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David Micklem, PhD
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Journal Articles

The Combination of AXL Inhibitor Bemcentinib and Low Dose Cytarabine Is Well Tolerated and Efficacious in Elderly Relapsed AML Patients: Update from the Ongoing BGBC003 Phase II Trial (NCT02488408)

Sonja Loges, MD PhD, Michael Heuser, Jörg Chromik, MD, Carlos Enrique Vigil, MD, Peter Paschka, MD, Francesca Re, MD, Nicola Di Renzo, MD, Roberto M. Lemoli, Daniele Giovanni Mattei, MD, Isabel Ben-Batalla, PhD, Monica Hellesoy, PhD, Katherine Lorens, MD, Joseph Birkett, PhD, Stuart McPherson, BSc, Jaya Nautiyal, PhD, David Micklem, PhD, Hani Gabra, MD PhD FRCPE, FRCP, James B. Lorens, PhD, Walter Fiedler, MD, Yesid Alvarado, MD, Bjorn T. Gjertsen, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 14.
https://doi.org/10.1182/blood-2020-136566
Published: 2020
Journal Articles

Durable Responses Observed in Elderly AML Patients Unfit for Intensive Chemotherapy with First-in Class Selective AXL Inhibitor Bemcentinib (BGB324) in Combination with LDAC: Phase II Open-Label Study

Sonja Loges, MD, PhD, Michael Heuser, MD, Jörg Chromik, MD, Carlos Enrique Vigil, MD, Peter Paschka, MD, Francesca Re, Nicola Di Renzo, MD, Roberto Massimo Lemoli, MD, Daniele Giovanni Mattei, MD, Isabel Ben Batalla, PhD, Monica Hellesoy, PhD, David Micklem, PhD, Robert J. Holt, PhD, James B. Lorens, PhD, Muhammad Shoaib, MD, Hassan Aly, MD PhD, Wouter Hanekom, MD, Walter Fiedler, MD, Jorge E. Cortes, MD, Bjorn T. Gjertsen, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3943.
https://doi.org/10.1182/blood-2019-128683
Published: 2019
Journal Articles

Single Cell-Level Signaling Profiling of Acute Myeloid Leukemia Following Treatment with Axl Kinase Inhibitor BGB324

Monica Hellesøy, PhD, Katarzyna Wnuk-Lipinska, PhD, Anna Boniecka, MSc, Eline Milde Nævdal, Hakon Reikvam, MDPhD, Sonja Loges, MDPhD, Jorge E. Cortes, MD, Jørn Skavland, PhD, Øystein Bruserud, MDPhD, Jim Lorens, PhD, David Micklem, PhD, Gro Gausdal, PhD, Bjorn T. Gjertsen, MD PhD
Journal: Blood
Blood (2015) 126 (23): 4931.
https://doi.org/10.1182/blood.V126.23.4931.4931
Published: 2015
Journal Articles

BGB324 Represents an Axl and BCR-ABL1 Inhibitor with Activity in the T315I Mutant

Robert Erdmann, PhDMSc, Heather Jorgensen, PhD, Isabel Ben-Batalla, PhD, Nils Kruse, PhD, David Micklem, PhD, Gunhild von Amsberg, MD, Philippe Schafhausen, MD, Alexander Schultze, MD MSc, Mark Wroblewski, MSc, Mascha Binder, Miguel Cubas-Cordova, MSc, Tobias Hadlich, MD, Melanie Janning, MD MSc, Stefanie Sawall, Victoria Gensch, Elaine K Allan, Leena Mukherjee, PhD, Heather Morrison, BSc, Jennifer Cassells, Nicolaus Kroeger, MD, James Lorens, MD, Richard E. Clark, MD, Steffen Koschmieder, MD, Peter Vandenberghe, MD PhD, Tim H. Brümmendorf, MD, Andreas Hochhaus, MD, Peter Carmeliet, MD PhD, Tessa L. Holyoake, MD PhD, Klaus Pantel, MD PhD, Carsten Bokemeyer, MD, Sonja Loges, MD PhD
Journal: Blood
Blood (2014) 124 (21): 4512.
https://doi.org/10.1182/blood.V124.21.4512.4512
Published: 2014