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Journal Articles

Trogocytosis drives red blood cell antigen loss in association with antibody-mediated immune suppression

Yoelys Cruz-Leal, Peter A. A. Norris, Lazaro Gil Gonzalez, Danielle Marjoram, Hanna Wabnitz, Yuexin Shan, Alan H. Lazarus
Journal: Blood
Blood (2024) 143 (9): 807–821.
https://doi.org/10.1182/blood.2023020860
Published: 2024
Includes: Multimedia, Supplemental data
Journal Articles

TEMRA: the CD8 subset in chronic ITP?

Alan H. Lazarus, John W. Semple
Journal: Blood
Blood (2023) 141 (20): 2409–2410.
https://doi.org/10.1182/blood.2023019859
Published: 2023
Journal Articles

Anti-inflammatory activity of CD44 antibodies in murine immune thrombocytopenia is mediated by Fcγ receptor inhibition

Peter A. A. Norris, Gurleen Kaur, Ramsha Khan, Guangheng Zhu, Heyu Ni, Alan H. Lazarus
Journal: Blood
Blood (2021) 137 (15): 2114–2124.
https://doi.org/10.1182/blood.2020009497
Published: 2021
Includes: Supplemental data
Journal Articles

Inhibition of platelet phagocytosis as an in vitro predictor for therapeutic potential of RBC antibodies in murine ITP

Ramsha Khan, Melissa Menard, Chao-Ching Jen, Xi Chen, Peter A. A. Norris, Alan H. Lazarus
Journal: Blood
Blood (2020) 135 (26): 2420–2424.
https://doi.org/10.1182/blood.2019003646
Published: 2020
Includes: Supplemental data
Journal Articles

Anti-Glycoprotein V Autoantibodies in Patients with Immune Thrombocytopenia: Regularly Detectable and Functionally Relevant

Richard Vollenberg, MD, Rabie Jouni, Peter A. A. Norris, BSc, Monika Burg-Roderfeld, PhD, Nina Cooper, MD, Mathias J Rummel, MD PhD, Gregor Bein, MD PhD, Irene Marini, Alan H Lazarus, PhD, Tamam Bakchoul, MD PhD, Ulrich J Sachs, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1141.
https://doi.org/10.1182/blood-2018-99-118090
Published: 2018
Journal Articles

Fcγ Receptors I and III on Splenic Macrophages Mediate GPIIb/IIIa Autoantibody-Dependent Phagocytosis of Platelets in Human Immune Thrombocytopenia

Peter A. A. Norris, BSc, George B. Segel, MD, Ulrich J Sachs, MD PhD, Behnaz Bayat, PhD, Gestur Vidarsson, PhD, Rick Kapur, MDPhDMSc, Christine M. Cserti-Gazdewich, BSc, MD FRCPC, Jeannie Callum, MD, Yulia Lin, MD FRCPC, Richard Burack, MD PhD, John W Semple, PhD, Alan H Lazarus, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 129.
https://doi.org/10.1182/blood-2018-99-117650
Published: 2018
Journal Articles

GPIbα is required for platelet-mediated hepatic thrombopoietin generation

Miao Xu, June Li, Miguel Antonio Dias Neves, Guangheng Zhu, Naadiya Carrim, Ruoying Yu, Sahil Gupta, John Marshall, Ori Rotstein, Jun Peng, Ming Hou, Shinji Kunishima, Jerry Ware, Donald R. Branch, Alan H. Lazarus, Zaverio M. Ruggeri, John Freedman, Heyu Ni
Journal: Blood
Blood (2018) 132 (6): 622–634.
https://doi.org/10.1182/blood-2017-12-820779
Published: 2018
Includes: Supplemental data
Journal Articles

Immunoglobulin G Fc glycans are not essential for antibody-mediated immune suppression to murine erythrocytes

Danielle Marjoram, Yoelys Cruz-Leal, Lidice Bernardo, Ngoc Phuong Lan Le, Max Crispin, Xiaojie Yu, Makoto Uchikawa, Alan H. Lazarus
Journal: Blood
Blood (2017) 130 (26): 2902–2905.
https://doi.org/10.1182/blood-2017-06-793729
Published: 2017
Includes: Supplemental data
Journal Articles

Erythrocyte-Specific Antibodies As a Potential New Therapeutic Modality in Autoimmune and Inflammatory Disorders Beyond Immune Thrombocytopenia (ITP)

Andrew R Crow, BRT, Rick Kapur, MDPhDMSc, Mark Jen, MSc, Patrick J Mott, MSc, Danielle Marjoram, MSc, Alaa Amash, PhD, Simrat S Kahlon, BSc, Issaka Yougbare, PhD, Heyu Ni, MD MSc, PhD, Michael Kim, BSc, John W Semple, PhD, Alan H Lazarus, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 231.
https://doi.org/10.1182/blood.V130.Suppl_1.231.231
Published: 2017
Journal Articles

Antibodies Against Macrophage CD44 Protect Platelets from FcγR-Mediated Phagocytosis: A Potential Mechanism for CD44 Antibody Amelioration of Murine Immune Thrombocytopenia

Peter A A Norris, BSc, Yawen Wang, MD, Guangheng Zhu, MD, Lin Wang, MD, Ming Huo, MD, Gregory D Fairn, PhD, Heyu Ni, MD MSc, PhD, Alan H Lazarus, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3639.
https://doi.org/10.1182/blood.V130.Suppl_1.3639.3639
Published: 2017
Journal Articles

Amelioration of Immune Thrombocytopenia in Human CD44 Transgenic Mice By Anti-Human CD44 Antibodies

Andrew R. Crow, BSc, Alaa Amash, PhD, Alan H Lazarus, PhD
Journal: Blood
Blood (2016) 128 (22): 167.
https://doi.org/10.1182/blood.V128.22.167.167
Published: 2016
Journal Articles

Antibody-mediated immune suppression is improved when blends of anti-RBC monoclonal antibodies are used in mice

Brief Report
Lidice Bernardo, Alaa Amash, Danielle Marjoram, Alan H. Lazarus
Journal: Blood
Blood (2016) 128 (8): 1076–1080.
https://doi.org/10.1182/blood-2016-01-692178
Published: 2016
Includes: Supplemental data
Journal Articles

CD20 + B-cell depletion therapy suppresses murine CD8 + T-cell–mediated immune thrombocytopenia

Brief Report
Li Guo, Rick Kapur, Rukshana Aslam, Edwin R. Speck, Anne Zufferey, Yajing Zhao, Michael Kim, Alan H. Lazarus, Heyu Ni, John W. Semple
Journal: Blood
Blood (2016) 127 (6): 735–738.
https://doi.org/10.1182/blood-2015-06-655126
Published: 2016
Includes: Supplemental data
Journal Articles

Monovalent Fc receptor blockade by an anti–Fcγ receptor/albumin fusion protein ameliorates murine ITP with abrogated toxicity

Xiaojie Yu, Melissa Menard, József Prechl, Varsha Bhakta, William P. Sheffield, Alan H. Lazarus
Journal: Blood
Blood (2016) 127 (1): 132–138.
https://doi.org/10.1182/blood-2015-08-664656
Published: 2016
Journal Articles

Anti-RhD Mediates Loss of RhD Antigen Following Anti-RhD Infusion

Harold Clifford Sullivan, MD, Connie Maridith Arthur, PhD, Seema Patel, PhD, Jeanne E. Hendrickson, MD, Alan H Lazarus, PhD, Sean R. Stowell, MD PhD
Journal: Blood
Blood (2015) 126 (23): 3570.
https://doi.org/10.1182/blood.V126.23.3570.3570
Published: 2015
Journal Articles

CD8 + T cells are predominantly protective and required for effective steroid therapy in murine models of immune thrombocytopenia

Li Ma, Elisa Simpson, June Li, Min Xuan, Miao Xu, Laura Baker, Yan Shi, Issaka Yougbaré, Xiaozhong Wang, Guangheng Zhu, Pingguo Chen, Gerald J. Prud’homme, Alan H. Lazarus, John Freedman, Heyu Ni
Journal: Blood
Blood (2015) 126 (2): 247–256.
https://doi.org/10.1182/blood-2015-03-635417
Published: 2015
Includes: Supplemental data
Journal Articles

Unveiling the Regulatory Role of CD8+ T-Cells in the Pathogenesis and Effective Steroid Treatment in ITP

Li Ma, PhD, Elisa K. Simpson, MSc., June Li, MSc, Min Xuan, PhD, Miao Xu, MSc, MD, Laura Baker, BSc., Yan Shi, MD, Guangheng Zhu, MD, Pingguo Chen, MD PhD, Alan H Lazarus, PhD, John J. Freedman, MD, Heyu Ni, MD PhD
Journal: Blood
Blood (2014) 124 (21): 576.
https://doi.org/10.1182/blood.V124.21.576.576
Published: 2014
Journal Articles

Allogeneic platelet transfusions prevent murine T-cell–mediated immune thrombocytopenia

Li Guo, Lei Yang, Edwin R. Speck, Rukhsana Aslam, Michael Kim, Christopher G. J. McKenzie, Alan H. Lazarus, Heyu Ni, Ming Hou, John Freedman, John W. Semple
Journal: Blood
Blood (2014) 123 (3): 422–427.
https://doi.org/10.1182/blood-2013-08-523308
Published: 2014
Includes: Supplemental data
Journal Articles

Megakaryocyte Abnormalities Occur In The Absence Of Cell-Mediated Immunity In a Murine Model Of Passive Immune Thrombocytopenia (ITP)

John W. Semple, PhD, Kristin Hunt, Yu Hou, Rukhsana Aslam, PhD, Edwin R. Speck, Heyu Ni, MD, PhD, Alan H Lazarus, PhD
Journal: Blood
Blood (2013) 122 (21): 3537.
https://doi.org/10.1182/blood.V122.21.3537.3537
Published: 2013
Journal Articles

Ivig, but Not a Monoclonal Anti-RBC Antibody, Requires the Presence of Gr-1 + Cells to Ameliorate Immune Thrombocytopenia in a Murine Model

Andrew R. Crow, BSc, Alan H Lazarus, PhD
Journal: Blood
Blood (2012) 120 (21): 268.
https://doi.org/10.1182/blood.V120.21.268.268
Published: 2012