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Ivo Touw, PhD
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Journal Articles

PML Plays a Key Role in Severe Congenital Neutropenia with Mutant ELANE Causing Neutrophil Elastase Protein Misfolding

Patricia Olofsen, MSc, Paulette van Strien, BSc, Onno Roovers, BSc, Hans De Looper, BSc, Remco Hoogenboezem, MSc, Dennis Bosch, BSc, Mehrnaz Ghazvini, PhD, Eric Bindels, PhD, Emma De Pater, PhD, Ivo Touw, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 213.
https://doi.org/10.1182/blood-2019-122423
Published: 2019
Journal Articles

A Leukemic Progression Model of Severe Congenital Neutropenia Uncovers a Novel Mechanism of AML Development Involving Elevated Inflammatory Responses, Mutation of CXXC4 and Decreased TET2 Levels

Patricia Olofsen, MSc, Szabolcs Fatrai, PhD, Paulette van Strien, BSc, Julia Obenauer, MSc, Remco Hoogenboezem, MSc, Claudia Erpelinck-Verschueren, B.Sc., Onno Roovers, BSc, Torsten Haferlach, MD, Peter Valk, PhD, Rebekka Schneider, MDPhD, Emma De Pater, PhD, Ivo Touw, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 540.
https://doi.org/10.1182/blood-2018-99-115914
Published: 2018
Journal Articles

Combinatorial CSF3R and RUNX1 Mutations Involved in the Leukemic Progression of Severe Congenital Neutropenia Confer a G-CSF-Dependent Premalignant State in Mice

Szabolcs Fatrai, PhD, Paulette van Strien, BSc, Julia Obenauer, MSc, BSc, M.M. Van den Heuvel-Eibrink, MD, Ivo Touw, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 543.
https://doi.org/10.1182/blood.V130.Suppl_1.543.543
Published: 2017
Journal Articles

Multiple Myeloma with a Deletion of Chromosome 17p: TP53 Mutations Are Highly Prevalent and Negatively Affect Prognosis

Davine Hofste op Bruinink, MD MSc, Hoogenboezem Remco, MSc, Mathijs A. Sanders, PhD, Christopher P Wardell, PhD, Cody Ashby, PhD, Eric M.J. Bindels, PhD, Claudia Erpelinck-Verschueren, BSc, Paulette van Strien, BSc, Jasper Koenders, BSc, François G. Kavelaars, BSc, Jie He, PhD, Mark Bailey, MSc, Tariq I Mughal, MD FRCP, Kristine Misund, PhD, Berna Beverloo, PhD, Bronno van der Holt, PhD, Ivo Touw, PhD, Anders Waage, MDPhD, Hervé Avet-Loiseau, MD PhD, Graham H Jackson, MD PhD, Gareth J Morgan, MD PhD, Brian A Walker, PhD, Pieter Sonneveld, MDPhD
Journal: Blood
Blood (2016) 128 (22): 3271.
https://doi.org/10.1182/blood.V128.22.3271.3271
Published: 2016
Journal Articles

Inflammatory Niche Signalling Drives Genotoxic Stress in Hematopoietic Stem Cells and Predicts Leukemic Evolution in Human Leukemia Predisposition Syndromes

Si Chen, MSCs, Noemi A. Zambetti, PhD, Zhen Ping, MSCs, Keane Kenswil, MSCs, Maria Mylona, PhD, Mathijs A. Sanders, PhD, Remco Hoogenboezem, MSc, Eric Bindels, PhD, Maria Adisty, Paulina M. H. van Strien, B.Sc., Cindy van der Leije, Theresia M Westers, PhD, Eline MP Cremers, MD, Chiara Milanese, PhD, Pier Mastroberardino, PhD, Johannes van Leeuwen, PhD, Bram Van der Eerden, PhD, Ivo Touw, PhD, Kuijpers Taco, Roland Kanaar, PhD, Arjan van der Loosdrecht, MD PhD, Thomas Vogl, PhD, Marc H.G.P. Raaijmakers, MD PhD
Journal: Blood
Blood (2016) 128 (22): 428.
https://doi.org/10.1182/blood.V128.22.428.428
Published: 2016