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Journal Articles

FT-4202, an Allosteric Activator of Pyruvate Kinase-R, Demonstrates Proof of Mechanism and Proof of Concept after a Single Dose and after Multiple Daily Doses in a Phase 1 Study of Patients with Sickle Cell Disease

R. Clark Brown, MD PhD, Kimberly Cruz, MD MS, Theodosia A. Kalfa, MD PhD, Frans A. Kuypers, PhD, Santosh L. Saraf, MD, Jeremie H. Estepp, MD, Luke R. Smart, MD, Punam Malik, MD, Mark Lerman, MD, Renae Mayer, MD, Maria D. Ribadeneira, PhD, Sanjeev Forsyth, MS, Patricia Schroeder, PhD, Eric Wu, PhD, Patrick Kelly, MD, Marilyn J. Telen, MD

Blood (2020) 136 (Supplement 1): 19–20.

https://doi.org/10.1182/blood-2020-134269

Published: 2020

Journal Articles

Early Initiation of Treatment with Rivipansel for Acute Vaso-Occlusive Crisis in Sickle Cell Disease (SCD) Achieves Earlier Discontinuation of IV Opioids and Shorter Hospital Stay: Reset Clinical Trial Analysis

Carlton D. Dampier, MD, Marilyn J. Telen, MD, Ted Wun, MD, Wally R Smith, MD, R. Clark Brown, MD PhD, Payal Desai, MD, Fuad A El Rassi, MD, Julie Kanter, MD, Beng R. Fuh, MD, Yves D. Pastore, MD, Jennifer A. Rothman, MD, James G. Taylor, MD, David Readett, BM, BS, MRCP, Jay N Lozier, MDPhD, John L. Magnani, PhD, Helen M Thackray, MD, Kathryn L. Hassell, MD

Blood (2020) 136 (Supplement 1): 18–19.

https://doi.org/10.1182/blood-2020-134803

Published: 2020

Journal Articles

Assessment of Cerebral Blood Flow and Oxygen Extraction in Pediatric Sickle Cell Disease with Non-Invasive Diffuse Optical Spectroscopies

Seung Yup Lee, PhD, Eashani Sathilingam, BS, Kyle R. Cowdrick, MS, Rowan O. Brothers, BS, Wilbur A. Lam, MDPhD, R. Clark Brown, MD PhD, Clinton H. Joiner, MD PhD, Claudia R. Morris, MD, Erin M. Buckley, PhD

Blood (2020) 136 (Supplement 1): 7–8.

https://doi.org/10.1182/blood-2020-142029

Published: 2020

Journal Articles

Study Design and Initial Baseline Characteristics in Solace-Kids: Crizanlizumab in Pediatric Patients with Sickle Cell Disease

Matthew M. Heeney, MD, David C. Rees, MD, Mariane de Montalembert, MD PhD, Isaac Odame, MD, R. Clark Brown, MD PhD, Yasser Wali, MD, Thu Thuy Nguyen, Du Lam, MD, Raquel Merino Herranz, Julie Kanter, MD

Blood (2020) 136 (Supplement 1): 22–24.

https://doi.org/10.1182/blood-2020-137081

Published: 2020

Journal Articles

Pharmacokinetics/Pharmacodynamics, Safety and Efficacy of Crizanlizumab in Patients with Sickle Cell Disease and a History of Vaso-Occlusive Crises: Results from the Phase II, Multicenter, Open-Label Solace-Adults Study

Darla Liles, MD, Kim Smith-Whitley, MD, R Clark Brown, MD PhD, Nirmish Shah, MD, Santosh M Nair, MD, Chiaki Tanaka, PhD, Shankaranand Bodla, Gessami Sanchez-Olle, PhD, Urs Albers, PhD, Julie Kanter, MD

Blood (2020) 136 (Supplement 1): 17–19.

https://doi.org/10.1182/blood-2020-137434

Published: 2020

Journal Articles

Efficacy and Safety of Voxelotor in Adolescents and Adults with Sickle Cell Disease: HOPE Trial 72-Week Analysis

Jo Howard, MBBChir, MRCP, FRCPath, Kenneth I. Ataga, MD, R. Clark Brown, MD PhD, Maureen Achebe, MD MPH, Videlis Nduba, MD, Amal El-Beshlawy, MD, Hoda Hassab, MD, Irene Agodoa, MD, Margaret Tonda, PharmD, Sarah Gray, PhD, Joshua Lehrer-Graiwer, MD MPhil, FACC, Elliott Vichinsky, MD

Blood (2020) 136 (Supplement 1): 19.

https://doi.org/10.1182/blood-2020-140553

Published: 2020

Journal Articles

Improvement in Red Blood Cell Physiology in Children with Sickle Cell Anemia Receiving Voxelotor

Satheesh Chonat, MD, Earl Fields, Hannah Baratz, Amanda Watt, Mira Pochron, PhD, Sandy Dixon, Margaret Tonda, PharmD, Joshua Lehrer-Graiwer, MD MPhil, FACC, Clark Brown, MD PhD, David R. Archer, PhD

Blood (2019) 134 (Supplement_1): 2281.

https://doi.org/10.1182/blood-2019-129351

Published: 2019

Journal Articles

Concomitant Hydroxyurea and Voxelotor: Results from the HOPE Study

Russell E. Ware, MD PhD, Clark Brown, MD PhD, Mariane de Montalembert, MD PhD, Margaret Tonda, PharmD, Barbara Tong, PhD, Carolyn Hoppe, MD, Joshua Lehrer-Graiwer, MD MPhil, FACC, Miguel R. Abboud, MD

Blood (2019) 134 (Supplement_1): 1003.

https://doi.org/10.1182/blood-2019-130767

Published: 2019

Journal Articles

Crizanlizumab 5.0 Mg/Kg Exhibits a Favorable Safety Profile in Patients with Sickle Cell Disease: Pooled Data from Two Phase II Studies

Julie Kanter, MD, Darla K Liles, MD, Kim Smith-Whitley, MD, Clark Brown, MD PhD, Abdullah Kutlar, MD, Brian Elliott, Amit Shah, Jeremie Lincy, Susan Poggio, Kenneth I. Ataga, MBBS

Blood (2019) 134 (Supplement_1): 991.

https://doi.org/10.1182/blood-2019-123965

Published: 2019

Journal Articles

The Pharmacokinetics (PK) of GBT440 Following Single Doses in Pediatric Patients with Sickle Cell Disease (SCD)

Carla B Washington, PhD, Michelle Green, PhD, Adlette C. Inati, MD, Clark Brown, MD PhD, Carolyn C Hoppe, MD, Winfred Wang, MD, Ganesh Balaratnam, MD, Sandra Dixon, MS, Erica Fong, Athiwat Hutchaleelaha, PhD, Margaret E Tonda, PharmD, Josh Lehrer, MD MPhil, FACC

Blood (2017) 130 (Supplement 1): 980.

https://doi.org/10.1182/blood.V130.Suppl_1.980.980

Published: 2017

Journal Articles

Initial Results from a Cohort in a Phase 2a Study (GBT440-007) Evaluating Adolescents with Sickle Cell Disease Treated with Multiple Doses of GBT440, a HbS Polymerization Inhibitor

Carolyn C Hoppe, MD, Adlette C. Inati, MD, Clark Brown, MD PhD, Winfred Wang, MD, Victor R. Gordeuk, MD, Robert Liem, MD, Gerald Woods, MD, Connie M. Piccone, MD, Erica Fong, Ganesh Balaratnam, MD, Sandy Dixon, Margaret E Tonda, PharmD, Carla B Washington, PhD, Yifah Yaron, MD PhD, Josh Lehrer, MD MPhil, FACC

Blood (2017) 130 (Supplement 1): 689.

https://doi.org/10.1182/blood.V130.Suppl_1.689.689

Published: 2017

Journal Articles

Effect of Acute Transfusion on Cerebral Oxygenation in Patients with Sickle Cell Disease

Maa-Ohui Quarmyne, MBChB, Janet Figueroa, MPH, Courtney McCracken, PhD, Charles T. Quinn, MD MS, Clark Brown, MD PhD, Clinton H. Joiner, MD PhD

Blood (2017) 130 (Supplement 1): 988.

https://doi.org/10.1182/blood.V130.Suppl_1.988.988

Published: 2017

Journal Articles

Variation in Serial TCD Velocity Measurements in the TCD with Transfusions Changing to Hydroxyurea (TWiTCH) Trial

Russell E. Ware, MD PhD, Adam Lane, PhD, William H Schultz, MHS PA, Hamayun Imran, MD, Margaret T. Lee, MD, Matthew M Heeney, MD, Clark Brown, MD PhD, Lori Luchtman-Jones, MD, Jennifer Webb, MD, Sherron Jackson, MD, Banu Aygun, MD, Scott T. Miller, MD, Jennifer A Rothman, MD, Alexis A. Thompson, MD MPH, Judy Luden, CCRP, Barry R Davis, MD PhD, Robert J. Adams, MD

Blood (2016) 128 (22): 1019.

https://doi.org/10.1182/blood.V128.22.1019.1019

Published: 2016

Journal Articles

TCD with Transfusions Changing to Hydroxyurea (TWiTCH): Hydroxyurea Therapy As an Alternative to Transfusions for Primary Stroke Prevention in Children with Sickle Cell Anemia

Russell E. Ware, MD PhD, Barry R Davis, MD PhD, William H Schultz, MHS PA, Clark Brown, MD PhD, Banu Aygun, MD, Sharada A. Sarnaik, MD, Isaac Odame, MD, Beng Fuh, MD, Alex George, MD, PhD, William Owen, MD, Lori Luchtman-Jones, MD, Zora R. Rogers, MD, Lee Hilliard, MD, Cynthia Gauger, MD, Connie M. Piccone, MD, Margaret T. Lee, MD, Janet Kwiatkowski, MD, Sherron Jackson, MD, Scott T. Miller, MD, Carla W Roberts, MD, Matthew M. Heeney, MD FRCP(C), Theodosia A. Kalfa, MD PhD, Stephen C Nelson, MD, Hamayun Imran, MD, Kerri A Nottage, MD MPH, Ofelia A. Alvarez, MD, Melissa Rhodes, MD, Alexis A. Thompson, MD, Jennifer Rothman, MD, Kathleen J. Helton, MD, Donna Roberts, MD, Jamie Coleman, MD, Melanie J Bonner, PhD, Abdullah Kutlar, MD, Niren Patel, MD, John C Wood, MD PhD, Linda Piller, MD, Peng Wei, PhD, Judy Luden, CCRP, Nicole A. Mortier, MHS, PA-C, Susan Stuber, MA, Naomi L.C. Luban, MD, Alan R. Cohen, MD, Sara L Pressel, MS, Robert J. Adams, MD MS

Blood (2015) 126 (23): 3.

https://doi.org/10.1182/blood.V126.23.3.3

Published: 2015

Journal Articles

Hydroxyurea Effectiveness in Children and Adolescents with Sickle Cell Anemia: A Large Retrospective, Population-Based Cohort Study

Maa-Ohui Quarmyne, MBChB MS, Wei Dong, MS MPH, Vaughn Barry, PhD MPH, Rodney Theodore, MPH, Olufolake A. Adisa, MD, Iris Buchanan, MD MSC, James Bost, PhD, Robert Clark Brown, MD PhD, Clinton H. Joiner, MD PhD, Peter A. Lane, MD

Blood (2015) 126 (23): 2179.

https://doi.org/10.1182/blood.V126.23.2179.2179

Published: 2015

Journal Articles

A Quick, Robust Protocol for Liver Iron Quantitation on 3.0 Tesla MRI Scanners

R. Clark Brown, MD PhD, Mitchell Turner, Binjian Sun, PhD, Richard Jones, PhD

Blood (2014) 124 (21): 4069.

https://doi.org/10.1182/blood.V124.21.4069.4069

Published: 2014

Journal Articles

Quantitation of Iron in Brain Structures of Children with Sickle Cell Disease and Transfusion Hemosiderosis

R. Clark Brown, MD PhD, Deqiang Qiu, PhD, Laura Hayes, MD, Vaughn Barry, PhD MPH, Richard Jones, PhD

Blood (2014) 124 (21): 1393.

https://doi.org/10.1182/blood.V124.21.1393.1393

Published: 2014

Journal Articles

Hydroxyurea Treatment of Young Children with Sickle Cell Anemia: Safety and Efficacy of Continued Treatment – the BABY HUG Follow-up Study

Zora R. Rogers, MD, Billie Fish, CCRP, Zhaoyu Luo, PhD, Rathi V. Iyer, MD, Courtney D. Thornburg, MD, MS, Sharada A. Sarnaik, MD, Sohail R. Rana, MD, Lori Luchtman-Jones, MD, Sherron M. Jackson, MD, Thomas H. Howard, MD, James F. Casella, MD, R. Clark Brown, MD, PhD, Ofelia A. Alvarez, MD, Jonathan C. Goldsmith, MD, Scott T. Miller, MD, Winfred C. Wang, MD

Blood (2011) 118 (21): 7.

https://doi.org/10.1182/blood.V118.21.7.7

Published: 2011

Journal Articles

Influence of Hemoglobin Level on Clinical Findings In Infants with Sickle Cell Anemia: Data From BABY HUG

Jeffrey D. Lebensburger, DO, Scott T Miller, MD, Thomas H. Howard, MD, James F. Casella, MD, R. Clark Brown, MD, PhD, Ming Lu, MS, Rathi V. Iyer, MD, Zora R. Rogers, MD, Winfred C. Wang, MD

Blood (2010) 116 (21): 1631.

https://doi.org/10.1182/blood.V116.21.1631.1631

Published: 2010

Journal Articles

Neurodevelopment in Infants with Sickle Cell Anemia: Baseline Data from the Baby HUG Trial

F. Daniel Armstrong, Ph.D., T. David Elkin, Ph.D., R. Clark Brown, MD, PhD, Penny Glass, Ph.D., Renee C. Rees, PhD, Winfred C. Wang, M.D., The Baby HUG Investigators

Blood (2008) 112 (11): 713.

https://doi.org/10.1182/blood.V112.11.713.713

Published: 2008

NARROW

FT-4202, an Allosteric Activator of Pyruvate Kinase-R, Demonstrates Proof of Mechanism and Proof of Concept after a Single Dose and after Multiple Daily Doses in a Phase 1 Study of Patients with Sickle Cell Disease

Early Initiation of Treatment with Rivipansel for Acute Vaso-Occlusive Crisis in Sickle Cell Disease (SCD) Achieves Earlier Discontinuation of IV Opioids and Shorter Hospital Stay: Reset Clinical Trial Analysis

Assessment of Cerebral Blood Flow and Oxygen Extraction in Pediatric Sickle Cell Disease with Non-Invasive Diffuse Optical Spectroscopies

Study Design and Initial Baseline Characteristics in Solace-Kids: Crizanlizumab in Pediatric Patients with Sickle Cell Disease

Pharmacokinetics/Pharmacodynamics, Safety and Efficacy of Crizanlizumab in Patients with Sickle Cell Disease and a History of Vaso-Occlusive Crises: Results from the Phase II, Multicenter, Open-Label Solace-Adults Study

Efficacy and Safety of Voxelotor in Adolescents and Adults with Sickle Cell Disease: HOPE Trial 72-Week Analysis

Improvement in Red Blood Cell Physiology in Children with Sickle Cell Anemia Receiving Voxelotor

Concomitant Hydroxyurea and Voxelotor: Results from the HOPE Study

Crizanlizumab 5.0 Mg/Kg Exhibits a Favorable Safety Profile in Patients with Sickle Cell Disease: Pooled Data from Two Phase II Studies

The Pharmacokinetics (PK) of GBT440 Following Single Doses in Pediatric Patients with Sickle Cell Disease (SCD)

Initial Results from a Cohort in a Phase 2a Study (GBT440-007) Evaluating Adolescents with Sickle Cell Disease Treated with Multiple Doses of GBT440, a HbS Polymerization Inhibitor

Effect of Acute Transfusion on Cerebral Oxygenation in Patients with Sickle Cell Disease

Variation in Serial TCD Velocity Measurements in the TCD with Transfusions Changing to Hydroxyurea (TWiTCH) Trial

TCD with Transfusions Changing to Hydroxyurea (TWiTCH): Hydroxyurea Therapy As an Alternative to Transfusions for Primary Stroke Prevention in Children with Sickle Cell Anemia

Hydroxyurea Effectiveness in Children and Adolescents with Sickle Cell Anemia: A Large Retrospective, Population-Based Cohort Study

A Quick, Robust Protocol for Liver Iron Quantitation on 3.0 Tesla MRI Scanners

Quantitation of Iron in Brain Structures of Children with Sickle Cell Disease and Transfusion Hemosiderosis

Hydroxyurea Treatment of Young Children with Sickle Cell Anemia: Safety and Efficacy of Continued Treatment – the BABY HUG Follow-up Study

Influence of Hemoglobin Level on Clinical Findings In Infants with Sickle Cell Anemia: Data From BABY HUG

Neurodevelopment in Infants with Sickle Cell Anemia: Baseline Data from the Baby HUG Trial

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American Society of Hematology

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