1-20 of 20
Juan A. Bueren, PhD
Close
Save search
Follow your search
Access your saved searches in your account
Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles

Lentiviral Mediated Gene Therapy for Pyruvate Kinase Deficiency: A Global Phase 1 Study for Adult and Pediatric Patients

José Luis López Lorenzo, MD, Susana Navarro, PhD, Ami J Shah, MD, Maria Grazia Roncarolo, MD, Julián Sevilla, MD PhD, Lucía Llanos, MD PhD, Begoña Pérez Camino de Gaisse, MD, Sol Sanchez, MD, Bertil Glader, MD PhD, May Chien, MD, Oscar Quintana Bustamante, PhD, Brian C Beard, PhD, Kenneth M Law, PhD, Miriam Zeini, PhD, Grace Choi, BS, Eileen Nicoletti, MD, Juan A Bueren, PhD, Gayatri R Rao, MD JD, Jonathan D Schwartz, MD, José C Segovia, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 47.
https://doi.org/10.1182/blood-2020-137246
Published: 2020
Journal Articles

Gene Therapy for Fanconi Anemia, Complementation Group a: Updated Results from Ongoing Global Clinical Studies of RP-L102

Agnieszka Czechowicz, MDPhD, Rajni Agarwal, MD, Julián Sevilla, MD PhD, Paula Río, PhD, Susana Navarro, PhD, Brian C Beard, PhD, Kenneth M Law, PhD, Grace Choi, BS, Miriam Zeini, PhD, Eileen Nicoletti, MD, John E Wagner, MD, Claire Booth, MBBS, PhD MSc, Jonathan D Schwartz, MD, Juan A Bueren, PhD, Maria Grazia Roncarolo, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 14.
https://doi.org/10.1182/blood-2020-137106
Published: 2020
Journal Articles

A Phase 1/2 Study of Lentiviral-Mediated Ex-Vivo Gene Therapy for Pediatric Patients with Severe Leukocyte Adhesion Deficiency-I (LAD-I): Results from Phase 1

Donald B. Kohn, MD, Gayatri R Rao, MD JD, Elena Almarza, PhD, Dayna Terrazas, RN, Eileen Nicoletti, MD, Augustine Fernandes, PhD, Caroline Kuo, MD, Satiro N. De Oliveira, MD, Theodore B. Moore, MD, Kenneth M Law, PhD, Brian C Beard, PhD, Julian Sevilla, MD PhD, Cristina Mesa-Núñez, PhD, Juan A Bueren, PhD, Jonathan D Schwartz, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 15.
https://doi.org/10.1182/blood-2020-142484
Published: 2020
Journal Articles

Correction of the Energetic Defects in Pyruvate Kinase Deficiency through Genome Editing in Hematopoietic Stem and Progenitor Cells

Sara Fañanas-Baquero, Oscar Quintana Bustamante, PhD, Daniel P. Dever, PhD, Omaira Alberquilla, Rebeca Sanchez-Dominguez, PhD, Joab Camarena, BS, Rolf Turk, José Luis López Lorenzo, MD, Paola Bianchi, BSc, PhD, Mark Behlke, MD PhD, Juan A Bueren, PhD, Matt Porteus, MD PhD, José C Segovia, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 29.
https://doi.org/10.1182/blood-2020-139117
Published: 2020
Journal Articles

A New Molecular Variant in the PTGS1 Gene That Abrogates Generation of Thromboxane A2 Synthesis and Associates with Platelet Dysfunction and Bleeding

Veronica Palma-Barqueros, MSc, Melissa Chan, PhD, Marilena Crescente, PhD, Jose Maria Bastida, Elena Almarza, PhD, Sara Suarez Varela, MD, Cristina Mesa-Núñez, PhD, Ignacio Casas-Avilés, MD, Natalia Bohdan, Jf Ruiz-Pividal, MSc, Jose Padilla, Nuria Revilla Calvo, MD, A Marín-Quilez, MSc, Marta Martín Izquierdo, MSc, Rocio Benito, PhD, Vicente Vicente, MD PhD, Juan A. Bueren, PhD, Jesus Maria . Hernández-Rivas, MD, José Ramón González-Porras, MD PhD, ML Edin, PhD, DC Zelding, MD, Tim Warner, PhD, Jose Rivera, PhD, Maria Luisa Lozano, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2375.
https://doi.org/10.1182/blood-2019-129200
Published: 2019
Journal Articles

Gene Therapy for Lad-I Immunodeficiency: Preclinical Evaluation of HSC Transduction Under Optimized GMP-Conditions

Elena Almarza, PhD, Cristina Mesa-Núñez, PhD, Carlos Damián, María Fernández-García, Begoña Díez-Cabezas, PhD, M Luz Lozano, Paula Rio, PhD, Rosa M Yañez, PhD, Ken Law, PhD, Brian C Beard, PhD, Jonathan D Schwartz, MD, Juan A. Bueren, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5751.
https://doi.org/10.1182/blood-2019-122878
Published: 2019
Journal Articles

NHEJ-Mediated Gene Editing, a Versatile Approach to Correct a Variety of Fanconi Anemia Genes in HSCs

Francisco J Roman-Rodriguez, PhD, Laura Ugalde, Lara A. Alvarez, Begoña Díez-Cabezas, PhD, Jordi Surrallés, PhD, Maria Jose Ramirez, PhD, Massimo Bogliolo, PhD, Helmut Hanenberg, MD PhD, Julian Sevilla, MD PhD, Sandra Rodriguez-Perales, PhD, Raul Torres-Ruiz, PhD, Juan A. Bueren, PhD, Paula Rio, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4639.
https://doi.org/10.1182/blood-2019-129946
Published: 2019
Journal Articles

Hematopoietic Engraftment of Fanconi Anemia Patients through 3 Years after Gene Therapy

Paula Rio, PhD, Susana Navarro, PhD, Rebeca Sanchez-Dominguez, PhD, Jose C Segovia, PhD, Wei Wang, PhD, Eva Merino, Rosa M Yañez, PhD, Jose Antonio Casado, PhD, Yari A. Gimenez, Francisco J Roman-Rodriguez, PhD, Omaira Alberquilla, Eva Galvez, MD, Raquel Hladun, MD, Jordi Barquinero, PhD, Anne Galy, PharmD, PhD, Nagore García de Andoín, MD, Ricardo López, MD PhD, Albert Catalá, MD PhD, Marina Cavazzana, Francois Lefrere, MD, Thierry Leblanc, MD, Jonathan D Schwartz, MD, Roser Pujol, PhD, Jordi Surrallés, PhD, Jean Soulier, MD PhD, Manfred Schmidt, PhD, Cristina Díaz de Heredia, MD PhD, Julian Sevilla, MD PhD, Juan A. Bueren, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4627.
https://doi.org/10.1182/blood-2019-129686
Published: 2019
Journal Articles

Changing the Natural History of Fanconi Anemia Complementation Group-A with Gene Therapy: Early Results of U.S. Phase I Study of Lentiviral-Mediated Ex-Vivo FANCA Gene Insertion in Human Stem and Progenitor Cells

Agnieszka Czechowicz, MD PhD, Maria Grazia Roncarolo, MD, Brian C Beard, PhD, Ken Law, PhD, Eileen Nicoletti, MD, Paula Río, PhD, Juan A. Bueren, PhD, Jonathan D Schwartz, MD, Sandeep Soni, MBBS
Journal: Blood
Blood (2019) 134 (Supplement_1): 3350.
https://doi.org/10.1182/blood-2019-127352
Published: 2019
Journal Articles

Advances in the Gene Therapy of Patients with Fanconi Anemia

Juan A. Bueren, PhD, Susana Navarro, PhD, Wei Wang, PhD, Rebeca Sanchez-Dominguez, PhD, Eva Merino, Jose C Segovia, PhD, Anne Galy, PharmD, PhD, María L. Lamana, MD PhD, Rosa M Yañez, PhD, Jose A Casado, PhD, Yari A. Gimenez, Francisco J Roman-Rodriguez, Lara A. Alvarez, Roser Pujol, PhD, Jordi Surralles, PhD, Ricardo López, MD PhD, Nagore García de Andoín, MD, Albert Catala, MD PhD, Eva Galvez, MD, Raquel Hladun, MD, Jonathan D Schwartz, MD, Manfred Schmidt, PhD, Cristina Díaz de Heredia, MD PhD, Paula Rio, PhD, Julian Sevilla, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1022.
https://doi.org/10.1182/blood-2018-99-111160
Published: 2018
Journal Articles

Efficient CRISPR/Cas9-Mediated Gene Editing of Pklr in Human Hematopoietic Progenitors and Stem Cells for the Gene Therapy of Pyruvate Kinase Deficiency

Oscar Quintana Bustamante, PhD, Sara Fañanas-Baquero, Daniel P. Dever, PhD, Alberquilla Omaira, Joab Camarena, BS, Rebeca Sanchez-Dominguez, PhD, Matias Morin, Val Fernandez, Miguel Angel Moreno-Pelayo, Juan A. Bueren, PhD, Matthew Porteus, MD PhD, Jose C Segovia, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 5792.
https://doi.org/10.1182/blood-2018-99-111772
Published: 2018
Journal Articles

Estrogens Enhance Human Hematopoietic Stem Cell Engraftment in a Xenogenic Transplantation Model

Sara Fañanas-Baquero, Israel Orman, Federico Becerra Aparicio, Silvia Bermudez de Miguel, Jordi Garcia Merino, Rosa M Yañez, PhD, Yolanda Fernandez, David Alfaro, Agustin Zapata, Juan A. Bueren, PhD, Jose C Segovia, PhD, Oscar Quintana Bustamante, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2042.
https://doi.org/10.1182/blood-2018-99-112104
Published: 2018
Journal Articles

Gene Editing of the Human Pklr Gene in Human Hematopoietic Progenitors to Correct Pyruvate Kinase Deficiency

Oscar Quintana-Bustamante, Sara Fañanas, Israel Orman, Agnès Gouble, PhD, Roman Galetto, PhD, Laurent Poirot, PhD, Juan A. Bueren, PhD, Jose C. Segovia, PhD
Journal: Blood
Blood (2016) 128 (22): 3513.
https://doi.org/10.1182/blood.V128.22.3513.3513
Published: 2016
Journal Articles

Epigenetic Alterations In Fanconi Anemia: Role In Disease Progression and Therapeutic Potential

Helio Belo, Gabriela Medeiros Silva, PhD, Bruno Cardoso, PhD, Beatriz Porto, PhD, José Barbot, M.D, Jorge Coutinho, M.D, Juan A Bueren, PhD, Jordi Surralles, PhD, Jose A Casado, PhD, Manuela Benedito, M.D, Hema Saturnino, M.D, Emília Costa, M.D, Maria Gomes Silva, MD, PhD, Antonio Almeida, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 4865.
https://doi.org/10.1182/blood.V122.21.4865.4865
Published: 2013
Journal Articles

Proteomics Analysis of Naturally Occurring CD4+/CD25+ Regulatory T Cells.

Marina I. Garin, PhD, Cheri C. Chu, MSC, Robin Wait, PhD, Juan A. Bueren, PhD, Robert I. Lechler, MD
Journal: Blood
Blood (2007) 110 (11): 3883.
https://doi.org/10.1182/blood.V110.11.3883.3883
Published: 2007
Journal Articles

Clinical Characteristics of Patients with Fanconi Anemia in Complementation Group J.

Angeles Dasi-Carpio, MD, PhD, Jose A. Casado, PhD, Guillermo Sanz, MD, Paula Rio, PhD, Maria-Teresa Santos, PhD, Juan A. Bueren, PhD, Jordi Surralles, PhD, Emilio Monteagudo, MD, Maria C. Carreras, MD
Journal: Blood
Blood (2006) 108 (11): 3769.
https://doi.org/10.1182/blood.V108.11.3769.3769
Published: 2006
Journal Articles

In Vitro and In Vivo Immunomodulatory Effects of Mesenchymal Stem Cells from Adipose Tissue.

Rosa M. Yañez, PhD, Maria L. Lamana, MD, PhD, Javier Garcia-Castro, PhD, Manuel Ramirez, MD, PhD, Juan A. Bueren, PhD
Journal: Blood
Blood (2005) 106 (11): 3098.
https://doi.org/10.1182/blood.V106.11.3098.3098
Published: 2005
Journal Articles

Retroviral Gene Transfer of Suicide Genes in Human T Lymphocytes: Improved Transduction Conditions for a Clinical Protocol.

María L. Lamana, MD, PhD, Rosa M. Yañez, PhD, Juan A. Bueren, PhD
Journal: Blood
Blood (2004) 104 (11): 5247.
https://doi.org/10.1182/blood.V104.11.5247.5247
Published: 2004
Journal Articles

Gene Therapy of the Human Erythrocyte Pyruvate Kinase Deficiency.

Jose C. Segovia, PhD, Nestor W. Meza Fellow, Oscar Quintana-Bustamante Fellow, Antonio Puyet, PhD, Paula Rio, PhD, Juan A. Bueren, PhD, Jose M. Bautista, PhD
Journal: Blood
Blood (2004) 104 (11): 1635.
https://doi.org/10.1182/blood.V104.11.1635.1635
Published: 2004
Journal Articles

Increased Generation of Hepatocytes Expressing Bone Marrow-Derived Markers after Hematopoietic Progenitors’ Mobilization in a Murine Model of Hepatic Damage.

Oscar Quintana-Bustamante Fellow, Alberto Alvarez-Barrientos, PhD, Isabel Fabregat, PhD, Juan A. Bueren, PhD, Jose C. Segovia, PhD
Journal: Blood
Blood (2004) 104 (11): 3600.
https://doi.org/10.1182/blood.V104.11.3600.3600
Published: 2004