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Journal Articles

Differential Effect of Rituximab on Relapse-Free Survival in De Novo and Relapsed Immune Thrombotic Thrombocytopenic Purpura in African-American and Caucasian Populations

Blood (2019) 134 (Supplement_1): 90.

https://doi.org/10.1182/blood-2019-129383

Published: 2019

Journal Articles

Efficacy of Adjuvant Low Dose Rituximab and Plasma Exchange for Acquired TTP with Severe ADAMTS13 Deficiency — Results of the ART Study

J. Evan Sadler, MD PhD, Joshua Muia, PhD, Leili Dolatshahi, MD, Lisa A. Westfield, MA, Patricia Nieters, RN, BSN, Anita Rodrigues, BA, Ana G. Antun, MD, Ara Metjian, MD, Jeffrey I. Zwicker, MD

Blood (2018) 132 (Supplement 1): 374.

https://doi.org/10.1182/blood-2018-99-113677

Published: 2018

Journal Articles

A Descriptive Analysis of the Demographics and Presenting Symptoms of Patients in the U.S. Thrombotic Microangiopathy (USTMA) TTP Registry

Elizabeth Davis, Ana G. Antun, MD, Lisa Baumann Kreuziger, MD MS, J. Evan Sadler, MD PhD, Spero R Cataland, MD, Meera Sridharan, MD, Todd Clover, MD, Andrew Johnson, MD, Keith McCrae, MD, Shruti Chaturvedi, MBBS,MS, Ronald S. Go, MD, Ming Yeong Lim, MBBChir, Marshall A. Mazepa, MD

Blood (2017) 130 (Supplement 1): 1049.

https://doi.org/10.1182/blood.V130.Suppl_1.1049.1049

Published: 2017

Journal Articles

Factors Associated with Mortality in Immune-Mediated Thrombotic Thrombocytopenic Purpura: Results from the United States Thrombotic Microangiopathy TTP Registry

Todd Clover, MD MS, Ronald S. Go, MD, Ana G. Antun, MD, Spero R Cataland, MD, Shruti Chaturvedi, MBBS,MS, Elizabeth Davis, Andrew Johnson, MD, Ming Yeong Lim, MBBChir, Meera Sridharan, MD, Keith McCrae, MD, J. Evan Sadler, MD PhD, Marshall A. Mazepa, MD, Lisa Baumann-Kreuziger, MS MD

Blood (2017) 130 (Supplement 1): 3624.

https://doi.org/10.1182/blood.V130.Suppl_1.3624.3624

Published: 2017

Journal Articles

The Impact of Detectable ADAMTS13 Inhibitor on the Clinical Presentation and Outcome of Patients with Immune Thrombotic Thrombocytopenic Purpura (iTTP): Analysis Using the United States Thrombotic Microangiopathy (USTMA) Clinical Registry

Meera Sridharan, MD, Ana G Antun, MD, Lisa Baumann Kreuziger, Assistant Professor. MD MS, Spero R Cataland, MD, Shruti Chaturvedi, MBBS,MS, Todd Clover, MD, Elizabeth Davis, Andrew Johnson, MD, Keith McCrae, MD, Ming Yeong Lim, MBBChir, J. Evan Sadler, MD PhD, Marshall A. Mazepa, MD, Ronald S Go, MD

Blood (2017) 130 (Supplement 1): 3620.

https://doi.org/10.1182/blood.V130.Suppl_1.3620.3620

Published: 2017

Journal Articles

Phylogenetic Analysis Identifies a Subset of ADAMTS13 Domains That Are Highly Conserved and Essential for Allosteric Regulation

Joshua Muia, PhD, Jian Zhu, PhD, Suellen Greco, DVM, Karen Vanhoorelbeke, PhD, Louis Deforche, PhD, Lisa Westfield, Garima Tyagi, PhD, J. Evan Sadler, MD PhD

Blood (2016) 128 (22): 1385.

https://doi.org/10.1182/blood.V128.22.1385.1385

Published: 2016

Journal Articles

The Involvement of Copper Transport in Von Willebrand Factor Multimer Assembly

Dhanalakshmi S. Anbukumar, Ph..D, Stephen G. Kaler, MD, J. Evan Sadler, MD, PhD

Blood (2016) 128 (22): 2530.

https://doi.org/10.1182/blood.V128.22.2530.2530

Published: 2016

Journal Articles

The Hunt for the "Minimal" Structure of a Functional ADAMTS13: Study of Deletion Mutations of ADAMTS13 By Small-Angle X-Ray Scattering

Jian Zhu, PhD, Joshua Muia, PhD, Louis Deforche, PhD, Karen Vanhoorelbeke, PhD, Niraj H. Tolia, PhD, J. Evan Sadler, MD PhD

Blood (2016) 128 (22): 254.

https://doi.org/10.1182/blood.V128.22.254.254

Published: 2016

Journal Articles

A Folded ADAMTS13 Conformation Identified By Small-Angle X-Ray Scattering Can Account for Allosteric Regulation By Distal Thrombospondin-1 and CUB Domains

Jian Zhu, PhD, Joshua Muia, PhD, Niraj H. Tolia, PhD, Lisa A Westfield, PhD, J. Evan Sadler, MD PhD

Blood (2014) 124 (21): 107.

https://doi.org/10.1182/blood.V124.21.107.107

Published: 2014

Journal Articles

Distinct Functions of pH-Sensing Histidine Residues in the Multimer Assembly and Storage of Von Willebrand Factor in Weibel-Palade Bodies

Jing Huang, PhD, MD, Lisa A Westfield, Ph.D, J. Evan Sadler, MD, PhD

Blood (2012) 120 (21): 3311.

https://doi.org/10.1182/blood.V120.21.3311.3311

Published: 2012

Journal Articles

An Optimized Fluorogenic Assay with Increased Sensitivity for ADAMTS13 Activity and Inhibitors for the Characterization of Patients with Thrombotic Thrombocytopenic Purpura,

Joshua Muia, Ph.D., Weiqiang Gao, MD, PhD, J. Evan Sadler, MD, PhD

Blood (2011) 118 (21): 3298.

https://doi.org/10.1182/blood.V118.21.3298.3298

Published: 2011

Journal Articles

Characterization of the Binding Between the Polymeric Platelet Adhesive Proteins, Multimerin 1 and Von Willebrand Factor

D'Andra Parker, BSc (Hon), Subia Tasneem, PhD, Nola Fuller, MSc, J. Evan Sadler, MD, PhD, Philip G de Groot, PhD, Catherine PM Hayward, MD, PhD

Blood (2011) 118 (21): 1144.

https://doi.org/10.1182/blood.V118.21.1144.1144

Published: 2011

Journal Articles

Small-Angle X-Ray Scattering Studies of ADAMTS13 Demonstrate a Conformational Response to Substrate Binding in Solution

Jian Zhu, PhD, Joshua Muia, Ph.D., Joseph D. Batchelor, Ph.D., Bruce C. Linders, Niraj H. Tolia, Ph.D., J. Evan Sadler, MD, PhD

Blood (2011) 118 (21): 1191.

https://doi.org/10.1182/blood.V118.21.1191.1191

Published: 2011

Journal Articles

Phospholipase D1 Is Required for Regulated Secretion of VWF Induced by the B-Subunits of Shiga-Like Toxins 1 and 2

Jing Huang, PhD, MD, Fang Liu, J. Evan Sadler, MD, PhD

Blood (2010) 116 (21): 2113.

https://doi.org/10.1182/blood.V116.21.2113.2113

Published: 2010

Journal Articles

Non-Catalytic Domains of ADAMTS13 Can Redirect the Substrate Specificity of ADAMTS5

Weiqiang Gao, MD, PhD, Elodee Tuley, BSc, J. Evan Sadler, MD, PhD

Blood (2010) 116 (21): 2211.

https://doi.org/10.1182/blood.V116.21.2211.2211

Published: 2010

Journal Articles

B Subunits of Shiga Toxin 2 Induce VWF Secretion by a cAMP-Independent Protein Kinase A Signaling Pathway.

Fang Liu, MD, PhD, Jing Huang, PhD, MD, J. Evan Sadler, MD, PhD

Blood (2009) 114 (22): 3046.

https://doi.org/10.1182/blood.V114.22.3046.3046

Published: 2009

Journal Articles

Shiga Toxin 1(Stx1) Stimulates Endothelial Cell VWF Secretion through a Ca 2+ /PKC Signaling Pathway That Does Not Require the Active Toxin Stx1A Subunit

Fang Liu, MD, PhD, Jing Huang, PhD, MD, J. Evan Sadler, MD, PhD

Blood (2008) 112 (11): 3931.

https://doi.org/10.1182/blood.V112.11.3931.3931

Published: 2008

Journal Articles

Assembly, Storage, and Secretion of Von Willebrand Factor.

J. Evan Sadler, MD, PhD

Blood (2008) 112 (11): sci-46.

https://doi.org/10.1182/blood.V112.11.sci-46.sci-46

Published: 2008

Journal Articles

Crystal Structure of Von Willebrand Factor (VWF) A1 Domain in Complex with Aptamer ARC1172, An Inhibitor of VWF-Platelet Binding

Ren-Huai Huang, PhD, David Fremont, PhD, Elodee A Tuley, John L Diener, PhD, Robert G Schaub, PhD, J. Evan Sadler, MD, PhD

Blood (2008) 112 (11): 257.

https://doi.org/10.1182/blood.V112.11.257.257

Published: 2008

Journal Articles

Binding of ADAMTS13 to Von Willebrand Factor Under Static Conditions and Under Fluid Shear Stress

Hendrik B Feys, PhD, Patricia J Anderson, PhD, J. Evan Sadler, MD, PhD

Blood (2008) 112 (11): 258.

https://doi.org/10.1182/blood.V112.11.258.258

Published: 2008

NARROW

Differential Effect of Rituximab on Relapse-Free Survival in De Novo and Relapsed Immune Thrombotic Thrombocytopenic Purpura in African-American and Caucasian Populations

Efficacy of Adjuvant Low Dose Rituximab and Plasma Exchange for Acquired TTP with Severe ADAMTS13 Deficiency — Results of the ART Study

A Descriptive Analysis of the Demographics and Presenting Symptoms of Patients in the U.S. Thrombotic Microangiopathy (USTMA) TTP Registry

Factors Associated with Mortality in Immune-Mediated Thrombotic Thrombocytopenic Purpura: Results from the United States Thrombotic Microangiopathy TTP Registry

The Impact of Detectable ADAMTS13 Inhibitor on the Clinical Presentation and Outcome of Patients with Immune Thrombotic Thrombocytopenic Purpura (iTTP): Analysis Using the United States Thrombotic Microangiopathy (USTMA) Clinical Registry

Phylogenetic Analysis Identifies a Subset of ADAMTS13 Domains That Are Highly Conserved and Essential for Allosteric Regulation

The Involvement of Copper Transport in Von Willebrand Factor Multimer Assembly

The Hunt for the "Minimal" Structure of a Functional ADAMTS13: Study of Deletion Mutations of ADAMTS13 By Small-Angle X-Ray Scattering

A Folded ADAMTS13 Conformation Identified By Small-Angle X-Ray Scattering Can Account for Allosteric Regulation By Distal Thrombospondin-1 and CUB Domains

Distinct Functions of pH-Sensing Histidine Residues in the Multimer Assembly and Storage of Von Willebrand Factor in Weibel-Palade Bodies

An Optimized Fluorogenic Assay with Increased Sensitivity for ADAMTS13 Activity and Inhibitors for the Characterization of Patients with Thrombotic Thrombocytopenic Purpura,

Characterization of the Binding Between the Polymeric Platelet Adhesive Proteins, Multimerin 1 and Von Willebrand Factor

Small-Angle X-Ray Scattering Studies of ADAMTS13 Demonstrate a Conformational Response to Substrate Binding in Solution

Phospholipase D1 Is Required for Regulated Secretion of VWF Induced by the B-Subunits of Shiga-Like Toxins 1 and 2

Non-Catalytic Domains of ADAMTS13 Can Redirect the Substrate Specificity of ADAMTS5

B Subunits of Shiga Toxin 2 Induce VWF Secretion by a cAMP-Independent Protein Kinase A Signaling Pathway.

Shiga Toxin 1(Stx1) Stimulates Endothelial Cell VWF Secretion through a Ca 2+ /PKC Signaling Pathway That Does Not Require the Active Toxin Stx1A Subunit

Assembly, Storage, and Secretion of Von Willebrand Factor.

Crystal Structure of Von Willebrand Factor (VWF) A1 Domain in Complex with Aptamer ARC1172, An Inhibitor of VWF-Platelet Binding

Binding of ADAMTS13 to Von Willebrand Factor Under Static Conditions and Under Fluid Shear Stress

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American Society of Hematology

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ASH Publications

American Society of Hematology

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