self-Renewal.

Larissa Balaian, Ph.D., Anil Sadarangani, Ph.D., George F. Widhopf, II, PhD, Rui-kun Zhong, MD, Charles Prussak, PhD, Marco A. Marra, PhD, John E Dick, PhD, Mark D. Minden, MD, PhD, Edward D. Ball, M.D., Dennis A. Carson, M.D., Catriona Jamieson, MD, PhD, Thomas J. Kipps, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 2560.
https://doi.org/10.1182/blood.V120.21.2560.2560
Published: 2012
Journal Articles

Selective Clearance of Chronic Lymphocytic Leukemia Cells in Vivo Following Treatment with UC99961, an Anti-ROR1 Monoclonal Antibody

Eva Hellqvist, Ph.D, Christina C.N. Wu, Ph.D., George F. Widhopf, II, PhD, Alice Shih, Rommel Tawatao, Fitzgerald Lao, Bing Cui, Ph.D., Charles Prussak, PhD, Anil Sadarangani, Ph.D., Dennis A. Carson, M.D., Catriona Jamieson, MD, PhD, Thomas J. Kipps, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 3886.
https://doi.org/10.1182/blood.V120.21.3886.3886
Published: 2012
Journal Articles

A Monoclonal Antibody Specifically Targeting CD44 Inhibits B-Cell Chronic Lymphocytic Leukemia Cell Survival In Vitro and In Vivo

Suping Zhang, PhD, Christina C.N. Wu, Ph.D., Jessie-Farah Fecteau, Ph.D., Bing Cui, PhD, Rongrong Wu, Laura Z. Rassenti, Ph.D., Fitzgerald S. Lao, B.S., Rommel Tawatao, B.S., Stefan Weigland, PhD, Charles Prussak, PhD, Dennis A. Carson, MD, Thomas J. Kipps, M.D., Ph.D
Journal: Blood
Blood (2011) 118 (21): 927.
https://doi.org/10.1182/blood.V118.21.927.927
Published: 2011
Journal Articles

Targeting of Chronic Lymphocytic Leukemia B Cells with a Novel Monoclonal Antibody to ROR1

Bing CUi, PhD, George F. Widhopf, II, PhD, Jian Yu, PhD, Daniel Martinez, BS, Esther Avery, B.S., Suping Zhang, PhD, Liguang Chen, MD, PhD, Rongrong Wu, Christina C.N. Wu, Ph.D., Charles Prussak, PhD, Thomas J. Kipps, M.D., Ph.D
Journal: Blood
Blood (2011) 118 (21): 984.
https://doi.org/10.1182/blood.V118.21.984.984
Published: 2011
Journal Articles

Highly Specific Inhibitor for Syk Induces Chronic Lymphocytic Leukemia Cell Apoptosis,

Liguang Chen, MD, PhD, George Chen, B.S., Jessie-Farah Fecteau, Ph.D., Greg Coffey, PhD, Charles Prussak, PhD, Dennis A. Carson, MD, Thomas Kipps, MD
Journal: Blood
Blood (2011) 118 (21): 3875.
https://doi.org/10.1182/blood.V118.21.3875.3875
Published: 2011
Journal Articles

Ad-ISF35-Transduced Autologous Cells Promote in Vitro and In Vivo Chemosensitization to FCR in Patients with Del(17p) / P53 Defective Chronic Lymphocytic Leukemia.

Januario E. Castro, M.D., Johanna Melo-Cardenas, B.Sc, Jose Sandoval-Sus, Mauricio Urquiza, Charles Prussak, PhD, Thomas J. Kipps, MD, PhD
Journal: Blood
Blood (2009) 114 (22): 376.
https://doi.org/10.1182/blood.V114.22.376.376
Published: 2009
Journal Articles

Active Immune Gene Therapy Using ISF35: Responses Associated with Priming for Death Receptor-Induced Apoptosis and Sensitivity to Fludarabine in Patients with CLL and Del 17p

William G Wierda, MD, PhD, Januario Castro, MD, Robier A Aguillon, MD, Deepa Sampath, PhD, Annette Jalayer, RN, Charles Prussak, PhD, Michael J Keating, MBBS, Thomas J Kipps, MD, PhD
Journal: Blood
Blood (2008) 112 (11): 3530.
https://doi.org/10.1182/blood.V112.11.3530.3530
Published: 2008
Journal Articles

A Phase I Study of Immune Gene Therapy for Patients with CLL Using Intranodal Injection of ISF35, a Membrane-Stable CD40 Binding Protein.

Januario Castro, MD, Jose D. Sandoval, MD, Johanna Melo-Cardenas, B.Sc, Denise Darrah, RN, Mauricio Urquiza, PhD, Charles Prussak, PhD, Thomas J. Kipps, MD, PhD
Journal: Blood
Blood (2008) 112 (11): 2100.
https://doi.org/10.1182/blood.V112.11.2100.2100
Published: 2008
Journal Articles

Highly Efficient Gene-Transfer into Chronic Lymphocytic Leukemia Cells Using Adenovirus Type 35 Genetic Vectors.

David C. Whitacre, PhD, Farah Hedjran, MS, Ingo Schmidt-Wolf, MD, Charles Prussak, PhD, Tony Reid, MD, PhD, Thomas J. Kipps, MD, PhD, David Whitacre
Journal: Blood
Blood (2005) 106 (11): 2109.
https://doi.org/10.1182/blood.V106.11.2109.2109
Published: 2005