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Janina Ratajczak, M.D.,Ph.D.
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Journal Articles

Quiescent Status of Very Small Embryonic Like Stem Cells (VSELs) Points to Pivotal Role of Autocrine Role of Insulin-Like Growth Factor-2 (Igf2) – Ras-Activating Guanine Nucleotide Exchange Factor (Rasgrf1) Axis in Regulating Proliferation of Embryonic Stem Cells.

Izabela Klich, Ph.D., Maciek Tarnowski, Ph.D., Dong-Myung Shin, Ph.D., Janina Ratajczak, M.D.,Ph.D., Magdalena Kucia, PhD, Mariusz Z Ratajczak, MD, PhD
Journal: Blood
Blood (2009) 114 (22): 1484.
https://doi.org/10.1182/blood.V114.22.1484.1484
Published: 2009
Journal Articles

In Vitro and In Vivo Evidence That Umbilical Cord Blood (UCB)-Derived CD45-/SSEA-4+/OCT-4+/CD133+/CXCR4+/Lin- Very Small Embryonic/Epiblast Like Stem Cells (VSELs) Do Not Contain Clonogenic Hematopoietic Progenitors but Are Highly Enriched in More Primitive Stem Cells - Novel View On Hierarchy of UCB Stem Cell Compartment.

Ewa K. Zuba-Surma, PhD, Izabela Klich, Ph.D., Marcin Wysoczynski, PhD, Nicholas J Greco, PhD, Mary J. Laughlin, MD, Mariusz Z Ratajczak, MD, PhD, Janina Ratajczak, M.D., Ph.D.
Journal: Blood
Blood (2009) 114 (22): 35.
https://doi.org/10.1182/blood.V114.22.35.35
Published: 2009
Journal Articles

Granulocyte-Derived Cationic Peptides (GDCPs) Present in Leucophoresis Products Enhance Homing of Hematopoietic Stem Cells (HSCs) to SDF-1 Gradient; Potential Implications for Accelerated Recovery of Hematopoiesis After Transplantation of Mobilized Peripheral Blood Stem Cells (PBSC).

HakMo Lee, PhD, Wan Wu, Marcin Wysoczynski, Magdalena Kucia, Ph.D., Mary J. Laughlin, MD, Janina Ratajczak, M.D., Ph.D., Mariusz Z Ratajczak, MD, PhD
Journal: Blood
Blood (2009) 114 (22): 371.
https://doi.org/10.1182/blood.V114.22.371.371
Published: 2009
Journal Articles

Mobilization Studies in Complement-Deficient Mice Reveal That AMD3100 Mobilization Depends On Complement Cascade Activation and Suggest Involvement of “Membrane Attack Complex - MAC” in Egress of Hematopoietic Stem/Progenitor Cells.

Marcin Wysoczynski, PhD, HakMo Lee, PhD, Rui Liu, M.D., Wan Wu, Janina Ratajczak,, M.D., Ph.D., Mariusz Z Ratajczak, MD, PhD
Journal: Blood
Blood (2009) 114 (22): 367.
https://doi.org/10.1182/blood.V114.22.367.367
Published: 2009
Journal Articles

Novel Mechanistic Insight Into Mobilization of Hematopoietic Stem/Progenitor Cells (HSPCs): Complement Cascade and Membrane Attack Complex Activated in Bone Marrow Sinusoids During Mobilization Release From Erythrocytes Sphingosine-1 Phosphate – An Underappreciated Chemoattractant Executing Egress of HSPCs.

HakMo Lee, PhD, Marcin Wysoczynski, PhD, Wan Wu, Rui Liu, M.D., Magdalena Kucia, Ph.D., Anna Janowska-Wieczorek, MD, PhD, Janina Ratajczak, M.D., Ph.D., Mariusz Z Ratajczak, MD, PhD
Journal: Blood
Blood (2009) 114 (22): 31.
https://doi.org/10.1182/blood.V114.22.31.31
Published: 2009
Journal Articles

Novel Observation That Mice Lacking the Fifth Complement Cascade Protein Component (C5) Are Very Poor Stem Cell Mobilizers Explained by Defective Egress of Granulocytes: A Novel Role for Bone Marrow Granulocytes to Act as “ice Breaker” Cells in Facilitating Egress of Hematopoietic Stem/Progenitor Cells

Wan Wu, MS, Hakmoo Lee, Ph.D., Marcin Wysoczynski, MS, Magdalena Kucia, Ph.D., Janina Ratajczak, M.D., Ph.D., Mariusz Z Ratajczak, M.D., Ph.D.
Journal: Blood
Blood (2008) 112 (11): 67.
https://doi.org/10.1182/blood.V112.11.67.67
Published: 2008
Journal Articles

Optimization of Isolation and Further Molecular and Functional Characterization of SSEA-4 + /Oct-4 + /CD133 + /CXCR4 + /LIN neg /CD45 neg Very Small Embryonic-Like (VSEL) Stem Cells Isolated from Umbilical Cord Blood.

Ewa K Zuba-Surma, Ph.D., Magdalena Kucia, Ph.D., Izabela Klich, Ph.D., Nicholas Greco, PhD, Mary L Laughlin, M.D., Ph.D., Philip Paul, Ph.D., Mariusz Z Ratajczak, M.D., Ph.D., Janina Ratajczak, M.D., Ph.D.
Journal: Blood
Blood (2008) 112 (11): 2316.
https://doi.org/10.1182/blood.V112.11.2316.2316
Published: 2008
Journal Articles

CD45 − /ALDH low /SSEA-4 + /Oct-4 + /CD133 + /CXCR4 + /Lin − Very Small Embryonic-Like (VSEL) Stem Cells Isolated from Umbilical Cord Blood as Potential Long Term Repopulating Hematopoietic Stem Cells

Ewa K Zuba-Surma, Ph.D., Magdalena Kucia, Ph.D., Rui Liu, M.D., Mariusz Z Ratajczak, M.D., Ph.D., Janina Ratajczak, M.D., Ph.D.
Journal: Blood
Blood (2008) 112 (11): 2444.
https://doi.org/10.1182/blood.V112.11.2444.2444
Published: 2008
Journal Articles

An in Vitro and in Vivo Evidence That Human Rhabdomyosarcomas (RMS) Express Functional CXCR7 Receptor: Overlapping and Distinct Role of CXCR4-SDF-1 and CXCR7-SDF-1/ITAC Axes in Regulating Metastatic Behavior of RMS Cells

Kasia Grymula, Ph.D., Maciek Tarnowski, Ph.D., Radoslaw Maksym, Magdalena Kucia, Ph.D., Janina Ratajczak, M.D., Ph.D., Mariusz Z Ratajczak, M.D., Ph.D.
Journal: Blood
Blood (2008) 112 (11): 4732.
https://doi.org/10.1182/blood.V112.11.4732.4732
Published: 2008