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David A. Fruman, PhD
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Journal Articles

mTOR Kinase Inhibitors Enhance Efficacy of TKIs in Preclinical Models of Ph-like B-ALL

Moran Gotesman, MD, Thanh-Trang T Vo, PhD, Sharmila Mallya, MS, Qi Zhang, MDPhD, Ce Shi, MD PhD, Markus Müschen, MD PhD, David M. Weinstock, MD, Charles Mullighan, MBBS, MSc, MD, Sarah K Tasian, MD, Marina Konopleva, MD PhD, David A. Fruman, PhD
Journal: Blood
Blood (2016) 128 (22): 2763.
https://doi.org/10.1182/blood.V128.22.2763.2763
Published: 2016
Journal Articles

Statins Potentiate the Cytotoxic Effect of ABT-199 in Diffuse Large B Cell Lymphoma

David A. Fruman, PhD, Jong-Hoon Scott Lee, B.S., Thanh-Trang T Vo, PhD, Shruti Bhatt, PhD, Jonathan H. Schatz, MD, Anthony Letai, MD PhD
Journal: Blood
Blood (2016) 128 (22): 3969.
https://doi.org/10.1182/blood.V128.22.3969.3969
Published: 2016
Journal Articles

The Dynamics of Stroma-Leukemia Interaction in the Hypoxic BM Niches in Vivo

Karine G. Harutyunyan, PhD, Felix Nwajei, M. Anna Zal, David A Fruman, PhD, Saradhi Mallampati, PhD, Xiaoping Sun, MD PhD, Tomasz Zal, Marina Konopleva, MD PhD
Journal: Blood
Blood (2014) 124 (21): 2396.
https://doi.org/10.1182/blood.V124.21.2396.2396
Published: 2014
Journal Articles

Dual Targeting of JAK2 Signaling with a Type II JAK2 Inhibitor and of mTOR with a TOR Kinase Inhibitor Induces Apoptosis in CRLF2 -Rearranged Ph-like Acute Lymphoblastic Leukemia

Ce Shi, Lina Han, PhD, Yoko Tabe, MD PhD, Hong Mu, MD PhD, Shuo-Chieh Wu, Jin Zhou, MD, PhD, Zhihong Zeng, MD, David A Fruman, PhD, Sarah K Tasian, MD, David M. Weinstock, MD, Marina Konopleva, MD PhD
Journal: Blood
Blood (2014) 124 (21): 3706.
https://doi.org/10.1182/blood.V124.21.3706.3706
Published: 2014
Journal Articles

The TOR Kinase Inhibitor INK128 Is Effective in Pre-B Acute Lymphoblastic Leukemia Models

David A Fruman, PhD, Matthew Robert Janes, MPH, Sharmila Mallya, MS, Collin C Vu, MD, Marie P. Shieh, MD, Michael B. Lilly, MD, Leonard S Sender, MD, Michael B Martin, PhD, Pingda Ren, PhD, Yi Liu, PhD, Christian Rommel, PhD
Journal: Blood
Blood (2011) 118 (21): 2585.
https://doi.org/10.1182/blood.V118.21.2585.2585
Published: 2011
Journal Articles

Targeting of a Novel MNK-eIF4E-b-Catenin Axis in Blast Crisis Chronic Myelogenous Leukemia Inhibits Leukemia Stem Cell Function

Sharon Lim, PhD, Tzuen Yih Saw, Sandy Chang, Min Zhang, MD, Matthew Robert Janes, MPH, David A Fruman, PhD, David A. Rizzieri, MD, Soo-Yong Tan, MBBS, FRCPath, DPhil, Charles Chuah, MD, S. Tiong Ong, MD
Journal: Blood
Blood (2011) 118 (21): 963.
https://doi.org/10.1182/blood.V118.21.963.963
Published: 2011