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Journal Articles

Combined Inhibition of HDAC and AKT As a Strategy to Overcome Multi-Drug Resistance in Patients with Multiple Myeloma

Mitsuhito Hirano, MD, Yoichi Imai, MD PhD, Takahiko Murayama, PhD, Kota Sato, MD PhD, Junichi Yamamoto, PhD, Takumi Ito, PhD, Muneyoshi Futami, MD PhD, Masaki Ri, Hiroshi Yasui, MD PhD, Noriko Gotoh, MD, Shinsuke Iida, MD PhD, Tadao Ishida, MD PhD, Hiroshi Handa, MD PhD, Arinobu Tojo, MD PhD

Blood (2019) 134 (Supplement_1): 4325.

https://doi.org/10.1182/blood-2019-122662

Published: 2019

Journal Articles

The Trifunctional Antibody (tri-31C2) Targeting CD38 and CD3 Has a Stronger Anti-Myeloma Effect Than the Chimeric Anti-CD38 Monoclonal Antibody (ch-31C2)

Tadao Ishida, MD PhD, Hiroshi Yasui, MD PhD, Kazuya Ishiguro, MD, Yuka Aoki, MD PhD, Hiroshi Ikeda, MD PhD

Blood (2016) 128 (22): 2097.

https://doi.org/10.1182/blood.V128.22.2097.2097

Published: 2016

Journal Articles

Role of Allogeneic Stem Cell Transplantation for Adult T-Cell Leukemia in an HTLV-1 Non-Endemic Area of Japan.

Akio Shigematsu, MD, PhD, Junji Tanaka, MD, PhD, Naoki Kobayashi, MD, PhD, Hiroshi Yasui, MD, PhD, Motohiro Shindo, MD, PhD, Yasutaka Kakinoki, MD, PhD, Kakinoki Yasutaka, MD, PhD, Satoshi Iyama, MD, PhD, Kuroda HIroyuki, MD, PhD, Tsutsumi Yutaka, MD.PhD, Satoshi Hashino, MD, PhD, Masahiro Imamura, MD, PhD, Takanori Teshima, MD, PhD

Blood (2012) 120 (21): 3089.

https://doi.org/10.1182/blood.V120.21.3089.3089

Published: 2012

Journal Articles

The Relationship of Myeloma Cells, Stromal Cells and Monocytes Under Bone Marrow Microenvironment

Hiroshi Ikeda, MD, PhD, Yuka Aoki, MD, Nasanori Nojima, MD, PhD, Hiroshi Yasui, MD, PhD, Toshiaki Hayashi, MD, PhD, Tadao Ishida, MD, PhD

Blood (2012) 120 (21): 4987.

https://doi.org/10.1182/blood.V120.21.4987.4987

Published: 2012

Journal Articles

Serotonin Receptor Antagonists Have an In Vitro and In Vivo Anti-Myeloma Effect That Is Mainly Mediated by Caspase Dependent Apoptosis.

Enrique M. Ocio, MD, PhD, Teru Hideshima, MD, PhD, Hiroshi Yasui, MD, PhD, Kiziltepe Tanyel, PhD, Hirosi Ikeda, MD, PhD, Yutaka Okawa, MD, PhD, Sonia Vallet, MD, Janice Jin, MD, Kenji Ishitsuka, MD, PhD, Noopur Raje, MD, Laurence Catley, MD, MBBS, FRACP, Kenneth C. Anderson, MD

Blood (2006) 108 (11): 2597.

https://doi.org/10.1182/blood.V108.11.2597.2597

Published: 2006

Journal Articles

Akt Inhibitor Perifosine-Induced Cytotoxicity Is Associated with Significant Downregulation of Survivin in Human Multiple Myeloma (MM) Cells.

Teru Hideshima, MD, PhD, Hiroshi Yasui, MD, PhD, Laurence Catley, MD, Noopur Raje, MD, Dharminder Chauhan, PhD, Kenji Ishitsuka, MD, PhD, Klaus Podar, MD, PhD, Constantine Mitsiades, MD, PhD, Yu-Tzu Tai, PhD, Sonia Vallet, MD, Tanyel Kizitepe, PhD, Enrique Ocio, MD, PhD, Hiroshi Ikeda, MD, PhD, Yutaka Okawa, MD, PhD, Hiromasa Hideshima, Nikhil C. Munshi, MD, Paul G. Richardson, MD, Kenneth C. Anderson, MD

Blood (2006) 108 (11): 3410.

https://doi.org/10.1182/blood.V108.11.3410.3410

Published: 2006

Journal Articles

Upregulation of c-Jun Induces Cell Death Via Caspase-Triggered c-Abl Cleavage in Human Multiple Myeloma.

Klaus Podar, MD, MSc, PhD, Marc S. Raab, MD, Giovanni Tonon, MD, PhD, Martin Sattler, PhD, Daniela Barila, PhD, Yu-Tzu Tai, PhD, Hiroshi Yasui, MD, PhD, Noopur Raje, MD, Ronald A. Depinho, MD, Teru Hideshima, MD, PhD, Dharminder Chauhan, JD, PhD, Kenneth C. Anderson, MD

Blood (2006) 108 (11): 3415.

https://doi.org/10.1182/blood.V108.11.3415.3415

Published: 2006

Journal Articles

Histone Deacetylase-6 (HDAC6) Modulates Akt and STAT3 Activity Via Heat Shock Protein (Hsp) 90 in Human Multiple Myeloma (MM) Cells.

Teru Hideshima, MD, PhD, James E. Bradner, MD, Hiroshi Yasui, MD, PhD, Noopur Raje, MD, Dharminder Chauhan, PhD, Klaus Podar, MD, PhD, Yu-Tzu Tai, PhD, Constantine Mitsiades, MD, PhD, Paul G. Richardson, MD, Ralph Mazitschek, PhD, Stuart L. Schreiber, PhD, Kenneth C. Anderson, MD

Blood (2006) 108 (11): 3426.

https://doi.org/10.1182/blood.V108.11.3426.3426

Published: 2006

Journal Articles

BIRB796 Inhibits p38 MAPK/Hsp27 Pathway and Enhances Cytotoxicity Triggered by Bortezomib, Hsp90 Inhibitor, and Dexamethasone in Multiple Myeloma.

Hiroshi Yasui, MD, PhD, Teru Hideshima, M.D., Ph.D., Hiroshi Ikeda, M.D., Ph.D., Janice Jin, M.D., Enrique M. Ocio, D., Ph.D., Tanyel Kiziltepe, Ph.D, Yutaka Okawa, M.D., Ph.D., Sonia Vallet, M.D., Ph.D., Shweta Chhetri, Kenji Ishitsuka, M.D., Ph.D., Yu-Tzu Tai, Ph.D., Klaus Podar, M.D., Ph.D., Dharminder Chauhan, Ph.D., Chris Pargellis, Ph.D., Neil Moss, Ph.D., Noopur Raje, M.D., Ph.D., Kenneth C. Anderson, M.D.

Blood (2006) 108 (11): 3440.

https://doi.org/10.1182/blood.V108.11.3440.3440

Published: 2006

Journal Articles

Epigenetic Modulation by Vidaza™ induces Apoptosis and Overcomes In Vitro Drug Resistance in Human Multiple Myeloma Cells.

Tanyel Kiziltepe, PhD, Laurence Catley, MD, Teru Hideshima, MD,PhD, Noopur Raje, MD, Hiroshi Yasui, MD,PhD, Sonia Vallet, MD, Hiroshi Ikeda, MD,PhD, Yutaka Okawa, MD,PhD, Kenneth C. Anderson, MD

Blood (2006) 108 (11): 5001.

https://doi.org/10.1182/blood.V108.11.5001.5001

Published: 2006

Journal Articles

The Small-Molecule VEGF-Receptor Inhibitor Pazopanib (GW786034B) Targets Both Tumor and Endothelial Cells in Multiple Myeloma.

Klaus Podar, MD, MSc, PhD, Giovanni Tonon, MD, PhD, Martin Sattler, PhD, Yu-Tzu Tai, PhD, Steven LeGouill, MD, Hiroshi Yasui, MD, PhD, Kenji Ishitsuka, MD, PhD, Rakesh Kumar, PhD, Lini N. Pandite, MD, Teru Hideshima, MD, PhD, Dharminder Chauhan, PhD, Kenneth C. Anderson, MD

Blood (2006) 108 (11): 5003.

https://doi.org/10.1182/blood.V108.11.5003.5003

Published: 2006

Journal Articles

Novel Etodolac Analog SDX-308 (CEP-18082) Induces Cytotoxicity in Multiple Myeloma Cells Associated with Inhibition of Wnt/β-Catenin Pathway.

Hiroshi Yasui, MD, PhD, Teru Hideshima, M.D., Ph.D., Hiroshi Ikeda, M.D., Ph.D., Enrique M. Ocio, M.D., Ph.D., Tanyel Kiziltepe, Ph.D., Sonia Vallet, M.D., Ph.D., Yutaka Okawa, M.D., Ph.D., Shweta Chhetri, Kumar Sukhdeo, Kenji Ishitsuka, M.D., Ph.D., Klaus Podar, M.D., Ph.D., Noopur Raje, M.D., Ph.D., Dharminder Chauhan, Ph.D., Daniel R. Cattasco, M.D., Ph.D., Kenneth C. Anderson, M.D.

Blood (2006) 108 (11): 5005.

https://doi.org/10.1182/blood.V108.11.5005.5005

Published: 2006

Journal Articles

Didox Induced Apoptosis Occurs by Inhibiting DNA Synthesis and Repair Via Down-Regulation of Ribonucleotide Reductase M1 in Multiple Myeloma (MM).

Noopur Raje, MD, Shaji Kumar, MD, Teru Hideshima, MD, PhD, Kenji Ishitsuka, MD, Hiroshi Yasui, MD, PhD, Norihiko Shiraishi, PhD, Tanyel Kiziltepe, PhD, Shweta Chhetri, BS, Nikhil C. Munshi, MD, Kenneth C. Anderson, MD

Blood (2005) 106 (11): 5153.

https://doi.org/10.1182/blood.V106.11.5153.5153

Published: 2005

Journal Articles

The Role of B Cell-Activating Factor (BAFF) in the Biology of Multiple Myeloma (MM).

Noopur Raje, MD, Shaji Kumar, MD, Teru Hideshima, MD, PhD, Kenji Ishitsuka, MD, Hiroshi Yasui, MD, PhD, Yu-Tzu Tai, PhD, Norihiko Shiraishi, PhD, Tanyel Kizeltepe, PhD, Shweta Chhetri, BS, Sonia Vallet, MD, Robert L. Schlossman, MD, Paul G. Richardson, MD, Nikhil C. Munshi, MD, Kenneth C. Anderson, MD

Blood (2005) 106 (11): 3380.

https://doi.org/10.1182/blood.V106.11.3380.3380

Published: 2005

Journal Articles

Perifosine, an Oral Bioactive Novel Alkyl-Phospholipid, Inhibits Akt and Induces In Vitro and In Vivo Cytotoxicity in Human Multiple Myeloma (MM) Cells.

Teru Hideshima, MD, PhD, Laurence Catley, MD, Hiroshi Yasui, MD, PhD, Kenji Ishitsuka, MD, PhD, Noopur Raje, MD, Constantine Mitsiades, MD, PhD, Klaus Podar, MD, PhD, Nikhil C. Munshi, MD, Dharminder Chauhan, PhD, Paul G. Richardson, MD, Kenneth C. Anderson, MD

Blood (2005) 106 (11): 250.

https://doi.org/10.1182/blood.V106.11.250.250

Published: 2005

Journal Articles

Targeting Src- Family Kinase Activation and Downstream Molecular Events To Overcome MM Cell Growth, Survival, and Drug- Resistance.

Klaus Podar, MD, PhD, Yu-Tzu Tai, PhD, Dean Abtahi, BS, Marc S. Raab, MD, Hiroshi Yasui, MD, PhD, Kenji Ishitsuka, MD, PhD, Norihiko Shiraishi, PhD, Laurence P. Catley, MD, Martin Sattler, PhD, Noopur Raje, MD, Teru Hideshima, MD, PhD, Dharminder Chauhan, JD, PhD

Blood (2005) 106 (11): 1583.

https://doi.org/10.1182/blood.V106.11.1583.1583

Published: 2005

Journal Articles

Up-Regulation of c-Jun contributes to the Induction of Apoptosis by Adaphostin in Human Multiple Myeloma Cells.

Klaus Podar, MD, PhD, Giovanni Tonon, MD, PhD, Marc S. Raab, MD, Martin Sattler, PhD, Dean Abtahi, BS, Yu-Tzu Tai, PhD, Steven LeGouill, MD, PhD, Kenji Ishitsuka, MD, PhD, Hiroshi Yasui, MD, PhD, Ron A. Depinho, MD, Teru Hideshima, MD, PhD, Dharminder Chauhan, JD, PhD, Kenneth C. Anderson, MD

Blood (2005) 106 (11): 1585.

https://doi.org/10.1182/blood.V106.11.1585.1585

Published: 2005

Journal Articles

JS-K, a GST-Activated Nitric Oxide Generator, Induces Apoptosis and Overcomes In Vitro Drug Resistance in Multiple Myeloma Cells.

Tanyel Kiziltepe, PhD, Kenji Ishitsuka, MD, PhD, Teru Hideshima, MD, PhD, Noopur Raje, MD, Norihiko Shiraishi, PhD, Hiroshi Yasui, MD, PhD, Laurence Catley, MD, Dharminder Chauhan, PhD, Joseph E. Saavedra, PhD, Larry K. Keefer, PhD, Paul J. Shami, MD, Kenneth C. Anderson, MD

Blood (2005) 106 (11): 1593.

https://doi.org/10.1182/blood.V106.11.1593.1593

Published: 2005

Journal Articles

TGF-β Receptor I Kinase Inhibitor Downregulates Cytokine Secretion and Multiple Myeloma Cell Growth in the Bone Marrow Microenvironment.

Toshiaki Hayashi, MD, PhD, Teru Hideshima, MD, PhD, Klaus Podar, MD, PhD, Paul Richardson, MD, Olivier Munoz, MD, Makoto Hamasaki, MD, PhD, Kenji Ishitsuka, MD, PhD, Hiroshi Yasui, MD, PhD, Alison Murphy, PhD, Glenn McEnroe, PhD, Sarvajit Chakravarty, PhD, Sundeep Dugar, PhD, Linda S. Higgins, PhD, Dharminder Chauhan, PhD, Kenneth C. Anderson, MD

Blood (2004) 104 (11): 2355.

https://doi.org/10.1182/blood.V104.11.2355.2355

Published: 2004

NARROW

Combined Inhibition of HDAC and AKT As a Strategy to Overcome Multi-Drug Resistance in Patients with Multiple Myeloma

The Trifunctional Antibody (tri-31C2) Targeting CD38 and CD3 Has a Stronger Anti-Myeloma Effect Than the Chimeric Anti-CD38 Monoclonal Antibody (ch-31C2)

Role of Allogeneic Stem Cell Transplantation for Adult T-Cell Leukemia in an HTLV-1 Non-Endemic Area of Japan.

The Relationship of Myeloma Cells, Stromal Cells and Monocytes Under Bone Marrow Microenvironment

Serotonin Receptor Antagonists Have an In Vitro and In Vivo Anti-Myeloma Effect That Is Mainly Mediated by Caspase Dependent Apoptosis.

Akt Inhibitor Perifosine-Induced Cytotoxicity Is Associated with Significant Downregulation of Survivin in Human Multiple Myeloma (MM) Cells.

Upregulation of c-Jun Induces Cell Death Via Caspase-Triggered c-Abl Cleavage in Human Multiple Myeloma.

Histone Deacetylase-6 (HDAC6) Modulates Akt and STAT3 Activity Via Heat Shock Protein (Hsp) 90 in Human Multiple Myeloma (MM) Cells.

BIRB796 Inhibits p38 MAPK/Hsp27 Pathway and Enhances Cytotoxicity Triggered by Bortezomib, Hsp90 Inhibitor, and Dexamethasone in Multiple Myeloma.

Epigenetic Modulation by Vidaza™ induces Apoptosis and Overcomes In Vitro Drug Resistance in Human Multiple Myeloma Cells.

The Small-Molecule VEGF-Receptor Inhibitor Pazopanib (GW786034B) Targets Both Tumor and Endothelial Cells in Multiple Myeloma.

Novel Etodolac Analog SDX-308 (CEP-18082) Induces Cytotoxicity in Multiple Myeloma Cells Associated with Inhibition of Wnt/β-Catenin Pathway.

Didox Induced Apoptosis Occurs by Inhibiting DNA Synthesis and Repair Via Down-Regulation of Ribonucleotide Reductase M1 in Multiple Myeloma (MM).

The Role of B Cell-Activating Factor (BAFF) in the Biology of Multiple Myeloma (MM).

Perifosine, an Oral Bioactive Novel Alkyl-Phospholipid, Inhibits Akt and Induces In Vitro and In Vivo Cytotoxicity in Human Multiple Myeloma (MM) Cells.

Targeting Src- Family Kinase Activation and Downstream Molecular Events To Overcome MM Cell Growth, Survival, and Drug- Resistance.

Up-Regulation of c-Jun contributes to the Induction of Apoptosis by Adaphostin in Human Multiple Myeloma Cells.

JS-K, a GST-Activated Nitric Oxide Generator, Induces Apoptosis and Overcomes In Vitro Drug Resistance in Multiple Myeloma Cells.

TGF-β Receptor I Kinase Inhibitor Downregulates Cytokine Secretion and Multiple Myeloma Cell Growth in the Bone Marrow Microenvironment.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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