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Edwin R. Speck, BRT
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Journal Articles

Gastrointestinal Flora Dictates the Biological Response in Murine Transfusion Related Acute Lung Injury (TRALI)

Rick Kapur, MDPhDMSc, Michael Kim, BSc, Johan Rebetz, PhD, Alisa Takabe-French, Noel Kim, Shanjeevan Shanmugabhavananthan, BSc, Edwin R. Speck, BRT, John W Semple, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 766.
https://doi.org/10.1182/blood.V130.Suppl_1.766.766
Published: 2017
Journal Articles

Interleukin (IL)-10 Is an Effective Therapeutic for Murine Transfusion Related Acute Lung Injury (TRALI)

Rick Kapur, MD PhD M.Sc., Michael Kim, BSc, Shanjee Shanmugabhavananthan, Jonathan Liu, Noel Kim, Stefan Milosevic, Edwin R. Speck, BRT, John W. Semple, PhD
Journal: Blood
Blood (2016) 128 (22): 92.
https://doi.org/10.1182/blood.V128.22.92.92
Published: 2016
Journal Articles

Successful Treatment of Thrombocytopenia with Staphylococcal Protein A (PRTX-100) in a Murine Model of Immune Thrombocytopenia (ITP)

John W. Semple, PhD, Edwin R. Speck, BRT, Rukhsana Aslam, PhD, Michael Kim, BSc, Anne Zufferey, PhD, Heyu Ni, MD PhD, Michelle Catalina, PhD, Richard Francovitch, PhD
Journal: Blood
Blood (2015) 126 (23): 1045.
https://doi.org/10.1182/blood.V126.23.1045.1045
Published: 2015
Journal Articles

CD4+CD25+Foxp3+ T Regulatory Cells Protect Against Murine Antibody-Mediated Transfusion-Related Acute Lung Injury (TRALI)

Rick Kapur, MD PhD, Michael Kim, BSc, Shanjee Shanmugabhavananthan, Edwin R. Speck, BRT, Rukhsana Aslam, PhD, Li Guo, MD, Anne Zufferey, PhD, John W. Semple, PhD
Journal: Blood
Blood (2015) 126 (23): 2342.
https://doi.org/10.1182/blood.V126.23.2342.2342
Published: 2015
Journal Articles

Murine Bone Marrow-Derived Megakaryocytes Are Capable of Antigen Cross-Presentation on Major Histocompatibility Class (MHC) I Molecules

Anne Zufferey, PhD, Edwin R. Speck, BRT, Li Guo, MD, Rukhsana Aslam, PhD, Rick Kapur, MD PhD, John W. Semple, PhD
Journal: Blood
Blood (2015) 126 (23): 3465.
https://doi.org/10.1182/blood.V126.23.3465.3465
Published: 2015
Journal Articles

C-Reactive Protein (CRP) Enhances Murine Antibody-Mediated Transfusion Related Acute Lung Injury (TRALI)

Rick Kapur, MD PhD, Michael Kim, BSc, Shanjee Shanmugabhavananthan, Edwin R. Speck, BRT, Rukhsana Aslam, PhD, Li Guo, MD, Anne Zufferey, PhD, John W. Semple, PhD
Journal: Blood
Blood (2015) 126 (23): 3561.
https://doi.org/10.1182/blood.V126.23.3561.3561
Published: 2015
Journal Articles

Thymic-Derived Tolerizing Dendritic Cells Are up-Regulated upon Treatment with Intravenous Immunoglobulin or Splenectomy in a Murine Model of Immune Thrombocytopenia

Rick Kapur, MD PhD, Rukhsana Aslam, PhD, Edwin R. Speck, BRT, Michael Kim, BSc, Anne Zufferey, PhD, Li Guo, MD, George B. Segel, MD, Heyu Ni, MD PhD, John W. Semple, PhD
Journal: Blood
Blood (2015) 126 (23): 2251.
https://doi.org/10.1182/blood.V126.23.2251.2251
Published: 2015
Journal Articles

CD20 B Cell Depleting Therapy Is Associated with up-Regulation of CD8 + CD25 high Foxp3 + T Regulatory Cells in a Murine Model of Immune Thrombocytopenia (ITP)

Li Guo, MD, Rukhsana Aslam, PhD, Yajing Zhao, Edwin R. Speck, BRT, Heyu Ni, MD PhD, John W. Semple, PhD
Journal: Blood
Blood (2014) 124 (21): 2785.
https://doi.org/10.1182/blood.V124.21.2785.2785
Published: 2014
Journal Articles

Antibody- and Cell-Mediated Immune Thrombocytopenia Are Differentially Sensitive to Intravenous Gammaglobulin Therapy

Leola Chow, PhD, Michael Kim, BSc, Edwin R. Speck, BRT, Rukhsana Aslam, PhD, Michelle Lee Webster, MSc, Pingguo Chen, PhD, Heyu Ni, MD, PhD, John Freedman, MD, John W. Semple, PhD
Journal: Blood
Blood (2008) 112 (11): 399.
https://doi.org/10.1182/blood.V112.11.399.399
Published: 2008
Journal Articles

A New Murine Model of Immune Thrombocytopenia: Evidence of Both Antibody- and CD8+ T Cell-Mediated Platelet Destruction.

Leola Chow, PhD, Heyu Ni, MD, PhD, Michael Kim, BSc, Edwin R. Speck, BRT, Rukhsana Aslam, PhD, Pingguo Chen, John Freedman, MD, John W. Semple, PhD
Journal: Blood
Blood (2007) 110 (11): 99.
https://doi.org/10.1182/blood.V110.11.99.99
Published: 2007
Journal Articles

The Specificity and Isotype of Monoclonal Anti-D Antibodies Dictates Their Ability To Inhibit Opsonized Platelet Phagocytosis.

John W. Semple, PhD, Rukhsana Aslam, PhD, Michael Kim, BSc, Edwin R. Speck, BRT, Donald I.H. Stewart, PhD, Erik Weirsma, PhD, John Freedman, MD, Mimi Kjaersgaard, MD
Journal: Blood
Blood (2006) 108 (11): 21.
https://doi.org/10.1182/blood.V108.11.21.21
Published: 2006
Journal Articles

Lipopolysaccharide Binds Platelet Toll-Like Receptor 4 and Mediates the Activation of Phagocytes in the Reticuloendothelial System (RES): A Novel Mechanism of Host Immunity.

John W. Semple, PhD, Rukhsana Aslam, PhD, Edwin R. Speck, BRT, John Freedman, MD
Journal: Blood
Blood (2006) 108 (11): 1093.
https://doi.org/10.1182/blood.V108.11.1093.1093
Published: 2006
Journal Articles

Nitrosylation of Platelet MHC Class I Molecules Directs Their Movement into the Immunosuppressive MHC Class I Processing Pathway within Antigen Presenting Cells.

John W. Semple, PhD, Edwin R. Speck, BRT, John Freedman, MD
Journal: Blood
Blood (2004) 104 (11): 837.
https://doi.org/10.1182/blood.V104.11.837.837
Published: 2004