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John R Jones, MD
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Journal Articles

The Addition of Carfilzomib to a Lenalidomide-Based Triplet Improves Outcomes in Newly Diagnosed Transplant Eligible Myeloma Patients with Renal Impairment: A Subgroup Analysis of the Myeloma XI Trial

Charlotte Pawlyn, BA,PhDMBBChir,MRCP,FRCPath, Tom Menzies, Faith E. Davies, Ritika Rana, Jennifer Pinney, Gordon Cook, MD, Walter Martin Gregory, PhD, Matthew W Jenner, John R Jones, MD, Martin F. Kaiser, MD FRCP, FRCPath, Roger G Owen, MD, Gareth Morgan, MD PhD, Graham H Jackson, MD MA, MB BS, FRCP, FRCPath, David Cairns, MSc, PhD, Mark T Drayson, MB ChB, PhD FRCPath
Journal: Blood
Blood (2020) 136 (Supplement 1): 40–43.
https://doi.org/10.1182/blood-2020-139238
Published: 2020
Journal Articles

Mutations in CRBN and Other Cereblon Pathway Genes Are Only Associated with Acquired Resistance to Immunomodulatory Drugs in a Subset of Patients and Cell Line Models

Amy Barber, PhD, John R Jones, MD, Harvey Che, Yann-Vai Le Bihan, Niels Weinhold, PhD, Cody Ashby, PhD, Brian A Walker, PhD, Christopher P. Wardell, PhD MSc, BSc, Hannah Wang, PhD, Martin F. Kaiser, MD FRCP, FRCPath, Graham H Jackson, MD MA, MB BS, FRCP, FRCPath, Faith E. Davies, Rajesh Chopra, MD, Gareth Morgan, MD PhD, Charlotte Pawlyn, BA,PhDMBBChir,MRCP,FRCPath
Journal: Blood
Blood (2020) 136 (Supplement 1): 6–7.
https://doi.org/10.1182/blood-2020-140024
Published: 2020
Journal Articles

Lenalidomide Maintenance Prolongs Progression-Free Survival and Does Not Impact the Aggressiveness of Clinical Relapse: Data from Long-Term Follow up of the Myeloma XI Trial

Charlotte Pawlyn, BA,PhDMBBChir,MRCP,FRCPath, Faith E. Davies, MD, Kara-Louise Royle, MSc, David Cairns, MSc, PhD, Gordon Cook, Mark T Drayson, MB ChB, PhD FRCPath, Walter M Gregory, PhD, Matthew Jenner, MBBS, MRCP, FRCPath, John R Jones, MD, Martin F. Kaiser, Roger G. Owen, MD, Nigel H. Russell, MD, Gareth Morgan, MDPhDFRCP, Graham Jackson, MA, MB BS, FRCP, FRCPath, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1889.
https://doi.org/10.1182/blood-2019-126103
Published: 2019
Journal Articles

Lenalidomide Induction and Maintenance Maximizes Outcome for Newly Diagnosed Transplant Eligible Myeloma Patients Irrespective of Risk Status: Long-Term Follow-up of the Myeloma XI Trial

Graham Jackson, MA, MB BS, FRCP, FRCPath, MD, Charlotte Pawlyn, BA,PhDMBBChir,MRCP,FRCPath, David Cairns, MSc, PhD, John R Jones, MD, Bhuvan Kishore, MB BS, MRCP, FRCPath, Mamta Garg, MD FRCP, FRCPath, Cathy Williams, MD MRCP, FRCPath, Kamaraj Karunanithi, MD FRCPath, Jindriska Lindsay, MD, MRCP, FRCPath, Nigel H. Russell, MD, Matthew Jenner, MBBS, MRCP, FRCPath, Gordon Cook, MB ChB, PhD FRCP(Glas), FRCPath, Mark T Drayson, MB ChB, PhD FRCPath, Roger G. Owen, MD, Walter M Gregory, PhD, Martin F. Kaiser, Faith E. Davies, MD, Gareth Morgan, MDPhDFRCP
Journal: Blood
Blood (2019) 134 (Supplement_1): 1910.
https://doi.org/10.1182/blood-2019-126160
Published: 2019
Journal Articles

Sex Differences in Multiple Myeloma Biology and Clinical Outcomes: Results from 3894 Patients in the Myeloma XI Trial

Sarah Anne Bird, David Cairns, MSc, PhD, Faith E. Davies, MD, Kevin Boyd, MB BS, BSc, MRCP, FRCPath, PhD, Gordon Cook, Mark T Drayson, MB ChB, PhD FRCPath, Walter M Gregory, PhD, Matthew Jenner, MBBS, MRCP, FRCPath, John R Jones, MD, Martin F. Kaiser, Roger G. Owen, MD, Nigel H. Russell, MD, Gareth Morgan, MDPhDFRCP, Graham Jackson, MA, MB BS, FRCP, FRCPath, MD, Charlotte Pawlyn, BA,PhDMBBChir,MRCP,FRCPath
Journal: Blood
Blood (2019) 134 (Supplement_1): 4374.
https://doi.org/10.1182/blood-2019-128041
Published: 2019
Journal Articles

Title - Myeloma XI Trial for Newly Diagnosed Multiple Myeloma (NDMM); Long Term Second Primary Malignancy (SPM) Incidence in the Context of Lenalidomide Maintenance

John R Jones, MD, David Cairns, MSc, PhD, Charlotte Pawlyn, BA,PhDMBBChir,MRCP,FRCPath, Faith E. Davies, MD, Rachel Sigsworth, Matthew Jenner, MBBS, MRCP, FRCPath, Martin F. Kaiser, Rebecca Mottram, BA, BSc, Mark T Drayson, MB ChB, PhD FRCPath, Gordon Cook, Walter M Gregory, PhD, Roger G. Owen, MD, Kevin Boyd, MB BS, BSc, MRCP, FRCPath, PhD, Graham Jackson, MA, MB BS, FRCP, FRCPath, MD, Gareth Morgan, MDPhDFRCP
Journal: Blood
Blood (2019) 134 (Supplement_1): 3132.
https://doi.org/10.1182/blood-2019-127469
Published: 2019
Journal Articles

Frailty-Adjusted Therapy in Transplant Non-Eligible Patients with Newly Diagnosed Multiple Myeloma (FiTNEss): A UK Myeloma Research Alliance Study, Myeloma XIV

David Cairns, MSc, PhD, Charlotte Pawlyn, BA,PhDMBBChir,MRCP,FRCPath, Kara-Louise Royle, MSc, Phillip Best, Jenny Bird, MD, Stella Bowcock, MD BA, FRCP, FRCPath, MA, Kevin Boyd, MB BS, BSc, MRCP, FRCPath, PhD, Bryony Dawkins, BA, MSc, Mark T Drayson, MB ChB, PhD FRCPath, Rowena Henderson, Matthew Jenner, MBBS, MRCP, FRCPath, John R Jones, MD, Martin F. Kaiser, Bhuvan Kishore, MB BS, MRCP, FRCPath, David Meads, Ba, MSc, PhD, Rebecca Mottram, BA, BSc, Neil K Rabin, Roger G. Owen, MD, Graham Jackson, MA, MB BS, FRCP, FRCPath, MD, Gordon Cook
Journal: Blood
Blood (2019) 134 (Supplement_1): 3153.
https://doi.org/10.1182/blood-2019-126207
Published: 2019
Journal Articles

Thrombotic Events in Patients with Myeloma Treated with Immunomodulatory Drugs; Results of the Myeloma XI Study

Charlotte A Bradbury, PhD MD FRCPath, FRCP, MSc, Matthew W Jenner, Alina Striha, MSc, Gordon Cook, MD PhD, Charlotte Pawlyn, BA,PhDMBBChir,MRCP,FRCPath, John R Jones, MD, David Cairns, BSc, MSc, PhD, Anna Hockaday, Andrea Paterson, Mark T Drayson, MD PhD, Roger G Owen, MD, Martin F Kaiser, MD, Walter M Gregory, PhD, Faith E. Davies, MD, Gareth J. Morgan, MD PhD, Graham H Jackson, MDPhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 553.
https://doi.org/10.1182/blood.V130.Suppl_1.553.553
Published: 2017
Journal Articles

Minimal Residual Disease in the Maintenance Setting in Myeloma: Prognostic Significance and Impact of Lenalidomide

Ruth M de Tute, PhD FRCPath, David Cairns, BSc, MSc, PhD, Andy Rawstron, PhD, Charlotte Pawlyn, BA,PhDMBBChir,MRCP,FRCPath, Faith E. Davies, MD, John R Jones, MD, Martin F Kaiser, MD, Anna Hockaday, Alina Striha, MSc, Rowena Henderson, PhD, Gordon Cook, PhD, Nigel H. Russell, Mark T Drayson, MD PhD, Matthew W Jenner, Walter M Gregory, PhD, Graham Jackson, MDPhD, Gareth J. Morgan, MD PhD, Roger G. Owen, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 904.
https://doi.org/10.1182/blood.V130.Suppl_1.904.904
Published: 2017
Journal Articles

The Mutational Landscape of Relapse in High Risk Myeloma Is Significantly Impacted By the Depth of Response but Not Maintenance Lenalidomide

John R Jones, MD, Niels Weinhold, PhD, Cody Cody Ashby, PhD, Charlotte Pawlyn, BA,PhDMBBChir,MRCP,FRCPath, Brian A Walker, PhD, Christopher P. Wardell, PhD, Lorenzo Melchor, Leo Rasche, MD, David C. Johnson, PhD, Sidra Ellis, Amy L Sherborne, PhD, Gordon Cook, MD PhD FRCP, FRCPath, Matthew W Jenner, Martin F Kaiser, MD, Walter M Gregory, PhD, Mark T Drayson, MD PhD, Roger G Owen, MD, Graham Jackson, MDPhD, Faith E. Davies, MD, Melvyn F. Greaves, PhD, Gareth J. Morgan, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 396.
https://doi.org/10.1182/blood.V130.Suppl_1.396.396
Published: 2017
Journal Articles

Lenalidomide Maintenance Significantly Improves Outcomes Compared to Observation Irrespective of Cytogenetic Risk: Results of the Myeloma XI Trial

Graham Jackson, MDPhD, Faith E Davies, MD, Charlotte Pawlyn, BA,PhDMBBChir,MRCP,FRCPath, David Cairns, BSc, MSc, PhD, Alina Striha, MSc, Anna Hockaday, Inga Sakauskiene, John R Jones, MD, Bhuvan Kishore, MD, Mamta Garg, MD, Cathy Williams, Kamaraj Karunanithi, Jindriska Lindsay, MD, Matthew W Jenner, Gordon Cook, MD PhD, Martin F Kaiser, MD, Mark T Drayson, MD PhD, Roger G Owen, MD, Nigel H. Russell, Walter M Gregory, PhD, Gareth J. Morgan, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 436.
https://doi.org/10.1182/blood.V130.Suppl_1.436.436
Published: 2017
Journal Articles

Molecular Characterisation of TP53 Aberrations in 1,777 Myeloma Trial Patients

Vallari Shah, MBBS, Amy L Sherborne, PhD, Sidra Ellis, David C. Johnson, PhD, Farzana Begum, Jack Kendall, Brian A Walker, PhD, John R Jones, MD, Charlotte Pawlyn, BA,PhDMBBChir,MRCP,FRCPath, Suvi Savola, Matthew W Jenner, Mark T Drayson, MD PhD, Roger G. Owen, MD, David Cairns, BSc, MSc, PhD, Walter M Gregory, PhD, Richard S Houlston, MD PhD, Faith E Davies, MD, Gordon Cook, MD PhD FRCP, FRCPath, Gareth J. Morgan, MD PhD, Graham Jackson, MDPhD, Martin F Kaiser, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4331.
https://doi.org/10.1182/blood.V130.Suppl_1.4331.4331
Published: 2017
Journal Articles

Factors Predicting Poor Outcomes for Myeloma Patients at Different Ages: Results from 3894 Patients in the Myeloma XI Trial

Charlotte Pawlyn, BA,PhDMBBChir,MRCP,FRCPath, Martin F Kaiser, MD, David Cairns, BSc, MSc, PhD, Alina Striha, MSc, John R Jones, MD, Vallari Shah, MBBS, Matthew W Jenner, Mark T Drayson, MD PhD, Roger G Owen, MD, Walter M Gregory, PhD, Gordon Cook, MD PhD, Graham Jackson, MDPhD, Gareth J. Morgan, MD PhD, Faith E Davies, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3040.
https://doi.org/10.1182/blood.V130.Suppl_1.3040.3040
Published: 2017
Journal Articles

Continuous Treatment with Lenalidomide Improves Outcomes in Newly Diagnosed Myeloma Patients Not Eligible for Autologous Stem Cell Transplant: Results of the Myeloma XI Trial

Charlotte Pawlyn, BA,PhDMBBChir,MRCP,FRCPath, Faith E. Davies, MD, David Cairns, BSc, MSc, PhD, Alina Striha, MSc, Phillip Best, Rachel Sigsworth, John R Jones, MD, Bhuvan Kishore, MD, Mamta Garg, MD, Cathy Williams, Kamaraj Karunanithi, Jindriska Lindsay, MD, Matthew W Jenner, Gordon Cook, MD PhD, Martin F Kaiser, MD, Mark T Drayson, MD PhD, Roger G Owen, MD, Nigel H. Russell, Walter M Gregory, PhD, Graham Jackson, MDPhD, Gareth J. Morgan, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1854.
https://doi.org/10.1182/blood.V130.Suppl_1.1854.1854
Published: 2017
Journal Articles

The Impact of Maintenance Lenalidomide on the Mutational Status of the Myeloma Clone at Relapse in the NCRI Myeloma XI Trial for Newly Diagnosed Multiple Myeloma Patients (NDMM)

John R Jones, MD, Niels Weinhold, PhD, Shweta S. Chavan, PhD, Charlotte Pawlyn, MB BChir, Lorenzo Melchor, PhD, David A Cairns, MSc, PhD, Dil B Begum, Charlotte Smith, Sidra Ellis, Amy Price, Amy L Sherborne, Brian A Walker, PhD, Christopher P Wardell, PhD, Gordon Cook, MD PhD, Matthew W Jenner, MD, Nigel H Russell, MD, Mark T Drayson, MD PhD, Roger G Owen, MD PhD, Faith E Davies, MD, Martin F Kaiser, MD, Graham H Jackson, MD PhD, Walter M Gregory, PhD, Mel Greaves, Gareth J Morgan, MD PhD
Journal: Blood
Blood (2016) 128 (22): 4412.
https://doi.org/10.1182/blood.V128.22.4412.4412
Published: 2016
Journal Articles

Lenalidomide Is a Highly Effective Maintenance Therapy in Myeloma Patients of All Ages; Results of the Phase III Myeloma XI Study

Graham H Jackson, MD PhD, Faith E Davies, MD, Charlotte Pawlyn, MB BChir, David A Cairns, MSc, PhD, Alina Striha, MSc, Corinne Collett, Anna Waterhouse, John R Jones, MD, Bhuvan Kishore, MBBS, MRCP, FRCPath, Mamta Garg, MD, Cathy D Williams, Kamaraj Karunanithi, MBBS, MD, Jindriska Lindsay, MD, Matthew W Jenner, MD, Gordon Cook, MDPhD, Martin F Kaiser, MD, Mark T Drayson, MD PhD, Roger G Owen, MB BCh, MD, Nigel H Russell, MD, Walter M Gregory, PhD, Gareth J Morgan, MD PhD
Journal: Blood
Blood (2016) 128 (22): 1143.
https://doi.org/10.1182/blood.V128.22.1143.1143
Published: 2016
Journal Articles

Primary IMiD Refractory Myeloma; Results from 3894 Patients Treated in the Phase III Myeloma XI Study

Charlotte Pawlyn, MB BChir, Faith E Davies, MD, Martin F Kaiser, MD, David A Cairns, MSc, PhD, Alina Striha, MSc, Corinne Collett, Anna Waterhouse, John R Jones, MD, Bhuvan Kishore, MBBS, MRCP, FRCPath, Mamta Garg, MD, Cathy D Williams, Kamaraj Karunanithi, MBBS, MD, Jindriska Lindsay, MD, Matthew W Jenner, MD, Gordon Cook, MD PhD, Mark T Drayson, MD PhD, Roger G Owen, MB BCh, MD, Nigel H Russell, MD, Walter M Gregory, PhD, Graham H Jackson, MD PhD, Gareth J Morgan, MD PhD
Journal: Blood
Blood (2016) 128 (22): 1144.
https://doi.org/10.1182/blood.V128.22.1144.1144
Published: 2016
Journal Articles

Identifying Ultra-High Risk Myeloma By Integrated Molecular Genetic and Gene Expression Profiling

Amy L Sherborne, Dil B Begum, Amy Price, David C Johnson, PhD, Sidra Ellis, Charlotte Smith, Fabio Mirabella, PhD, Karen Menezes, Scott Kimber, John R Jones, MD, Charlotte Pawlyn, MB BChir, Richard S Houlston, MD PhD FRCP, Nigel H. Russell, V, MD, Matthew W Jenner, MD, Gordon Cook, Alina Striha, MSc, Corinne Collett, Anna Waterhouse, Walter M Gregory, PhD, David A Cairns, MSc, PhD, Mark T Drayson, MD PhD, Roger G Owen, MD PhD, Faith E Davies, MD, Gareth J Morgan, MD PhD, Graham H Jackson, MD PhD, Martin F Kaiser, MD
Journal: Blood
Blood (2016) 128 (22): 4407.
https://doi.org/10.1182/blood.V128.22.4407.4407
Published: 2016
Journal Articles

Inhibition of the Epigenetic Modifier EZH2 Upregulates Cell Cycle Control Genes to Inhibit Myeloma Cell Growth and Overcome High-Risk Disease Features

Charlotte Pawlyn, MB BChir, Michael Bright, PhD, Amy Buros, PhD, Caleb K. Stein, MS, Zoe Walters, PhD, Lauren Aronson, PhD, Fabio Mirabella, PhD, Martin F Kaiser, MD, John R Jones, MD, Brian A Walker, PhD, Graham H Jackson, MD PhD, Paul Clarke, PhD, Leif Bergsagel, MD, Paul Workman, PhD, Marta Chesi, PhD, Gareth J Morgan, MD PhD, Faith E Davies, MD
Journal: Blood
Blood (2016) 128 (22): 3289.
https://doi.org/10.1182/blood.V128.22.3289.3289
Published: 2016
Journal Articles

Response Adapted Induction Treatment Improves Outcomes for Myeloma Patients; Results of the Phase III Myeloma XI Study

Graham H Jackson, MD PhD, Faith E Davies, MD, Charlotte Pawlyn, MB BChir, David A Cairns, MSc, PhD, Alina Striha, MSc, Corinne Collett, Anna Waterhouse, John R Jones, MD, Bhuvan Kishore, MBBS, MRCP, FRCPath, Mamta Garg, MD, Cathy D Williams, Kamaraj Karunanithi, MBBS, MD, Jindriska Lindsay, MD, Matthew W Jenner, MD, Gordon Cook, MDPhD, Martin F Kaiser, MD, Mark T Drayson, MD PhD, Roger G Owen, MB BCh, MD, Nigel H Russell, MD, Walter M Gregory, PhD, Gareth J Morgan, MD PhD
Journal: Blood
Blood (2016) 128 (22): 244.
https://doi.org/10.1182/blood.V128.22.244.244
Published: 2016