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Journal Articles

FLT3 Ligand-DM1 Conjugate Selectively Targets Acute Myeloid Leukemia Cells with FLT3 Expression

Dengyang Zhang, PhD, Yao Guo, PhD, Yuming Zhao, MD, Liuting Yu, Zhiguang Chang, PhD, Han Zhong Pei, Junbin Huang, MDPhD, Chun Chen, MDPhD, Hongman Xue, MDPhD, Yihang Pan, MD, Ningning Li, PhD, Chengming Zhu, PhD, Zhizhuang Joe Zhao, PhD, Jian Yu, PhD, Yun Chen, PhD

Blood (2020) 136 (Supplement 1): 30–31.

https://doi.org/10.1182/blood-2020-140200

Published: 2020

Journal Articles

Wnt5a Induces Association of ROR1 with Ca 2+ /Calmodulin-Dependent Protein Kinase II and ROR1-Dependent Calcium Influx in Chronic Lymphocytic Leukemia

Liguang Chen, PhD, Yun Chen, PhD, Jian Yu, PhD, Ling Zhang, Laura Z. Rassenti, PhD, Thomas J. Kipps, MD, PhD

Blood (2018) 132 (Supplement 1): 1846.

https://doi.org/10.1182/blood-2018-99-119811

Published: 2018

Journal Articles

Cirmtuzumab Blocks Production of Proinflammatory Factors By Inhibiting Wnt5a/ROR1 Induced Activation of NF-Kappa B in Chronic Lymphocytic Leukemia

Yun Chen, PhD, Michael Y. Choi, MD, Liguang Chen, PhD, Jian Yu, PhD, Ling Zhang, Emanuela M. Ghia, PhD, Elsa Sanchez-Lopez, PhD, George F. Widhopf II, PhD, Karen Messer, PhD, Laura Z. Rassenti, PhD, Catriona Jamieson, MD PhD, Thomas J. Kipps, MD PhD

Blood (2018) 132 (Supplement 1): 4415.

https://doi.org/10.1182/blood-2018-99-111996

Published: 2018

Journal Articles

Wnt5a Induces ROR1 to Complex with DOCK2 and Promote Proliferation of Chronic Lymphocytic Leukemia Cells

Md Kamrul Hasan, PhD, Jian Yu, PhD, George F. Widhopf II, PhD, Laura Z. Rassenti, PhD, Liguang Chen, PhD, Zhouxin Shen, PhD, Steven P. Briggs, PhD, Thomas J. Kipps, MD

Blood (2017) 130 (Supplement 1): 388.

https://doi.org/10.1182/blood.V130.Suppl_1.388.388

Published: 2017

Journal Articles

Durable and Specific Inhibition of ROR1 Signaling Associates with Prolonged Progression Free Survival in Patients with Chronic Lymphocytic Leukemia Treated with Cirmtuzumab

Michael Choi, MD, George F. Widhopf II, PhD, Jian Yu, PhD, Liguang Chen, PhD, Md. Kamrul Hasan, PhD, Laura Z. Rassenti, PhD, Emily Pittman, PhD, Karen Messer, PhD, Charlene Gutierrez, BS, Reilly Lilianna Kidwell, BSc, Charles E. Prussak, PharmD, PhD, Januario E Castro, MD, Catriona Jamieson, MD PhD, Thomas J. Kipps, MD

Blood (2017) 130 (Supplement 1): 829.

https://doi.org/10.1182/blood.V130.Suppl_1.829.829

Published: 2017

Journal Articles

Wnt5a Induces ROR1 to Bind and Activate Cortactin, Which Functions in Planar Cell Polarity and Migration of Chronic Lymphocytic Leukemia Cells

Md Kamrul Hasan, PhD, Jian Yu, PhD, George F. Widhopf II, PhD, Laura Z. Rassenti, PhD, Thomas J. Kipps, MD

Blood (2017) 130 (Supplement 1): 389.

https://doi.org/10.1182/blood.V130.Suppl_1.389.389

Published: 2017

Journal Articles

Wnt5a Can Induce Activation of Rac1 and Proliferation in Mantle Cell Lymphoma Via a ROR1-Dependent, but BTK-Independent, Signaling Pathway

Jian Yu, PhD, Yun Chen, PhD, Liguang Chen, PhD, Ling Zhang, Laura Z. Rassenti, PhD, George F. Widhopf II, PhD, Thomas J. Kipps, MD

Blood (2017) 130 (Supplement 1): 4019.

https://doi.org/10.1182/blood.V130.Suppl_1.4019.4019

Published: 2017

Journal Articles

Wnt5a Induces Interleukin-6 Via a ROR1-Dependent Pathway in Chronic Lymphocytic Leukemia, Leading to Leukemia-Cell Activation of STAT3

Yun Chen, PhD, Liguang Chen, PhD, Jian Yu, PhD, Ling Zhang, Laura Z. Rassenti, PhD, Thomas J. Kipps, MD

Blood (2017) 130 (Supplement 1): 4282.

https://doi.org/10.1182/blood.V130.Suppl_1.4282.4282

Published: 2017

Journal Articles

Nurse-like Cells Express High-Levels of Wnt5a, Which Induces ROR1-Dependent Signaling That Promotes Migration and Survival of Neoplastic Cells in Chronic Lymphocytic Leukemia

Yun Chen, PhD, Liguang Chen, PhD, Jian Yu, PhD, Ling Zhang, Laura Z. Rassenti, PhD, Thomas J. Kipps, MD

Blood (2017) 130 (Supplement 1): 3007.

https://doi.org/10.1182/blood.V130.Suppl_1.3007.3007

Published: 2017

Journal Articles

Wnt5a Induces ROR1 to Complex with HS1, Which Undergoes Tyrosine Phosphorylation and Contributes to Planar-Cell-Polarity Migration in Chronic Lymphocytic Leukemia

Md Kamrul Hasan, PhD, Jian Yu, PhD, Liguang Chen, PhD, Bing Cui, PhD, Zhouxin Shen, PhD, George F. Widhopf, II, PhD, Laura Z. Rassenti, PhD, Steven P. Briggs, PhD, Thomas J. Kipps, MD, PhD

Blood (2016) 128 (22): 301.

https://doi.org/10.1182/blood.V128.22.301.301

Published: 2016

Journal Articles

Cirmtuzumab Targets ROR1 to Inhibit Ibrutinib-Resistant, Wnt5a-Induced Rac1 Activation in Chronic Lymphocytic Leukemia

Jian Yu, PhD, Liguang Chen, PhD, Bing Cui, PhD, Christina Wu, PhD, Michael Y. Choi, MD, Yun Chen, PhD, Ling Zhang, Laura Z. Rassenti, PhD, George F. Widhopf, II, PhD, Thomas J. Kipps, MD, PhD

Blood (2016) 128 (22): 2034.

https://doi.org/10.1182/blood.V128.22.2034.2034

Published: 2016

Journal Articles

Wnt5a Induces Association of ROR1 with 14-3-3ζ to Enhance Chemotaxis and Proliferation in Chronic Lymphocytic Leukemia

Jian Yu, PhD, Liguang Chen, PhD, Yun Chen, PhD, Ling Zhang, Laura Z. Rassenti, PhD, George F. Widhopf, II, PhD, Zhouxin Shen, PhD, Steven P. Briggs, PhD, Thomas J. Kipps, MD, PhD

Blood (2016) 128 (22): 349.

https://doi.org/10.1182/blood.V128.22.349.349

Published: 2016

Journal Articles

Immunotherapeutic Targeting of ROR1-Dependent, Non-Canonical Wnt5a-Signaling By Cirmtuzumab: A First-in-Human Phase I Trial for Patients with Intractable Chronic Lymphocytic Leukemia

Michael Y. Choi, MD, George F. Widhopf, II, PhD, Jian Yu, PhD, Reilly L Kidwell, BS, BA, CCRC, Laura Z. Rassenti, PhD, Charlene Gutierrez, Susette Gorak, Tiffany Juarez, PhD, Emily Pittman, PhD, Hongying Li, PhD, Karen Messer, PhD, Charles Prussak, PhD, Januario E. Castro, MD, Catriona Jamieson, MD PhD, Thomas J. Kipps, MD, PhD

Blood (2016) 128 (22): 3224.

https://doi.org/10.1182/blood.V128.22.3224.3224

Published: 2016

Journal Articles

Structural Features of ROR1 Required for Complexing with ROR2 and Enhancing Chemokine-Induced Migration and Leukemia-Cell Proliferation, Which Can be Blocked By the Anti-ROR1 Mab Cirmtuzumab (UC-961)

Jian Yu, PhD, Liguang Chen, MD PhD, George F. Widhopf, II, PhD, Suping Zhang, PhD, Bing Cui, PhD, Rongrong Wu, PhD, Ling Zhang, PhD, Thomas J. Kipps, MD, PhD

Blood (2015) 126 (23): 1741.

https://doi.org/10.1182/blood.V126.23.1741.1741

Published: 2015

Journal Articles

High-Level Expression of ROR1 Associates with Early Disease Progression in Patients with Chronic Lymphocytic Leukemia

Bing Cui, PhD, Liguang Chen, MD PhD, Laura Z. Rassenti, PhD, Emanuela M. Ghia, PhD, Jian Yu, PhD, Ling Zhang, PhD, Donna S Neuberg, ScD, William Wierda, MD PhD, Michael Keating, MBBS, Kanti R. Rai, MD, Neil E. Kay, MD, Jennifer R. Brown, MD PhD, John C. Byrd, MD, John Gribben, MDDSc, Thomas J. Kipps, MD, PhD

Blood (2015) 126 (23): 1713.

https://doi.org/10.1182/blood.V126.23.1713.1713

Published: 2015

Journal Articles

Targeting Of Chronic Lymphocytic Leukemia B Cells With a Humanized Monoclonal Antibody Specific For ROR1

George F. Widhopf, II, PhD, Bing Cui, Ph.D., Christina C.N. Wu, PhD, Jian Yu, PhD, Fitzgerald Lao, Rommel Tawatao, Rongrong Wu, Esther Avery, B.S., Anil Sadarangani, PhD, Charles Prussak, PhD, Catriona HM Jamieson, MD, PhD, Dennis A. Carson, M.D., Thomas J. Kipps, MD, PhD

Blood (2013) 122 (21): 2873.

https://doi.org/10.1182/blood.V122.21.2873.2873

Published: 2013

Journal Articles

Preclinical Development Of ROR1 Peptide Based Vaccine With Activity Against Chronic Lymphocytic Leukemia In ROR1 Transgenic Mice

Jian Yu, PhD, Bing Cui, Ph.D., George F. Widhopf, II, PhD, Liguang Chen, MD, PhD, Laura Rassenti, PhD, Zhengran Wang, BS, Shuyu Ma, BS, Tomoko Hayashi, M.D., Ph.D., Dennis A. Carson, M.D., Thomas J. Kipps, MD, PhD

Blood (2013) 122 (21): 4174.

https://doi.org/10.1182/blood.V122.21.4174.4174

Published: 2013

Journal Articles

Human ROR1 Activates AKT and Accelerates Leukemia Cell Proliferation

Suping Zhang, PhD, Liguang Chen, MD, PhD, Ling Zhang, Jian Yu, PhD, Laura Z. Rassenti, Ph.D., Thomas J. Kipps, MD, PhD

Blood (2012) 120 (21): 3872.

https://doi.org/10.1182/blood.V120.21.3872.3872

Published: 2012

Journal Articles

Targeting of Chronic Lymphocytic Leukemia B Cells with a Novel Monoclonal Antibody to ROR1

Bing CUi, PhD, George F. Widhopf, II, PhD, Jian Yu, PhD, Daniel Martinez, BS, Esther Avery, B.S., Suping Zhang, PhD, Liguang Chen, MD, PhD, Rongrong Wu, Christina C.N. Wu, Ph.D., Charles Prussak, PhD, Thomas J. Kipps, M.D., Ph.D

Blood (2011) 118 (21): 984.

https://doi.org/10.1182/blood.V118.21.984.984

Published: 2011

Journal Articles

Agelastatin A (AgA), a Marine Sponge Derived Alkaloid, Inhibits Wnt/Beta-Catenin Signaling and Selectively Induces Apoptosis in Chronic Lymphocytic Leukemia Independently of p53

Michael Y. Choi, MD, Johanna Melo Cardenas, BSc, Desheng Lu, MD, PhD, Jian Yu, PhD, E. Paige Stout, PhD, Raymond P. Wu, Ph.D., John M Horton, B.S., Allison Gomez, Julio A. Diaz-Perez, M.D., M.S., Dennis A. Carson, M.D., Tadeusz F. Molinski, PhD, Thomas J. Kipps, M.D., Ph.D, Januario E. Castro, M.D.

Blood (2011) 118 (21): 1786.

https://doi.org/10.1182/blood.V118.21.1786.1786

Published: 2011

NARROW

FLT3 Ligand-DM1 Conjugate Selectively Targets Acute Myeloid Leukemia Cells with FLT3 Expression

Wnt5a Induces Association of ROR1 with Ca 2+ /Calmodulin-Dependent Protein Kinase II and ROR1-Dependent Calcium Influx in Chronic Lymphocytic Leukemia

Cirmtuzumab Blocks Production of Proinflammatory Factors By Inhibiting Wnt5a/ROR1 Induced Activation of NF-Kappa B in Chronic Lymphocytic Leukemia

Wnt5a Induces ROR1 to Complex with DOCK2 and Promote Proliferation of Chronic Lymphocytic Leukemia Cells

Durable and Specific Inhibition of ROR1 Signaling Associates with Prolonged Progression Free Survival in Patients with Chronic Lymphocytic Leukemia Treated with Cirmtuzumab

Wnt5a Induces ROR1 to Bind and Activate Cortactin, Which Functions in Planar Cell Polarity and Migration of Chronic Lymphocytic Leukemia Cells

Wnt5a Can Induce Activation of Rac1 and Proliferation in Mantle Cell Lymphoma Via a ROR1-Dependent, but BTK-Independent, Signaling Pathway

Wnt5a Induces Interleukin-6 Via a ROR1-Dependent Pathway in Chronic Lymphocytic Leukemia, Leading to Leukemia-Cell Activation of STAT3

Nurse-like Cells Express High-Levels of Wnt5a, Which Induces ROR1-Dependent Signaling That Promotes Migration and Survival of Neoplastic Cells in Chronic Lymphocytic Leukemia

Wnt5a Induces ROR1 to Complex with HS1, Which Undergoes Tyrosine Phosphorylation and Contributes to Planar-Cell-Polarity Migration in Chronic Lymphocytic Leukemia

Cirmtuzumab Targets ROR1 to Inhibit Ibrutinib-Resistant, Wnt5a-Induced Rac1 Activation in Chronic Lymphocytic Leukemia

Wnt5a Induces Association of ROR1 with 14-3-3ζ to Enhance Chemotaxis and Proliferation in Chronic Lymphocytic Leukemia

Immunotherapeutic Targeting of ROR1-Dependent, Non-Canonical Wnt5a-Signaling By Cirmtuzumab: A First-in-Human Phase I Trial for Patients with Intractable Chronic Lymphocytic Leukemia

Structural Features of ROR1 Required for Complexing with ROR2 and Enhancing Chemokine-Induced Migration and Leukemia-Cell Proliferation, Which Can be Blocked By the Anti-ROR1 Mab Cirmtuzumab (UC-961)

High-Level Expression of ROR1 Associates with Early Disease Progression in Patients with Chronic Lymphocytic Leukemia

Targeting Of Chronic Lymphocytic Leukemia B Cells With a Humanized Monoclonal Antibody Specific For ROR1

Preclinical Development Of ROR1 Peptide Based Vaccine With Activity Against Chronic Lymphocytic Leukemia In ROR1 Transgenic Mice

Human ROR1 Activates AKT and Accelerates Leukemia Cell Proliferation

Targeting of Chronic Lymphocytic Leukemia B Cells with a Novel Monoclonal Antibody to ROR1

Agelastatin A (AgA), a Marine Sponge Derived Alkaloid, Inhibits Wnt/Beta-Catenin Signaling and Selectively Induces Apoptosis in Chronic Lymphocytic Leukemia Independently of p53

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American Society of Hematology

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American Society of Hematology

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