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Journal Articles

The Phosphoinositide Kinase Pikfyve Regulates Lysosomal Biogenesis in Macrophages By Modulating the Transcription Factor EB (TFEB)

Francina Gonzalez, MSc, Aae Suzuki, Jessica Guzman, Lynn Spruce, Steven H Seeholzer, PhD, Charles S. Abrams, MD, Sang Hee Min, MDhD

Blood (2017) 130 (Supplement 1): 2276.

https://doi.org/10.1182/blood.V130.Suppl_1.2276.2276

Published: 2017

Journal Articles

Pleckstrin-2 Plays an Essential Role in the Pathogenesis of JAK2 V617F -Induced Myeloproliferative Neoplasms

Baobing Zhao, PhD, Yang Mei, PhD, Ronen Sumagin, PhD, Jing Yang, Chelsea Thorsheim, Liang Zhao, PhD, Timothy J. Stalker, PhD, Jeremy Q. Wen, John Crispino, PhD MBA, Charles S. Abrams, MD, Peng Ji, MD PhD

Blood (2016) 128 (22): 798.

https://doi.org/10.1182/blood.V128.22.798.798

Published: 2016

Journal Articles

Pikfyve Deficiency Disrupts Lysosomal Maturation and Degradative Function in Macrophages, and Causes Systemic Inflammation in Mice

Sang Hee Min, MD, Aae Suzuki, Jessica Guzman, Lehn Weaver, MD PhD, Charles S. Abrams, MD

Blood (2016) 128 (22): 704.

https://doi.org/10.1182/blood.V128.22.704.704

Published: 2016

Journal Articles

Platelet Pitp-Alpha Promotes Thrombin Generation and the Dissemination of Tumor Metastasis, but Has Minimal Effect on Vascular Plug Formation

Liang Zhao, PhD, Lurong Lian, Aae Suzuki, Timothy J. Stalker, PhD, Sang H Min, MD, Sriram Krishnaswamy, PhD MD, Amy Durham, VMD, Charles S. Abrams, MD

Blood (2015) 126 (23): 418.

https://doi.org/10.1182/blood.V126.23.418.418

Published: 2015

Journal Articles

Role for Megakaryocyte Phosphatidylinositol Transfer Proteins-Alpha and -Beta in TGF Beta-Mediated Regulation of Hematopoietic Homeostasis

Hal E. Broxmeyer, PhD, Maegan L. Capitano, PhD, Liang Zhao, PhD, Scott Cooper, MAS, Charles S. Abrams, MD

Blood (2015) 126 (23): 780.

https://doi.org/10.1182/blood.V126.23.780.780

Published: 2015

Journal Articles

Pikfyve Regulates Lysosomal Biogenesis and Functions in Macrophages

Sang H Min, MD, Lehn Weaver, MD PhD, Aae Suzuki, Jessica Guzman, Charles S. Abrams, MD

Blood (2015) 126 (23): 887.

https://doi.org/10.1182/blood.V126.23.887.887

Published: 2015

Journal Articles

Pikfyve Is Essential for Lysosomal Homeostasis in Macrophages

Sang H Min, MD, Aae Suzuki, Jessica Guzman, Charles S. Abrams, MD

Blood (2014) 124 (21): 461.

https://doi.org/10.1182/blood.V124.21.461.461

Published: 2014

Journal Articles

Platelet Pitpa Is Not Essential for Hemostasis, but Is Required for Tumor Metastasis Formation

Liang Zhao, PhD, Aae Suzuki, Timothy J. Stalker, PhD, Lurong Lian, MD, Min Sang, MD, Amy C Durham, VMD, Charles S. Abrams, MD

Blood (2014) 124 (21): 342.

https://doi.org/10.1182/blood.V124.21.342.342

Published: 2014

Journal Articles

Loss Of Phosphatidylinositol Transfer Proteins (PITPs) Causes Thrombocytopenia Due To a Defect In Thrombopoiesis

Aae Suzuki, Liang Zhao, Ph.D., Yuhuan Wang, PhD, Lurong Lian, Sang H. Min, MD, Mortimer Poncz, MD, Charles S. Abrams, MD

Blood (2013) 122 (21): 2313.

https://doi.org/10.1182/blood.V122.21.2313.2313

Published: 2013

Journal Articles

Pikfyve Deletion In Platelets Causes Aberrant Platelet Lysosomal Storage Associated With Inappropriate Inflammatory Response

Sang H Min, MD, Aae Suzuki, Timothy J. Stalker, PhD, Jessica Guzman, Liang Zhao, Ph.D., Lurong Lian, Ronghua Meng, PhD, Michael S. Marks, PhD, John K Choi, MD, PhD, Charles S. Abrams, MD

Blood (2013) 122 (21): 24.

https://doi.org/10.1182/blood.V122.21.24.24

Published: 2013

Journal Articles

Pikfyve-Deficient Platelets Mediate Inflammation and Thrombosis by Releasing Aberrant Granules

Sang H Min, MD, Aae Suzuki, Liang Zhao, Ph.D., Lurong Lian, Timothy J. Stalker, PhD, John K. Choi, MD, PhD, Charles S. Abrams, MD

Blood (2012) 120 (21): 262.

https://doi.org/10.1182/blood.V120.21.262.262

Published: 2012

Journal Articles

RhoA Is Essential for Maintaining Normal Megakaryocyte Ploidy Distribution and Platelet Generation

Aae Suzuki, Jae-Won Shin, Ph.D., Yuhuan Wang, PhD, Mortimer Poncz, MD, John K. Choi, MD, PhD, Dennis E Discher, Ph.D., Christopher L. Carpenter, MD, PhD, Lurong Lian, Liang Zhao, Ph.D., Yanfeng Wang, Charles S. Abrams, MD

Blood (2012) 120 (21): 385.

https://doi.org/10.1182/blood.V120.21.385.385

Published: 2012

Journal Articles

Class I Phosphatidylinositol Transfer Proteins (PITPs) Promote Platelet Activation by Functioning As Essential Cofactors for Phospholipid Kinases and Hydrolases

Liang Zhao, Ph.D., Lurong Lian, M.D., Aae Suzuki, Charles S. Abrams, MD

Blood (2012) 120 (21): 91.

https://doi.org/10.1182/blood.V120.21.91.91

Published: 2012

Journal Articles

Class I Phosphatidylinositol Transfer Proteins (PITPs) Promote PIP2 Synthesis and IP3 Production in Mouse Platelets

Liang Zhao, Ph.D., Lurong Liang, M.D., Aae Suzuki, Sang Min, MD, Charles S. Abrams, MD

Blood (2011) 118 (21): 363.

https://doi.org/10.1182/blood.V118.21.363.363

Published: 2011

Journal Articles

Loss of PIKFyve Kinase Function Driven by Platelet Factor 4 Promoter Results in Platelet Lysosomal Storage Defects and Infiltration of Multiple Organs with Vacuolated Macrophages

Sang Min, MD, Aae Suzuki, Liang Zhao, Ph.D., Lurong Lian, Timothy J. Stalker, PhD, John K. Choi, MD, PhD, Charles S. Abrams, MD

Blood (2011) 118 (21): 697.

https://doi.org/10.1182/blood.V118.21.697.697

Published: 2011

Journal Articles

Mice That Lack RhoA In Their Platelets Have Normal Actin Dynamics, but Have Macrothrombocytopenia

Aae Suzuki, Lurong Lian, Liang Zhao, Sang H. Min, MD, Yuhuan Wang, Mortimer Poncz, MD, John K Choi, Christopher L. Carpenter, MD, PhD, Charles S. Abrams, MD

Blood (2010) 116 (21): 549.

https://doi.org/10.1182/blood.V116.21.549.549

Published: 2010

Journal Articles

Loss of PIKFyve In Murine Platelets Leads to Aberrant Platelet Granule Biogenesis and a Pleomorphic Phenotype with Multiorgan Failure

Sang H. Min, MD, Aae Suzuki, Liang Zhao, Lurong Lian, Sidney W. Whiteheart, PhD, Michael S. Marks, PhD, John K. Choi, MD, PhD, Charles S. Abrams, MD

Blood (2010) 116 (21): 159.

https://doi.org/10.1182/blood.V116.21.159.159

Published: 2010

Journal Articles

Loss of Individual PIP5KI Isoforms Demonstrate That Spatial PIP2 Synthesis Is Required for Platelet Second Messenger Formation & Integrity of the Actin Cytoskeleton

Yanfeng Wang, M.D., Lurong Lian, M.D., Aae Suzuki, Rustem I. Litvinov, M.D., Timothy J. Stalker, Ph.D., Alec A. Schmaier, Lawrence F. Brass, MD, PhD, John Weisel, Ph.D., Charles S. Abrams, MD

Blood (2008) 112 (11): 109.

https://doi.org/10.1182/blood.V112.11.109.109

Published: 2008

Journal Articles

Impaired Actin Assembly and Lamellipodia Formation in ATE1 Knockout Platelets.

Lurong Lian, M.D., Anna S. Kashina, Ph.D., Karen P. Fong, Ph.D., Yanfeng Wang, M.D., Charles S. Abrams, MD

Blood (2008) 112 (11): 1834.

https://doi.org/10.1182/blood.V112.11.1834.1834

Published: 2008

Journal Articles

Platelets Lacking Both Pleckstrin and Pleckstrin-2 Have a Marked Deficient Cell Spreading and Actin Assembly

Yanfeng Wang, M.D., Lurong Lian, M.D., John H. Hartwig, PhD, Charles S. Abrams, MD

Blood (2008) 112 (11): 253.

https://doi.org/10.1182/blood.V112.11.253.253

Published: 2008

NARROW

The Phosphoinositide Kinase Pikfyve Regulates Lysosomal Biogenesis in Macrophages By Modulating the Transcription Factor EB (TFEB)

Pleckstrin-2 Plays an Essential Role in the Pathogenesis of JAK2 V617F -Induced Myeloproliferative Neoplasms

Pikfyve Deficiency Disrupts Lysosomal Maturation and Degradative Function in Macrophages, and Causes Systemic Inflammation in Mice

Platelet Pitp-Alpha Promotes Thrombin Generation and the Dissemination of Tumor Metastasis, but Has Minimal Effect on Vascular Plug Formation

Role for Megakaryocyte Phosphatidylinositol Transfer Proteins-Alpha and -Beta in TGF Beta-Mediated Regulation of Hematopoietic Homeostasis

Pikfyve Regulates Lysosomal Biogenesis and Functions in Macrophages

Pikfyve Is Essential for Lysosomal Homeostasis in Macrophages

Platelet Pitpa Is Not Essential for Hemostasis, but Is Required for Tumor Metastasis Formation

Loss Of Phosphatidylinositol Transfer Proteins (PITPs) Causes Thrombocytopenia Due To a Defect In Thrombopoiesis

Pikfyve Deletion In Platelets Causes Aberrant Platelet Lysosomal Storage Associated With Inappropriate Inflammatory Response

Pikfyve-Deficient Platelets Mediate Inflammation and Thrombosis by Releasing Aberrant Granules

RhoA Is Essential for Maintaining Normal Megakaryocyte Ploidy Distribution and Platelet Generation

Class I Phosphatidylinositol Transfer Proteins (PITPs) Promote Platelet Activation by Functioning As Essential Cofactors for Phospholipid Kinases and Hydrolases

Class I Phosphatidylinositol Transfer Proteins (PITPs) Promote PIP2 Synthesis and IP3 Production in Mouse Platelets

Loss of PIKFyve Kinase Function Driven by Platelet Factor 4 Promoter Results in Platelet Lysosomal Storage Defects and Infiltration of Multiple Organs with Vacuolated Macrophages

Mice That Lack RhoA In Their Platelets Have Normal Actin Dynamics, but Have Macrothrombocytopenia

Loss of PIKFyve In Murine Platelets Leads to Aberrant Platelet Granule Biogenesis and a Pleomorphic Phenotype with Multiorgan Failure

Loss of Individual PIP5KI Isoforms Demonstrate That Spatial PIP2 Synthesis Is Required for Platelet Second Messenger Formation & Integrity of the Actin Cytoskeleton

Impaired Actin Assembly and Lamellipodia Formation in ATE1 Knockout Platelets.

Platelets Lacking Both Pleckstrin and Pleckstrin-2 Have a Marked Deficient Cell Spreading and Actin Assembly

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American Society of Hematology

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American Society of Hematology

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