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Journal Articles

Novel R41Q- and R46Q-PAR1-Modified Mice Enable Proof-of-Concept Studies for In Vivo Protective Mechanisms of Action for Activated Protein C (APC) in Sepsis and Stroke

Ranjeet Kumar Sinha, PhD MSc, Yaoming Wang, PhD, Zhen Zhao, PhD, Jose A. Fernandez, MD PhD, Naveen Gupta, Xiao Xu, MSc, Greg Martin, MSc, Sergey Kupriyanov, PhD MSc, Laurent O Mosnier, PhD, Berislav Zlokovic, PhD, John H. Griffin, PhD

Blood (2016) 128 (22): 13.

https://doi.org/10.1182/blood.V128.22.13.13

Published: 2016

Journal Articles

Activated Protein C (APC) Therapy Ameliorates Chronic Graft Versus Host Disease By Cell Signaling Mechanisms That Require Cleavage at Arg46 in PAR1 on T Cells

Ranjeet Kumar Sinha, PhD MSc, Ryan P Flynn, PhD, Jose A. Fernandez, MD PhD, Xiao Xu, MSc, Greg Martin, MSc, Sergey Kupriyanov, PhD MSc, John H. Griffin, PhD, Bruce R. Blazar, MD

Blood (2016) 128 (22): 808.

https://doi.org/10.1182/blood.V128.22.808.808

Published: 2016

Journal Articles

Coagulation Factor V Mediates Inhibition of Tissue Factor Signaling By Activated Protein C

Hartmut Weiler, Hai-Po Liang, PhD, Edward J Kerschen, PhD, Alireza Rezaie, PhD, Jose A. Fernandez, MD PhD, Rodney M. Camire, PhD, Wolfram Ruf, MD, John H. Griffin, PhD, Raffaele Toso, PhD

Blood (2015) 126 (23): 216.

https://doi.org/10.1182/blood.V126.23.216.216

Published: 2015

Journal Articles

Plasma Constitutive Serum Amyloid A4 Is Procoagulant and Is Elevated in Venous Thrombosis Patients

John H. Griffin, PhD, Jose A. Fernandez, MD PhD, Ranjeet Kumar Sinha, PhD MSc, Darlene J. Elias, MD, Hiroshi Deguchi, MD PhD

Blood (2015) 126 (23): 3486.

https://doi.org/10.1182/blood.V126.23.3486.3486

Published: 2015

Journal Articles

Acylcarnitines Are Novel Anticoagulant Lipids That Target Factor Xa and That Are Reduced in Plasma of Venous Thrombosis Patients Based on Untargeted and Targeted Metabolomics

Hiroshi Deguchi, MD PhD, Yajnavalka Banerjee, PhD, Gary Siuzdak, PhD, Sunia Trauger, PhD, Ewa Kalisiak, PhD, Jose A. Fernandez, MD PhD, Linh Hoang, Minerva Tran, Subramanian Yegneswaran, PhD, Darlene J Elias, MD, John H. Griffin, PhD

Blood (2014) 124 (21): 2797.

https://doi.org/10.1182/blood.V124.21.2797.2797

Published: 2014

Journal Articles

Factor V Inhibits PAR2-Mediated Lethal Inflammation

Edward J Kerschen, PhD, Hai-Po Helena Liang, Jose A. Fernandez, MD, PhD, Raffaella Toso, PhD, Wolfram Ruf, MD, Rodney M. Camire, PhD, John H. Griffin, PhD, Hartmut Weiler, PhD

Blood (2012) 120 (21): 3360.

https://doi.org/10.1182/blood.V120.21.3360.3360

Published: 2012

Journal Articles

In Vitro and in Vivo Neutralization of Murine Activated Protein C

Laurent Burnier, PhD, Jose A. Fernandez, MD, PhD, John H. Griffin, PhD

Blood (2012) 120 (21): 3364.

https://doi.org/10.1182/blood.V120.21.3364.3364

Published: 2012

Journal Articles

Insight in Protein S Deficiency From Mouse Models

Sara Calzavarini, PhD, François Saller, PhD, Jose A. Fernandez, MD, PhD, Linda Kadi, PhD, Anne C. Brisset, PhD, Laurent Burnier, PhD, Monica Azevedo, Béatrice Ternon, John H. Griffin, PhD, Anne Angelillo-Scherrer, MD

Blood (2011) 118 (21): 529.

https://doi.org/10.1182/blood.V118.21.529.529

Published: 2011

Journal Articles

Plasma High Density Lipoprotein and Anticoagulant Response to Activated Protein C (APC) and Protein S

Jose A. Fernandez, MD, PhD, Hiroshi Deguchi, MD, PhD, Natalie M Pecheniuk, Ph.D., Subramanian Yegneswaran, PhD, Carole L Banka, Ph. D., John H. Griffin, PhD

Blood (2011) 118 (21): 2249.

https://doi.org/10.1182/blood.V118.21.2249.2249

Published: 2011

Journal Articles

Lyso-Sulfatide Binds Factor Xa and Potently Inhibits Thrombin Generation.

Subramanian Yegneswaran, PhD, Yajnavalka Banerjee, PhD, Jose A. Fernandez, MD, PhD, Hiroshi Deguchi, MD, PhD, John H. Griffin, PhD

Blood (2010) 116 (21): 1130.

https://doi.org/10.1182/blood.V116.21.1130.1130

Published: 2010

Journal Articles

Activation of the PI3K-Akt Pathway by Activated Protein C Occurs Via a Novel Receptor, Apolipoprotein E Receptor 2 (ApoER2)

Xia V. Yang, PhD, Yajnavalka Banerjee, PhD, Jose A. Fernandez, MD, PhD, Hiroshi Deguchi, MD, PhD, Xiao Xu, Laurent O. Mosnier, PhD, Rolf T Urbanus, MD, Phillip G deGroot, PhD, Tara C White, Owen J.T. McCarty, PhD, John H. Griffin, PhD

Blood (2008) 112 (11): 695.

https://doi.org/10.1182/blood.V112.11.695.695

Published: 2008

Journal Articles

In Vivo Anti-Thrombotic Potency of Engineered Activated Protein C Variants.

Laurent O. Mosnier, PhD, Jose A. Fernandez, MD/PhD, Antonella Zampolli, PhD, Xia V. Yang, PhD, Zaverio M. Ruggeri, MD, John H. Griffin, PhD

Blood (2007) 110 (11): 2704.

https://doi.org/10.1182/blood.V110.11.2704.2704

Published: 2007

Journal Articles

Mechanisms for Mortality Reduction by Activated Protein C in Severe Sepsis.

Edward J. Kerschen, PhD, Brian C. Cooley, PhD, Francis J. Castellino, PhD, Shaun R. Coughlin, MD, PhD, Jose A. Fernandez, MD, PhD, John H. Griffin, PhD, Hartmut Weiler, PhD

Blood (2006) 108 (11): 1.

https://doi.org/10.1182/blood.V108.11.1.1

Published: 2006

Journal Articles

Exosite-Specific Inhibition of Thrombin Using Photo-Crosslinked Fluorescent Reporter Peptides.

Subramanian Yegneswaran, PhD, Theresa Tiefenbrunn, Jose’ A. Fernandez, MD, PhD, Philip E. Dawson, PhD

Blood (2005) 106 (11): 1954.

https://doi.org/10.1182/blood.V106.11.1954.1954

Published: 2005

Journal Articles

Sustained Pharmacological Activation of Protein C (PC) in Baboons.

Andras Gruber, MD, Jose A. Fernandez, MD, PhD, Ulla M. Marzec, Leslie Bush, John H. Griffin, PhD, Stephen R. Hanson, PhD, Enrico Di Cera, MD

Blood (2004) 104 (11): 3499.

https://doi.org/10.1182/blood.V104.11.3499.3499

Published: 2004

Journal Articles

Targeted Replacement of the Murine Thrombomodulin Gene with Human Thrombomodulin Coding Sequence Results in Decreased Protein C Activation and Enhanced Thrombotic Response to Photochemical Injury.

Thomas J. Raife, MD, Rochelle A. Erger, Katina M. Wilson, Jose A. Fernandez, MD, PhD, Jennifer Alternburg, Hyung-Suk Kim, John H. Griffin, PhD, Nobuyo Maeda, PhD, Steven R. Lentz, MD, PhD

Blood (2004) 104 (11): 2980.

https://doi.org/10.1182/blood.V104.11.2980.2980

Published: 2004

NARROW

Novel R41Q- and R46Q-PAR1-Modified Mice Enable Proof-of-Concept Studies for In Vivo Protective Mechanisms of Action for Activated Protein C (APC) in Sepsis and Stroke

Activated Protein C (APC) Therapy Ameliorates Chronic Graft Versus Host Disease By Cell Signaling Mechanisms That Require Cleavage at Arg46 in PAR1 on T Cells

Coagulation Factor V Mediates Inhibition of Tissue Factor Signaling By Activated Protein C

Plasma Constitutive Serum Amyloid A4 Is Procoagulant and Is Elevated in Venous Thrombosis Patients

Acylcarnitines Are Novel Anticoagulant Lipids That Target Factor Xa and That Are Reduced in Plasma of Venous Thrombosis Patients Based on Untargeted and Targeted Metabolomics

Factor V Inhibits PAR2-Mediated Lethal Inflammation

In Vitro and in Vivo Neutralization of Murine Activated Protein C

Insight in Protein S Deficiency From Mouse Models

Plasma High Density Lipoprotein and Anticoagulant Response to Activated Protein C (APC) and Protein S

Lyso-Sulfatide Binds Factor Xa and Potently Inhibits Thrombin Generation.

Activation of the PI3K-Akt Pathway by Activated Protein C Occurs Via a Novel Receptor, Apolipoprotein E Receptor 2 (ApoER2)

In Vivo Anti-Thrombotic Potency of Engineered Activated Protein C Variants.

Mechanisms for Mortality Reduction by Activated Protein C in Severe Sepsis.

Exosite-Specific Inhibition of Thrombin Using Photo-Crosslinked Fluorescent Reporter Peptides.

Sustained Pharmacological Activation of Protein C (PC) in Baboons.

Targeted Replacement of the Murine Thrombomodulin Gene with Human Thrombomodulin Coding Sequence Results in Decreased Protein C Activation and Enhanced Thrombotic Response to Photochemical Injury.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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