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Genmin Lu, PhD
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Journal Articles

Reversal of Betrixaban-Induced Anticoagulation in Healthy Volunteers By Andexanet Alfa

Mark Crowther, MD, Genmin Lu, PhD, Janet M. Leeds, PhD, Joyce Lin, BS, Pamela B. Conley, PhD, Alexander Gold, MD, Stuart J. Connolly, MD, John T. Curnutte, MD PhD
Journal: Blood
Blood (2016) 128 (22): 143.
https://doi.org/10.1182/blood.V128.22.143.143
Published: 2016
Journal Articles

Andexanet Alfa, a Universal Antidote Under Development for Factor Xa Inhibitors, Reverses Rivaroxaban-Induced Inhibition of Thrombin Generation Initiated By the Intrinsic Coagulation Pathway Independent of TFPI

Genmin Lu, PhD, Joyce Lin, BS, John T. Curnutte, MDPhD, Pamela B. Conley, PhD
Journal: Blood
Blood (2016) 128 (22): 3831.
https://doi.org/10.1182/blood.V128.22.3831.3831
Published: 2016
Journal Articles

Andexanet Alfa Reverses Anticoagulation Effects of Enoxaparin and Associated Bleeding in a Rabbit Acute Hemorrhage Model

Polly Pine, PhD, Genmin Lu, PhD, Deogracias Canivel, Pratikhya Pratikhya, BS, MSc, Francis DeGuzman, PhD, Mark Karbarz, PhD, Kentaro Takeda, BS, John Malinowski, PhD, Janet M. Leeds, PhD, John T. Curnutte, MD PhD, Pamela B. Conley, PhD
Journal: Blood
Blood (2016) 128 (22): 1445.
https://doi.org/10.1182/blood.V128.22.1445.1445
Published: 2016
Journal Articles

Pharmacokinetic and Pharmacodynamic (PKPD) Modeling to Determine the Andexanet Alfa Dose to Reverse the Anticoagulant Activity of Direct Fxa Inhibitors

Leeds Janet, PhD, Genmin Lu, PhD, John T. Curnutte, MDPhD, Pamela B. Conley, PhD, Jaap W. Mandema, PhD
Journal: Blood
Blood (2015) 126 (23): 1135.
https://doi.org/10.1182/blood.V126.23.1135.1135
Published: 2015
Journal Articles

Reversal of Heparin-Induced Anticoagulation By Andexanet Alfa, a Universal Antidote for Factor Xa Inhibitors

Genmin Lu, PhD, Joyce Lin, BS, John T. Curnutte, MDPhD, Pamela B. Conley, PhD
Journal: Blood
Blood (2015) 126 (23): 2329.
https://doi.org/10.1182/blood.V126.23.2329.2329
Published: 2015
Journal Articles

A Phase 2 Randomized, Double-Blind, Placebo-Controlled Trial Demonstrating Reversal of Edoxaban-Induced Anticoagulation in Healthy Subjects By Andexanet Alfa (PRT064445), a Universal Antidote for Factor Xa (fXa) Inhibitors

Mark Crowther, MD, Gallia G. Levy, MD PhD, Genmin Lu, PhD, Janet Leeds, PhD, Joyce Lin, BS, Pratikhya Pratikhya, MS, Pamela B. Conley, PhD, Stuart Connolly, MD, John T. Curnutte, MDPhD
Journal: Blood
Blood (2014) 124 (21): 4269.
https://doi.org/10.1182/blood.V124.21.4269.4269
Published: 2014
Journal Articles

PRT064445 but Not Recombinant Fviia Reverses Rivaroxaban Induced Anticoagulation As Measured by Reduction in Blood Loss in a Rabbit Liver Laceration Model

Stanley J Hollenbach, BS, JD, Genmin Lu, PhD, Siusze Tan, BS, Gail Lee, BS, Hutchaleelaha Athiwat, PhD, Mayuko Inagaki, BS, Uma Sinha, PhD
Journal: Blood
Blood (2012) 120 (21): 3414.
https://doi.org/10.1182/blood.V120.21.3414.3414
Published: 2012
Journal Articles

Recombinant Antidote for Reversal of Anticoagulation by Factor Xa Inhibitors.

Genmin Lu, PhD, Francis R. DeGuzman, Sanjay Lakhotia, PhD, Stanley J Hollenbach, David R Phillips, PhD, Uma Sinha, PhD
Journal: Blood
Blood (2008) 112 (11): 983.
https://doi.org/10.1182/blood.V112.11.983.983
Published: 2008