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Journal Articles

Mitochondrial Fate of Regenerative Hematopoietic Stem Cells Is Sequentially Controlled By Two Specific Conformations of Connexin-43

Abhishek K Singh, PhD, Ashley M Wellendorf, B.S., Breanna Bohan, B.S., Daniel Gonzalez-Nieto, PhD, Luis C Barrio, MD PhD, Ashwini S. Hinge, PhD, Marie-Dominique Filippi, PhD, Jose A. Cancelas, MD

Blood (2020) 136 (Supplement 1): 32–33.

https://doi.org/10.1182/blood-2020-141676

Published: 2020

Journal Articles

RhoA Targeting Suppresses Cold-Induced Platelet Lesion and Allows Refrigerated Storage of Functional Human Platelets to Fourteen Days

Shailaja N Hegde, PhD, Huzoor Akbar, PhD, Shawnagay Nestheide, BS, Ashley M Wellendorf, B.S., Breanna Bohan, James F Johnson, Yi Zheng, PhD, Jose A Cancelas, MD

Blood (2019) 134 (Supplement_1): 99.

https://doi.org/10.1182/blood-2019-125359

Published: 2019

Journal Articles

Differential Metabolomics and Lipidomics of Hypoxic/Hypocapnic Long-Term Stored Red Cells Associate with Improved 24-Hour Recovery after Transfusion

Tatsuro Yoshida, PhD, Angelo D'Alessandro, PhD, Xiaoyun Fu, PhD, Travis Nemkov, PhD, Davide Stefanoni, Michael Dioguardi, BS, Neeta Rugg, Shawnagay Nestheide, BS, William Iselin, BA, Andrew Dunham, PhD, James C. Zimring, MD PhD, Jose A Cancelas, MD

Blood (2019) 134 (Supplement_1): 4994.

https://doi.org/10.1182/blood-2019-125961

Published: 2019

Journal Articles

Long-Term Hypoxic/Hypocapnic Storage of Red Blood Cells Results in Amelioration of Lesion Hallmarks and Increased In Vivo recovery at 24 Hours Post-Transfusion

Jose A Cancelas, MD, F. Bernadette West, MD, Matthew Karaffin, MD, Tatsuro Yoshida, PhD, Neeta Rugg, Pamela Whitley, MS, MT(ASCP), SBB, Michael Dioguardi, BS, Scott Brooks, CCRP, Michael Wellington, William Iselin, BA, Andrew Dunham, PhD

Blood (2019) 134 (Supplement_1): 4995.

https://doi.org/10.1182/blood-2019-128559

Published: 2019

Journal Articles

Disruption of the Akt-FoxO Axis As a Safeguard Mechanism for the Hematopoietic Stem Cell Compartment during Chronic Metabolic Stress

Vinothini Govindarajah, PhD, Jung-Mi Lee, PhD, Michael Solomon, Bryan Goddard, Ramesh C. Nayak, PhD, Jose A Cancelas, MD, Damien Reynaud

Blood (2019) 134 (Supplement_1): 1201.

https://doi.org/10.1182/blood-2019-127222

Published: 2019

Journal Articles

The Small Molecule IODVA1 Inhibits the Rac Guanine Nucleotide Exchange Factor Vav3 and Overcomes TKI-Resistance in Ph + (BCR-ABL1) B-ALL

Nicolas Nassar, PhD, Shailaja N Hegde, PhD, Anjelika Gasilina, Mark Wunderlich, MS, Gurdat Premnauth, Edward Merino, PhD, Yuan Lin, PhD, Reza Ahmadian, PhD, Yi Zheng, PhD, Benjamin Mizukawa, Lisa Privette Vinnedge, PhD, Jose A Cancelas, MD

Blood (2019) 134 (Supplement_1): 4647.

https://doi.org/10.1182/blood-2019-130250

Published: 2019

Journal Articles

Bone Marrow Hematopoietic Connexin 43 Is Required for Mitotransfer and AMPK Dependent Mesenchymal Microenvironment Regeneration after Irradiation

Abhishek K Singh, PhD, Karin Golan, PhD, Mark J Althoff, BS, Ekaterina Petrovich-Kopitman, Ashley M Wellendorf, B.S., Fatima Mohmoud, B.S., Mayla Bertagna, MSc, Daniel Gonzalez-Nieto, PhD, Luis C Barrio, MD PhD, Tsvee Lapidot, PhD, Jose A Cancelas, MD PhD

Blood (2018) 132 (Supplement 1): 872.

https://doi.org/10.1182/blood-2018-99-118292

Published: 2018

Journal Articles

Basal Polarity Complex Scribble Is Required for Leukemic Initiation and Propagation through Negative Regulation of Apical Polarity Complex Activator Cdc42 and Hypoxia Inducing Factor-1α

Shailaja N Hegde, PhD, Mark J Althoff, BS, Ramesh C. Nayak, PhD, Ashley M Wellendorf, B.S., Fatima Mohmoud, B.S., Gang Huang, PhD, Yi Zheng, PhD, Maria T Diaz-Meco, PhD, Jorge Moscat, PhD, Jose A Cancelas, MD PhD

Blood (2018) 132 (Supplement 1): 551.

https://doi.org/10.1182/blood-2018-99-118919

Published: 2018

Journal Articles

Connexin-43 Is a Negative Regulator of Mitochondrial Fission, Mitophagy and Apoptosis of Dividing Hematopoietic Stem Cells through the Drp1-Pink1 Axis

Blood (2018) 132 (Supplement 1): 639.

https://doi.org/10.1182/blood-2018-99-118663

Published: 2018

Journal Articles

Uncoupling Sickle Hematopoiesis Induced Angiotensin Receptor Signaling in Sickle Nephropathy

Swarnava Roy, PhD, Parul Rai, MD, Marthe-Sandrine Eiymo Mwa Mpollo, PhD, Kyung-Hee Chang, PhD, Tilat Rizvi, Loberg Anastacia, Bruce J. Aronow, PhD, Tadashi Inagami, PhD, David Witte, MD, Jose A Cancelas, MD PhD, Punam Malik, MD

Blood (2017) 130 (Supplement 1): 440.

https://doi.org/10.1182/blood.V130.Suppl_1.440.440

Published: 2017

Journal Articles

Scribble Controls HSC Self-Renewal through Polarity-Dependent Activation of the Hippo Signaling Pathway

Mark J Althoff, BS, Ramesh C. Nayak, PhD, Shailaja Hegde, PhD, Ashley M Wellendorf, B.S., Fatima Mohmoud, B.S., Maria T Diaz-Meco, PhD, Jorge Moscat, PhD, Jose A Cancelas, MD PhD

Blood (2017) 130 (Supplement 1): 710.

https://doi.org/10.1182/blood.V130.Suppl_1.710.710

Published: 2017

Journal Articles

Treatment of Bleeding in Severely Thrombocytopenic Patients with Transfusion of Dimethyl Sulfoxide (DMSO) Cryopreserved Platelets (CPP) Is Safe - Report of a Phase 1 Dose Escalation Safety Trial

Sherrill J. Slichter, MD, Larry J. Dumont, PhD MBA, Jose A. Cancelas, MD PhD, Terry Gernsheimer, MD, Zbigniew Szczepiorkowski, MD PhD, Nancy M. Dunbar, MD, Stephen Medlin, DO, FACP, MeLinh Jones, B.S., Neeta Rugg, M.S., Gautham Prakash, B.S., Greggory J. Housler, MSc, MBA, Victor W. MacDonald, PhD, Peter Hmel, M.S., Janet H. Ransom, PhD

Blood (2016) 128 (22): 1030.

https://doi.org/10.1182/blood.V128.22.1030.1030

Published: 2016

Journal Articles

Atypical Protein Kinase C λ/I Oncogenic Signaling through the Chromatin Modifier Satb2 Is Required for Leukemic B-Cell Progenitor Differentiation Arrest and Leukemogenesis

Ramesh C Nayak, Mark Jordan Althoff, BS, Ashley Wellendorf, Fatima Mohmoud, Maria Diaz-Meco, Jorge Moscat, Jose A. Cancelas, MD PhD

Blood (2016) 128 (22): 1201.

https://doi.org/10.1182/blood.V128.22.1201.1201

Published: 2016

Journal Articles

TRAF6 Is Essential for Maintaining Hematopoietic Stem Cell Homeostasis

Jing Fang, MD PhD, Lyndsey Bolanos, BSc, Juana Serrano-Lopez, PhD, Susanne Christie, Jose A Cancelas, MD PhD, Daniel T Starczynowski, PhD

Blood (2016) 128 (22): 568.

https://doi.org/10.1182/blood.V128.22.568.568

Published: 2016

Journal Articles

Mitochondria Transfer from Hematopoietic Stem and Progenitor Cells to Pdgfrα + /Sca-1 - /CD48 dim BM Stromal Cells Via CX43 Gap Junctions and AMPK Signaling Inversely Regulate ROS Generation in Both Cell Populations

Karin Golan, PhD, Ashley Wellendorf, Yuji Takihara, MD PhD, Anju Kumari, PhD, Eman Khatib-Massalha, Msc, Orit Kollet, PhD, Hui Cheng, PhD, Tao Cheng, MD, Mark J. Althoff, Shiri Gur-Cohen, PhD, Tomer Itkin, PhD, Marie-Dominique Fillipi, PhD, Jose A Cancelas, MD PhD, Toshio Suda, MD PhD, Tsvee Lapidot, PhD

Blood (2016) 128 (22): 5.

https://doi.org/10.1182/blood.V128.22.5.5

Published: 2016

Journal Articles

Long-Lasting Dysregulation of the Hematopoietic Stem Cell Compartment in Obesity

Jung-Mi Lee, PhD, Bryan Goddard, Ashwini S. Hinge, PhD, Bruce J. Aronow, PhD, Nathan Salomonis, PhD, Marie-Dominique Filippi, PhD, H. Leighton Grimes, PhD, Jose A Cancelas, MD PhD, Damien Reynaud, PhD

Blood (2015) 126 (23): 245.

https://doi.org/10.1182/blood.V126.23.245.245

Published: 2015

Journal Articles

Upregulation of Vav3 Is Required for Leukemogenesis By BCR-ABL through Polycomb Repression Complex Dependent De-Repression of the Cdkn2a Locus

Megha Desai, PhD, Kyung-Hee Chang, PhD, E. David Muench, BS, Anjelika Gasilina, Ashley Wellendorf, Xose R Bustelo, H. Leighton Grimes, PhD, Nicolas Nassar, PhD, Jose A Cancelas, MD PhD

Blood (2015) 126 (23): 3661.

https://doi.org/10.1182/blood.V126.23.3661.3661

Published: 2015

Journal Articles

Systemic Inflammation Recruits Ccr7 + Dendritric-Biased Granulocyte-Macrophage Progenitors to Lymphatic Circulation in a Non-Canonical Traf6-Dependent Manner

Juana Serrano-Lopez, PhD, Josefina Serrano, Cuiping Zhang, MD PhD, Ashley Wellendorf, Jing Fang, MDPhD, Joaquin Sanchez-Garcia, H. Leighton Grimes, PhD, Daniel T Starczynowski, PhD, Jose A Cancelas, MD PhD

Blood (2015) 126 (23): 785.

https://doi.org/10.1182/blood.V126.23.785.785

Published: 2015

Journal Articles

EGFR Signaling in Osteoblasts Regulates Circadian Rhythm of HSPC in Circulation

Sachin Kumar, PhD, Jeff Vassallo, PhD, Kalpana Nattamai, MSc, Jose A Cancelas, MD PhD, Hartmut Geiger, PhD

Blood (2015) 126 (23): 665.

https://doi.org/10.1182/blood.V126.23.665.665

Published: 2015

Journal Articles

Sqstm1 Is Required to Retain Hematopoietic Stem Cell/ Progenitors As a Negative Regulator of Macrophage-Dependent Inflammatory Signaling in the Bone Marrow Osteoblastic Niche

Kyung-Hee Chang, PhD, Amitava Sengupta, PhD, Ramesh C Nayak, Angeles Duran, Sang Jun Lee, Ronald Pratt, Ashley Wellendorf, Sarah Hill, Marcus Watkins, Roberto Civitelli, Daniel T Starczynowski, PhD, Maria T Diaz-Meco, Jorge Moscat, Jose A Cancelas, MD PhD

Blood (2014) 124 (21): 350.

https://doi.org/10.1182/blood.V124.21.350.350

Published: 2014

NARROW

Mitochondrial Fate of Regenerative Hematopoietic Stem Cells Is Sequentially Controlled By Two Specific Conformations of Connexin-43

RhoA Targeting Suppresses Cold-Induced Platelet Lesion and Allows Refrigerated Storage of Functional Human Platelets to Fourteen Days

Differential Metabolomics and Lipidomics of Hypoxic/Hypocapnic Long-Term Stored Red Cells Associate with Improved 24-Hour Recovery after Transfusion

Long-Term Hypoxic/Hypocapnic Storage of Red Blood Cells Results in Amelioration of Lesion Hallmarks and Increased In Vivo recovery at 24 Hours Post-Transfusion

Disruption of the Akt-FoxO Axis As a Safeguard Mechanism for the Hematopoietic Stem Cell Compartment during Chronic Metabolic Stress

The Small Molecule IODVA1 Inhibits the Rac Guanine Nucleotide Exchange Factor Vav3 and Overcomes TKI-Resistance in Ph + (BCR-ABL1) B-ALL

Bone Marrow Hematopoietic Connexin 43 Is Required for Mitotransfer and AMPK Dependent Mesenchymal Microenvironment Regeneration after Irradiation

Basal Polarity Complex Scribble Is Required for Leukemic Initiation and Propagation through Negative Regulation of Apical Polarity Complex Activator Cdc42 and Hypoxia Inducing Factor-1α

Connexin-43 Is a Negative Regulator of Mitochondrial Fission, Mitophagy and Apoptosis of Dividing Hematopoietic Stem Cells through the Drp1-Pink1 Axis

Uncoupling Sickle Hematopoiesis Induced Angiotensin Receptor Signaling in Sickle Nephropathy

Scribble Controls HSC Self-Renewal through Polarity-Dependent Activation of the Hippo Signaling Pathway

Treatment of Bleeding in Severely Thrombocytopenic Patients with Transfusion of Dimethyl Sulfoxide (DMSO) Cryopreserved Platelets (CPP) Is Safe - Report of a Phase 1 Dose Escalation Safety Trial

Atypical Protein Kinase C λ/I Oncogenic Signaling through the Chromatin Modifier Satb2 Is Required for Leukemic B-Cell Progenitor Differentiation Arrest and Leukemogenesis

TRAF6 Is Essential for Maintaining Hematopoietic Stem Cell Homeostasis

Mitochondria Transfer from Hematopoietic Stem and Progenitor Cells to Pdgfrα + /Sca-1 - /CD48 dim BM Stromal Cells Via CX43 Gap Junctions and AMPK Signaling Inversely Regulate ROS Generation in Both Cell Populations

Long-Lasting Dysregulation of the Hematopoietic Stem Cell Compartment in Obesity

Upregulation of Vav3 Is Required for Leukemogenesis By BCR-ABL through Polycomb Repression Complex Dependent De-Repression of the Cdkn2a Locus

Systemic Inflammation Recruits Ccr7 + Dendritric-Biased Granulocyte-Macrophage Progenitors to Lymphatic Circulation in a Non-Canonical Traf6-Dependent Manner

EGFR Signaling in Osteoblasts Regulates Circadian Rhythm of HSPC in Circulation

Sqstm1 Is Required to Retain Hematopoietic Stem Cell/ Progenitors As a Negative Regulator of Macrophage-Dependent Inflammatory Signaling in the Bone Marrow Osteoblastic Niche

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American Society of Hematology

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ASH Publications

American Society of Hematology

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