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Christopher B. Benton, MD
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Journal Articles

Evolutionary Action Score Identifies a Subset of TP53 Mutated Myelodysplastic Syndrome with Favorable Prognosis

Rashmi Kanagal-Shamanna, MD, Guillermo Montalban Bravo, MD, Panagiotis Katsonis, Koji Sasaki, MD, Caleb Class, PhD, Christopher B. Benton, MD, Elias Jabbour, MD, Kelly S. Chien, MD, Rajyalakshmi Luthra, PhD, Carlos E. Bueso-Ramos, MD PhD, Tapan M. Kadia, MD, Michael Andreeff, MD PhD, Nicholas J. Short, MD, Naval Daver, MD, Mark Routbort, MD PhD, Joseph D. Khoury, MD, Keyur Patel, MD PhD, Irene Ganan-Gomez, PhD, Yue Wei, PhD, Gautam Borthakur, MD, Farhad Ravandi, MBBS, Kim-Anh Do, PhD, Kelly A. Soltysiak, PhD, Olivier Lichtarge, L. Jeffrey Medeiros, MD, Hagop M. Kantarjian, MD, Guillermo Garcia-Manero, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 4–5.
https://doi.org/10.1182/blood-2020-141411
Published: 2020
Journal Articles

Outcomes in Molecular Subgroups and Resistance Patterns with Ten-Day Decitabine and Venetoclax (DEC10-VEN) in Acute Myeloid Leukemia

Abhishek Maiti, MBBS, Caitlin R. Rausch, PharmD, Jorge E. Cortes, MD, Naveen Pemmaraju, MD, Naval G. Daver, MD, Farhad Ravandi, MD, Guillermo Garcia-Manero, MD, Gautam M. Borthakur, MD, Kiran Naqvi, MDMPH, Maro Ohanian, DO, Nicholas J. Short, MD, Yesid Alvarado, MD, Christopher B. Benton, MD, Tapan M. Kadia, MD, Koichi Takahashi, MD, Musa Yilmaz, MD, Nitin Jain, MD, Steven M. Kornblau, MD, Koji Sasaki, MD, Michael Andreeff, MD PhD, Prithviraj Bose, MD, Alessandra Ferrajoli, MD, Ghayas C. Issa, MD, Elias Jabbour, MD, Lucia Masarova, MD, Michael E. Rytting, MD, Philip A. Thompson, MBBS, Sa A Wang, MD, Sergej Konoplev, Zhining Chen, Maitrayee Goswami, Rita Maduike, Julio A Guerrero, RN, Qi Zhang, PhD, Antonio Cavazos, Helen Ma, MS, Carol A. Bivins, RN, Allison Wade, Shadiat L Adewale, Susan Tse, Robin Thomas, Kenneth Vaughan, RN, Sherry A. Pierce, BSN, BA, Jing Ning, PhD, Wei Qiao, PhD, John S. Welch, MD PhD, Keyur P. Patel, MBBS, PhD, Hagop M. Kantarjian, MD, Marina Y Konopleva, MD PhD, Courtney D. DiNardo, MD MSc
Journal: Blood
Blood (2019) 134 (Supplement_1): 645.
https://doi.org/10.1182/blood-2019-128547
Published: 2019
Journal Articles

Genomic Context and TP53 Allele Frequency Define Prognostic Subgroups and Response Outcomes in TP53 Mutated Myelodysplastic Syndromes

Guillermo Montalban-Bravo, MD, Rashmi Kanagal-Shamanna, MD, Christopher B. Benton, MD, Caleb Class, PhD, Kelly S. Chien, MD, Koji Sasaki, MD, Kiran Naqvi, MDMPH, Yesid Alvarado, MD, Tapan M. Kadia, MD, Farhad Ravandi, MD, Jorge E. Cortes, MD, Naval G. Daver, MD, Koichi Takahashi, MD, Courtney D. DiNardo, MDMSc, Elias Jabbour, MD, Gautam M. Borthakur, MD, Naveen Pemmaraju, MD, Marina Y Konopleva, MD PhD, Sherry A. Pierce, BSN, BA, Carlos E. Bueso-Ramos, MD PhD, Michael Andreeff, MD PhD, Keyur P. Patel, MBBS, PhD, Hagop M. Kantarjian, MD, Guillermo Garcia-Manero, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1711.
https://doi.org/10.1182/blood-2019-124978
Published: 2019
Journal Articles

Evolutionary Action (EA) Score of TP53 Mutations Defines Prognostic Subsets within TP53 Mutated Myelodysplastic Syndromes and Acute Myeloid Leukemia

Rashmi Kanagal-Shamanna, MD, Guillermo Montalban-Bravo, MD, Caleb Class, PhD, Koji Sasaki, MD, Christopher B. Benton, MD, Kelly Soltysiak, PhD, Elias Jabbour, MD, Tapan M. Kadia, MD, Carlos E. Bueso-Ramos, MD PhD, Keyur P. Patel, MBBS, PhD, Mark Routbort, MD PhD, Irene Ganan-Gomez, PhD, Yue Wei, PhD, Gautam M. Borthakur, MD, Farhad Ravandi, MD, Kim-Anh Do, PhD, L. Jeffrey Medeiros, MD, Hagop M. Kantarjian, MD, Guillermo Garcia-Manero, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1719.
https://doi.org/10.1182/blood-2019-130545
Published: 2019
Journal Articles

Ten-Day Decitabine with Venetoclax (DEC10-VEN) in Acute Myeloid Leukemia: Updated Results of a Phase II Trial

Abhishek Maiti, MBBS, Courtney D. DiNardo, MDMSc, Caitlin R. Rausch, PharmD, Jorge E. Cortes, MD, Naveen Pemmaraju, MD, Naval G. Daver, MD, Farhad Ravandi, MD, Guillermo Garcia-Manero, MD, Gautam M. Borthakur, MD, Kiran Naqvi, MDMPH, Maro N. Ohanian, DO, Nicholas J. Short, MD, Yesid Alvarado, MD, Christopher B. Benton, MD, Tapan M. Kadia, MD, Koichi Takahashi, MD, Musa E. Yilmaz, MD, Nitin Jain, MD, Steven M. Kornblau, MD, Koji Sasaki, MD, Michael Andreeff, MD PhD, Prithviraj Bose, MD, Alessandra Ferrajoli, MD, Ghayas C. Issa, MD, Elias Jabbour, MD, Lucia Masarova, MD, Michael E. Rytting, MD, Philip A. Thompson, MBBS, Sa A Wang, MD, Sergej Konoplev, Zhining Chen, Maitrayee Goswami, Rita Maduike, Julio A Guerrero, RN, Qi Zhang, PhD, Antonio Cavazos, Helen Ma, MS, Carol A. Bivins, RN, Allison Wade, Shadiat L Adewale, Susan Tse, Robin Thomas, Kenneth Vaughan, RN, Sherry A. Pierce, BSN, BA, Jing Ning, PhD, Wei Qiao, PhD, John S. Welch, MD PhD, Hagop M. Kantarjian, MD, Marina Y Konopleva, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2637.
https://doi.org/10.1182/blood-2019-127803
Published: 2019
Journal Articles

Liposomal Cytarabine and Daunorubicin (CPX-351) in Combination with Gemtuzumab Ozogamicin (GO) in Relapsed Refractory (R/R) Patients with Acute Myeloid Leukemia (AML) and Post-Hypomethylating Agent (Post-HMA) Failure High-Risk Myelodysplastic Syndrome (HR-MDS)

Jorge M. Ramos Perez, Tapan M. Kadia, MD, Guillermo Montalban-Bravo, MD, Christopher B. Benton, MD, Stefan Faderl, Koji Sasaki, MD, Kiran Naqvi, MDMPH, Jorge E. Cortes, MD, Naval G. Daver, MD, Courtney D. DiNardo, MDMSc, Elias Jabbour, MD, Gautam M. Borthakur, MD, Hind Al Azzawi, Naveen Pemmaraju, MD, Marina Y Konopleva, MD PhD, Sherry A. Pierce, BSN, BA, Nitin Jain, MD, Maro Ohanian, DO, Guillermo Garcia-Manero, MD, Michael Andreeff, MD PhD, Hagop M. Kantarjian, MD, Farhad Ravandi, MD, Yesid Alvarado, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2642.
https://doi.org/10.1182/blood-2019-129137
Published: 2019
Journal Articles

Identification of Gene Expression Signatures in Leukemia Stem Cells and Minimal Residual Disease Following Treatment of Adverse Risk Acute Myeloid Leukemia

Ghayas C. Issa, MD, Christopher B. Benton, MD, Vakul Mohanty, PhD, Yifei Shen, PhD, Zoe Alaniz, Feng Wang, PhD, P. Andrew Futreal, PhD, Wei Wang, MD PhD, Jeffrey L. Jorgensen, MD PhD, Nicholas Navin, PhD, Marina Y Konopleva, MD PhD, Ken Chen, PhD, Michael Andreeff, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2717.
https://doi.org/10.1182/blood-2019-130540
Published: 2019
Journal Articles

Outcomes of Relapsed or Refractory Acute Myeloid Leukemia after Frontline Hypomethylating Agent with Venetoclax Regimens

Abhishek Maiti, MBBS, Caitlin R. Rausch, PharmD, Jorge E. Cortes, MD, Naveen Pemmaraju, MD, Naval G. Daver, MD, Farhad Ravandi, MD, Guillermo Garcia-Manero, MD, Gautam M. Borthakur, MD, Kiran Naqvi, MDMPH, Maro Ohanian, DO, Nicholas J. Short, MD, Yesid Alvarado, MD, Christopher B. Benton, MD, Christopher B. Benton, MD, Tapan M. Kadia, MD, Koichi Takahashi, MD, Musa E. Yilmaz, MD, Nitin Jain, MD, Steven M. Kornblau, MD, Guillermo Montalban Bravo, MD, Koji Sasaki, MD, Michael Andreeff, MD PhD, Prithviraj Bose, MD, Alessandra Ferrajoli, MD, Ghayas C. Issa, MD, Elias Jabbour, MD, Lucia Masarova, MD, Michael E. Rytting, MD, Philip A. Thompson, MBBS, Sa A Wang, MD, Sergej Konoplev, Zhining Chen, Maitrayee Goswami, Rita Maduike, Julio A Guerrero, RN, Qi Zhang, PhD, Antonio Cavazos, Helen Ma, MS, Carol A. Bivins, RN, Allison Wade, Shadiat L Adewale, Susan Tse, Robin Thomas, Kenneth Vaughan, RN, Sherry A. Pierce, BSN, BA, Jing Ning, PhD, Wei Qiao, PhD, John S. Welch, MD PhD, Hagop M. Kantarjian, MD, Marina Y Konopleva, MD PhD, Courtney D. DiNardo, MD MSc
Journal: Blood
Blood (2019) 134 (Supplement_1): 738.
https://doi.org/10.1182/blood-2019-128909
Published: 2019
Journal Articles

Phase I Study of Palbociclib Alone and in Combination in Patients with Relapsed and Refractory (R/R) Leukemias

Tapan M. Kadia, MD, Marina Y. Konopleva, MD PhD, Guillermo Garcia-Manero, MD, Christopher B. Benton, MD, William G. Wierda, MD PhD, Prithviraj Bose, MD, Musa E. Yilmaz, MD, Elias J. Jabbour, MD, Steven M. Kornblau, MD, Kapil N. Bhalla, MD, Naveen Pemmaraju, MD, Nitin Jain, MD, Rashmi Malla, RN, BSN, Gautam Borthakur, MD, Jorge E. Cortes, MD, Farhad Ravandi, MD, Hagop M. Kantarjian, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4057.
https://doi.org/10.1182/blood-2018-99-117334
Published: 2018
Journal Articles

Long Term Follow-up on Phase 2 Study on the Efficacy and Safety of Blinatumomab in Adult Patients with Relapsed Refractory B-Precursor Acute Lymphoblastic Leukemia

Iman Aboudalle, MD, Hagop M. Kantarjian, MD, Nicholas J Short, MD, Farhad Ravandi, MD, Koji Sasaki, MD, Guillermo Garcia-Manero, MD, Guillermo Montalban-Bravo, MD, Jorge E. Cortes, MD, Christopher B. Benton, MD, Ghayas C. Issa, MD, Maria Khouri, Patrice Nasnas, MD, Susan M. O'Brien, MD, Elias J. Jabbour, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4017.
https://doi.org/10.1182/blood-2018-99-117507
Published: 2018
Journal Articles

Isavuconazole (ISAV) As Primary Anti-Fungal Prophylaxis in Acute Myeloid Leukemia or Myelodysplastic Syndrome: An Open-Label, Prospective Study

Prithviraj Bose, MD, David McCue, Nathan P. Wiederhold, PharmD, Tapan M. Kadia, MD, Gautam Borthakur, MD, Farhad Ravandi, MD, Musa Yilmaz, MD, Koichi Takahashi, MD, Philip A. Thompson, MBBS, Naveen Pemmaraju, MD, Naval G. Daver, MD, Jan A. Burger, MD PhD, Jorge E. Cortes, MD, Guillermo Garcia-Manero, MD, Srdan Verstovsek, MD PhD, Marina Y. Konopleva, MD PhD, Nitin Jain, MD, Courtney D. DiNardo, MD MSc, Yesid Alvarado, MD, Kiran Naqvi, MD MPH, Steven M. Kornblau, MD, Alessandra Ferrajoli, MD, William G. Wierda, MD PhD, Zeev E. Estrov, MD, Christopher B. Benton, MD, Lucia Masarova, MD, Guillermo Montalban-Bravo, MD, Koji Sasaki, MD, Caitlin R. Rausch, PharmD, Kayleigh Marx, PharmD, Wei Qiao, PhD, Xuelin Huang, PhD, Carol A. Bivins, RN, Sherry A. Pierce, BSN, BA, Hagop M. Kantarjian, MD, Dimitrios P. Kontoyiannis, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2674.
https://doi.org/10.1182/blood-2018-99-111727
Published: 2018
Journal Articles

Distinct Gene Expression Patterns of Minimal Residual Disease (MRD) Cells in High-Risk AML Patients Identified By RNA-Sequencing

Christopher B. Benton, MD, Ahmed Al Rawi, Feng Wang, PhD, Jianhua Zhang, PhD, Jeffrey L. Jorgensen, MD PhD, Hong Mu, MD PhD, Wendy Schober, Zoe Alaniz, Curtis Gumbs, Andy Futreal, PhD, Guillermo Garcia-Manero, MD, Hagop M. Kantarjian, MD, Nicholas Navin, PhD, Marina Y. Konopleva, MD PhD, Michael Andreeff, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2757.
https://doi.org/10.1182/blood-2018-99-120260
Published: 2018
Journal Articles

Safety and Tolerability of Lurbinectedin (PM01183) in Patients with Acute Myeloid Leukemia and Myelodysplastic Syndrome

Kelly S. Chien, MD, Christopher B. Benton, MD, Ayalew Tefferi, MD, José Rodríguez, MD PhD, Farhad Ravandi, MD, Naval G. Daver, MD, Elias J. Jabbour, MD, Nitin Jain, MD, Yesid Alvarado, MD, Monica Kwari, BSN, Sherry A. Pierce, BSN, BA, Abhishek Maiti, MBBS, Marisa J Hornbaker, BS, Margarida Almeida Santos, PhD, Sara Martinez, MD, Mariano Siguero, Darci Zblewski, APRN, C-NP, Aref Al-Kali, MD, William J. Hogan, MBBCh, Hagop M. Kantarjian, MD, Animesh Pardanani, MBBS, PhD, Guillermo Garcia-Manero, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2722.
https://doi.org/10.1182/blood-2018-99-115673
Published: 2018
Journal Articles

Landscape of TP53 Abnormalities and Their Clinical Relevance in Patients with Myelodysplastic Syndromes and Acute Myeloid Leukemia

Guillermo Montalban-Bravo, MD, Christopher B. Benton, MD, Rashmi Kanagal-Shamanna, MD, Koji Sasaki, MD, Rita Assi, MD, Tapan M. Kadia, MD, Farhad Ravandi, MD, Irene Ganan-Gomez, PhD, Jorge E. Cortes, MD, Naval G. Daver, MD, Koichi Takahashi, MD, Courtney D. DiNardo, MD MSc, Elias J. Jabbour, MD, Gautam Borthakur, MD, Naveen Pemmaraju, MD, Marina Y. Konopleva, MD PhD, Sherry A. Pierce, BSN, BA, Carlos E. Bueso-Ramos, MD PhD, Steven M. Kornblau, MD, Keyur Patel, MD PhD, Simona Colla, PhD, Hagop M. Kantarjian, MD, Michael Andreeff, MD PhD, Guillermo Garcia-Manero, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2791.
https://doi.org/10.1182/blood-2018-99-119706
Published: 2018
Journal Articles

Cladribine Combined with Idarubicin and High-Dose AraC (CLIA2) As a Frontline and Salvage Treatment for Young Patients (≤65 yrs) with Acute Myeloid Leukemia

Mansour Alfayez, MD, Hagop M. Kantarjian, MD, Farhad Ravandi, MD, Guillermo Garcia-Manero, MD, Marina Y. Konopleva, MD PhD, Naval G. Daver, MD, Courtney D. DiNardo, MD MSc, Gautam Borthakur, MD, Prithviraj Bose, MD, Michael Andreeff, MD PhD, Yesid Alvarado, MD, Musa E. Yilmaz, MD, Naveen Pemmaraju, MD, Steven M. Kornblau, MD, Zeev E. Estrov, MD, Christopher B. Benton, MD, Koichi Takahashi, MD, Kiran Naqvi, MD MPH, Rebecca Slack, MS, Rubiul Islam, MD, Elias J. Jabbour, MD, Jorge E. Cortes, MD, Tapan M. Kadia, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4039.
https://doi.org/10.1182/blood-2018-99-119271
Published: 2018
Journal Articles

Five-Day Versus Ten-Day Schedules of Decitabine in Older Patients with Newly Diagnosed Acute Myeloid Leukemia: Results of a Randomized Phase II Study

Nicholas J Short, MD, Hagop M. Kantarjian, MD, Sanam Loghavi, MD, Xuelin Huang, PhD, Wei Qiao, PhD, Gautam Borthakur, MD, Tapan M. Kadia, MD, Naval G. Daver, MD, Maro N. Ohanian, DO, Courtney D. DiNardo, MDMSc, Zeev E. Estrov, MD, Rashmi Kanagal-Shamanna, MD, Abhishek Maiti, MBBS, Christopher B. Benton, MD, Prithviraj Bose, MD, Yesid Alvarado, MD, Elias J. Jabbour, MD, Steven M. Kornblau, MD, Naveen Pemmaraju, MD, Nitin Jain, MD, Yvonne Gasior, RN, Mary Ann Richie, Sherry A. Pierce, BSN, BA, Jorge E. Cortes, MD, Marina Y. Konopleva, MD PhD, Guillermo Garcia-Manero, MD, Farhad Ravandi, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 84.
https://doi.org/10.1182/blood-2018-99-115367
Published: 2018
Journal Articles

Pattern of Immune-Mediated Toxicities in Patients with Myelodysplastic Syndrome (MDS) Treated with Nivolumab and Ipilimumab

Caitlin R. Rausch, PharmD, Shilpa Paul, PharmD, Guillermo Montalban Bravo, MD, Elias J. Jabbour, MD, Naval G. Daver, MD, Yesid Alvarado, MD, Courtney D. DiNardo, MD MSc, Farhad Ravandi, MD, Gautam Borthakur, MD, Prithviraj Bose, MD, Naveen Pemmaraju, MD, Kiran Naqvi, MD MPH, Steven M. Kornblau, MD, Jorge E. Cortes, MD, Tapan M. Kadia, MD, Marina Y. Konopleva, MD PhD, Maro N. Ohanian, DO, Sherry A. Pierce, BSN, BA, Yvonne Gasior, RN, Christopher B. Benton, MD, Nitin Jain, MD, Koichi Takahashi, MD, Lucia Masarova, MD, Michael Andreeff, MD PhD, Zeev E. Estrov, MD, Hagop M. Kantarjian, MD, Guillermo Garcia-Manero, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4367.
https://doi.org/10.1182/blood-2018-99-116714
Published: 2018
Journal Articles

Final Report of a Phase II Study of Guadecitabine (SGI-110) in Patients (pts) with Previously Untreated Myelodysplastic Syndrome (MDS)

Guillermo Garcia-Manero, MD, Koji Sasaki, MD, Guillermo Montalban-Bravo, MD, Kristy R. Bodden, Prithviraj Bose, MD, Yesid Alvarado, MD, Naval G. Daver, MD, Gautam Borthakur, MD, Farhad Ravandi, MD, Koichi Takahashi, MD, Jorge E. Cortes, MD, Elias J. Jabbour, MD, Kiran Naqvi, MDMPH, Courtney D. DiNardo, MDMSc, Christopher B. Benton, MD, Naveen Pemmaraju, MD, Tapan M. Kadia, MD, Maro N. Ohanian, DO, Sherry A. Pierce, BSN, BA, Hagop M. Kantarjian, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 232.
https://doi.org/10.1182/blood-2018-99-116838
Published: 2018
Journal Articles

Results of a Phase 2, Open-Label Study of Idarubicin (I), Cytarabine (A) and Nivolumab (Nivo) in Patients with Newly Diagnosed Acute Myeloid Leukemia (AML) and High-Risk Myelodysplastic Syndrome (MDS)

Rita Assi, MD, Hagop M. Kantarjian, MD, Naval G. Daver, MD, Guillermo Garcia-Manero, MD, Christopher B. Benton, MD, Philip A. Thompson, MBBS, Gautam Borthakur, MD, Tapan M. Kadia, MD, Yesid Alvarado, MD, Elias J. Jabbour, MD, Marina Y. Konopleva, MD PhD, Koichi Takahashi, MD, Steven M. Kornblau, MD, Courtney D. DiNardo, MDMSc, Zeev E. Estrov, MD, Wilmer Flores, Sreyashi Basu, PhD, James P Allison, PhD, Padmanee Sharma, MD PhD, Sherry A. Pierce, BSN, BA, Allison Pike, RN, Jorge E. Cortes, MD, Farhad Ravandi, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 905.
https://doi.org/10.1182/blood-2018-99-116078
Published: 2018
Journal Articles

Evolutionary Action Score of Missense TP53 Mutations Can Predict Outcome in Patients with Myelodysplastic Syndrome and Acute Myeloid Leukemia

Rashmi Kanagal-Shamanna, MD, Koji Sasaki, MD, Guillermo Montalban Bravo, MD, Christopher B. Benton, MD, Elias J. Jabbour, MD, Gautam Borthakur, MD, Tapan M. Kadia, MD, Carlos E. Bueso-Ramos, MD PhD, Keyur Patel, MD PhD, Farhad Ravandi, MD, Hagop M. Kantarjian, MD, Guillermo Garcia-Manero, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1820.
https://doi.org/10.1182/blood-2018-99-119095
Published: 2018