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Gang Bao, PhD
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Journal Articles

Engineered Human Umbilical Cord Derived Erythroid Progenitor Cells (HUDEP2) with Sickle or β-Thalassemia Mutation: An in-Vitro System for Testing Pharmacological Induction of Fetal Hemoglobin

So Hyun Park, BS, Ciaran M Lee, PhD, Yankai Zhang, PhD, Alicia Chang, MD, Vivien A Sheehan, MD PhD, Gang Bao, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3478.
https://doi.org/10.1182/blood-2018-99-114241
Published: 2018
Journal Articles

Highly Efficient Editing of the Beta-Globin Gene in Patient Derived Hematopoietic Stem and Progenitor Cells to Treat Sickle Cell Disease

So Hyun Park, BS, Ciaran M Lee, PhD, Daniel P. Dever, PhD, Timothy H Davis, BS, Joab Camarena, BS, Yankai Zhang, PhD, Matthew Porteus, MD PhD, Vivian A Sheehan, MD PhD, Gang Bao, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2192.
https://doi.org/10.1182/blood-2018-99-117371
Published: 2018
Journal Articles

Persistence of CRISPR/Cas9-Edited Hematopoietic Stem and Progenitor Cells and Reactivation of Fetal Hemoglobin in Nonhuman Primates

Olivier Humbert, PhD, Stefan Radtke, PhD, Ray R Carillo, Anai M Perez, Sowmya Somashekar Reddy, Lauren E Schefter, Christopher Lux, MDPhD, Sowmya Pattabhi, PhD, Olivier Negre, PhD, Ciaran M Lee, PhD, Jennifer Adair, PhD, Christopher Peterson, PhD, Gang Bao, PhD, David J. Rawlings, MD, Andrew M. Scharenberg, MD, Hans-Peter Kiem, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 806.
https://doi.org/10.1182/blood-2018-99-112996
Published: 2018
Journal Articles

Sickle Human Umbilical Cord Derived Erythroid Progenitor Cells (S-HUDEP2): An Ideal in-Vitro System for Screening Anti-Sickling Compounds for Sickle Cell Disease

Alicia Chang, MD, So Hyun Park, BS, Ciaran M Lee, PhD, Alireza Paikari, MD, Gang Bao, PhD, Vivien A Sheehan, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3675.
https://doi.org/10.1182/blood-2018-99-117158
Published: 2018
Journal Articles

Preclinical Development of HBB Gene Correction in Autologous Hematopoietic Stem and Progenitor Cells to Treat Severe Sickle Cell Disease

Daniel P. Dever, PhD, Joab Camarena, BS, Ciaran Lee, PhD, Christopher Vakulskas, PhD, Mark Behlke, MD PhD, Gang Bao, PhD, Matthew Porteus, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4620.
https://doi.org/10.1182/blood.V130.Suppl_1.4620.4620
Published: 2017
Journal Articles

Therapeutic Crispr/Cas9 Genome Editing for Treating Sickle Cell Disease

So Hyun Park, BS, Ciaran M Lee, PhD, Harshavardhan Deshmukh, MS, Gang Bao, PhD
Journal: Blood
Blood (2016) 128 (22): 4703.
https://doi.org/10.1182/blood.V128.22.4703.4703
Published: 2016
Journal Articles

Re-Creating Hereditary Persistence of Fetal Hemoglobin (HPFH) to Treat Sickle Cell Disease (SCD) and β-Thalassemia

Michelle I Lin, PhD, Elizabeth J Paik, PhD, Bibhu P Mishra, PhD, Song Chou, PhD, Ying Zhang, PhD, Kaleigh Tomkinson, MS, Michael A Pettiglio, BS, Andrew Sanginario, BS, Amanda Woo, BS, Min Jin Lee, BS, Melanie Allen, MS, Thomas J Cradick, PhD, Tirtha Chakraborty, PhD, Matthew Porteus, MD PhD, Ciaran M Lee, PhD, Gang Bao, PhD, Annarita Miccio, PhD, Annalisa Lattanzi, PhD, Fulvio Mavilio, PhD, Chad A Cowan, PhD, Rodger Novak, MD, Ante S Lundberg, MD
Journal: Blood
Blood (2016) 128 (22): 4708.
https://doi.org/10.1182/blood.V128.22.4708.4708
Published: 2016
Journal Articles

Gene Editing with Crispr-Cas9 for Treating Beta-Hemoglobinopathies

Ciaran Lee, PhD, Gang Bao, PhD, Matthew H. Porteus, MD PhD, Tatjana Cornu, PhD, Annarita Miccio, PhD, Thomas Cradick, Toni Cathomen, PhD, Ante Lundberg, MD, Fulvio Mavilio, PhD
Journal: Blood
Blood (2015) 126 (23): 3376.
https://doi.org/10.1182/blood.V126.23.3376.3376
Published: 2015
Journal Articles

Platelet Adhesion, Spreading and Activation Are Mediated By Mechanosensing of Matrix Stiffness

Yongzhi Qiu, PhD, Ashley C Brown, PhD, David R Myers, PhD, Yumiko Sakurai, MSc, Robert Mannino, BS, Reginald Tran, BS, Byungwook Ahn, PhD, Elaissa Hardy, PhD, Matthew F Kee, Sanjay Kumar, MD, PhD, Gang Bao, PhD, Thomas H Barker, PhD, Wilbur A Lam, MD PhD
Journal: Blood
Blood (2014) 124 (21): 1438.
https://doi.org/10.1182/blood.V124.21.1438.1438
Published: 2014
Journal Articles

Platelet Mechanosensing: Adhesion and Spreading On Immobilized Fibrinogen Depends On Substrate Stiffness

Yongzhi Qiu, PhD, Ashley C Brown, PhD, Woo Jin Jung, Yumiko Sakurai, MSc, Robert Mannino, David R Myers, PhD, Reginald Tran, BS, Gang Bao, PhD, Thomas H Barker, PhD, Wilbur Lam, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 384.
https://doi.org/10.1182/blood.V120.21.384.384
Published: 2012
Journal Articles

A Biological Delivery Platform for Zinc Finger Nucleases Using Transferrin-Mediated Endocytosis

Steffen E. Meiler, MD, William S. Dynan, PhD, Matthew Porteus, MD, PhD, David L. Spector, PhD, Gang Bao, PhD, Zhong Chen, MD, Jay Pandey, PhD, Deepika Goyal, PhD, R. Ileng Kumaran, PhD, Marlene Wade, Davies Agyekum
Journal: Blood
Blood (2011) 118 (21): 1071.
https://doi.org/10.1182/blood.V118.21.1071.1071
Published: 2011