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Journal Articles

Expression of the Tigit/CD226/CD155 Receptors/Ligand System in Chronic Lymphocytic Leukemia

Francesca Arruga, PhD, Giulia Guerra, Denis Baev, PhD, Catherine Hoofd, PhD, Marta Coscia, MD PhD, Giovanni Francesco D'Arena, MD, Gianluca Gaidano, MD PhD, Richard R. Furman, MD, Silvia Deaglio, MD PhD

Blood (2019) 134 (Supplement_1): 5454.

https://doi.org/10.1182/blood-2019-128308

Published: 2019

Journal Articles

Vls-101 Is a Novel Therapeutic Antibody-Drug Conjugate (ADC) Targeting Receptor Tyrosine Kinase-like Orphan Receptor 1 (ROR1) in Richter's Syndrome (RS)

Tiziana Vaisitti, PhD, Katti Jessen, PhD, Thanh-Trang Vo, PhD, Mira Ko, Francesca Arruga, PhD, Nicoletta Vitale, PhD, Esteban Braggio, PhD, Arianna Di Napoli, Amy Chadburn, MD, John N. Allan, MD, Richard R. Furman, MD, Langdon L. Miller, Brian J Lanutti, PhD, Silvia Deaglio, MD PhD

Blood (2019) 134 (Supplement_1): 2856.

https://doi.org/10.1182/blood-2019-126827

Published: 2019

Journal Articles

The Dual PI3K-δ/γ Inhibitor Duvelisib in Combination with the Bcl-2 Inhibitor Venetoclax Shows Promising Responses in Richter Syndrome-PDX Models

Andrea Iannello, PhD, Francesca Arruga, PhD, Nicoletta Vitale, PhD, Elisa Marchi, Richard R. Furman, MD, John N. Allan, MD, Silvia Coma, PhD, Jonathan A. Pachter, PhD, Silvia Deaglio, MD PhD, Tiziana Vaisitti, PhD

Blood (2019) 134 (Supplement_1): 2862.

https://doi.org/10.1182/blood-2019-125754

Published: 2019

Journal Articles

CD79b Expression in Richter's Transformation

John N. Allan, MD, Erica B Bhavsar, BS, Tiziana Vaisitti, PhD, Vincent Sarno, Yifang Liu, Francesca Arruga, PhD, Maureen Joyce, Mathias Schulz, MD MBA, Silvia Deaglio, MD PhD, Richard R. Furman, MD, Amy Chadburn, MD

Blood (2019) 134 (Supplement_1): 4279.

https://doi.org/10.1182/blood-2019-128305

Published: 2019

Journal Articles

NOTCH1 Stabilization By PEST Mutations Enhances IgM-Mediated Activity in Chronic Lymphocytic Leukemia

Francesca Arruga, PhD, Valeria Bracciamà, Alison Yeomans, PhD, Annalisa D'Avola, PhD, Marta Coscia, MD, Giovanni Francesco D'Arena, MD, Gianluca Gaidano, MD PhD, John N. Allan, MD, Richard R. Furman, MD, Graham Packham, PhD, Silvia Deaglio, MD PhD, Francesco Forconi, MD DM, PhD FRCPath

Blood (2018) 132 (Supplement 1): 1832.

https://doi.org/10.1182/blood-2018-99-118064

Published: 2018

Journal Articles

Genetic and Molecular Characterization of Novel Richter Syndrome Patient-Derived Xenograft Models

Tiziana Vaisitti, PhD, John N. Allan, MD, Esteban Braggio, PhD, Francesca Arruga, PhD, Amy Chadburn, MD, Richard R. Furman, MD, Silvia Deaglio, MD

Blood (2017) 130 (Supplement 1): 4297.

https://doi.org/10.1182/blood.V130.Suppl_1.4297.4297

Published: 2017

Journal Articles

Mutations in NOTCH1 PEST Domain Orchestrate CCL19-Driven Homing of Chronic Lymphocytic Leukemia (CLL) Cells By Modulating the Tumor Suppressor Gene DUSP22

Blood (2016) 128 (22): 969.

https://doi.org/10.1182/blood.V128.22.969.969

Published: 2016

Journal Articles

NOTCH1 Mutated IGHV Unmutated Chronic Lymphocytic Leukemia Cells Are Characterized By a Constitutive Overexpression of Nucleophosmin-1 and Ribosome-Associated Components

Blood (2014) 124 (21): 3308.

https://doi.org/10.1182/blood.V124.21.3308.3308

Published: 2014

Journal Articles

Extracellular Nicotinamide Phosphoribosyltransferase (NAMPT) Shapes the CLL Microenvironment Promoting Macrophage M2 Polarization Via a Non-Enzymatic Mechanism

Valentina Audrito, Sara Serra, Davide Brusa, PhD, Francesca Mazzola, PhD, Francesca Arruga, PhD, Tiziana Vaisitti, PhD, Marta Coscia, MD PhD, Rossana Maffei, Davide Rossi, MD, Tao Wang, PhD, Giorgio Inghirami, MD, Menico Rizzi, PhD, Gianluca Gaidano, MD, Cynthia Wolberger, PhD, Nadia Raffaelli, PhD, Silvia Deaglio

Blood (2014) 124 (21): 3316.

https://doi.org/10.1182/blood.V124.21.3316.3316

Published: 2014

Journal Articles

NOTCH1 Mutations Are Associated with Low CD20 Expression in Chronic Lymphocytic Leukemia: Evidences for a NOTCH1 -Mediated Epigenetic Regulatory Mechanism

Blood (2014) 124 (21): 296.

https://doi.org/10.1182/blood.V124.21.296.296

Published: 2014

Journal Articles

Functional Effects Of NOTCH1 Mutations In Chronic Lymphocytic Leukemia Patients

Francesca Arruga, PhD, Branimir Gizdic, Sara Serra, Tiziana Vaisitti, PhD, Davide Rossi, Marta Coscia, MD, PhD, Luca Laurenti, MD, Giovanni D'Arena, Ozren Jaksic, MD, PhD, Giorgio Inghirami, Gianluca Gaidano, Silvia Deaglio, MD, PhD

Blood (2013) 122 (21): 4117.

https://doi.org/10.1182/blood.V122.21.4117.4117

Published: 2013

Journal Articles

Harmonized Testing for BCR-ABL Kinase Domain Mutations In CML: Results of a Survey and First Control Round within 28 National Reference Laboratories In Europe

Blood (2010) 116 (21): 894.

https://doi.org/10.1182/blood.V116.21.894.894

Published: 2010

Journal Articles

Foxo Transcription Factor Activity Is Retained in Quiescent Chronic Myeloid Leukaemia Stem Cells and Activated by Tyrosine Kinase Inhibitors to Mediate “induced-quiescence” in More Mature progenitors.

Daniela Cilloni, MD, PhD, Francesca Pellicano, PhD, Vignir G Helgason, PhD, Cristina Panuzzo, PhD, Francesca Messa, PhD, Brian J Huntly, MD, Elaine Allan, PhD, Francesca Arruga, PhD, Enrico Bracco, PhD, Giuseppe Saglio, MD, Tessa L Holyoake, MD

Blood (2009) 114 (22): 187.

https://doi.org/10.1182/blood.V114.22.187.187

Published: 2009

Journal Articles

Genome-Wide Screening for Dominant Modifiers in Drosophila Identified New Cluster of Genes Involved in BCR-ABL Signalling and CML Progression.

Francesca Messa, PhD, Monica Pradotto, PhD, Francesca Arruga, PhD, Roberto Bernardoni, PhD, Enrico Bracco, PhD, Chiara Maffè, PhD, Emanuela Messa, MD, Sonia Carturan, PhD, Elisabetta Signorino, PhD, Elisabetta Greco, MD, Antonia Rotolo, MD, Ilaria Iacobucci, PhD, Giovanni Martinelli, MD, Giuseppe Saglio, MD, Daniela Cilloni, MD, PhD

Blood (2009) 114 (22): 2186.

https://doi.org/10.1182/blood.V114.22.2186.2186

Published: 2009

Journal Articles

Disabled Gene Is Involved in CML Progression and Its Expression Level at Diagnosis Can Predict Major Molecular Response (MMR) to Imatinib Therapy.

Daniela Cilloni, MD, PhD, Francesca Arruga, PhD, Francesca Messa, PhD, Monica Pradotto, PhD, Enrico Bracco, PhD, Sonia Carturan, PhD, Chiara Maffè, PhD, Emanuela Messa, MD, Antonia Rotolo, MD, Elisabetta Greco, MD, Ilaria Iacobucci, PhD, Roberto Bernardoni, Fabrizio Pane, MD, Thea Kalebic, MD, Giovanni Martinelli, Michele Baccarani, MD, Giuseppe Saglio, MD

Blood (2009) 114 (22): 3964.

https://doi.org/10.1182/blood.V114.22.3964.3964

Published: 2009

Journal Articles

Identification of Rab5 as a Gene Involved in Chronic Myeloid Leukemia (CML) Progression.

Daniela Cilloni, MD, PhD, Monica Pradotto, PhD, Francesca Messa, PhD, Francesca Arruga, PhD, Enrico Bracco, PhD, Sonia Carturan, PhD, Chiara Maffè, PhD, Emanuela Messa, MD, Antonia Rotolo, MD, Elisabetta Greco, MD, Ilaria Iacobucci, PhD, Thea Kalebic, MD, Roberto Bernardoni, Fabrizio Pane, MD, Giovanni Martinelli, MD, Michele Baccarani, M.D., Giuseppe Saglio, MD

Blood (2009) 114 (22): 3470.

https://doi.org/10.1182/blood.V114.22.3470.3470

Published: 2009

Journal Articles

The Non Receptor Transmembrane Tyrosine Kinase STYK1 Represents a Novel Lymphocyte Marker, Whose Expression Is Deregulated in Leukemia, and a Potential Molecular Druggable Target

Blood (2008) 112 (11): 5334.

https://doi.org/10.1182/blood.V112.11.5334.5334

Published: 2008

Journal Articles

Single Base Pair Mutation Detection by PNA Direct PCR Clamping: Application to Bcr-Abl T315I Mutation

Blood (2008) 112 (11): 4224.

https://doi.org/10.1182/blood.V112.11.4224.4224

Published: 2008

Journal Articles

Imatinib Induced Re-Activation of FoxO3 Transcription Factor in CML Is Responsible for the Induction of a Quiescent Status of CD34 Leukaemic Progenitor Cells.

Daniela Cilloni, MD, PhD, Cristina Panuzzo, PhD, Francesca Messa, PhD, Francesca Arruga, PhD, Enrico Bracco, PhD, Roberto Bernardoni, PhD, Sonia Carturan, PhD, Marisa Pautasso, MD, Emanuela Messa, MD, Alessandro Morotti, MD, Monica Pradotto, PhD, Ilaria Iacobucci, Thea Kalebic, MD, Giovanni Martinelli, MD, Giuseppe Saglio, MD

Blood (2008) 112 (11): 1090.

https://doi.org/10.1182/blood.V112.11.1090.1090

Published: 2008

Journal Articles

Identification of Genes Sustaining Bcr-Abl Oncogenic Signalling and CML Progression through a Genetic Tool Based on Human Bcr-Abl Transgenic Drosophila Melanogaster.

Daniela Cilloni, Francesca Messa, PhD, Roberto Bernardoni, PhD, Francesca Arruga, PhD, Monica Pradotto, PhD, Enrico Bracco, PhD, Cristina Panuzzo, PhD, Chiara Maffè, PhD, Emanuela Messa, MD, Ilaria Iacobucci, Thea Kalebic, MD, Giovanni Martinelli, MD, Michele Baccarani, MD, Giuseppe Saglio, MD

Blood (2008) 112 (11): 1091.

https://doi.org/10.1182/blood.V112.11.1091.1091

Published: 2008

NARROW

Expression of the Tigit/CD226/CD155 Receptors/Ligand System in Chronic Lymphocytic Leukemia

Vls-101 Is a Novel Therapeutic Antibody-Drug Conjugate (ADC) Targeting Receptor Tyrosine Kinase-like Orphan Receptor 1 (ROR1) in Richter's Syndrome (RS)

The Dual PI3K-δ/γ Inhibitor Duvelisib in Combination with the Bcl-2 Inhibitor Venetoclax Shows Promising Responses in Richter Syndrome-PDX Models

CD79b Expression in Richter's Transformation

NOTCH1 Stabilization By PEST Mutations Enhances IgM-Mediated Activity in Chronic Lymphocytic Leukemia

Genetic and Molecular Characterization of Novel Richter Syndrome Patient-Derived Xenograft Models

Mutations in NOTCH1 PEST Domain Orchestrate CCL19-Driven Homing of Chronic Lymphocytic Leukemia (CLL) Cells By Modulating the Tumor Suppressor Gene DUSP22

NOTCH1 Mutated IGHV Unmutated Chronic Lymphocytic Leukemia Cells Are Characterized By a Constitutive Overexpression of Nucleophosmin-1 and Ribosome-Associated Components

Extracellular Nicotinamide Phosphoribosyltransferase (NAMPT) Shapes the CLL Microenvironment Promoting Macrophage M2 Polarization Via a Non-Enzymatic Mechanism

NOTCH1 Mutations Are Associated with Low CD20 Expression in Chronic Lymphocytic Leukemia: Evidences for a NOTCH1 -Mediated Epigenetic Regulatory Mechanism

Functional Effects Of NOTCH1 Mutations In Chronic Lymphocytic Leukemia Patients

Harmonized Testing for BCR-ABL Kinase Domain Mutations In CML: Results of a Survey and First Control Round within 28 National Reference Laboratories In Europe

Foxo Transcription Factor Activity Is Retained in Quiescent Chronic Myeloid Leukaemia Stem Cells and Activated by Tyrosine Kinase Inhibitors to Mediate “induced-quiescence” in More Mature progenitors.

Genome-Wide Screening for Dominant Modifiers in Drosophila Identified New Cluster of Genes Involved in BCR-ABL Signalling and CML Progression.

Disabled Gene Is Involved in CML Progression and Its Expression Level at Diagnosis Can Predict Major Molecular Response (MMR) to Imatinib Therapy.

Identification of Rab5 as a Gene Involved in Chronic Myeloid Leukemia (CML) Progression.

The Non Receptor Transmembrane Tyrosine Kinase STYK1 Represents a Novel Lymphocyte Marker, Whose Expression Is Deregulated in Leukemia, and a Potential Molecular Druggable Target

Single Base Pair Mutation Detection by PNA Direct PCR Clamping: Application to Bcr-Abl T315I Mutation

Imatinib Induced Re-Activation of FoxO3 Transcription Factor in CML Is Responsible for the Induction of a Quiescent Status of CD34 Leukaemic Progenitor Cells.

Identification of Genes Sustaining Bcr-Abl Oncogenic Signalling and CML Progression through a Genetic Tool Based on Human Bcr-Abl Transgenic Drosophila Melanogaster.

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American Society of Hematology

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American Society of Hematology

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