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Journal Articles

Functionally Distinct Subsets of Monocytes in Mouse and Human Blood

Catherine S Rhee, PhD, Elizabeth W Scadden, Chea L Phillip, Bum-Kyu Lee, PhD, Meeta Mistry, Friedrich F Hoyer, MD, Hiroki Kato, MD PhD, Giovanna Mantica, Jonghwan Kim, PhD, Matthias Nahrendorf, PhD, Michael K Mansour, MD PhD, David B Sykes, MD PhD, David T. Scadden, MD

Blood (2019) 134 (Supplement_1): 438.

https://doi.org/10.1182/blood-2019-124054

Published: 2019

Journal Articles

What Links Neutropenia to Immature Cardiolipin in Patients with Barth Syndrome (tafazzin-deficiency)?

Jihee Sohn, PhD, Thomas Brouse, Najihah Aziz, David B Sykes, MD PhD

Blood (2019) 134 (Supplement_1): 3579.

https://doi.org/10.1182/blood-2019-123680

Published: 2019

Journal Articles

Niche Transfer of Small Non-Coding RNAs Regulates Hematopoietic Response to Stress

Youmna Kfoury, PhD, Fei Ji, Michael Mazzola, BS, David B Sykes, MD PhD, Anselmo Anthony, Yasutoshi Akiyama, Allison Scherer, PhD, Francois Mercier, MD FRCPC, Nicolas Severe, PhD, Borja Saez, Jefferson Seidl, BA, Ani Papazian, BS, Thomas Brouse, Michael K Mansour, MD PhD, Pavel Ivanov, Ruslan I Sadreyev, PhD, David T. Scadden, MD

Blood (2019) 134 (Supplement_1): 1207.

https://doi.org/10.1182/blood-2019-124794

Published: 2019

Journal Articles

Loss of FLT3 Sensitizes Myeloid Cells to Differentiation Via DHODH Inhibition

Amy N Sexauer, MD PhD, Brian Do, David B Sykes, MD PhD

Blood (2019) 134 (Supplement_1): 2712.

https://doi.org/10.1182/blood-2019-128910

Published: 2019

Journal Articles

DHODH Inhibitors in the Treatment of Acute Myeloid Leukemia: Defining the Mechanism of Action and the Basis of the Metabolic Therapeutic Window

Peggy P. Hsu, MD PhD, Youmna Kfoury, PhD, Najihah Aziz, Jenna Elkhoury, Brittany Hallgren, David T. Scadden, MD, Matthew Vander Heiden, MD PhD, David B Sykes, MD PhD

Blood (2018) 132 (Supplement 1): 2716.

https://doi.org/10.1182/blood-2018-99-113387

Published: 2018

Journal Articles

Specific Bone Marrow Mesenchymal Subsets in Patients with Myelodysplastic Syndromes Harbor Molecular Perturbations That Alter the Dynamics of Competition between Pre-Leukemic Clones and Normal Cells

Youmna Kfoury, PhD, Esha Jain, Jason R Myers, MS, Fei Ji, David B Sykes, MD PhD, Francois Mercier, MD FRCPC, Ani Papazian, BS, Cam Le, Mark A Randolph, M.A.Sc., David P. Steensma, MD, Omar I Abdel-Wahab, MD, Laura M. Calvi, MD, Ruslan I Sadreyev, PhD, Michael W. Becker, MD, David T. Scadden, MD

Blood (2018) 132 (Supplement 1): 938.

https://doi.org/10.1182/blood-2018-99-115242

Published: 2018

Journal Articles

Osteoblastic Cell-Derived Extracellular Vesicles Transfer Small RNAs That Alter the Physiology of Hematopoietic Cells In Vivo

Youmna Kfoury, PhD, Anthony Anselmo, PhD, Jefferson Seidl, BA, Ani Papazian, BS, Francois Mercier, MD FRCPC, David B Sykes, MD PhD, Nicolas Severe, PhD, Borja Saez, PhD, Ruslan I Sadreyev, PhD, David T. Scadden, MD

Blood (2017) 130 (Supplement 1): 93.

https://doi.org/10.1182/blood.V130.Suppl_1.93.93

Published: 2017

Journal Articles

A Genome-Wide, In Vivo, Dropout CRISPR Screen in Acute Myeloid Leukemia Identifies an Essential Role for Beta-Galactosylation in Leukemic Cell Homing

Francois Mercier, MD, Jiantao Shi, PhD, David B Sykes, MD PhD, Elizabeth Miller, Toshihiko Oki, MD PhD, Cheuk-Him Man, PhD, Xiao-Jing Yan, MD PhD, Youmna Kfoury, PhD, Dongjun Lee, PhD, John G Doench, PhD, Franziska Michor, PhD, David T. Scadden, MD

Blood (2017) 130 (Supplement 1): 2493.

https://doi.org/10.1182/blood.V130.Suppl_1.2493.2493

Published: 2017

Journal Articles

Inhibition of the Enzyme Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia

David B. Sykes, MD PhD, Youmna Sami Kfoury, PhD, Francois Mercier, MD, Mathias Wawer, PhD, Amir Schajnovitz, PhD, Hanna Meyer, PhD, Kerry A Pierce, PhD, Detlef Stoeckigt, PhD, Clary B Clish, PhD, Paul A Clemons, PhD, Andreas Janzer, PhD, David T. Scadden, MD

Blood (2016) 128 (22): 1656.

https://doi.org/10.1182/blood.V128.22.1656.1656

Published: 2016

Journal Articles

Neutrophils Derived from Ezh2 -/- Progenitor Cells Demonstrate Aberrant Erythroid Lineage Gene Expression

Albert Perez-Ladaga, PhD, Huafeng Xie, PhD, Stuart H. Orkin, MD, David B. Sykes, MD PhD, Benjamin L. Ebert, MD PhD, Rafael Bejar, MDPhD

Blood (2015) 126 (23): 4112.

https://doi.org/10.1182/blood.V126.23.4112.4112

Published: 2015

Journal Articles

Immunotoxin Enables Non-Genotoxic Conditioning for Hematopoietic Stem Cell Transplantation

Rahul Palchaudhuri, PhD, Borja Saez, PhD, Jonathan Hoggatt, PhD, Amir Schajnovitz, David B. Sykes, MD PhD, Michael K Mansour, MD PhD, David T. Scadden, MD

Blood (2015) 126 (23): 32.

https://doi.org/10.1182/blood.V126.23.32.32

Published: 2015

Journal Articles

Differentiation Induction In Acute Myeloid Leukemia Using Site-Specific DNA-Targeting

Rahul Palchaudhuri, PhD, Kwan-Keat Ang, Borja Saez, PhD, David B. Sykes, MD, PhD, Gregory L. Verdine, PhD, David T. Scadden, MD

Blood (2013) 122 (21): 3940.

https://doi.org/10.1182/blood.V122.21.3940.3940

Published: 2013

Journal Articles

Functional Defects In Neutrophils Derived From Ezh2 Null Mice

Albert Perez-Ladaga, PhD, Bennett Caughey, Huafeng Xie, PhD, Stuart H. Orkin, MD, David B. Sykes, MD, PhD, Benjamin L. Ebert, MD, PhD, Rafael Bejar, MD, PhD

Blood (2013) 122 (21): 1556.

https://doi.org/10.1182/blood.V122.21.1556.1556

Published: 2013

Journal Articles

Targeting Pre-B Cell Receptor and BCL6 In TCF3-PBX1 B-Lineage Acute Lymphoblastic Leukemia

Huimin Geng, PhD, Christian Hurtz, PhD, Zhengshan Chen, MD, PhD, Wei-Yi Chen, PhD, Erica Ballabio, PhD, Gang Xiao, PhD, Soo-mi Kweon, PhD, Rahul Nahar, PhD, Seyedmehdi Sojaee, PhD, Lai N. Chan, PhD, Behzad Kharabi Masouleh, MD, David B. Sykes, MD, PhD, Ari Melnick, MD, Robert Roeder, PhD, Thomas Milne, PhD, Markus Muschen, MD

Blood (2013) 122 (21): 349.

https://doi.org/10.1182/blood.V122.21.349.349

Published: 2013

Journal Articles

Identifying Small Molecules That Overcome HoxA9-Mediated Differentiation Arrest in Acute Myeloid Leukemia

David B. Sykes, MD, PhD, Mark K Haynes, PhD, Nicola Tolliday, PhD, Anna Waller, PhD, Julien M Cobert, BA, Brian A. Szekely, MS, Tom P. Hasaka, PhD, Larry Sklar, PhD, Leonard I. Zon, MD, David T. Scadden, MD

Blood (2012) 120 (21): 3513.

https://doi.org/10.1182/blood.V120.21.3513.3513

Published: 2012

Journal Articles

Aldehyde Dehydrogenase 3a2 (Aldh3a2) Represents a Distinct Metabolic Vulnerability in MLL-AF9 AML Leukemia Initiating Cells

Blood (2012) 120 (21): 208.

https://doi.org/10.1182/blood.V120.21.208.208

Published: 2012

Journal Articles

TEMPI: A Reversible Syndrome Following Treatment with Bortezomib

Wilfried A. Schroyens, MD, PhD, Casey L. O'Connell, MD, Martha Q Lacy, MD, Eyal C. Attar, MD, Noopur Raje, MD, Bradley G. Somer, MD, Flavia G Rosado, MD, James Hoyer, MD, Donald I. Feinstein, MD, David B. Sykes, MD, PhD

Blood (2012) 120 (21): 986.

https://doi.org/10.1182/blood.V120.21.986.986

Published: 2012

Journal Articles

Niche-Based Screening Identifies Novel Small Molecules That Overcome Stromal Effects in Multiple Myeloma

Blood (2012) 120 (21): 571.

https://doi.org/10.1182/blood.V120.21.571.571

Published: 2012

Journal Articles

The TEMPI Syndrome: Telangiectasias, Elevated Erythropoietin and Erythrocytosis, Monoclonal Gammopathy, Perinephric Fluid Collections, and Intrapulmonary Shunting

David B. Sykes, MD, PhD, Wilfried A. Schroyens, MD, PhD, Casey L. O'Connell, MD, Donald I. Feinstein, MD, Hasan Bazari, MD, Douglas M. Dahl, MD, Robert B. Colvin, MD, Bernard P. Paelinck, MD, PhD, Raul N. Uppot, MD, Bart Op de Beeck, MD, William Boswell, MD, Noopur S. Raje, MD, Nancy Lee Harris, MD, Eyal C. Attar, MD

Blood (2011) 118 (21): 1037.

https://doi.org/10.1182/blood.V118.21.1037.1037

Published: 2011

NARROW

Functionally Distinct Subsets of Monocytes in Mouse and Human Blood

What Links Neutropenia to Immature Cardiolipin in Patients with Barth Syndrome (tafazzin-deficiency)?

Niche Transfer of Small Non-Coding RNAs Regulates Hematopoietic Response to Stress

Loss of FLT3 Sensitizes Myeloid Cells to Differentiation Via DHODH Inhibition

DHODH Inhibitors in the Treatment of Acute Myeloid Leukemia: Defining the Mechanism of Action and the Basis of the Metabolic Therapeutic Window

Specific Bone Marrow Mesenchymal Subsets in Patients with Myelodysplastic Syndromes Harbor Molecular Perturbations That Alter the Dynamics of Competition between Pre-Leukemic Clones and Normal Cells

Osteoblastic Cell-Derived Extracellular Vesicles Transfer Small RNAs That Alter the Physiology of Hematopoietic Cells In Vivo

A Genome-Wide, In Vivo, Dropout CRISPR Screen in Acute Myeloid Leukemia Identifies an Essential Role for Beta-Galactosylation in Leukemic Cell Homing

Inhibition of the Enzyme Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia

Neutrophils Derived from Ezh2 -/- Progenitor Cells Demonstrate Aberrant Erythroid Lineage Gene Expression

Immunotoxin Enables Non-Genotoxic Conditioning for Hematopoietic Stem Cell Transplantation

Differentiation Induction In Acute Myeloid Leukemia Using Site-Specific DNA-Targeting

Functional Defects In Neutrophils Derived From Ezh2 Null Mice

Targeting Pre-B Cell Receptor and BCL6 In TCF3-PBX1 B-Lineage Acute Lymphoblastic Leukemia

Identifying Small Molecules That Overcome HoxA9-Mediated Differentiation Arrest in Acute Myeloid Leukemia

Aldehyde Dehydrogenase 3a2 (Aldh3a2) Represents a Distinct Metabolic Vulnerability in MLL-AF9 AML Leukemia Initiating Cells

TEMPI: A Reversible Syndrome Following Treatment with Bortezomib

Niche-Based Screening Identifies Novel Small Molecules That Overcome Stromal Effects in Multiple Myeloma

The TEMPI Syndrome: Telangiectasias, Elevated Erythropoietin and Erythrocytosis, Monoclonal Gammopathy, Perinephric Fluid Collections, and Intrapulmonary Shunting

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American Society of Hematology

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ASH Publications

American Society of Hematology

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