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Journal Articles

The Central Role of MAPK-ERK Signaling in IL7-Dependent and IL7-Independent Steroid Resistance Reveals a Broad Application of MEK-Inhibitors Compared to JAK1/2-Inhibition in T-ALL

Jordy C.G. Van Der Zwet, MD, Jessica G.C.A.M. Buijs-Gladdines, Valentina Cordo', MSc, Donna Debets, MSc, Willem K. Smits, Zhongli Chen, MSc, Jelle Dylus, Guido Zaman, PhD, Maarten Altelaar, PhD, Koichi Oshima, MD PhD, Beat Bornhauser, Jean-Pierre Bourquin, MD PhD, Jan Cools, PhD, Adolfo A. Ferrando, MD PhD, Josef Vormoor, MD PhD, Rob Pieters, MDPhDMSc, Britta Julia Vormoor, MD, Jules P.P. Meijerink, PhD

Blood (2020) 136 (Supplement 1): 20.

https://doi.org/10.1182/blood-2020-139305

Published: 2020

Journal Articles

Phospho-Proteomic Profiling of T-Cell Acute Lymphoblastic Leukemia Identifies Targetable Kinase Activities and Novel Treatment Combination Strategies

Valentina Cordo', MSc, Rico Hagelaar, Sander Piersma, Richard Goeij-de Haas, Thang V Pham, Jelle Dylus, Guido Zaman, PhD, Connie Jimenez, PhD, Jules P.P. Meijerink, PhD

Blood (2020) 136 (Supplement 1): 14–15.

https://doi.org/10.1182/blood-2020-139259

Published: 2020

Journal Articles

A Test to Quantify NOTCH Pathway Activity in T Cell Acute Lymphoblastic Leukemia Patients

Kirsten Canté-Barrett, PhD, Laurent Holtzer, PhD, Henk van Ooijen, PhD, Rico Hagelaar, Valentina Cordo', MSc, Wim Verhaegh, PhD, Anja van de Stolpe, MD PhD, Jules P.P. Meijerink, PhD

Blood (2019) 134 (Supplement_1): 4661.

https://doi.org/10.1182/blood-2019-122856

Published: 2019

Journal Articles

The Clinical and Functional Relevance of the Transforming AKT E17K Mutation in T-ALL

Jordy C.G. Van Der Zwet, MD, Jessica G.C.A.M. Buijs-Gladdines, Izabela Mollova, BSc, Laura Graus, BSc, Frank L. Bos, PhD, Anne C. Rios, PhD, Jules P.P. Meijerink, PhD

Blood (2019) 134 (Supplement_1): 3804.

https://doi.org/10.1182/blood-2019-124669

Published: 2019

Journal Articles

MAPK-ERK Pathway Activation: The Achilles' Heel of IL-7R‒Induced Steroid Resistance

Jordy C.G. Van Der Zwet, MD, Jessica G.C.A.M. Buijs-Gladdines, Willem K. Smits, Zhongli Chen, MSc, Jules P.P. Meijerink, PhD

Blood (2019) 134 (Supplement_1): 1292.

https://doi.org/10.1182/blood-2019-124721

Published: 2019

Journal Articles

Phospho-Proteomic Profiling of T-Cell Acute Lymphoblastic Leukemia Identifies Specific Kinase Activation Signatures That Can Predict Response to Targeted Therapy

Valentina Cordo', MSc, Rico Hagelaar, Sander Piersma, Thang V Pham, Connie Jimenez, PhD, Jules P.P. Meijerink, PhD

Blood (2019) 134 (Supplement_1): 4649.

https://doi.org/10.1182/blood-2019-122898

Published: 2019

Journal Articles

Identification of a Novel T-ALL Entity with NKX2-1/NKX2-2 Rearrangements

Blood (2010) 116 (21): 3139.

https://doi.org/10.1182/blood.V116.21.3139.3139

Published: 2010

Journal Articles

Clinical Relevance of NOTCH1 and FBXW7 Mutations in DCOG and COALL T-ALL Patient Cohorts.

Linda Zuurbier, Irene Homminga, Jessica Buijs-Gladdines, Valerie de Haas, MD, PhD, Martin Horstman, Rob Pieters, Jules P.P. Meijerink, PhD.

Blood (2009) 114 (22): 1603.

https://doi.org/10.1182/blood.V114.22.1603.1603

Published: 2009

Journal Articles

Deletion of the Protein Tyrosine Phosphatase Gene PTPN2 in T-Cell Acute Lymphoblastic Leukemia.

Maria Kleppe, Idoya Lahortiga, PhD, Tiama El Chaar, Kim De Keersmaecker, PhD, Nicole Mentens, Carlos Graux, MD, PhD, Katrien Van Roosbroeck, Adolfo A. Ferrando, MD, PhD, Anton W Langerak, PhD, Jules P.P. Meijerink, PhD, Francois Sigaux, MD, Torsten Haferlach, MD, Iwona Wlodarska, PhD, Peter Vandenberghe, MD, PhD, Jean Soulier, MD, PhD, Jan Cools, PhD

Blood (2009) 114 (22): 141.

https://doi.org/10.1182/blood.V114.22.141.141

Published: 2009

Journal Articles

Oncogenic Transcriptional Programs Controlled by TLX1/HOX11 and TLX3/HOX11L2 in T-ALL.

Giusy Della Gatta, PhD, Teresa Palomero, PhD, Maria Luisa Sulis, MD, Xavier Solé, PhD, Wei Keat Lim, PhD, Kim De Keersmaecker, PhD, Pedro Jose Real Luna, PhD, Valeria Tosello, PhD, Fotini Gounari, PhD, Barbara Kee, PhD, Jack Lenz, PhD, Michelle Kelliher, PhD, Peter D. Aplan, MD, Jules P.P. Meijerink, PhD., Andrea Califano, PhD, Adolfo Ferrando

Blood (2009) 114 (22): 676.

https://doi.org/10.1182/blood.V114.22.676.676

Published: 2009

Journal Articles

Expression of Mir-196b Is Not Exclusively MLL -Driven but Especially Linked to Activation of HOXA Genes in Children with Acute Lymphoblastic Leukemia.

Diana Schotte, Ellen Lange-Turenhout, Dominique JPM Stumpel, Ronald W. Stam, Ph.D., Jessica Buijs-Gladdines, Jules P.P. Meijerink, PhD., Rob Pieters, Ph.D., Prof., Monique L. Den Boer, PhD

Blood (2009) 114 (22): 580.

https://doi.org/10.1182/blood.V114.22.580.580

Published: 2009

Journal Articles

In-Vitro Efficacy of the Deoxyguanoside Analogs Forodesine (BCX-1777) and ARA-G in Pediatric Acute Lymphoblastic Leukemia.

Irene Homminga, MD, Michel C. Zwaan, MD, PhD, Amel Seghouani, MD, Chantal Y. Manz, PhD, Shanta Bantia, PhD, Wilco Smits, Rob Pieters, MD, PhD, Jules P.P. Meijerink, PhD

Blood (2009) 114 (22): 2038.

https://doi.org/10.1182/blood.V114.22.2038.2038

Published: 2009

Journal Articles

Late Relapses of Childhood T-ALL Are Frequently Second T-ALL.

Tomasz Szczepanski, MD, PhD, Vincent H.J. van der Velden, PhD, Pieter Van Vlierberghe, Bernd Gruhn, MD, PhD, Renate Panzer-Grumayer, MD, PhD, Monica Spinelli, Helene Cave, PhD, Udo zur Stadt, PhD, Dario Campana, MD, PhD, Andre Schrauder, MD, PhD, Elisabeth van Wering, PhD, Jules P.P. Meijerink, PhD, Jacques J.M. van Dongen, MD, PhD

Blood (2007) 110 (11): 1435.

https://doi.org/10.1182/blood.V110.11.1435.1435

Published: 2007

Journal Articles

Poor Survival of CD34 Positive and CD13/33 Positive Patients in Pediatric T-Cell Acute Lymphoblastic Leukemia Is Not Explained by Expression of Multidrug Resistance Genes.

Martine van Grotel, MSc, Max M. van Noesel, MD,PhD, M.M. Van Den Heuvel, MD,PhD, Rob Pieters, MD,PhD, Jules P.P. Meijerink, PhD

Blood (2007) 110 (11): 4219.

https://doi.org/10.1182/blood.V110.11.4219.4219

Published: 2007

Journal Articles

Prognostic Significance of Molecular-Cytogenetic Abnormalities in Pediatric T-ALL Is Not Explained by Immunophenotypic Differences.

Martine van Grotel, MSc, Anton W. Langerak, PhD, H. Berna Beverloo, PhD, Jessica G.C.A.M. Buijs-Gladdines, Nicole B. Burger, Max M. van Noesel, MD PhD, Rob Pieters, MD PhD, Jules P.P. Meijerink, PhD

Blood (2007) 110 (11): 4220.

https://doi.org/10.1182/blood.V110.11.4220.4220

Published: 2007

Journal Articles

CALM-AF10 and HOX11L2 Abnormalities Define Poor Prognostic Subgroups in Pediatric T-Cell Acute Lymphoblastic Leukemia.

Martine van Grotel, MSc, Jules P.P. Meijerink, PhD, Max M. van Noesel, MD, PhD, H. Berna Beverloo, PhD, Anton W. Langerak, PhD, Tim S. Poulsen, PhD, Elisabeth R. van Wering, MD, PhD, E. Gritta Janka-Schaub, MD, PhD, Rob Pieters, MD, PhD

Blood (2005) 106 (11): 3279.

https://doi.org/10.1182/blood.V106.11.3279.3279

Published: 2005

Journal Articles

Genome-Wide Identification of Prednisolone-Responsive Genes in Primary Acute Lymphoblastic Leukemia Cells.

Wim J.E. Tissing, MD, Monique L. den Boer, PhD, Jules P.P. Meijerink, PhD, Renee X. Menezes, PhD, Sigrid Swagemakers, PhD, Peter J. van der Spek, PhD, Stephen E. Sallan, MD, PhD, Scott Armstrong, MD, PhD, Robrecht Pieters, MD, PhD

Blood (2005) 106 (11): 103.

https://doi.org/10.1182/blood.V106.11.103.103

Published: 2005

Journal Articles

Activating FLT3 Mutations in CD4 + /CD8 − Pediatric T-Cell Acute Lymphoblastic Leukemias.

Pieter Van Vlierberghe, MSc, Jules P.P. Meijerink, PhD, Ronald W. Stam, PhD, Wendy van der Smissen, Elisabeth R. van Wering, H. Berna Beverloo, PhD, Rob Pieters

Blood (2005) 106 (11): 1465.

https://doi.org/10.1182/blood.V106.11.1465.1465

Published: 2005

Journal Articles

RNA Expression Levels of (Co)Chaperone Molecules of the Glucocorticoid Receptor Are Not Related to In Vitro Prednisolone Resistance in Childhood ALL.

Wim Tissing, MD, Jules P.P. Meijerink, PhD, Monique L. den Boer, PhD, Bas Brinkhof, Rob Pieters, MD, PhD

Blood (2004) 104 (11): 4485.

https://doi.org/10.1182/blood.V104.11.4485.4485

Published: 2004

Journal Articles

Somatic Mutations and Polymorphisms of the Glucocorticoid Receptor Gene Are Not Related to Glucocorticoid Resistance in Childhood ALL.

Wim Tissing, MD, Jules P.P. Meijerink, PhD, Monique L. Den Boer, PhD, Bas Brinkhof, Liesbeth van Rossum, MD, Elisabeth R. van Wering, MD, Jan Willem Koper, PhD, Pieter Sonneveld, MD, Rob Pieters, MD

Blood (2004) 104 (11): 1960.

https://doi.org/10.1182/blood.V104.11.1960.1960

Published: 2004

NARROW

The Central Role of MAPK-ERK Signaling in IL7-Dependent and IL7-Independent Steroid Resistance Reveals a Broad Application of MEK-Inhibitors Compared to JAK1/2-Inhibition in T-ALL

Phospho-Proteomic Profiling of T-Cell Acute Lymphoblastic Leukemia Identifies Targetable Kinase Activities and Novel Treatment Combination Strategies

A Test to Quantify NOTCH Pathway Activity in T Cell Acute Lymphoblastic Leukemia Patients

The Clinical and Functional Relevance of the Transforming AKT E17K Mutation in T-ALL

MAPK-ERK Pathway Activation: The Achilles' Heel of IL-7R‒Induced Steroid Resistance

Phospho-Proteomic Profiling of T-Cell Acute Lymphoblastic Leukemia Identifies Specific Kinase Activation Signatures That Can Predict Response to Targeted Therapy

Identification of a Novel T-ALL Entity with NKX2-1/NKX2-2 Rearrangements

Clinical Relevance of NOTCH1 and FBXW7 Mutations in DCOG and COALL T-ALL Patient Cohorts.

Deletion of the Protein Tyrosine Phosphatase Gene PTPN2 in T-Cell Acute Lymphoblastic Leukemia.

Oncogenic Transcriptional Programs Controlled by TLX1/HOX11 and TLX3/HOX11L2 in T-ALL.

Expression of Mir-196b Is Not Exclusively MLL -Driven but Especially Linked to Activation of HOXA Genes in Children with Acute Lymphoblastic Leukemia.

In-Vitro Efficacy of the Deoxyguanoside Analogs Forodesine (BCX-1777) and ARA-G in Pediatric Acute Lymphoblastic Leukemia.

Late Relapses of Childhood T-ALL Are Frequently Second T-ALL.

Poor Survival of CD34 Positive and CD13/33 Positive Patients in Pediatric T-Cell Acute Lymphoblastic Leukemia Is Not Explained by Expression of Multidrug Resistance Genes.

Prognostic Significance of Molecular-Cytogenetic Abnormalities in Pediatric T-ALL Is Not Explained by Immunophenotypic Differences.

CALM-AF10 and HOX11L2 Abnormalities Define Poor Prognostic Subgroups in Pediatric T-Cell Acute Lymphoblastic Leukemia.

Genome-Wide Identification of Prednisolone-Responsive Genes in Primary Acute Lymphoblastic Leukemia Cells.

Activating FLT3 Mutations in CD4 + /CD8 − Pediatric T-Cell Acute Lymphoblastic Leukemias.

RNA Expression Levels of (Co)Chaperone Molecules of the Glucocorticoid Receptor Are Not Related to In Vitro Prednisolone Resistance in Childhood ALL.

Somatic Mutations and Polymorphisms of the Glucocorticoid Receptor Gene Are Not Related to Glucocorticoid Resistance in Childhood ALL.

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American Society of Hematology

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American Society of Hematology

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