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Fernando F. Costa, M.D.
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Journal Articles

IRS2 Associates With JAK2 and May Be Involved In Cell Proliferation Pathways In Chronic Myeloproliferative Neoplasms

Paula de Melo Campos, MD, Joao Machado-Neto, MSc, Adriana Silva Santos Duarte, PhD, Rafaela Mendonça, Irene Lorand-Metze, MD, PhD, Fernando F. Costa, M.D., Ph.D., Sara T O Saad, MD, PhD, Fabiola Traina, M.D., Ph.D.
Journal: Blood
Blood (2013) 122 (21): 1598.
https://doi.org/10.1182/blood.V122.21.1598.1598
Published: 2013
Journal Articles

Simvastatin Reduces the in Vitro Adhesion of Sickle Cell Disease Neutrophils to Endothelial Layers

Andreia A Canalli, B.Sc., Ph.D., Renata P. Ferreira, B.Sc., Sara T.O. Saad, MD, PhD, Nicola Conran, B.Sc, PhD, Fernando F. Costa, M.D., Ph.D.
Journal: Blood
Blood (2008) 112 (11): 2489.
https://doi.org/10.1182/blood.V112.11.2489.2489
Published: 2008
Journal Articles

Platelets from Sickle Cell Disease Individuals Demonstrate Increased Adhesive Properties That Are Reversed by Hydroxyurea Therapy in Association with Alterations in Intraplatelet cAMP and α IIb α 3 Integrin Activation

Renata P. Ferreira, B.Sc., Carla F. Franco-Penteado, Ph.D., Sara T.O. Saad, M.D., Ph.D., Fernando F. Costa, M.D., Ph.D., Nicola Conran, Ph.D.
Journal: Blood
Blood (2008) 112 (11): 2472.
https://doi.org/10.1182/blood.V112.11.2472.2472
Published: 2008
Journal Articles

Increased Expression of the cGMP-Specific Phophodiesterase, PDE9A, in Sickle Cell Disease (SCD) Reticulocytes and Neutrophils, and Induction of Erythroid γ Globin Expression and Reduction of SCD Neutrophil Adhesion Following PDE9A Inhibition.

Camila B. Almeida, M.Sc., Sara T.O. Saad, M.D., Ph.D., Fernando F. Costa, M.D., Ph.D., Nicola Conran, PhD
Journal: Blood
Blood (2007) 110 (11): 3397.
https://doi.org/10.1182/blood.V110.11.3397.3397
Published: 2007
Journal Articles

The Cyclic GMP-Dependent Pathway Is Involved in the Mechanisms of Action of Hydroxyurea.

Yusuke Suzuki, PhD, Lakiea Bailey, M.S., Abdullah Kutlar, M.D., Nicola Conran, Ph.D., Fernando F. Costa, M.D., Karin M. Gaensler, M.D., Tohru Ikuta, M.D., Ph.D.
Journal: Blood
Blood (2007) 110 (11): 2256.
https://doi.org/10.1182/blood.V110.11.2256.2256
Published: 2007
Journal Articles

The Adhesion of Sickle Cell Disease Neutrophils to Endothelial Layers, In Vitro , Is Mediated by the Mac-1, LFA-1 and VLA-4 Integrins.

Andreia A. Canalli, MSc, Renata F. Proenca, B.Sc., Sara T.O. Saad, M.D., Ph.D., Nicola Conran, Ph.D., Fernando F. Costa, M.D., Ph.D.
Journal: Blood
Blood (2007) 110 (11): 2264.
https://doi.org/10.1182/blood.V110.11.2264.2264
Published: 2007
Journal Articles

Hydroxyurea Reverses Increased Adhesive Properties of Neutrophils in Sickle Cell Disease.

Andreia A. Canalli, BSc, MSc, Nicola Conran, B.Sc., Ph.D., Sara T.O. Saad, M.D., Ph.D., Fernando F. Costa, M.D., Ph.D.
Journal: Blood
Blood (2006) 108 (11): 1231.
https://doi.org/10.1182/blood.V108.11.1231.1231
Published: 2006
Journal Articles

cAMP-PKA Signaling Plays an Important Role in Augmented Neutrophil Adhesion and Chemotaxis in Sickle Cell Disease.

Carla Franco-Penteado, BS, MSc, PhD, Andreia A. Canalli, B.Sc., M.Sc., Renata P. Ferreira, Sara T.O. Saad, M.D., Ph.D., Fernando F. Costa, M.D., Ph.D., Nicola Conran, B.Sc., Ph.D.
Journal: Blood
Blood (2006) 108 (11): 1232.
https://doi.org/10.1182/blood.V108.11.1232.1232
Published: 2006
Journal Articles

Anti-Inflammatory Effect of Hydroxyurea Therapy in Sickle Cell Disease.

Carolina Lanaro, BSc, Carla F. Franco-Penteado, B.Sc., M.Sc., Ph.D., Nicola Conran, B.Sc., Ph.D., Sara T.O. Saad, M.D., Ph.D., Fernando F. Costa, M.D., Ph.D.
Journal: Blood
Blood (2006) 108 (11): 3806.
https://doi.org/10.1182/blood.V108.11.3806.3806
Published: 2006
Journal Articles

Characterization of Gene Expression Profiles of Plasma Cells in Patients with Multiple Myeloma.

Manoela M. Ortega, BSc, PhD, Anderson F. Cunha, B.Sc., Ph.D., Dulcineia M. Alberquerque, B.Sc., Ph.D., Adriana S.S Duarte, B.Sc., M.Sc., Carmino De Souza, M.D., Ph.D., Irene Lorand-Metze, M.D., Ph.D., Fernando F. Costa, M.D., Ph.D., Carmen S.P. Lima, M.D., Ph.D.
Journal: Blood
Blood (2006) 108 (11): 5082.
https://doi.org/10.1182/blood.V108.11.5082.5082
Published: 2006
Journal Articles

Increased GM-CSF Levels in Sickle Cell Disease Are Associated with Increased Leukocyte Counts and Are Reversed by Hydroxyurea.

Nicola Conran, Ph.D, Tohru Ikuta, M.D., Ph.D., Sara T.O. Saad, M.D., PhD, Fernando F. Costa, M.D., Ph.D.
Journal: Blood
Blood (2004) 104 (11): 3573.
https://doi.org/10.1182/blood.V104.11.3573.3573
Published: 2004
Journal Articles

Global Gene Expression Profile of Human Bone Marrow before and after Hydroxyurea Administration in Sickle Cell Anemia.

Flavia C. Costa, M.Sc., Anderson F. Cunha, Ph.D., Andre Fattori, M.D., Tarcisio S. Peres, B.S., Gustavo G.L. Costa, B.Sc., Sara T.O. Saad, M.D., Ph. D, Fernando F. Costa, M.D., Ph.D.
Journal: Blood
Blood (2004) 104 (11): 3750.
https://doi.org/10.1182/blood.V104.11.3750.3750
Published: 2004