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Journal Articles

Phase 1 Clinical Trial of Adoptive Immunotherapy for Acute Myelogenous Leukemia and Myelodysplastic Syndrome, Using Gene-Modified Autologous Lymphocytes Expressing WT1-Specific T-Cell Receptor

Kazushi Tanimoto, MD PhD, Hiroshi Fujiwara, MD PhD, Isao Tawara, MD PhD, Masahiro Masuya, MD PhD, Shinichi Kageyama, MD PhD, Tetsuya Nishida, MD PhD, Makoto Murata, MD PhD, Seitaro Terakura, MD PhD, Yoshiki Akatsuka, MD PhD, Hiroaki Ikeda, MD PhD, Yoshihiro Miyahara, MD PhD, Ikuei Nukaya, PhD, Kazutoh Takesako, PhD, Nobuhiko Emi, MD PhD, Naoyuki Katayama, MD PhD, Hiroshi Shiku, MD PhD, Masaki Yasukawa, MD PhD

Blood (2016) 128 (22): 1653.

https://doi.org/10.1182/blood.V128.22.1653.1653

Published: 2016

Journal Articles

Tumor-Specific Donor Lymphocyte Infusion for Tumor Relapse after MHC-Haploidentical Hematopoietic Stem Cell Transplantation

Isao Tawara, MD PhD, Kana Okamori, MS, Naoyuki Katayama, MD PhD, Hiroshi Shiku, MD PhD, Hiroaki Ikeda, MD PhD

Blood (2016) 128 (22): 2157.

https://doi.org/10.1182/blood.V128.22.2157.2157

Published: 2016

Journal Articles

Targeting Aurora Kinase with a Superior T-Cell Receptor Gene-Transfer Vector

Nicholas Casey, PhD, Hiroshi Fujiwara, MD PhD, Kazushi Tanimoto, MDPhD, Sachiko Okamoto, PhD, Junichi Mineno, PhD, Kiyotaka Kuzushima, MD PhD, Hiroshi Shiku, MD PhD, Masaki Yasukawa, MD PhD

Blood (2015) 126 (23): 4291.

https://doi.org/10.1182/blood.V126.23.4291.4291

Published: 2015

Journal Articles

Immunotherapy with Chimeric Antigen Receptor Targeting Intracellular WT1 Gene Product Complexed with HLA-a*24:02 Molecule

Hiroaki Ikeda, MD PhD, Yasushi Akahori, PhD, Motohiro Yoneyama, Yuki Orito, Yoshihiro Miyahara, Yasunori Amaishi, Sachiko Okamoto, Junichi Mineno, PhD, Kazutoh Takesako, PhD, Hiroshi Fujiwara, MD PhD, Masaki Yasukawa, MD PhD, Hiroshi Shiku, MD PhD

Blood (2015) 126 (23): 4292.

https://doi.org/10.1182/blood.V126.23.4292.4292

Published: 2015

Journal Articles

Adoptive Transfer of WT1-Specific TCR Gene-Transduced Lymphocytes in Patients with Myelodysplastic Syndrome and Acute Myeloid Leukemia

Isao Tawara, MD PhD, Masahiro Masuya, MD PhD, Shinichi Kageyama, MD PhD, Tetsuya Nishida, MD PhD, Seitaro Terakura, MD PhD, Makoto Murata, MD PhD, Hiroshi Fujiwara, MD PhD, Yoshiki Akatsuka, MD PhD, Hiroaki Ikeda, MD PhD, Yoshihiro Miyahara, MD PhD, Daisuke Tomura, PhD, Ikuei Nukaya, PhD, Kazutoh Takesako, PhD, Nobuhiko Emi, MDPhD, Masaki Yasukawa, MD PhD, Naoyuki Katayama, MD PhD, Hiroshi Shiku, MD PhD

Blood (2015) 126 (23): 97.

https://doi.org/10.1182/blood.V126.23.97.97

Published: 2015

Journal Articles

Concomitant Administration of Gene-Modified T Cells Expressing a Chimeric CD16-CD3ζ Receptor with Mogamulizmab Synergistically Suppresses Adult T Cell Leukemia Cells in Vivo

Kazushi Tanimoto, MD PhD, Hiroshi Fujiwara, MD PhD, Hiroki Tanaka, MD, Fumihiro Ochi, MD, Hiroaki Asai, MDPhD, Sachiko Okamoto, PhD, Junichi Mineno, PhD, Kiyotaka Kuzushima, MD PhD, Hiroshi Shiku, MD PhD, John Barrett, MD, Masaki Yasukawa, MD PhD

Blood (2014) 124 (21): 307.

https://doi.org/10.1182/blood.V124.21.307.307

Published: 2014

Journal Articles

Tumor-Specific TCR-Engineered Donor Lymphocyte Infusion Therapy with Reduced GvHD Induction Utilizing Novel Retrovirus Vector Silencing Endogenous TCR Expression

Hiroaki Ikeda, MD PhD, Hiroaki Ueno, Isao Tawara, MD, PhD, Ayumi Kawamura, Naoko Imai, MD PhD, Sachiko Okamoto, PhD, Junichi Mineno, PhD, Kazutoh Takesako, PhD, Naoyuki Katayama, MD PhD, Hiroshi Shiku, MD PhD

Blood (2014) 124 (21): 656.

https://doi.org/10.1182/blood.V124.21.656.656

Published: 2014

Journal Articles

Co-Administration Of Gene-Modified CD4 + T Cells Targeting HLA Class I-Restricted WT1 Epitope Diversely Enhances The Antitumor Effect Mediated By Redirected T-Cell Based Adoptive Immunotherapy Against Human Leukemia

Hiroshi Fujiwara, MD, PhD, Fumihiro Ochi, MD, Toshiki Ochi, MD, PhD, Hiroaki Asai, MD, PhD, Yukihiro Miyazaki, MD, PhD, Taichi Azuma, MD, PhD, Sachiko Okamoto, PhD, Junichi Mineno, PhD, Miwako Narita, MD, PhD, Kiyotaka Kuzushima, MD, PhD, Hiroshi Shiku, MD, PhD, Masaki Yasukawa, MD, PhD

Blood (2013) 122 (21): 144.

https://doi.org/10.1182/blood.V122.21.144.144

Published: 2013

Journal Articles

Redirected CD4 + T Cells towards HLA Class I-Restricted WT1 Epitope Successfully Display Multifactorial Helper Function for the Enhancement of Antileukemia Efficacy Mediated by Redirected T-Cell Based Immunocelltherapy.

Yukihiro Miyazaki, MD, Hiroshi Fujiwara, MD, PhD, Toshiki Ochi, MD, PhD, Sachiko Okamoto, PhD, Hiroaki Asai, MD, Junichi Mineno, PhD, Miwako Narita, MD, PhD, Kiyotaka Kuzushima, MD, PhD, Hiroshi Shiku, MD, PhD, Masaki Yasukawa, MD, PhD

Blood (2012) 120 (21): 3153.

https://doi.org/10.1182/blood.V120.21.3153.3153

Published: 2012

Journal Articles

Human Telomerase Reverse Transcriptase–specific T-Cell Receptor Gene Transfer Redirects T Cells to Display an Effective Antitumor Reactivity Against Adult T-Cell Leukemia

Hiroshi Fujiwara, MD, PhD, Fumihiro Ochi, Yukihiro Miyazaki, MD, Hiroaki Asai, MD, Takashi Ishida, MD, PhD, Sachiko Okamoto, PhD, Junichi Mineno, PhD, Kiyotaka Kuzushima, MD, PhD, Hiroshi Shiku, MD, PhD, Masaki Yasukawa, MD, PhD

Blood (2012) 120 (21): 1902.

https://doi.org/10.1182/blood.V120.21.1902.1902

Published: 2012

Journal Articles

Therapeutically Infused Redirected T Cells Targeting WT1 Successfully Inhibited Leukemia Stem Cells in Vivo

Hiroaki Asai, MD, Hiroshi Fujiwara, MD, PhD, Toshiki Ochi, MD, PhD, Yukihiro Miyazaki, MD, Fumihiro Ochi, Sachiko Okamoto, PhD, Junichi Mineno, PhD, Kiyotaka Kuzushima, MD, PhD, Hiroshi Shiku, MD, PhD, Masaki Yasukawa, MD, PhD

Blood (2012) 120 (21): 4221.

https://doi.org/10.1182/blood.V120.21.4221.4221

Published: 2012

Journal Articles

Redirected CD4 + T Cells Using WT1-Specific T-Cell Receptor Gene Transfer Can Supply Multifactorial Help to Enhance the Anti-Leukemia Reactivity Mediated by Similarly Redirected CD8 + T Cells Using the Identical Gene Transfer

Toshiki Ochi, MD, PhD, Hiroshi Fujiwara, MD, PhD, Sachiko Okamoto, PhD, Hiroaki Asai, MD, Yukihiro Miyazaki, MD, Toshiaki Shirakata, MD, PhD, Junichi Mineno, PhD, Kiyotaka Kuzushima, MD, PhD, Hiroshi Shiku, MD, PhD, Masaki Yasukawa, MD, PhD

Blood (2011) 118 (21): 645.

https://doi.org/10.1182/blood.V118.21.645.645

Published: 2011

Journal Articles

Forced Expression of CC Chemokine Receptor 2 Enhances Anti-Cancer Reactivity Mediated by T Lymphocytes Beforehand Redirected Toward WT1 Inside the Tumor Microenvironment

Hiroaki Asai, MD, Hiroshi Fujiwara, MD, PhD, Toshiki Ochi, MD, PhD, Jun An, MD, PhD, Toshiaki Shirakata, MD, PhD, Kozo Nagai, MD, Yukihiro Miyazaki, MD, Junichi Mineno, PhD, Kiyotaka Kuzushima, MD, PhD, Hiroshi Shiku, MD, PhD, Masaki Yasukawa, MD, PhD

Blood (2011) 118 (21): 2059.

https://doi.org/10.1182/blood.V118.21.2059.2059

Published: 2011

Journal Articles

Human Telomerase Reverse Transcriptase-Specific T-Cell Receptor Gene Transfer Redirects T-Lymphocytes to Exert Effective Antitumor Reactivity Against Adult T-Cell Leukemia,

Yukihiro Miyazaki, MD, Hiroshi Fujiwara, MD, PhD, Toshiki Ochi, MD, PhD, Hiroaki Asai, MD, Kozo Nagai, MD, Takashi Ishida, MD, PhD, Sachiko Okamoto, PhD, Junichi Mineno, PhD, Kiyotaka Kuzushima, MD, PhD, Hiroshi Shiku, MD, PhD, Masaki Yasukawa, MD, PhD

Blood (2011) 118 (21): 4169.

https://doi.org/10.1182/blood.V118.21.4169.4169

Published: 2011

Journal Articles

Engineering of Human T-Cells with a Novel Aurora-A Kinase-Specific T-Cell Receptor Gene Transfer Confers Anti-Leukemia Reactivity

Kozo Nagai, MD, Hiroshi Fujiwara, MD, PhD, Toshiki Ochi, MD, PhD, Jun An, MD, Toshiaki Shirakata, MD, PhD, Junichi Mineno, PhD, Kiyotaka Kuzushima, MD, Hiroshi Shiku, MD, PhD, J. Joseph Melenhorst, PhD, Emma Gostic, David A Price, MD, PhD, Masaki Yasukawa, MD, PhD

Blood (2010) 116 (21): 4290.

https://doi.org/10.1182/blood.V116.21.4290.4290

Published: 2010

Journal Articles

Dual Engineering of Human CD8 + T-Cells with WT1-Specific TCR Gene and Chemokine Receptor Gene Transfer Confers Functionally Strengthened Anti-Cancer Reactivity

Yukihiro Miyazaki, MD, Hiroshi Fujiwara, MD, PhD, Toshiki Ochi, MD, PhD, An Jun, MD, Toshiaki Shirakata, Kozo Nagai, MD, Sachiko Okamoto, PhD, Junichi Mineno, PhD, Kiyotaka Kuzushima, MD, Hiroshi Shiku, MD, PhD, Masaki Yasukawa, MD, PhD

Blood (2010) 116 (21): 4295.

https://doi.org/10.1182/blood.V116.21.4295.4295

Published: 2010

Journal Articles

Augmented Expression of WT1-Specific TCR and Inhibition of Mispaired-TCR Formation In TCR-Gene Modified T-Cells Can Concomitantly Be Achieved Using a Novel Retroviral Vector with Silencers for Endogenous TCRs

Toshiki Ochi, MD, PhD, Hiroshi Fujiwara, MD, PhD, Sachiko Okamoto, PhD, Jun An, Kozo Nagai, MD, Toshiaki Shirakata, MD, PhD, Junichi Mineno, PhD, Kiyotaka Kuzushima, MD, PhD, Hiroshi Shiku, MD, PhD, Masaki Yasukawa, MD, PhD

Blood (2010) 116 (21): 1020.

https://doi.org/10.1182/blood.V116.21.1020.1020

Published: 2010

Journal Articles

Gene Expression Profiling of Diffuse Large B-Cell Lymphomas Supervised by CD5 Expression

Kana Miyazaki, MD, PhD, Motoko Yamaguchi, MD, PhD, Hiroshi Imai, MD, PhD, Satoshi Tamaru, MD, PhD, Tohru Kobayashi, MD, PhD, Hiroshi Shiku, MD, PhD, Naoyuki Katayama, MD, PhD

Blood (2010) 116 (21): 4164.

https://doi.org/10.1182/blood.V116.21.4164.4164

Published: 2010

Journal Articles

Development of Novel Stem Cell Transplantation and Gene-Immunotherapy Using WT1-Specific T-Cell Receptor Gene.

Toshiki Ochi, MD, Hiroshi Fujiwara, MD, PhD, Kozo Nagai, MD, Toshiaki Shirakata, MD, PhD, Kiyotaka Kuzushima, MD, PhD, Sachiko Okamoto, PhD, Junichi Mineno, PhD, Hiroshi Shiku, MD, PhD, Hidetoshi Ozawa, PhD, Fumihiko Ishikawa, MD, PhD, Masaki Yasukawa, MD, PhD

Blood (2009) 114 (22): 3028.

https://doi.org/10.1182/blood.V114.22.3028.3028

Published: 2009

Journal Articles

De Novo CD5 + Diffuse Large B-Cell Lymphoma: Result of a Detail Morphologic Evaluation and Long-Term Follow Up of 128 Patients.

Motoko Yamaguchi, MD, PhD, Naoya Nakamura, MD, PhD, Ritsuro Suzuki, MD, PhD, Yoshitoyo Kagami, MD, PhD, Masataka Okamoto, MD, PhD, Ryo Ichinohasama, MD, PhD, Tadashi Yoshino, MD, PhD, Junji Suzumiya, MD, PhD, Takuhei Murase, MD, PhD, Ikuo Miura, MD, PhD, Masami Hirano, MD, PhD, Yasuo Morishima, MD, PhD, Hiroshi Shiku, MD, PhD, Ryuzo Ueda, MD, PhD, Shigeo Nakamura, MD, PhD

Blood (2007) 110 (11): 1564.

https://doi.org/10.1182/blood.V110.11.1564.1564

Published: 2007

NARROW

Phase 1 Clinical Trial of Adoptive Immunotherapy for Acute Myelogenous Leukemia and Myelodysplastic Syndrome, Using Gene-Modified Autologous Lymphocytes Expressing WT1-Specific T-Cell Receptor

Tumor-Specific Donor Lymphocyte Infusion for Tumor Relapse after MHC-Haploidentical Hematopoietic Stem Cell Transplantation

Targeting Aurora Kinase with a Superior T-Cell Receptor Gene-Transfer Vector

Immunotherapy with Chimeric Antigen Receptor Targeting Intracellular WT1 Gene Product Complexed with HLA-a*24:02 Molecule

Adoptive Transfer of WT1-Specific TCR Gene-Transduced Lymphocytes in Patients with Myelodysplastic Syndrome and Acute Myeloid Leukemia

Concomitant Administration of Gene-Modified T Cells Expressing a Chimeric CD16-CD3ζ Receptor with Mogamulizmab Synergistically Suppresses Adult T Cell Leukemia Cells in Vivo

Tumor-Specific TCR-Engineered Donor Lymphocyte Infusion Therapy with Reduced GvHD Induction Utilizing Novel Retrovirus Vector Silencing Endogenous TCR Expression

Co-Administration Of Gene-Modified CD4 + T Cells Targeting HLA Class I-Restricted WT1 Epitope Diversely Enhances The Antitumor Effect Mediated By Redirected T-Cell Based Adoptive Immunotherapy Against Human Leukemia

Redirected CD4 + T Cells towards HLA Class I-Restricted WT1 Epitope Successfully Display Multifactorial Helper Function for the Enhancement of Antileukemia Efficacy Mediated by Redirected T-Cell Based Immunocelltherapy.

Human Telomerase Reverse Transcriptase–specific T-Cell Receptor Gene Transfer Redirects T Cells to Display an Effective Antitumor Reactivity Against Adult T-Cell Leukemia

Therapeutically Infused Redirected T Cells Targeting WT1 Successfully Inhibited Leukemia Stem Cells in Vivo

Redirected CD4 + T Cells Using WT1-Specific T-Cell Receptor Gene Transfer Can Supply Multifactorial Help to Enhance the Anti-Leukemia Reactivity Mediated by Similarly Redirected CD8 + T Cells Using the Identical Gene Transfer

Forced Expression of CC Chemokine Receptor 2 Enhances Anti-Cancer Reactivity Mediated by T Lymphocytes Beforehand Redirected Toward WT1 Inside the Tumor Microenvironment

Human Telomerase Reverse Transcriptase-Specific T-Cell Receptor Gene Transfer Redirects T-Lymphocytes to Exert Effective Antitumor Reactivity Against Adult T-Cell Leukemia,

Engineering of Human T-Cells with a Novel Aurora-A Kinase-Specific T-Cell Receptor Gene Transfer Confers Anti-Leukemia Reactivity

Dual Engineering of Human CD8 + T-Cells with WT1-Specific TCR Gene and Chemokine Receptor Gene Transfer Confers Functionally Strengthened Anti-Cancer Reactivity

Augmented Expression of WT1-Specific TCR and Inhibition of Mispaired-TCR Formation In TCR-Gene Modified T-Cells Can Concomitantly Be Achieved Using a Novel Retroviral Vector with Silencers for Endogenous TCRs

Gene Expression Profiling of Diffuse Large B-Cell Lymphomas Supervised by CD5 Expression

Development of Novel Stem Cell Transplantation and Gene-Immunotherapy Using WT1-Specific T-Cell Receptor Gene.

De Novo CD5 + Diffuse Large B-Cell Lymphoma: Result of a Detail Morphologic Evaluation and Long-Term Follow Up of 128 Patients.

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American Society of Hematology

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American Society of Hematology

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