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Journal Articles

Outcome of Children with Different Non-Malignant Disorders Given Alphabeta T and B-Cell Depleted HLA-Haploidentical Hematopoietic Stem Cell Transplantation (TBdepl-haploHSCT)

Pietro Merli, MD, Daria Pagliara, MD PhD, Federica Galaverna, MD PhD, Giuseppina Li Pira, PhD, Valentina Bertaina, PhD, Stefania Gaspari, MD, Emilia Boccieri, MD, Marco Becilli, MD, Giovanna Del Principe, MD, Olivia Marini, PhD, Francesca Del Bufalo, MD, Francesco Quagliarella, MD, Antonio Giacomo Grasso, MD, Tiziana Corsetti, PhD, Matteo Di Nardo, MD, Luisa Strocchio, MD, Mattia Algeri, MD, Franco Locatelli, MD PhD

Blood (2020) 136 (Supplement 1): 2–4.

https://doi.org/10.1182/blood-2020-142703

Published: 2020

Journal Articles

Comparative Analysis of Alpha-Beta T-Cell and B-Cell Depleted (abTCD) HLA-Haploidentical Hematopoietic Stem Cell Transplantation (haplo-HSCT) Versus Abtcd Haplo-HSCT with T-Cell Add-Back of Rivogenlecleucel Cell [Donor T Cells Transduced with the Inducible Caspase 9 (iC9) Gene Safety Switch] in Children with High-Risk Acute Leukemia (AL) in Remission

Annalisa Ruggeri, MD, Pietro Merli, MD, Mattia Algeri, MD, Marco Zecca, Franca Fagioli, MD, Giuseppina Li Pira, PhD, Valentina Bertaina, PhD, Arcangelo Prete, MD, Mauro Montanari, MD, Francesca Del Bufalo, MD, Luciana Vinti, MD, Daria Pagliara, MD PhD, Melissa Aldinger, PharmD, Kai Chan, Paul Woodard, Federica Galaverna, MD, Franco Locatelli, MD

Blood (2019) 134 (Supplement_1): 145.

https://doi.org/10.1182/blood-2019-125366

Published: 2019

Journal Articles

Clinical Outcomes after Allogeneic Hematopoietic Stem Cell Transplantation in Patients with Transfusion-Dependent β-Thalassemia Treated at the Bambino Gesù Children's Hospital, Rome, Italy

Pietro Merli, MD, Annalisa Ruggeri, MD, Mattia Algeri, MD, Giuseppina Li Pira, PhD, Giulia Ceglie, MD, Katiana Gruppioni, MPH, Sanjeev Kommera, MS, Jenfue Maa, PhD, Franco Locatelli, MD PhD

Blood (2019) 134 (Supplement_1): 969.

https://doi.org/10.1182/blood-2019-123440

Published: 2019

Journal Articles

Academic, Phase I/II Trial on T Cells Expressing a Second Generation, CD19-Specific Chimeric Antigen Receptor (CAR) and Inducible Caspase 9 Safety Switch for the Treatment of B-Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL) and B-Cell Non-Hodgkin Lymphoma (B-NHL) in Children

Francesca Del Bufalo, MD, Concetta Quintarelli, PhD, Biagio De Angelis, PhD, Ignazio Caruana, PhD, Matilde Sinibaldi, PhD, Luciana Vinti, MD, Pietro Merli, MD, Mattia Algeri, MD, Annalisa Ruggeri, MD, Federica Galaverna, MD, Valentina Cirillo, PhD, Maria Giuseppina Cefalo, MD, Giuseppina Li Pira, PhD, Giovanna Leone, MD, Valentina Bertaina, PhD, Franca Fassio, PhD, Monica Gunetti, PhD, Stefano Iacovelli, PhD, Franco Locatelli, MD PhD

Blood (2019) 134 (Supplement_1): 1341.

https://doi.org/10.1182/blood-2019-129821

Published: 2019

Journal Articles

Long-Term Outcome of Children with Acute Leukemia (AL) Given Alphabeta T and B-Cell Depleted HLA-Haploidentical Hematopoietic Stem Cell Transplantation (TBdepl-haploHSCT)

Pietro Merli, MD, Daria Pagliara, MD PhD, Mattia Algeri, MD, Federica Galaverna, MD, Giuseppina Li Pira, PhD, Valentina Bertaina, PhD, Mauro Montanari, MD, Giovanna Leone, MD, Stefania Gaspari, MD, Michele Massa, MD, Valentina Cirillo, PhD, Maria Giuseppina Cefalo, MD, Simone Biagini, MSc, Marco Becilli, MD, Elia Girolami, MSc, Roberto Carta, MD, Annalisa Ruggeri, MD, Franco Locatelli, MD PhD

Blood (2019) 134 (Supplement_1): 799.

https://doi.org/10.1182/blood-2019-128416

Published: 2019

Journal Articles

CD19 Redirected CAR NK Cells Are Equally Effective but Less Toxic Than CAR T Cells

Concetta Quintarelli, PhD, Simona Sivori, PhD, Simona Caruso, PhD, Simona Carlomagno, PhD, Iolanda Boffa, PhDstudent, Domenico Orlando, PhDstudent, Marika Guercio, Biancamaria Cembrola, PhD, Angela Pitisci, Stefano Di Cecca, PhD, Giuseppina Li Pira, PhD, Luciana Vinti, MD, Biagio De Angelis, PhD, Lorenzo Moretta, MD PhD, Franco Locatelli

Blood (2018) 132 (Supplement 1): 3491.

https://doi.org/10.1182/blood-2018-99-118005

Published: 2018

Journal Articles

Patient-Derived Chimeric Antigen Receptor T-Cell Production Based on a Gammaretroviral Vector Platform Is Not Associated with Generation of CAR+ Leukemia Blasts

Concetta Quintarelli, PhD, Iolanda Boffa, PhDstudent, Matilde Sinibaldi, Domenico Orlando, PhDstudent, Marika Guercio, Stefano Di Cecca, PhD, Simona Caruso, PhD, Angela Pitisci, Valentina Bertaina, Francesca Del Bufalo, MD, Pietro Merli, MD, Mattia Algeri, MD, Federica Galaverna, MD, Luciana Vinti, MD, Giuseppina Li Pira, PhD, Biagio De Angelis, PhD, Franco Locatelli

Blood (2018) 132 (Supplement 1): 2204.

https://doi.org/10.1182/blood-2018-99-119413

Published: 2018

Journal Articles

Alpha/Beta T-Cell and B-Cell Depletion HLA-Haploidentical Hematopoietic Stem Cell Transplantation Is an Effective Treatment for Children/Young Adults with Acute Leukemia

Pietro Merli, MD, Mattia Algeri, MD, Giuseppina Li Pira, PhD, Michela Falco, PhD, Daniela Pende, PhD, Valentina Bertaina, Daria Pagliara, MD PhD, Federica Galaverna, MD, Annalisa Ruggeri, MD PhD, Concetta Quintarelli, PhD, Lorenzo Moretta, MD PhD, Alice Bertaina, MD PhD, Franco Locatelli

Blood (2018) 132 (Supplement 1): 2169.

https://doi.org/10.1182/blood-2018-99-117136

Published: 2018

Journal Articles

Clinical Outcome and Immune Recovery after Adoptive Infusion of BPX-501 Cells (donor T cells transduced with iC9 suicide gene) in Children with Hemoglobinopathies and Diamond-Blackfan Anemia Given α/β T-Cell Depleted HLA-Haploidentical Stem Cell Transplantation (HSCT)

Alice Bertaina, MDPhD, Pietro Merli, MD, Daria Pagliara, MD, Giuseppina Li Pira, PhD, Biagio De Angelis, PhD, Letizia Pomponia Brescia, MD, Luisa Strocchio, MD, Francesca Del Bufalo, MD, Mauro Montanari, MD, Barbarella Lucarelli, MD, Mattia Algeri, MD, Martha French, PhD, Annemarie Moseley, MDPhD, Franco Locatelli, MD

Blood (2016) 128 (22): 2286.

https://doi.org/10.1182/blood.V128.22.2286.2286

Published: 2016

Journal Articles

Outcome of Children with Primary Immune-Deficiencies (PIDs) Enrolled in a Phase I-II Trial Based on the Infusion of BPX-501 Donor T Cells Genetically Modified with a Novel Suicide Gene (inducible Caspase 9, iC9) after T-Cell Depleted HLA-Haploidentical Allogeneic Stem Cell Transplantation (haplo-HSCT)

Neena Kapoor, MD, Alice Bertaina, MD PhD, Pietro Merli, MD, Swati Naik, MD, Waseem Qasim, MBBS PhD, Mary Slatter, MD, Reem Elfeky, MD, Barbarella Lucarelli, MD, Monika Smogorzewska, PhD, Giuseppina Li Pira, PhD, Valentina Bertaina, PhD, Annemarie Moseley, MD PhD, Franco Locatelli, MD

Blood (2016) 128 (22): 72.

https://doi.org/10.1182/blood.V128.22.72.72

Published: 2016

Journal Articles

T-Cell Depleted HLA-Haploidentical Allogeneic Hematopoietic Stem Cell Transplantation (haplo-HSCT) Followed By Donor Lymphocyte Infusion with T Cells Transduced with the Inducible Caspase 9 (iC9) Suicide Gene in Children with Hematological Malignancies

Barbarella Lucarelli, MD, Alice Bertaina, MD PhD, Pietro Merli, MD, Concetta Quintarelli, PhD, Daniela Pende, MD, Michela Falco, PhD, Maria Giuseppina Cefalo, MD, Giuseppina Li Pira, PhD, Ignazio Caruana, PhD, Letizia Pomponia Brescia, MD, Luisa Strocchio, MD, Giuseppe Maria Milano, MD, Valentina Bertaina, PhD, Matilde Sinibaldi, PhD, Mattia Algeri, MD, Lorenzo Moretta, MD, Joanna Stanson, Annemarie Moseley, MD PhD, Franco Locatelli, MD

Blood (2016) 128 (22): 4683.

https://doi.org/10.1182/blood.V128.22.4683.4683

Published: 2016

Journal Articles

Children with Acute Leukemia Given Hematopoietic Stem Cell Transplantation (HSCT) from an HLA-Compatible Sibling, or an Unrelated Donor (UD) or an HLA-Haploidentical Relative after Alpha/Beta T-Cell Depletion Have a Comparable Outcome

Alice Bertaina, MDPhD, Barbarella Lucarelli, MD, Riccardo Masetti, MD, Pietro Merli, MD, Roberto Rondelli, MD, Giuseppina Li Pira, PhD, Marco Andreani, PhD, Lavinia Grapulin, MD, Daniela Pende, MD, Michela Falco, PhD, Maria Rita Pinto, MD, Valentina Bertaina, PhD, Maria Teresa Romano, MD, Stefano Ceccarelli, MD, Letizia Pomponia Brescia, MD, Daria Pagliara, MD, Alessandro Moretta, MD, Lorenzo Moretta, MD, Franco Locatelli, Prof, MD PhD

Blood (2015) 126 (23): 195.

https://doi.org/10.1182/blood.V126.23.195.195

Published: 2015

Journal Articles

BPX-501 Cells (donor T cells transduced with iC9 suicide gene) Are Able to Clear Life-Threatening Viral Infections in Children with Primary Immune Deficiencies Given Alpha/Beta T-Cell Depleted HLA-Haploidentical Hematopoietic Stem Cell Transplantation (haplo-HSCT)

Barbarella Lucarelli, MD, Pietro Merli, MD, Alice Bertaina, MDPhD, Matilde Sinibaldi, PhD, Stefania Gaspari, MD, Luisa Strocchio, MD, Angela Pitisci, PhD, Giuseppina Li Pira, PhD, Giuseppe Maria Milano, MD, Annemarie Moseley, MDPhD, Concetta Quintarelli, PhD, Franco Locatelli, Prof, MD PhD

Blood (2015) 126 (23): 4299.

https://doi.org/10.1182/blood.V126.23.4299.4299

Published: 2015

Journal Articles

Clinical Outcome after Adoptive Infusion of BPX-501 Cells (donor T cells transduced with iC9 suicide gene) in Children Given Alpha/Beta T-Cell Depleted HLA-Haploidentical Hematopoietic Stem Cell Transplantation (haplo-HSCT): Preliminary Results of a Phase I-II Trial

Franco Locatelli, Prof, MD PhD, Pietro Merli, MD, Giuseppina Li Pira, PhD, Valentina Bertaina, PhD, Barbarella Lucarelli, MD, Letizia Pomponia Brescia, MD, Mauro Montanari, MD, Daniela Pende, MD, Michela Falco, PhD, Daria Pagliara, MD, Maria Giuseppina Cefalo, MD, Alessandro Moretta, MD, Concetta Quintarelli, PhD, Brigitte Strahm, MD, Waseem Qasim, MBBS PhD, Mary Slatter, Lorenzo Moretta, MD, Annemarie Moseley, MDPhD, Alice Bertaina, MDPhD

Blood (2015) 126 (23): 1931.

https://doi.org/10.1182/blood.V126.23.1931.1931

Published: 2015

Journal Articles

Immune Reconstitution after Adoptive Infusion of BPX501 Cells (donor T cells transduced with iC9 suicide gene) in Children Given Alpha/Beta T-Cell Depleted HLA-Haploidentical Hematopoietic Stem Cell Transplantation (haplo-HSCT): Preliminary Phenotypic and Functional Results of a Phase I-II Trial

Pietro Merli, MD, Giuseppina Li Pira, PhD, Valentina Bertaina, PhD, Matilde Sinibaldi, PhD, Barbarella Lucarelli, MD, Letizia Pomponia Brescia, MD, Giuseppe Palumbo, MD, Giuseppe Maria Milano, MD, Maria Teresa Romano, MD, Valentina Cirillo, PhD, Luisa Strocchio, MD, Irma Airoldi, PhD, Luciana Vinti, MD, Concetta Quintarelli, PhD, Lorenzo Moretta, MD, Annemarie Moseley, MDPhD, Alice Bertaina, MDPhD, Franco Locatelli, Prof, MD PhD

Blood (2015) 126 (23): 3093.

https://doi.org/10.1182/blood.V126.23.3093.3093

Published: 2015

Journal Articles

Generation of Cytomegalovirus (CMV)-Specific CD4 and CD8 T Cell Lines Using Protein-Spanning Pools of pp65 and IE1 Derived Peptides.

Erica Dander, Giuseppina Li Pira, PhD, Ettore Biagi, MD, Fabrizio Manca, MD, Andrea Biondi, MD, Giovanna D’Amico, PhD

Blood (2005) 106 (11): 477.

https://doi.org/10.1182/blood.V106.11.477.477

Published: 2005

NARROW

Outcome of Children with Different Non-Malignant Disorders Given Alphabeta T and B-Cell Depleted HLA-Haploidentical Hematopoietic Stem Cell Transplantation (TBdepl-haploHSCT)

Clinical Outcomes after Allogeneic Hematopoietic Stem Cell Transplantation in Patients with Transfusion-Dependent β-Thalassemia Treated at the Bambino Gesù Children's Hospital, Rome, Italy

Academic, Phase I/II Trial on T Cells Expressing a Second Generation, CD19-Specific Chimeric Antigen Receptor (CAR) and Inducible Caspase 9 Safety Switch for the Treatment of B-Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL) and B-Cell Non-Hodgkin Lymphoma (B-NHL) in Children

Long-Term Outcome of Children with Acute Leukemia (AL) Given Alphabeta T and B-Cell Depleted HLA-Haploidentical Hematopoietic Stem Cell Transplantation (TBdepl-haploHSCT)

CD19 Redirected CAR NK Cells Are Equally Effective but Less Toxic Than CAR T Cells

Patient-Derived Chimeric Antigen Receptor T-Cell Production Based on a Gammaretroviral Vector Platform Is Not Associated with Generation of CAR+ Leukemia Blasts

Alpha/Beta T-Cell and B-Cell Depletion HLA-Haploidentical Hematopoietic Stem Cell Transplantation Is an Effective Treatment for Children/Young Adults with Acute Leukemia

Clinical Outcome and Immune Recovery after Adoptive Infusion of BPX-501 Cells (donor T cells transduced with iC9 suicide gene) in Children with Hemoglobinopathies and Diamond-Blackfan Anemia Given α/β T-Cell Depleted HLA-Haploidentical Stem Cell Transplantation (HSCT)

T-Cell Depleted HLA-Haploidentical Allogeneic Hematopoietic Stem Cell Transplantation (haplo-HSCT) Followed By Donor Lymphocyte Infusion with T Cells Transduced with the Inducible Caspase 9 (iC9) Suicide Gene in Children with Hematological Malignancies

Children with Acute Leukemia Given Hematopoietic Stem Cell Transplantation (HSCT) from an HLA-Compatible Sibling, or an Unrelated Donor (UD) or an HLA-Haploidentical Relative after Alpha/Beta T-Cell Depletion Have a Comparable Outcome

BPX-501 Cells (donor T cells transduced with iC9 suicide gene) Are Able to Clear Life-Threatening Viral Infections in Children with Primary Immune Deficiencies Given Alpha/Beta T-Cell Depleted HLA-Haploidentical Hematopoietic Stem Cell Transplantation (haplo-HSCT)

Clinical Outcome after Adoptive Infusion of BPX-501 Cells (donor T cells transduced with iC9 suicide gene) in Children Given Alpha/Beta T-Cell Depleted HLA-Haploidentical Hematopoietic Stem Cell Transplantation (haplo-HSCT): Preliminary Results of a Phase I-II Trial

Immune Reconstitution after Adoptive Infusion of BPX501 Cells (donor T cells transduced with iC9 suicide gene) in Children Given Alpha/Beta T-Cell Depleted HLA-Haploidentical Hematopoietic Stem Cell Transplantation (haplo-HSCT): Preliminary Phenotypic and Functional Results of a Phase I-II Trial

Generation of Cytomegalovirus (CMV)-Specific CD4 and CD8 T Cell Lines Using Protein-Spanning Pools of pp65 and IE1 Derived Peptides.

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American Society of Hematology

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American Society of Hematology

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