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Jeff Lightfoot, PhD
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Journal Articles

Inhibition of c-Myc By Apto-253 As an Innovative Therapeutic Approach to Induce Cell Cycle Arrest and Apoptosis in Acute Myeloid Leukemia

Hongying Zhang, MD PhD, Andrea Local, PhD, Khalid Benbatoul, Peter Folger, Susan Sheng, PhD, Luis Esquivies, PhD, Jeff Lightfoot, PhD, Avanish Vellanki, William G. Rice, PhD
Journal: Blood
Blood (2016) 128 (22): 1716.
https://doi.org/10.1182/blood.V128.22.1716.1716
Published: 2016
Journal Articles

Discovery of Selective Dual Inhibitors of Bromodomain Protein BRD4 and JAK2 for Treatment of Hematologic Malignancies

Ram S. Upadhayaya, PhD, Raghava Reddy Kethiri, PhD, Avanish Vellanki, Jeff Lightfoot, PhD, Andrea Local, PhD, William G. Rice, PhD
Journal: Blood
Blood (2016) 128 (22): 5212.
https://doi.org/10.1182/blood.V128.22.5212.5212
Published: 2016
Journal Articles

Clinical Pharmacokinetics of Apto-253 Support Its Use As a Novel Agent for the Treatment of Relapsed or Refractory Hematologic Malignancies

William G. Rice, PhD, Jeff Lightfoot, PhD, Hongying Zhang, MD PhD, Tiffany Cheng, MSc, Avanish Vellanki, Robert Peralta, MSc, DVM, Stephen B Howell, MD, Andrea Local, Fannie Chau, Luis Esquivies
Journal: Blood
Blood (2015) 126 (23): 4934.
https://doi.org/10.1182/blood.V126.23.4934.4934
Published: 2015
Journal Articles

APTO-253 Induces KLF4 to Promote Potent in Vitro Pro-Apoptotic Activity in Hematologic Cancer Cell Lines and Antitumor Efficacy As a Single Agent and in Combination with Azacitidine in Animal Models of Acute Myelogenous Leukemia (AML)

William G Rice, PhD, Avanish Vellanki, MBS, MBA, Yoon Lee, PhD, Jeff Lightfoot, PhD, Robert Peralta, MSc, DVM, Mona Jamerlan, MSc, Hongnan Jin, Ronnie Lum, PhD, Tiffany Cheng, MSc
Journal: Blood
Blood (2014) 124 (21): 4813.
https://doi.org/10.1182/blood.V124.21.4813.4813
Published: 2014