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Journal Articles

Comprehensive Genetic Analysis Revealed Myeloid/Natural Killer (NK) Cell Precursor Acute Leukemia As a Novel Distinctive Leukemia Entity

Akira Nishimura, MD, Kazuaki Yokoyama, MD PhD, Chika Yamagishi, MD, Toshihiko Imamura, MD PhD, Takuya Naruto, MD PhD, Tomohiro Morio, MD PhD, Yukie Tanaka, PhD, Akinori Kanai, PhD, Hirotaka Matsui, MD PhD, Naoko Higuchi, MD, Akiko Takada, MD, Haruna Okuno, MD, Shoji Saito, MD PhD, Shuhei Karakawa, MD PhD, Shogo Kobayashi, MD, Daisuke Hasegawa, MD PhD, Hiroyuki Fujisaki, MD PhD, Daiichiro Hasegawa, MD PhD, Kazutoshi Koike, MD PhD, Takashi Koike, MD, Shinya Rai, MD PhD, Katsutsugu Umeda, MD PhD, Hideki Sano, MD, Yujin Sekinaka, MD PhD, Atsushi Ogawa, MD PhD, Akitoshi Kinoshita, MD PhD, Norio Shiba, MD PhD, Mizuka Miki, MD, Fumihiko Kimura, MD PhD, Hideki Nakayama, MD, Yozo Nakazawa, MD PhD, Takashi Taga, MD PhD, Tomohiko Taki, MD PhD, Souichi Adachi, MD PhD, Atsushi Manabe, MD PhD, Katsuyoshi Koh, MD, Yasushi Ishida, MD PhD, Arinobu Tojo, MD PhD, Masatoshi Takagi, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 14–15.
https://doi.org/10.1182/blood-2020-139312
Published: 2020
Journal Articles

Etoposide, Cytarabine and Mitoxantrone- or Fludarabine, Cytarabine and Granulocyte Colony-Stimulating Factor-Based Intensive Reinduction Chemotherapy Is Recommended for Children with Relapsed Acute Myeloid Leukemia: The Results from the Japanese Pediatric Leukemia/Lymphoma Study Group (JPLSG) AML-05R Study

Hiroshi Moritake, MD PhD, Shiro Tanaka, PhD, Takako Miyamura, MD PhD, Hideki Nakayama, MD, Norio Shiba, MD PhD, Akira Shimada, MDPhD, Kiminori Terui, MD PhD, Yuki Yuza, MD PhD, Katsuyoshi Koh, MD, Hiroaki Goto, MD, PhD, Harumi Kakuda, MD PhD, Akiko M Saito, MD PhD, Daisuke Hasegawa, MD PhD, Shotaro Iwamoto, MD, Takashi Taga, MD PhD, Souichi Adachi, MD PhD, Daisuke Tomizawa, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 6.
https://doi.org/10.1182/blood-2020-133272
Published: 2020
Journal Articles

Discontinuation of Tyrosine Kinase Inhibitor in Children with Chronic Myeloid Leukemia (JPLSG STKI-14 study)

Haruko Shima, MD PhD, Akiko Kada, MPH, Akihiko Tanizawa, MD PhD, Yuki Yuza, MD PhD, Akihiro Watanabe, Masaki Ito, MD, Hideko Uryu, Katsuyoshi Koh, MD, Chihaya Imai, MD PhD, Nao Yoshida, MD PhD, Yuhki Koga, MD, Naoto Fujita, MD PhD, Akiko M Saito, MD PhD, Souichi Adachi, MD PhD, Eiichi Ishii, MD PhD, Hiroyuki Shimada, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 25.
https://doi.org/10.1182/blood-2019-122623
Published: 2019
Journal Articles

Clinical Features of Children with Polycythemia Vera, Essential Thrombocythemia, and Primary Myelofibrosis in Japan: Retrospective Nationwide Survey

Hisashi Ishida, MD PhD, Takeo Sarashina, MD PhD, Risa Matsumura, Katsutsugu Umeda, MD, PhD, Tetsuo Mitsui, MD PhD, Naoto Fujita, MD PhD, Daisuke Tomizawa, MD PhD, Kevin Y Urayama, PhD MPH, Yasushi Ishida, MD PhD, Takashi Taga, MD PhD, Masatoshi Takagi, MD PhD, Souichi Adachi, MD PhD, Atsushi Manabe, MD PhD, Toshihiko Imamura, MD PhD, Katsuyoshi Koh, MD, Akira Shimada, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2958.
https://doi.org/10.1182/blood-2019-123429
Published: 2019
Journal Articles

NUDT15 Variants Confer High Incidence of Secondary Malignancies of ALL in Children

Masanori Yoshida, MD, Kazuhiko Nakabayashi, PhD, Aiko Sato-Otsubo, PhD, Shinichi Tsujimoto, MD PhD, Kaoru Yoshida, MD, Ryota Shirai, MD, Tomoo Osumi, MD, Yuki Yuza, MD PhD, Masatoshi Takagi, MD PhD, Hiroyuki Takahashi, MD PhD, Katsuyoshi Koh, MD, Akitoshi Kinoshita, MD PhD, Moeko Hino, MD, Toshihiko Imamura, MD PhD, Yozo Nakazawa, MD PhD, Okuya Mayuko, MD PhD, Harumi Kakuda, MD PhD, Masashi Sanada, MD, Kimikazu Matsumoto, MD, PhD, Daisuke Tomizawa, MD PhD, Nobutaka Kiyokawa, MD PhD, Akira Ohara, MD PhD, Atsushi Manabe, MD PhD, Kenichiro Hata, MD PhD, Jun J. Yang, PhD, Motohiro Kato, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2751.
https://doi.org/10.1182/blood-2019-125713
Published: 2019
Journal Articles

Targeting Critical Kinases and Anti-Apoptotic Molecules Overcomes Steroid Resistance in Infant MLL-Rearranged Leukemia

Anne Pieta De Groot, Yoriko Saito, MD, Eiryo Kawakami, Mari Hashimoto, Yuki Aoki, Rintaro Ono, MD PhD, Ikuko Ogahara, Saera Fujiki, Akiko Kaneko, Takashi Watanabe, PhD, Masatoshi Takagi, MD PhD, Daisuke Tomizawa, MD PhD, Katsuyoshi Koh, MD, Mariko Eguchi, MD, Eiichi Ishii, MD PhD, Osamu Ohara, Leonard Shultz, PhD, Shuki Mizutani, Fumihiko Ishikawa, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3885.
https://doi.org/10.1182/blood-2019-129719
Published: 2019
Journal Articles

Predictive Factors of the Development of Leukemia in Patients with Transient Abnormal Myelopoiesis and Down Syndrome: The Jccg Study JPLSG TAM-10

Genki Yamato, MD PhD, Hideki Muramatsu, MD PhD, Tomoyuki Watanabe, PhD, Takao Deguchi, MD PhD, Shotaro Iwamoto, MD, Daisuke Hasegawa, MD PhD, Kiminori Terui, MD PhD, Takahiro Ueda, MD PhD, Tomoko Yokosuka, Tsutomu Toki, PhD, Shiro Tanaka, PhD, Ryu Yanagisawa, Katsuyoshi Koh, MD, Akiko M Saito, MD PhD, Keizo Horibe, MD PhD, Yasuhide Hayashi, MD PhD, Souichi Adachi, MD PhD, Shuki Mizutani, Takashi Taga, MD PhD, Etsuro Ito, MD PhD, Kenichiro Watanabe, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3833.
https://doi.org/10.1182/blood-2019-125465
Published: 2019
Journal Articles

Post-Induction Minimal Residual Disease Measured By Flow Cytometry and Deep Sequencing of Mutant GATA1 Are Both Significant Prognostic Factors for Children with Myeloid Leukemia and Down Syndrome: A Nationwide Prospective Study of the Japanese Pediatric Leukemia/Lymphoma Study Group

Takashi Taga, MD PhD, Shiro Tanaka, PhD, Kiminori Terui, MD PhD, Shotaro Iwamoto, MD, Hidefumi Hiramatsu, MD PhD, Takako Miyamura, MD PhD, Yoshiko Hashii, MD PhD, Daisuke Hasegawa, MD PhD, Hiroshi Moritake, MD PhD, Hideki Nakayama, MD, Hiroyuki Takahashi, MD PhD, Akira Shimada, MD PhD, Tomohiko Taki, MD PhD, Tsutomu Toki, PhD, Etsuro Ito, MD PhD, Katsuyoshi Koh, MD, Daiichiro Hasegawa, MD PhD, Asahito Hama, MD PhD, Akiko M Saito, MD PhD, Souichi Adachi, MD PhD, Daisuke Tomizawa, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3848.
https://doi.org/10.1182/blood-2019-123302
Published: 2019
Journal Articles

Late Effects in Survivors of Infant Acute Lymphoblastic Leukemia from the 3 Consecutive Japanese Nationwide Clinical Trials

Yuki Aoki, Akira Hayakawa, MD PhD, Kazutoshi Koike, MD PhD, Hisamichi Tauchi, MD PhD, Eiichi Ishii, MD PhD, Katsuyoshi Koh, MD, Takako Miyamura, MD PhD, Yasushi Ishida, MD PhD, Akiko Kada, MPH, Akiko M Saito, MD PhD, Atsushi Manabe, MD PhD, Keizo Horibe, MD PhD, Shuki Mizutani, MD PhD, Miho Maeda, MD, Daisuke Tomizawa, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4559.
https://doi.org/10.1182/blood-2019-123881
Published: 2019
Journal Articles

Intensive Chemotherapy Along with Aggressive Supportive Care Can Spare Stem Cell Transplantation in a Subset of Patients without Compromising an Outcome in Infants with Acute Lymphoblastic Leukemia; A Report from the Japanese Pediatric Leukemia/Lymphoma Study Group (JPLSG) Trial MLL-10

Daisuke Tomizawa, MD PhD, Takako Miyamura, MD PhD, Toshihiko Imamura, MD PhD, Tomoyuki Watanabe, PhD, Akiko Moriya Saito, MD PhD, Atsushi Ogawa, MD PhD, Yoshihiro Takahashi, MD PhD, Masahiro Hirayama, MD PhD, Yuki Arakawa, MD, Tomohiko Taki, MD PhD, Takao Deguchi, MD PhD, Toshinori Hori, MD PhD, Sakae Omori, PhD, Masami Haba, PhD, Akihiro Iguchi, MD PhD, Yuuki Koga, MD PhD, Atsushi Manabe, MD PhD, Keizo Horibe, MD PhD, Eiichi Ishii, MD PhD, Katsuyoshi Koh, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2626.
https://doi.org/10.1182/blood-2019-121328
Published: 2019
Journal Articles

NUDT15 Genetic Variation Is the Strongest Predictive Marker of Tolerance to 6-Mercaptopurine in Japanese Childhood ALL Patients: A Genome-Wide Association Study

Yoichi Tanaka, PhD, Kevin Y Urayama, PhD MPH, Makiko Mori, MD, Daisuke Hasegawa, MD PhD, Yasushi Noguchi, MD, Masakatsu Yanagimachi, MD PhD, Dai Keino, MD PhD, Setsuo Ota, MD PhD, Koshi Akahane, MD PhD, Mayumi Hangai, MD, Takahisa Kawaguchi, Masatoshi Takagi, MD PhD, Katsuyoshi Koh, MD, Fumihiko Matsuda, Atsushi Manabe, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1347.
https://doi.org/10.1182/blood-2019-129440
Published: 2019
Journal Articles

Clinical Feature and Genetic Alterations in Myeloid/Natural Killer (NK) Cell Precursor Acute Leukemia and Myeloid/NK Cell Acute Leukemia

Akira Nishimura, MD, Kazuaki Yokoyama, MD PhD, Chika Yamagishi, MD, Takuya Naruto, MD PhD, Tomohiro Morio, MD PhD, Akinori Kanai, PhD, Hirotaka Matsui, MD PhD, Naoko Higuchi, MD, Akiko Takada, MD, Haruna Okuno, MD, Shoji Saito, MD, Shuhei Karakawa, MD, Shogo Kobayashi, MD, Hideki Sano, MD, Takashi Koike, MD, Daisuke Hasegawa, MD PhD, Hiroyuki Fujisaki, MD, PhD, Daiichiro Hasegawa, MD PhD, Kazutoshi Koike, MD, Atsushi Ogawa, MD PhD, Akitoshi Kinoshita, MD PhD, Norio Shiba, MD PhD, Mizuka Miki, MD, Hideki Nakayama, MD, Yozo Nakazawa, MD, PhD, Toshihiko Imamura, MD PhD, Takashi Taga, MD PhD, Souichi Adachi, MD PhD, Katsuyoshi Koh, MD, Atsushi Manabe, MD PhD, Tomohiko Taki, MD PhD, Yasushi Ishida, MD PhD, Arinobu Tojo, MD PhD, Masatoshi Takagi, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2824.
https://doi.org/10.1182/blood-2018-99-118627
Published: 2018
Journal Articles

Tolerable Dose of 6-Mercaptopurine and Prognostic Impact of NUDT15-Deficient Genotype in Childhood Acute Lymphoblastic Leukemia

Yoichi Tanaka, PhD, Motohiro Kato, MD PhD, Takaya Moriyama, MD PhD, Yuki Arakawa, MD, Daisuke Hasegawa, MD PhD, Junya Fujimura, MD PhD, Dai Keino, MD PhD, Atsushi Sato, MD, Takahiro Ueda, MD PhD, Yuichi Taneyama, MD, Masatoshi Takagi, MD PhD, Masaki Yamamoto, MD, Masaki Matsuoka, MD, Moeko Hino, MD, Hiroki Hori, MD PhD, Katsuyoshi Koh, MD, Allen Eng Juh Yeoh, MD, Jun J. Yang, PhD, Atsushi Manabe, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4032.
https://doi.org/10.1182/blood-2018-99-114290
Published: 2018
Journal Articles

Hematopoietic Stem-Cell Transplantation in Children with Refractory Acute Myeloid Leukemia

Yasuhiro Okamoto, MD, Kazuko Kudo, MD PhD, Ken Tabuchi, MD, Daisuke Tomizawa, MD PhD, Takashi Taga, MD PhD, Hiroaki Goto, MD, Hiromasa Yabe, MD, PhD, Yozo Nakazawa, MD, PhD, Katsuyoshi Koh, MD, Kazuhiro Ikegame, MD PhD, Nao Yoshida, MD PhD, Naoyuki Uchida, MD PhD, Kenichiro Watanabe, MD PhD, Yuuki Koga, MD PhD, Masami Inoue, MD, Koji Kato, MD PhD, Yoshiko Atsuta, MD PhD, Hiroyuki Ishida, MD, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4632.
https://doi.org/10.1182/blood-2018-99-111322
Published: 2018
Journal Articles

Hematopoietic Cell Transplantation for Children with Acute Megakaryoblastic Leukemia without Down Syndrome

Asahito Hama, Takashi Taga, MD PhD, Daisuke Tomizawa, MD PhD, Hideki Muramatsu, MD PhD, Daiichiro Hasegawa, MD PhD, Souichi Adachi, MD PhD, Nao Yoshida, MD PhD, Maiko Noguchi, MD, Masami Inoue, MD, Keiko Oakada, MD, Katsuyoshi Koh, MD, Yoshiko Atsuta, MD PhD, Hiroyuki Ishida, MD, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4671.
https://doi.org/10.1182/blood-2018-99-114062
Published: 2018
Journal Articles

Distribution and Clinical Features of NOTCH1 Signaling Activating Alterations in Pediatric T-Cell Acute Lymphoblastic Leukemia (T-ALL)

Shunsuke Kimura, MD, Masafumi Seki, MD, PhD, Kenichi Yoshida, MD PhD, Hiroo Ueno, MD, Yasuhito Nannya, MD PhD, Kentaro Ohki, MD PhD, Motohiro Kato, MD PhD, Katsuyoshi Koh, MD, Ryoji Kobayashi, MD, Takao Deguchi, MD PhD, Yoshiko Hashii, MD PhD, Toshihiko Imamura, MD PhD, Atsushi Sato, MD, Nobutaka Kiyokawa, MD PhD, Atsushi Manabe, MD PhD, Keizo Horibe, MD PhD, Akira Ohara, MD, Masashi Sanada, MD PhD, Mitsuteru Hiwatari, MD PhD, Masao Kobayashi, MD PhD, Akira Oka, MD PhD, Satoru Miyano, PhD, Seishi Ogawa, MD PhD, Junko Takita, MD, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4089.
https://doi.org/10.1182/blood-2018-99-111092
Published: 2018
Journal Articles

Clinical Significance of Natural Killer Cell-Mediated Alloreactivity in Unrelated Cord Blood Transplantation for Children with Acute Leukemia: A Japanese National Registry Study

Hirotoshi Sakaguchi, MD PhD, Nobuyoshi Arima, MD PhD, Atsushi Narita, MD PhD, Sae Ishimaru, MD, Daisuke Tomizawa, MD PhD, Daiichiro Hasegawa, MD PhD, Motohiro Kato, MD, Hiroyuki Ishida, MD PhD, Junya Kanda, MD, Masami Inoue, MD PhD, Nao Yoshida, MD PhD, Katsuyoshi Koh, MD, Jiro Inagaki, MD PhD, Atsushi Ogawa, MD PhD, Tsukasa Hori, MD PhD, Yoshiko Hashii, MD, PhD, Koji Kato, MD, PhD, Yoshiko Atsuta, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3315.
https://doi.org/10.1182/blood.V130.Suppl_1.3315.3315
Published: 2017
Journal Articles

Clonal Evolution Mechanisms and Collateral Sensitivity to Impdh Inhibitor Therapy in Relapsed Lymphoblastic Leukemia

Chelsea Dieck, Gannie Tzoneva, PhD, Koichi Oshima, MD PhD, Alberto Ambesi-Impiombato, Marta Sanchez-Martin, PhD, Maria Luisa Sulis, MD, Motohiro Kato, MD PhD, Katsuyoshi Koh, MD, Maddalena Paganin, PhD, Giuseppe Basso, MD, Julie M. Gastier-Foster, PhD, Mignon L. Loh, MD, Renate Kirschner-Schwabe, PhD, Chioma Madubata, Raul Rabadan, Adolfo A. Ferrando, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2602.
https://doi.org/10.1182/blood.V130.Suppl_1.2602.2602
Published: 2017
Journal Articles

Evaluation of Nudt15 -Guided Thiopurine Dose Individualization In Vivo Using CRISPR/Cas9-Edited Mouse Model

Takaya Moriyama, MDPhD, Rina Nishii, Laura Janke, DVM, PhD, Lie Li, Chen Ru, Scott A Brown, PhD, Ting-Nien Lin, Chase Suiter, Kentaro Kihira, MD, Hidemi Toyoda, MD PhD, Motohiro Kato, MD PhD, Atushi Manabe, MD PhD, Katsuyoshi Koh, MD, Masatoshi Takagi, MD PhD, Hiroki Hori, MD PhD, Jun J. Yang, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3879.
https://doi.org/10.1182/blood.V130.Suppl_1.3879.3879
Published: 2017
Journal Articles

The Epigenetic and Genetic Landscapes of Pediatric T-Cell Acute Lymphoblastic Leukemia (T-ALL)

Shunsuke Kimura, Masafumi Seki, MD,PhD, Tomoko Kawai, PhD, Kenichi Yoshida, MD PhD, Tomoya Isobe, Hiroo Ueno, MD, Yusuke Shiozawa, MD , PhD, Hiromichi Suzuki, MD , PhD, Yuichi Shiraishi, PhD, Kenichi Chiba, B.A., Hiroko Tanaka, B.A., Kentaro Ohki, MD PhD, Motohiro Kato, MD, Katsuyoshi Koh, MD, Ryoji Hanada, MD, Ryoji Kobayashi, MD, Takao Deguchi, MD PhD, Yoshiko Hashii, MD, PhD, Toshihiko Imamura, MD, PhD, Atsushi Sato, MD, Nobutaka Kiyokawa, MD PhD, Atushi Manabe, MD PhD, Keizo Horibe, Akira Ohara, MD, Masashi Sanada, MD PhD, Masao Kobayashi, MD PhD, Akira Oka, MD PhD, Yasuhide Hayashi, MD PhD, Satoru Miyano, PhD, Kenichiro Hata, MD PhD, Seishi Ogawa, MD PhD, Junko Takita, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1444.
https://doi.org/10.1182/blood.V130.Suppl_1.1444.1444
Published: 2017