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Journal Articles

Novel Cellular Immunotherapy Using Allogeneic Vγ9/δ2-T Cells Gene-Modified to Express HTLV-1 P40Tax-Specific TCR for the Treatment of Adult T Cell Leukemia

Hiroshi Fujiwara, MD PhD, Satoshi Okumura, Yoshihiro Miyahara, Linan Wan, Isao Tawara, MD PhD, Tatsuro Jo, MD PhD, Yuetsu Tanaka, PhD, Yoshimasa Tanaka, PhD, Hiroaki Ikeda, Hiroshi Shiku

Blood (2019) 134 (Supplement_1): 3216.

https://doi.org/10.1182/blood-2019-122412

Published: 2019

Journal Articles

Identification of T Cell Receptors Specific to Antigens Presented By HLA-B5401 on IPS Cell-Derived Hematopoietic Stem Cells in a Patient with Acquired Aplastic Anemia Carrying B5401-Lacking Leukocytes

Noriharu Nakagawa, MD, Mahmoud Ibrahim Elbadry, MD, Yoshiki Akatsuka, MD, Hiroshi Hamana, Kiyomi Shitaoka, Yoshinori Yoshida, MD PhD, Kazuhisa Chonabayashi, MD PhD, Tatsuya Imi, MD, Yoshitaka Zaimoku, MD, Katsuto Takenaka, Hiroshi Fujiwara, MD PhD, Hiroyuki Kishi, PhD, Shinji Nakao, MD PhD

Blood (2017) 130 (Supplement 1): 2458.

https://doi.org/10.1182/blood.V130.Suppl_1.2458.2458

Published: 2017

Journal Articles

Development of T-Cell Therapy By Exploiting Modified Antibodies Specific for A2/NY-ESO-1 for Refractory Myeloma

Masaki Maruta, MD, Toshiki Ochi, MD PhD, Kazushi Tanimoto, MD PhD, Taichi Azuma, MD PhD, Hiroshi Fujiwara, MD PhD, Masaki Yasukawa, MD PhD

Blood (2017) 130 (Supplement 1): 1913.

https://doi.org/10.1182/blood.V130.Suppl_1.1913.1913

Published: 2017

Journal Articles

Phase 1 Clinical Trial of Adoptive Immunotherapy for Acute Myelogenous Leukemia and Myelodysplastic Syndrome, Using Gene-Modified Autologous Lymphocytes Expressing WT1-Specific T-Cell Receptor

Kazushi Tanimoto, MD PhD, Hiroshi Fujiwara, MD PhD, Isao Tawara, MD PhD, Masahiro Masuya, MD PhD, Shinichi Kageyama, MD PhD, Tetsuya Nishida, MD PhD, Makoto Murata, MD PhD, Seitaro Terakura, MD PhD, Yoshiki Akatsuka, MD PhD, Hiroaki Ikeda, MD PhD, Yoshihiro Miyahara, MD PhD, Ikuei Nukaya, PhD, Kazutoh Takesako, PhD, Nobuhiko Emi, MD PhD, Naoyuki Katayama, MD PhD, Hiroshi Shiku, MD PhD, Masaki Yasukawa, MD PhD

Blood (2016) 128 (22): 1653.

https://doi.org/10.1182/blood.V128.22.1653.1653

Published: 2016

Journal Articles

Function of Integrin αIIbβ3 in Essential Thrombocythemia with Calreticulin Mutation

Jun Yamanouchi, MD PhD, Takaaki Hato, MDPhD, Etsuko Matsubara, MDPhD, Taichi Azuma, MDPhD, Hiroshi Fujiwara, MD PhD, Yoshihiro Yakushijin, MDPhD, Masaki Yasukawa, MD PhD

Blood (2015) 126 (23): 4079.

https://doi.org/10.1182/blood.V126.23.4079.4079

Published: 2015

Journal Articles

Targeting Aurora Kinase with a Superior T-Cell Receptor Gene-Transfer Vector

Nicholas Casey, PhD, Hiroshi Fujiwara, MD PhD, Kazushi Tanimoto, MDPhD, Sachiko Okamoto, PhD, Junichi Mineno, PhD, Kiyotaka Kuzushima, MD PhD, Hiroshi Shiku, MD PhD, Masaki Yasukawa, MD PhD

Blood (2015) 126 (23): 4291.

https://doi.org/10.1182/blood.V126.23.4291.4291

Published: 2015

Journal Articles

Immunotherapy with Chimeric Antigen Receptor Targeting Intracellular WT1 Gene Product Complexed with HLA-a*24:02 Molecule

Hiroaki Ikeda, MD PhD, Yasushi Akahori, PhD, Motohiro Yoneyama, Yuki Orito, Yoshihiro Miyahara, Yasunori Amaishi, Sachiko Okamoto, Junichi Mineno, PhD, Kazutoh Takesako, PhD, Hiroshi Fujiwara, MD PhD, Masaki Yasukawa, MD PhD, Hiroshi Shiku, MD PhD

Blood (2015) 126 (23): 4292.

https://doi.org/10.1182/blood.V126.23.4292.4292

Published: 2015

Journal Articles

Adoptive Transfer of WT1-Specific TCR Gene-Transduced Lymphocytes in Patients with Myelodysplastic Syndrome and Acute Myeloid Leukemia

Isao Tawara, MD PhD, Masahiro Masuya, MD PhD, Shinichi Kageyama, MD PhD, Tetsuya Nishida, MD PhD, Seitaro Terakura, MD PhD, Makoto Murata, MD PhD, Hiroshi Fujiwara, MD PhD, Yoshiki Akatsuka, MD PhD, Hiroaki Ikeda, MD PhD, Yoshihiro Miyahara, MD PhD, Daisuke Tomura, PhD, Ikuei Nukaya, PhD, Kazutoh Takesako, PhD, Nobuhiko Emi, MDPhD, Masaki Yasukawa, MD PhD, Naoyuki Katayama, MD PhD, Hiroshi Shiku, MD PhD

Blood (2015) 126 (23): 97.

https://doi.org/10.1182/blood.V126.23.97.97

Published: 2015

Journal Articles

Multicenter Phase II Study of Lenalidomide in Patients with Relapsed Adult T-Cell Leukemia-Lymphoma

Hiroshi Fujiwara, MD PhD, Takashi Ishida, MD PhD, Kisato Nosaka, MD PhD, Naoya Taira, MD, Yasunobu Abe, MD PhD, Yoshitaka Imaizumi, MD PhD, Yukiyoshi Moriuchi, MD, Tatsuro Jo, MD PhD, Kenichi Ishizawa, MD, PhD, Kensei Tobinai, MD PhD, Kunihiro Tsukasaki, MD PhD, Shigeki Ito, MD PhD, Makoto Yoshimitsu, Maki Otsuka, Michinori Ogura, MD, Shuichi Midorikawa, PhD, Wanda Ruiz, PhD, Tomoko Ohtsu, MD

Blood (2015) 126 (23): 181.

https://doi.org/10.1182/blood.V126.23.181.181

Published: 2015

Journal Articles

Concomitant Administration of Gene-Modified T Cells Expressing a Chimeric CD16-CD3ζ Receptor with Mogamulizmab Synergistically Suppresses Adult T Cell Leukemia Cells in Vivo

Kazushi Tanimoto, MD PhD, Hiroshi Fujiwara, MD PhD, Hiroki Tanaka, MD, Fumihiro Ochi, MD, Hiroaki Asai, MDPhD, Sachiko Okamoto, PhD, Junichi Mineno, PhD, Kiyotaka Kuzushima, MD PhD, Hiroshi Shiku, MD PhD, John Barrett, MD, Masaki Yasukawa, MD PhD

Blood (2014) 124 (21): 307.

https://doi.org/10.1182/blood.V124.21.307.307

Published: 2014

Journal Articles

Activation Status of Integrin αIIbβ3 in Essential Thrombocythemia with Calreticulin Mutation

Jun Yamanouchi, MD PhD, Takaaki Hato, MDPhD, Etsuko Matsubara, MDPhD, Taichi Azuma, MDPhD, Hideyuki Nakanishi, MD, Hiroshi Fujiwara, MD PhD, Yoshihiro Yakushijin, MDPhD, Masaki Yasukawa, MD PhD

Blood (2014) 124 (21): 4571.

https://doi.org/10.1182/blood.V124.21.4571.4571

Published: 2014

Journal Articles

Co-Administration Of Gene-Modified CD4 + T Cells Targeting HLA Class I-Restricted WT1 Epitope Diversely Enhances The Antitumor Effect Mediated By Redirected T-Cell Based Adoptive Immunotherapy Against Human Leukemia

Hiroshi Fujiwara, MD, PhD, Fumihiro Ochi, MD, Toshiki Ochi, MD, PhD, Hiroaki Asai, MD, PhD, Yukihiro Miyazaki, MD, PhD, Taichi Azuma, MD, PhD, Sachiko Okamoto, PhD, Junichi Mineno, PhD, Miwako Narita, MD, PhD, Kiyotaka Kuzushima, MD, PhD, Hiroshi Shiku, MD, PhD, Masaki Yasukawa, MD, PhD

Blood (2013) 122 (21): 144.

https://doi.org/10.1182/blood.V122.21.144.144

Published: 2013

Journal Articles

Redirected CD4 + T Cells towards HLA Class I-Restricted WT1 Epitope Successfully Display Multifactorial Helper Function for the Enhancement of Antileukemia Efficacy Mediated by Redirected T-Cell Based Immunocelltherapy.

Yukihiro Miyazaki, MD, Hiroshi Fujiwara, MD, PhD, Toshiki Ochi, MD, PhD, Sachiko Okamoto, PhD, Hiroaki Asai, MD, Junichi Mineno, PhD, Miwako Narita, MD, PhD, Kiyotaka Kuzushima, MD, PhD, Hiroshi Shiku, MD, PhD, Masaki Yasukawa, MD, PhD

Blood (2012) 120 (21): 3153.

https://doi.org/10.1182/blood.V120.21.3153.3153

Published: 2012

Journal Articles

Human Telomerase Reverse Transcriptase–specific T-Cell Receptor Gene Transfer Redirects T Cells to Display an Effective Antitumor Reactivity Against Adult T-Cell Leukemia

Hiroshi Fujiwara, MD, PhD, Fumihiro Ochi, Yukihiro Miyazaki, MD, Hiroaki Asai, MD, Takashi Ishida, MD, PhD, Sachiko Okamoto, PhD, Junichi Mineno, PhD, Kiyotaka Kuzushima, MD, PhD, Hiroshi Shiku, MD, PhD, Masaki Yasukawa, MD, PhD

Blood (2012) 120 (21): 1902.

https://doi.org/10.1182/blood.V120.21.1902.1902

Published: 2012

Journal Articles

Therapeutically Infused Redirected T Cells Targeting WT1 Successfully Inhibited Leukemia Stem Cells in Vivo

Hiroaki Asai, MD, Hiroshi Fujiwara, MD, PhD, Toshiki Ochi, MD, PhD, Yukihiro Miyazaki, MD, Fumihiro Ochi, Sachiko Okamoto, PhD, Junichi Mineno, PhD, Kiyotaka Kuzushima, MD, PhD, Hiroshi Shiku, MD, PhD, Masaki Yasukawa, MD, PhD

Blood (2012) 120 (21): 4221.

https://doi.org/10.1182/blood.V120.21.4221.4221

Published: 2012

Journal Articles

Abrogation of Myeloid Derived Suppressor Cell-Like Inhibitory Activity of K562 Restores Antigen Presenting Cell Functions

Kazushi Tanimoto, MD, PhD, Pawel Muranski, MD, Nancy F. Hensel, BS, Keyvan Keyvanfar, BS, Hiroshi Fujiwara, MD, PhD, A. John Barrett, MD, J. Joseph Melenhorst, PhD

Blood (2012) 120 (21): 4118.

https://doi.org/10.1182/blood.V120.21.4118.4118

Published: 2012

Journal Articles

Redirected CD4 + T Cells Using WT1-Specific T-Cell Receptor Gene Transfer Can Supply Multifactorial Help to Enhance the Anti-Leukemia Reactivity Mediated by Similarly Redirected CD8 + T Cells Using the Identical Gene Transfer

Toshiki Ochi, MD, PhD, Hiroshi Fujiwara, MD, PhD, Sachiko Okamoto, PhD, Hiroaki Asai, MD, Yukihiro Miyazaki, MD, Toshiaki Shirakata, MD, PhD, Junichi Mineno, PhD, Kiyotaka Kuzushima, MD, PhD, Hiroshi Shiku, MD, PhD, Masaki Yasukawa, MD, PhD

Blood (2011) 118 (21): 645.

https://doi.org/10.1182/blood.V118.21.645.645

Published: 2011

Journal Articles

A Glycan Wedge Between βTD and βI Domains Activates Integrin αIIbβ3,

Jun Yamanouchi, MD, PhD, Takaaki Hato, MD, PhD, Hiroshi Fujiwara, MD, PhD, Yoshihiro Yakushijin, MD, PhD, Masaki Yasukawa, MD, PhD

Blood (2011) 118 (21): 3259.

https://doi.org/10.1182/blood.V118.21.3259.3259

Published: 2011

Journal Articles

Forced Expression of CC Chemokine Receptor 2 Enhances Anti-Cancer Reactivity Mediated by T Lymphocytes Beforehand Redirected Toward WT1 Inside the Tumor Microenvironment

Hiroaki Asai, MD, Hiroshi Fujiwara, MD, PhD, Toshiki Ochi, MD, PhD, Jun An, MD, PhD, Toshiaki Shirakata, MD, PhD, Kozo Nagai, MD, Yukihiro Miyazaki, MD, Junichi Mineno, PhD, Kiyotaka Kuzushima, MD, PhD, Hiroshi Shiku, MD, PhD, Masaki Yasukawa, MD, PhD

Blood (2011) 118 (21): 2059.

https://doi.org/10.1182/blood.V118.21.2059.2059

Published: 2011

Journal Articles

Human Telomerase Reverse Transcriptase-Specific T-Cell Receptor Gene Transfer Redirects T-Lymphocytes to Exert Effective Antitumor Reactivity Against Adult T-Cell Leukemia,

Yukihiro Miyazaki, MD, Hiroshi Fujiwara, MD, PhD, Toshiki Ochi, MD, PhD, Hiroaki Asai, MD, Kozo Nagai, MD, Takashi Ishida, MD, PhD, Sachiko Okamoto, PhD, Junichi Mineno, PhD, Kiyotaka Kuzushima, MD, PhD, Hiroshi Shiku, MD, PhD, Masaki Yasukawa, MD, PhD

Blood (2011) 118 (21): 4169.

https://doi.org/10.1182/blood.V118.21.4169.4169

Published: 2011

NARROW

Novel Cellular Immunotherapy Using Allogeneic Vγ9/δ2-T Cells Gene-Modified to Express HTLV-1 P40Tax-Specific TCR for the Treatment of Adult T Cell Leukemia

Identification of T Cell Receptors Specific to Antigens Presented By HLA-B5401 on IPS Cell-Derived Hematopoietic Stem Cells in a Patient with Acquired Aplastic Anemia Carrying B5401-Lacking Leukocytes

Development of T-Cell Therapy By Exploiting Modified Antibodies Specific for A2/NY-ESO-1 for Refractory Myeloma

Phase 1 Clinical Trial of Adoptive Immunotherapy for Acute Myelogenous Leukemia and Myelodysplastic Syndrome, Using Gene-Modified Autologous Lymphocytes Expressing WT1-Specific T-Cell Receptor

Function of Integrin αIIbβ3 in Essential Thrombocythemia with Calreticulin Mutation

Targeting Aurora Kinase with a Superior T-Cell Receptor Gene-Transfer Vector

Immunotherapy with Chimeric Antigen Receptor Targeting Intracellular WT1 Gene Product Complexed with HLA-a*24:02 Molecule

Adoptive Transfer of WT1-Specific TCR Gene-Transduced Lymphocytes in Patients with Myelodysplastic Syndrome and Acute Myeloid Leukemia

Multicenter Phase II Study of Lenalidomide in Patients with Relapsed Adult T-Cell Leukemia-Lymphoma

Concomitant Administration of Gene-Modified T Cells Expressing a Chimeric CD16-CD3ζ Receptor with Mogamulizmab Synergistically Suppresses Adult T Cell Leukemia Cells in Vivo

Activation Status of Integrin αIIbβ3 in Essential Thrombocythemia with Calreticulin Mutation

Co-Administration Of Gene-Modified CD4 + T Cells Targeting HLA Class I-Restricted WT1 Epitope Diversely Enhances The Antitumor Effect Mediated By Redirected T-Cell Based Adoptive Immunotherapy Against Human Leukemia

Redirected CD4 + T Cells towards HLA Class I-Restricted WT1 Epitope Successfully Display Multifactorial Helper Function for the Enhancement of Antileukemia Efficacy Mediated by Redirected T-Cell Based Immunocelltherapy.

Human Telomerase Reverse Transcriptase–specific T-Cell Receptor Gene Transfer Redirects T Cells to Display an Effective Antitumor Reactivity Against Adult T-Cell Leukemia

Therapeutically Infused Redirected T Cells Targeting WT1 Successfully Inhibited Leukemia Stem Cells in Vivo

Abrogation of Myeloid Derived Suppressor Cell-Like Inhibitory Activity of K562 Restores Antigen Presenting Cell Functions

Redirected CD4 + T Cells Using WT1-Specific T-Cell Receptor Gene Transfer Can Supply Multifactorial Help to Enhance the Anti-Leukemia Reactivity Mediated by Similarly Redirected CD8 + T Cells Using the Identical Gene Transfer

A Glycan Wedge Between βTD and βI Domains Activates Integrin αIIbβ3,

Forced Expression of CC Chemokine Receptor 2 Enhances Anti-Cancer Reactivity Mediated by T Lymphocytes Beforehand Redirected Toward WT1 Inside the Tumor Microenvironment

Human Telomerase Reverse Transcriptase-Specific T-Cell Receptor Gene Transfer Redirects T-Lymphocytes to Exert Effective Antitumor Reactivity Against Adult T-Cell Leukemia,

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American Society of Hematology

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ASH Publications

American Society of Hematology

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