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Journal Articles

Transient Activation Of Inflammatory Molecules By Epigenetic Modifiers Likely Plays a Role In Expansion Of Transplantable Human Cord Blood Stem/Progenitor Cells

Nadim Mahmud, MD, PhD, Benjamin Petro, BS, Xinmin Li, PhD, Simona Taioli, MS, Alvin Li, John G. Quigley, MD, Donald Lavelle, Ph.D.

Blood (2013) 122 (21): 1170.

https://doi.org/10.1182/blood.V122.21.1170.1170

Published: 2013

Journal Articles

Elevated Levels Of γ-Globin Gene Promoter 5-Hydroxymethylcytosine are Associated With Increased DNA Hypomethylation and HbF Expression

Maria Armila Ruiz, BS, Angela Rivers, MD, PhD, Kestis Vaitkus, Tatiana Kouznetsova, M.S., Nadim Mahmud, MD, PhD, Joseph DeSimone, PhD, Donald Lavelle, PH.D.

Blood (2013) 122 (21): 438.

https://doi.org/10.1182/blood.V122.21.438.438

Published: 2013

Journal Articles

RN-1, a New and Potent Lsd-1 Inhibitor, Increases γ-Globin Expression In a Humanized Sickle Cell Mouse Model

Angela Rivers, MD, PhD, Maria Armila Ruiz, BS, Kestis Vaitkus, Tatiana Kouznetsova, M.S., Joseph DeSimone, PhD, Donald Lavelle, Ph.D.

Blood (2013) 122 (21): 561.

https://doi.org/10.1182/blood.V122.21.561.561

Published: 2013

Journal Articles

Dynamic Regulation of 5-Hydroxymethylcytosine At the γ-Globin Promoter During Erythroid Differentiation

Maria Armila Ruiz, B.S., Kestis Vaitkus, Aparna Vasanthakumar, PhD, Angela Rivers, MD, PhD, Tatiana Kouznetsova, M.S., Joseph DeSimone, PhD, Lucy A. Godley, MD, PhD, Donald Lavelle, Ph.D.

Blood (2012) 120 (21): 824.

https://doi.org/10.1182/blood.V120.21.824.824

Published: 2012

Journal Articles

Combinatorial Effect of Pharmacological Inhibitors of Lsd-1 and DNMT on γ-Globin Synthesis in Cultured Baboon Bone Marrow Erythroid Progenitors

Donald Lavelle, Ph.D., Kestis Vaitkus, Maria Armila Ruiz, B.S., Angela Rivers, MD, PhD, James D. Engel, PhD, Joseph DeSimone, PhD

Blood (2012) 120 (21): 249.

https://doi.org/10.1182/blood.V120.21.249.249

Published: 2012

Journal Articles

Quantitative Analysis of Tissue and Developmental Stage-Specific Differences in DNA Methylation throughout the β-Globin Gene Locus by DNA MassARRAY,

Maria Armila Ruiz, B.S., Kestutis Vaitkus, B.S., Tatiana Kouznetsova, B.S., Joseph DeSimone, PhD, Yogen Saunthararajah, MD, Donald Lavelle, Ph.D.

Blood (2011) 118 (21): 3196.

https://doi.org/10.1182/blood.V118.21.3196.3196

Published: 2011

Journal Articles

Oral Administration of Low-Dose Decitabine and Tetrahydrouridine In Combination Increases Fetal Hemoglobin to Therapeutic Levels In the Absence of Cytotoxicity and Reduces Inter-Individual Drug Bioavailability In Baboons

Donald Lavelle, Ph.D., Kestutis Vaitkus, B.S., Maria Armila Ruiz, B.S., Cassandra List, B.S., Tatiana Kouznetsova, B.S., Joseph DeSimone, PhD, Yogen Saunthararajah, MD

Blood (2011) 118 (21): 2147.

https://doi.org/10.1182/blood.V118.21.2147.2147

Published: 2011

Journal Articles

Gender Is A Major Determinant of Cytidine Analogue Metabolism and May Contribute to Differences in Treatment Outcomes

Reda Z Mahfouz, MD, Ania Jankowska, PhD, Quteba Ebrahem, MD, Zhenbo Hu, MD, Kenneth K. Chan, Ph.D, Donald Lavelle, Ph.D., Joseph DeSimone, PhD, Mikkael A. Sekeres, MD, MS, Ramon V. Tiu, MD, BS, Jaroslaw P. Maciejewski, MD, PhD, Yogen Saunthararajah, M.D.

Blood (2011) 118 (21): 1434.

https://doi.org/10.1182/blood.V118.21.1434.1434

Published: 2011

Journal Articles

The Effects of Environmental Cues on Hematopoietic Stem Cell Colony Fetal Hemoglobin Production.

Jennifer L Nichols, B.S., Donald Lavelle, Ph.D., Joseph DeSimone, PhD

Blood (2010) 116 (21): 3860.

https://doi.org/10.1182/blood.V116.21.3860.3860

Published: 2010

Journal Articles

γ-Globin Gene (HBG) Promoter Methylation and Gene Expression Is Affected by the Micro-Environment In Adult but Not Fetal Erythroid Cells

Donald Lavelle, Ph.D., Yogenthiran Saunthararajah, MD, Nadim Mahmud, MBBS, PhD, Vinzon Ibanez, PhD, Maria Armila Ruiz, PhD, Kestis Vaitkus, PhD, Tatiana Kouznetsova, Joseph DeSimone, PhD

Blood (2010) 116 (21): 4271.

https://doi.org/10.1182/blood.V116.21.4271.4271

Published: 2010

Journal Articles

Tetrahydrouridine Co-Administration Improves Oral Bioavailability and Dampens Inter-Individual Variability of Decitabine Pharmacokinetics In Baboons

Donald Lavelle, Ph.D., Kestis Vaitkus, YongHua Ling, Nicola Smith, Kenneth K. Chan, PhD, Joseph DeSimone, PhD, Yogenthiran Saunthararajah, MD

Blood (2010) 116 (21): 2081.

https://doi.org/10.1182/blood.V116.21.2081.2081

Published: 2010

Journal Articles

RNAi Targeting MBD2 Increases γ-Globin Expression in a CID-Dependent Human β-YAC Murine Fetal Bone Marrow Cell Line.

Virryan Banzon, MS, Tatiana Kousnetzova, M.S., Maria Hankewych, B.S., Kenneth Peterson, Ph.D., Joseph DeSimone, Ph.D., Donald Lavelle, Ph.D.

Blood (2007) 110 (11): 1769.

https://doi.org/10.1182/blood.V110.11.1769.1769

Published: 2007

Journal Articles

Polymorphic Pvu II Sites in the Stage-Selector Elements of the Baboon (P. anubis) γ-Globin Gene Promoter May Determine HbF Levels by Reducing DNA Methylation Density.

Donald Lavelle, Ph.D., Mahipal Singh, Ph.D., Kestas Vaitkus, D.V.M., Maria Hankewych, B.S., Lauren Wilson, Joseph DeSimone, Ph.D.

Blood (2004) 104 (11): 1211.

https://doi.org/10.1182/blood.V104.11.1211.1211

Published: 2004

Journal Articles

Changes in Globin Gene Methylation and Covalent Histone Modifications of Chromatin Associated with the ε-, γ-, and β-Globin Promoters of the Baboon (P. Anubis) during Development.

Donald Lavelle, Ph.D., Kestas Vaitkus, D.V.M., Maria Hankewych, B.S., Mahipal Singh, Ph.D., Joseph DeSimone, Ph.D.

Blood (2004) 104 (11): 1206.

https://doi.org/10.1182/blood.V104.11.1206.1206

Published: 2004

Journal Articles

The Effect of Decitabine on Covalent Histone Modifications of Chromatin Associated with the ε-,γ -, and β-Globin Gene Promoters in the Baboon (P. anubis).

Donald Lavelle, Ph.D., Kestas Vaitkus, D.V.M., Maria Hankewych, B.S., Mahipal Singh, Ph.D., Joseph DeSimone, Ph.D.

Blood (2004) 104 (11): 378.

https://doi.org/10.1182/blood.V104.11.378.378

Published: 2004

NARROW

Transient Activation Of Inflammatory Molecules By Epigenetic Modifiers Likely Plays a Role In Expansion Of Transplantable Human Cord Blood Stem/Progenitor Cells

Elevated Levels Of γ-Globin Gene Promoter 5-Hydroxymethylcytosine are Associated With Increased DNA Hypomethylation and HbF Expression

RN-1, a New and Potent Lsd-1 Inhibitor, Increases γ-Globin Expression In a Humanized Sickle Cell Mouse Model

Dynamic Regulation of 5-Hydroxymethylcytosine At the γ-Globin Promoter During Erythroid Differentiation

Combinatorial Effect of Pharmacological Inhibitors of Lsd-1 and DNMT on γ-Globin Synthesis in Cultured Baboon Bone Marrow Erythroid Progenitors

Quantitative Analysis of Tissue and Developmental Stage-Specific Differences in DNA Methylation throughout the β-Globin Gene Locus by DNA MassARRAY,

Oral Administration of Low-Dose Decitabine and Tetrahydrouridine In Combination Increases Fetal Hemoglobin to Therapeutic Levels In the Absence of Cytotoxicity and Reduces Inter-Individual Drug Bioavailability In Baboons

Gender Is A Major Determinant of Cytidine Analogue Metabolism and May Contribute to Differences in Treatment Outcomes

The Effects of Environmental Cues on Hematopoietic Stem Cell Colony Fetal Hemoglobin Production.

γ-Globin Gene (HBG) Promoter Methylation and Gene Expression Is Affected by the Micro-Environment In Adult but Not Fetal Erythroid Cells

Tetrahydrouridine Co-Administration Improves Oral Bioavailability and Dampens Inter-Individual Variability of Decitabine Pharmacokinetics In Baboons

RNAi Targeting MBD2 Increases γ-Globin Expression in a CID-Dependent Human β-YAC Murine Fetal Bone Marrow Cell Line.

Polymorphic Pvu II Sites in the Stage-Selector Elements of the Baboon (P. anubis) γ-Globin Gene Promoter May Determine HbF Levels by Reducing DNA Methylation Density.

Changes in Globin Gene Methylation and Covalent Histone Modifications of Chromatin Associated with the ε-, γ-, and β-Globin Promoters of the Baboon (P. Anubis) during Development.

The Effect of Decitabine on Covalent Histone Modifications of Chromatin Associated with the ε-,γ -, and β-Globin Gene Promoters in the Baboon (P. anubis).

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American Society of Hematology

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American Society of Hematology

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