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John T. Curnutte, MDPhD
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Journal Articles

Andexanet Alfa, a Universal Antidote Under Development for Factor Xa Inhibitors, Reverses Rivaroxaban-Induced Inhibition of Thrombin Generation Initiated By the Intrinsic Coagulation Pathway Independent of TFPI

Genmin Lu, PhD, Joyce Lin, BS, John T. Curnutte, MDPhD, Pamela B. Conley, PhD
Journal: Blood
Blood (2016) 128 (22): 3831.
https://doi.org/10.1182/blood.V128.22.3831.3831
Published: 2016
Journal Articles

Pharmacokinetic and Pharmacodynamic (PKPD) Modeling to Determine the Andexanet Alfa Dose to Reverse the Anticoagulant Activity of Direct Fxa Inhibitors

Leeds Janet, PhD, Genmin Lu, PhD, John T. Curnutte, MDPhD, Pamela B. Conley, PhD, Jaap W. Mandema, PhD
Journal: Blood
Blood (2015) 126 (23): 1135.
https://doi.org/10.1182/blood.V126.23.1135.1135
Published: 2015
Journal Articles

Reversal of Heparin-Induced Anticoagulation By Andexanet Alfa, a Universal Antidote for Factor Xa Inhibitors

Genmin Lu, PhD, Joyce Lin, BS, John T. Curnutte, MDPhD, Pamela B. Conley, PhD
Journal: Blood
Blood (2015) 126 (23): 2329.
https://doi.org/10.1182/blood.V126.23.2329.2329
Published: 2015
Journal Articles

Predicting Cerdulatinib Therapeutic Concentrations in Patients with Relapsed/Refractory B Cell Malignancies Using Preclinical Models and Clinical PK/PD and Tumor Response Correlates

Greg P. Coffey, PhD, Jiajia Feng, MD, Glenn Michelson, MD, Janet Leads, PhD, John T. Curnutte, MDPhD, Anjali Pandey, PhD, Pamela B. Conley, PhD
Journal: Blood
Blood (2015) 126 (23): 3706.
https://doi.org/10.1182/blood.V126.23.3706.3706
Published: 2015
Journal Articles

Clinical and Correlative Results of a Phase 1 Study of Cerdulatinib (PRT062070) a Dual SYK/JAK Inhibitor in Patients with Relapsed/Refractory B Cell Malignancies

Paul A Hamlin, Jr., MD, Ian Flinn, MD, Nina wagner-Johnston, MD, Jan A Burger, MD PhD, Glenn Michelson, MD, Anjali Pandey, PhD, Matt Birrell, Greg P. Coffey, PhD, Janet M Leeds, PhD, John T. Curnutte, MDPhD, Manish R. Patel, MD
Journal: Blood
Blood (2015) 126 (23): 3929.
https://doi.org/10.1182/blood.V126.23.3929.3929
Published: 2015
Journal Articles

A Phase I Open-Label, Multi-Dose Escalation Study of the Dual Syk/Jak Inhibitor PRT062070 (Cerdulatinib) in Patients with Relapsed/Refractory B Cell Malignancies

Manish Patel, Paul Hamlin, MD, Donald K Strickland, MD, Anjali Pandey, PhD, Greg Coffey, PhD, Janet M Leeds, PhD, Gallia G. Levy, MD PhD, John T. Curnutte, MDPhD, Nina Wagner-Johnston, Ian W. Flinn, MD
Journal: Blood
Blood (2014) 124 (21): 3103.
https://doi.org/10.1182/blood.V124.21.3103.3103
Published: 2014
Journal Articles

A Phase 2 Randomized, Double-Blind, Placebo-Controlled Trial Demonstrating Reversal of Edoxaban-Induced Anticoagulation in Healthy Subjects By Andexanet Alfa (PRT064445), a Universal Antidote for Factor Xa (fXa) Inhibitors

Mark Crowther, MD, Gallia G. Levy, MD PhD, Genmin Lu, PhD, Janet Leeds, PhD, Joyce Lin, BS, Pratikhya Pratikhya, MS, Pamela B. Conley, PhD, Stuart Connolly, MD, John T. Curnutte, MDPhD
Journal: Blood
Blood (2014) 124 (21): 4269.
https://doi.org/10.1182/blood.V124.21.4269.4269
Published: 2014