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Karlheinz Holzmann, Dr. rer. nat.
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Journal Articles

Rituximab and Obinutuzumab Induce Direct B-Cell Death Via B-Cell Receptor (BCR) Signaling, but Rituximab Elicits Stronger BCR-Derived Pro-Survival Signals Diminishing Apoptosis

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Jennifer Edelmann, MD PhD, Arran Dokal, MSc, PhD, Karlheinz Holzmann, Dr. rer. nat., David James Britton, BSc, PhD, Emma Vilventhraraja, MSc, PhD, Ryan Jack Smith, PhD, Mark S Cragg, Prof, Andrejs Braun, PhD, Hartmut Döhner, MD, Pedro Cutillas, PhD, John G. Gribben, MD DSc
Journal: Blood
Blood (2019) 134 (Supplement_1): 1579.
https://doi.org/10.1182/blood-2019-128704
Published: 2019
Journal Articles

Anti-CD20 Monoclonal Antibodies Hijack the B-Cell Receptor Signaling Cascade Thereby Activating the NOTCH1 Signaling Pathway

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Jennifer Edelmann, MD, David James Britton, BSc, PhD, Emma Vilventhraraja, MSc, PhD, Arran Dokal, MSc, PhD, Karlheinz Holzmann, Dr. rer. nat., Mark C Cragg, Andrejs Braun, PhD, Pedro Cutillas, PhD, John G. Gribben
Journal: Blood
Blood (2018) 132 (Supplement 1): 588.
https://doi.org/10.1182/blood-2018-99-116490
Published: 2018
Journal Articles

MYC Pathway Activation Is Frequently Observed in Treatment-Naive CLL and Defines a Subgroup with Particular Benefit from the Addition of Rituximab to Chemotherapy

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Johannes Bloehdorn, MD, Julia Krzykalla, MSc, Billy Michael Chelliah Jebaraj, PhD, Karlheinz Holzmann, Dr. rer. nat., Jasmin Bahlo, PhD, Sandra Robrecht, PhD, Kathryn Humphrey, Michael Wenger, Eugen Tausch, MD, Christof Schneider, MD, Lars Bullinger, MD, Kirsten Fischer, MD, Michael Hallek, MD, Daniel Mertens, Axel Benner, Hartmut Döhner, MD, Stephan Stilgenbauer
Journal: Blood
Blood (2018) 132 (Supplement 1): 1866.
https://doi.org/10.1182/blood-2018-99-116937
Published: 2018
Journal Articles

High-Resolution SNP-Array Profiling of "Ultra-High Risk" CLL Cases Reveals New Recurrent Genomic Alterations

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Jennifer Edelmann, MD PhD, Karlheinz Holzmann, Dr. rer. nat., Eugen Tausch, MD, Anna Dolnik, PhD, Tamara J. Blätte, MSc, Stefan Ibach, Dr, Jenny Saub, Daniel Mertens, PhD, Lars Bullinger, MD, Kirsten Fischer, MD, Valentin Goede, MD, John G. Gribben, MDDSc FMedSci, Michael J. Hallek, MD, Hartmut Döhner, MD, Stephan Stilgenbauer, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2992.
https://doi.org/10.1182/blood.V130.Suppl_1.2992.2992
Published: 2017
Journal Articles

Rituximab Activates NOTCH1 Signaling in CLL Cells and Induces Changes in the Cytokine Repertoire Favoring a Tumor-Protective Microenvironment

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Jennifer Edelmann, MD PhD, Karlheinz Holzmann, Dr. rer. nat., Doriana DiBella, Emma Vilventhraraja, Stephen A Beers, PhD, Mark Cragg, PhD, Andrejs Braun, PhD, John G. Gribben, MDDSc FMedSci
Journal: Blood
Blood (2017) 130 (Supplement 1): 2996.
https://doi.org/10.1182/blood.V130.Suppl_1.2996.2996
Published: 2017