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Emanuela M. Ghia, PhD
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Journal Articles

Cirmtuzumab Consolidation for Treatment of Patients with Detectable CLL on Venetoclax

Benjamin Heyman, MD, Michael Y. Choi, MD, Emanuela M. Ghia, PhD, George F. Widhopf II, PhD, Minya Pu, PhD, Emily Pittman, PhD, Karen Messer, PhD, Catriona Jamieson, MD PhD, Thomas J. Kipps, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 13.
https://doi.org/10.1182/blood-2020-134711
Published: 2020
Journal Articles

Cirmtuzumab, a ROR1 Targeted Mab, Reverses Cancer Stemness, and Its Combination with Ibrutinib Is Safe and Effective: Planned Analysis of the Cirll Phase 1/2 Trial for CLL and MCL

Michael Y. Choi, MD, Emanuela M. Ghia, PhD, Tanya Siddiqi, MD, William G. Wierda, MD PhD, Hun Ju Lee, Jacqueline C. Barrientos, MD MS, Nicole Lamanna, MD, Alec Goldenberg, Dimitrios Tzachanis, MD PhD, Erin G. Reid, MD MS, Elizabeth K Weihe, MD, Laura Z. Rassenti, PhD, Iris Isufi, MD, Stewart Bieler, BA, Xen Ianopulos, MD PhD, James B. Breitmeyer, MD PhD, Catriona Jamieson, MD PhD, Thomas J. Kipps, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1755.
https://doi.org/10.1182/blood-2019-131498
Published: 2019
Journal Articles

High-Level ROR1 and BCL2, Cancer-Stemness, and BCL2 Mutations Associate with Venetoclax Resistance in Chronic Lymphocytic Leukemia

Emanuela M. Ghia, PhD, Laura Z. Rassenti, PhD, Michael Y. Choi, MD, Elvin Chu, George F. Widhopf II, PhD, Thomas J. Kipps, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 476.
https://doi.org/10.1182/blood-2019-131426
Published: 2019
Journal Articles

Identification of Genotype-Specific Therapeutic Vulnerabilities By Comparative Dynamic BH3 Profiling Analysis of Human and Murine CLL

Shanye Yin, PhD, Salma Parvin, PhD, Elisa Ten Hacken, PhD, Rebecca Valentin, MD, Heather Joyal, Laura Z. Rassenti, PhD, Emanuela M. Ghia, PhD, Thomas J. Kipps, MD PhD, Donna S Neuberg, ScD, Lili Wang, MD PhD, Matthew S. Davids, MD, Ruben D. Carrasco, MD PhD, Anthony G. Letai, MD PhD, Catherine J. Wu, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4281.
https://doi.org/10.1182/blood-2019-127293
Published: 2019
Journal Articles

Activation of NF-Kappa B-p62-NRF2 Signaling Supports the Survival of CLL Cells That Express High Levels of ROR1

Elsa Sanchez-Lopez, PhD, Emanuela M. Ghia, PhD, Laura Antonucci, PhD, Laura Z. Rassenti, PhD, Yun Chen, PhD, Thomas J. Kipps, MD PhD, Michael Karin, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3122.
https://doi.org/10.1182/blood-2018-99-115564
Published: 2018
Journal Articles

Tecfidera Modulates Activation of Malignant B-Cells: Correlative Analysis from a Phase 1 Clinical Trial in Patients with Chronic Lymphocytic Leukemia

Christina Wu, PhD, Emanuela M. Ghia, PhD, Fitzgerald Lao, Minya Pu, PhD, Karen Messer, PhD, Laura Z. Rassenti, PhD, Thomas J. Kipps, MD PhD, Dennis A. Carson, MD, Michael Y. Choi, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3143.
https://doi.org/10.1182/blood-2018-99-119292
Published: 2018
Journal Articles

Cirmtuzumab Inhibits Non-Canonical Wnt Signaling without Enhancing Canonical Wnt/β-Catenin Signaling in Chronic Lymphocytic Leukemia

Han Zhang, PhD, Suping Zhang, PhD, Emanuela M. Ghia, PhD, Michael Y. Choi, MD, Jieyu Zhang, MS, Liguang Chen, PhD, George F. Widhopf II, PhD, Laura Z. Rassenti, PhD, Thomas J. Kipps, MD, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2652.
https://doi.org/10.1182/blood-2018-99-119606
Published: 2018
Journal Articles

Cirmtuzumab Blocks Production of Proinflammatory Factors By Inhibiting Wnt5a/ROR1 Induced Activation of NF-Kappa B in Chronic Lymphocytic Leukemia

Yun Chen, PhD, Michael Y. Choi, MD, Liguang Chen, PhD, Jian Yu, PhD, Ling Zhang, Emanuela M. Ghia, PhD, Elsa Sanchez-Lopez, PhD, George F. Widhopf II, PhD, Karen Messer, PhD, Laura Z. Rassenti, PhD, Catriona Jamieson, MD PhD, Thomas J. Kipps, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4415.
https://doi.org/10.1182/blood-2018-99-111996
Published: 2018
Journal Articles

ROR1 Expression Is Associated with Oncogenic Dedifferentiation in Chronic Lymphocytic Leukemia

Emanuela M. Ghia, PhD, Michael Y. Choi, MD, George F. Widhopf II, PhD, Laura Z. Rassenti, PhD, Thomas J. Kipps, MD, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1853.
https://doi.org/10.1182/blood-2018-99-119711
Published: 2018
Journal Articles

Splicing Modulation Perturbs Key Survival Pathways and Sensitizes Chronic Lymphocytic Leukemia to Venetoclax Treatment

Elisa Ten Hacken, PhD, Rebecca Valentin, MD, Jing Sun, PhD, Jing Deng, PhD, Angela Brooks, PhD, Lillian Werner, MS, Fara Faye Regis, BS, Michaela Gruber, MD PhD, Jessica Wong, BS, Zachary Cartun, BS, Michael Seiler, PhD, Peter Smith, PhD, Michael Thomas, PhD, Silvia Buonamici, PhD, Emanuela M. Ghia, PhD, Ekaterina Kim, PhD, Laura Z. Rassenti, PhD, Jan A. Burger, MD PhD, Thomas J. Kipps, MD, Matthew Meyerson, MDPhD, Donna S. Neuberg, ScD, Ruben D. Carrasco, MD PhD, Lili Wang, MD PhD, Matthew S. Davids, MD, Anthony Letai, MD PhD, Catherine J. Wu, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 264.
https://doi.org/10.1182/blood.V130.Suppl_1.264.264
Published: 2017
Journal Articles

High-Level Expression of ROR1 Associates with Early Disease Progression in Patients with Chronic Lymphocytic Leukemia

Bing Cui, PhD, Liguang Chen, MD PhD, Laura Z. Rassenti, PhD, Emanuela M. Ghia, PhD, Jian Yu, PhD, Ling Zhang, PhD, Donna S Neuberg, ScD, William Wierda, MD PhD, Michael Keating, MBBS, Kanti R. Rai, MD, Neil E. Kay, MD, Jennifer R. Brown, MD PhD, John C. Byrd, MD, John Gribben, MDDSc, Thomas J. Kipps, MD, PhD
Journal: Blood
Blood (2015) 126 (23): 1713.
https://doi.org/10.1182/blood.V126.23.1713.1713
Published: 2015
Journal Articles

Comprehensive Bulk and Single Cell Transcriptomic Characterization of SF3B1 Mutation Reveals Its Pleiotropic Effects in Chronic Lymphocytic Leukemia

Jean Fan, BS, Lili Wang, MD PhD, Angela N Brooks, PhD, Youzhong Wan, PhD, Donna S Neuberg, ScD, Laura Z. Rassenti, PhD, Emanuela M. Ghia, PhD, Thomas J. Kipps, MD, PhD, Jennifer R. Brown, MD PhD, Shuqiang Li, Kenneth J Livak, Matthew M. Meyerson, PhD, Peter V. Kharchenko, PhD, Catherine J. Wu, MD
Journal: Blood
Blood (2015) 126 (23): 2906.
https://doi.org/10.1182/blood.V126.23.2906.2906
Published: 2015
Journal Articles

ROR1 Negative Chronic Lymphocytic Leukemia (CLL) Have a Distinctive Gene Expression Signature and May Represent an Indolent-Disease Subtype

Emanuela M. Ghia, PhD, Laura Z. Rassenti, PhD, Liguang Chen, MD PhD, Bing Cui, PhD, Christopher Deboever, BS, Kelly A. Frazer, Thomas J. Kipps, MD, PhD
Journal: Blood
Blood (2015) 126 (23): 2932.
https://doi.org/10.1182/blood.V126.23.2932.2932
Published: 2015
Journal Articles

ROR1 Can Interact With TCL1 and Enhance Leukemogenesis In Eµ-TCL1 Transgenic Mice

George F. Widhopf, II, PhD, Bing Cui, Ph.D., Emanuela M. Ghia, PhD, Liguang Chen, MD, PhD, Karen Messer, PhD, Zhouxin Shen, Steven P. Briggs, Ph.D, Carlo M. Croce, MD, Thomas J. Kipps, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 868.
https://doi.org/10.1182/blood.V122.21.868.868
Published: 2013
Journal Articles

Lenalidomide Inhibits Proliferation Of Chronic Lymphocytic Leukemia Cells Via a Cereblon/p21 WAF1/Cip1 -Dependent Mechanism

Jessie-Farah Fecteau, Ph.D., Laura G Corral, Diahnn Futalan, Svetlana Gaidarova, MS, Ila Bharati, BS, Brian Cathers, PhD, Emanuela M. Ghia, PhD, Maria Schwaederlé, PharmaD, Antonia Lopez-Girona, Ph.D., Davorka Messmer, PhD, Thomas J. Kipps, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 4139.
https://doi.org/10.1182/blood.V122.21.4139.4139
Published: 2013
Journal Articles

Genomic Analysis of Serial Chronic Lymphocytic Leukemia Samples Suggests That Epigenetic Changes, Rather Than Clonal Evolution, May Drive the Progression of This Leukemia

Emanuela M. Ghia, PhD, Erin Smith, PhD, Christopher DeBoever, Laura Z. Rassenti, Ph.D., Sophie Rozenzhak, Peter Shepard, PhD, Hakan Alakus, M.D., Olivier Harismendy, PhD, Christian L Barrett, Ph.D., Kelly A Frazer, Ph.D., Thomas J. Kipps, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 4563.
https://doi.org/10.1182/blood.V120.21.4563.4563
Published: 2012
Journal Articles

Fd-895 and Pladienolide B Inhibit mRNA Splicing and Induce Apoptosis in Chronic Lymphocytic Leukemia

Manoj Kumar Kashyap, PhD, Deepak Kumar, PhD, Harrison Jones Jones, BS, Maria Schwaederlé, PharmaD, Emanuela M. Ghia, PhD, Reymond Villa, PhD, James J La Clair, PhD, Michael D Burkart, PhD, Thomas J. Kipps, MD, PhD, Januario E. Castro, M.D.
Journal: Blood
Blood (2012) 120 (21): 3890.
https://doi.org/10.1182/blood.V120.21.3890.3890
Published: 2012
Journal Articles

The Target Genes and Prognostic Significance of Mir-150 in Chronic Lymphocytic Leukemia

Marek Mraz, MD, PhD, Laura Z. Rassenti, Ph.D., Emanuela M. Ghia, PhD, Liguang Chen, MD, PhD, Jessie-Farah Fecteau, Ph.D., Sarka Pospisilova, Dr, PhD, Hongying Li, PhD, Karen Messer, PhD, Thomas J. Kipps, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 3859.
https://doi.org/10.1182/blood.V120.21.3859.3859
Published: 2012
Journal Articles

Treatment of Chronic Lymphocytic Leukemia Patients with Lenalidomide Induces Down-Regulation of miR342-3p Associated with Over-Expression of Tumor Suppressor RASSF4,

Emanuela M. Ghia, PhD, Lillian Werner, Danelle F. James, M.D., Donna Neuberg, ScD, Laura G Corral, Senior, Scientist, Laura Z. Rassenti, Ph.D., Carlo M. Croce, MD, Thomas J. Kipps, M.D., Ph.D
Journal: Blood
Blood (2011) 118 (21): 3885.
https://doi.org/10.1182/blood.V118.21.3885.3885
Published: 2011
Journal Articles

Relative Prognostic Significance of ZAP-70 and IGHV1-69 Expression in Chronic Lymphocytic Leukemia,

Laura Z. Rassenti, Ph.D., Emanuela M. Ghia, PhD, Lillian Werner, Donna Neuberg, ScD, George F. Widhopf, II, PhD, Thomas J. Kipps, M.D., Ph.D
Journal: Blood
Blood (2011) 118 (21): 3891.
https://doi.org/10.1182/blood.V118.21.3891.3891
Published: 2011