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Charlotte Hellmich, MBBChir
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Journal Articles

Mitochondrial Function Is Impaired in a Subset of Aged Haematopoietic Stem Cells in Response to Infection

Charlotte Hellmich, MBBChir, Jayna J Mistry, BSc, Jamie A Moore, BSc, MSc, Aisha Jibril, BSc, Kristian M Bowles, MBBS, PhD, Stuart A Rushworth, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 27–28.
https://doi.org/10.1182/blood-2020-140311
Published: 2020
Journal Articles

Myeloma Derived Mitochondrial Damage Associated Molecular Patterns Promote Pro-Tumoral Expansion By Inducing a Pro-Inflammatory Signature in the Bone Marrow Microenvironment

Aisha Jibril, BSc, Jayna J Mistry, BSc, Jamie A Moore, BSc, MSc, Charlotte Hellmich, MBBChir, Victoria Willimott, MB BS, Kristian M Bowles, MBBS, PhD, Stuart A Rushworth, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 1.
https://doi.org/10.1182/blood-2020-139811
Published: 2020
Journal Articles

Myeloma Derived Extracellular Vesicles Containing Endoplasmic Reticulum Remodel the Bone Marrow Microenvironment Towards a Pro-Tumoral Senescent Phenotype

Yu Sun, BSc, MSc, PhD, Jayna J Mistry, BSc, Jamie A Moore, BSc, MSc, Charlotte Hellmich, MBBChir, Christopher R Marlein, PhD, Anna Haestier, Cesar A. Gomez, MD PhD FRCPath, Christopher J Morris, PhD, Kristian M Bowles, MBBS, PhD, Stuart A Rushworth, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 689.
https://doi.org/10.1182/blood-2019-128268
Published: 2019
Journal Articles

Free Fatty Acid Uptake By Hematopoietic Stem and Progenitor Cells Drives Immune Cell Expansion in Response to Salmonella Typhimurium infection

Jayna J Mistry, BSc, Jamie A Moore, BSc, MSc, Charlotte Hellmich, MBBChir, Christopher R Marlein, PhD, Naiara Beraza, PhD, Federica Di Palma, PhD, Kristian M Bowles, MBBS, PhD, Stuart A Rushworth, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1197.
https://doi.org/10.1182/blood-2019-128237
Published: 2019
Journal Articles

Superoxide Drives PI3 Kinase Mediated Mitochondria Transfer from the Bone Marrow Microenvironment to Hematopoietic Stem Cells in Response to Salmonella Typhimurium

Jayna J Mistry, BSc, Christopher R Marlein, PhD, Jamie A Moore, BSc, MSc, Charlotte Hellmich, MBBChir, Iain Macauley, PhD BSc, Naiara Beraza, PhD, Yu Sun, BSc, MSc, PhD, Adam Morfakis, BSc, Angela Patterson, PhD, Rebecca H Horton, Devina Divekar, Christopher J Morris, PhD, Anna Haestier, Bsc, PgD MBBS, MRCOG, Federica Di Palma, PhD, Kristian M Bowles, MBBS, PhD, Stuart A Rushworth, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2490.
https://doi.org/10.1182/blood-2019-128241
Published: 2019
Journal Articles

Daratumumab Inhibits AML Metabolic Capacity and Tumor Growth through Inhibition of CD38 Mediated Mitochondrial Transfer from Bone Marrow Stromal Cells to Blasts in the Leukemic Microenvironment

Jayna J Mistry, BSc, Charlotte Hellmich, MBBChir, Jamie A Moore, BSc, MSc, Christopher R Marlein, PhD, Genevra Pillinger, MB BS, Angela Collins, MBBS, Kristian M Bowles, MBBS, PhD, Stuart A Rushworth, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1385.
https://doi.org/10.1182/blood-2019-128592
Published: 2019
Journal Articles

Acute Myeloid Leukemia Export Mitochondria in Extracellular Vesicles Which Induces Pro-Tumoral Changes in Bone Marrow Macrophages

Jamie A Moore, BSc, MSc, Jayna J Mistry, BSc, Rebecca H Horton, Charlotte Hellmich, MBBChir, Adam Pattinson, MSc, BSc, Adam Morfakis, BSc, Yu Sun, BSc, MSc, PhD, Matthew Lawes, MD, Christopher J Morris, PhD, Anna Haestier, Kristian M Bowles, MBBS, PhD, Stuart A Rushworth, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1427.
https://doi.org/10.1182/blood-2019-128447
Published: 2019
Journal Articles

Stressed Hematopoiesis Induces Mitochondrial Trafficking to Hematopoietic Stem Cells

Jayna J Mistry, BSc, Christopher Richard Marlein, BSc, Iain Macauley, PhD BSc, Rebecca H Horton, Adam Morfakis, BSc, Charlotte Hellmich, MBBChir, BSc, MRCP, Anna Haestier, Bsc, PgD MBBS, MRCOG, Kristian Bowles, MBBS, PhD, Stuart Rushworth, PhD BSc
Journal: Blood
Blood (2018) 132 (Supplement 1): 3849.
https://doi.org/10.1182/blood-2018-99-110930
Published: 2018
Journal Articles

NOX2 Derived Superoxide Induces Pro-Tumoral p16INK4a Driven Senescence in the AML Bone Marrow Microenvironment

Charlotte Hellmich, MBBChir, BSc, MRCP, Amina Abdul-Aziz, MSc, Yu Sun, BSc, MSc, Christopher Richard Marlein, BSc, Eoghan Forde, Rachel E Piddock, BSc, Manar Shafat, MSc, Adam Morfakis, BSc, Mehta Tarang, Federica Di Palma, Christopher Ingham, Angela Collins, MBBS, Anna Haestier, Bsc, PgD MBBS, MRCOG, Judith Campisi, PhD, Kristian Bowles, MBBS, PhD, Stuart Rushworth, PhD BSc
Journal: Blood
Blood (2018) 132 (Supplement 1): 2770.
https://doi.org/10.1182/blood-2018-99-115274
Published: 2018
Journal Articles

All-Trans Retinoic Acid (ATRA) up-Regulates Cell Surface CD38 Expression Which Promotes Pro-Tumoral Mitochondrial Trafficking from Stromal Cells to Multiple Myeloma

Christopher Richard Marlein, BSc, Rebecca H Horton, Rachel E Piddock, BSc, Jayna J Mistry, BSc, Charlotte Hellmich, MBBChir, BSc, MRCP, Cesar A. Gomez, MD PhD FRCPath, Kristian Bowles, MBBS, PhD, Stuart Rushworth, PhD BSc
Journal: Blood
Blood (2018) 132 (Supplement 1): 3153.
https://doi.org/10.1182/blood-2018-99-110323
Published: 2018