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Journal Articles

The JAK2V617F-Bearing Megakaryocytes Promote Hematopoietic Stem/Progenitor Cell Expansion through the Thrombopoietin/MPL Signaling

Yu Zhang, BS, Chi Hua Sarah Lin, PhD, Kenneth Kaushansky, MD, Huichun Zhan, MD

Blood (2017) 130 (Supplement 1): 2932.

https://doi.org/10.1182/blood.V130.Suppl_1.2932.2932

Published: 2017

Journal Articles

The JAK2 V617F -Bearing Vascular Niche Regulates Hematopoietic Stem/Progenitor Cell Regeneration Following Radiation Injury

Chi Hua Sarah Lin, PhD, Yu Zhang, BS, Kenneth Kaushansky, MD, Huichun Zhan, MD

Blood (2017) 130 (Supplement 1): 4217.

https://doi.org/10.1182/blood.V130.Suppl_1.4217.4217

Published: 2017

Journal Articles

JAK2 V617F -Mutant Vascular Niche Promotes JAK2 V617F Clonal Expansion in Myeloproliferative Neoplasms

Huichun Zhan, MD, Chi Hua Sarah Lin, PhD, Yarden Segal, Kenneth Kaushansky, MD

Blood (2016) 128 (22): 952.

https://doi.org/10.1182/blood.V128.22.952.952

Published: 2016

Journal Articles

JAK2 V617F -Mutant Megakaryocytes Contribute to Stem Cell Expansion in Myeloproliferative Neoplasms

Huichun Zhan, MD, Yupo Ma, MD PhD, Kenneth Kaushansky, MD

Blood (2015) 126 (23): 485.

https://doi.org/10.1182/blood.V126.23.485.485

Published: 2015

Journal Articles

A Novel Activating JAK2 Mutation, JAK2R564Q, Causes Familial Essential Thrombocytosis (fET) Via Mechanisms Distinct From JAK2V617F

Leah Etheridge, PhD, Lana M Corbo, BS, Kenneth Kaushansky, MD, Edward Chan, MD, Ian S Hitchcock, PhD

Blood (2011) 118 (21): 123.

https://doi.org/10.1182/blood.V118.21.123.123

Published: 2011

Journal Articles

Lineage Restricted JAK2V617F Expression and Its Role in Thrombosis and Hemostasis; The Potential Involvement of Endothelial JAK2V617F in Clotting Abnormalities

Ian S Hitchcock, PhD, Michelle E Roh, BS, Veena Sangkhae, BS, Leah Etheridge, PhD, Rose Chen, BS, Norma E Fox, BS, Kenneth Kaushansky, MD

Blood (2011) 118 (21): 1737.

https://doi.org/10.1182/blood.V118.21.1737.1737

Published: 2011

Journal Articles

Functional Interaction Between c-MPL and Tensin2: A Novel and Potentially Important Pathway in Thrombopoietin Mediated Signaling.

Andre Scott Jung, MD, Alexis Kaushansky, Kenneth Kaushansky, MD

Blood (2009) 114 (22): 3609.

https://doi.org/10.1182/blood.V114.22.3609.3609

Published: 2009

Journal Articles

Thrombopoietin-Mediated Ubiquitination and Degradation of C-Mpl

Sebastian J Saur, Amy Geddis, MD, PhD, Kenneth Kaushansky, MD, Ian Hitchcock, PhD

Blood (2008) 112 (11): 2889.

https://doi.org/10.1182/blood.V112.11.2889.2889

Published: 2008

Journal Articles

The Homodimeric Hematopoietic Cytokine Receptor C-Mpl Requires Cross Phosphorylation in Order to Signal Cell Proliferation

Justin Persico, MD, Imawati Budjahardo, MD, PhD, Kenneth Kaushansky, MD

Blood (2008) 112 (11): 3734.

https://doi.org/10.1182/blood.V112.11.3734.3734

Published: 2008

Journal Articles

Erythropoietin Stimulates Thrombopoiesis in the Absence of C-Mpl Signaling

Norma E Fox, BSc, Rose Chen, BSc, Ian Hitchcock, PhD, Kenneth Kaushansky, MD, Amy Geddis, MD, PhD

Blood (2008) 112 (11): 2451.

https://doi.org/10.1182/blood.V112.11.2451.2451

Published: 2008

Journal Articles

Selective Inhibition of JAK2 Driven Erythroid Differentiation of Polycythemia Vera Progenitors

Ifat Geron, MS, Annelie Abrahamsson, MS, Charlene Barroga, PhD, Edward Kavelerchik, MD, Jason R. Gotlib, MD MS, John D. Hood, PhD, Jeffrey Durocher, PhD, Chi Ching Mak, PhD, Glen Noronha, PhD, Richard Soll, PhD, Ayalew Tefferi, MD, Kenneth Kaushansky, MD, Catriona H.M. Jamieson, MD PhD

Blood (2007) 110 (11): 1526.

https://doi.org/10.1182/blood.V110.11.1526.1526

Published: 2007

Journal Articles

Inhibition of JAK2 V617F-Induced Erythroid Skewing of Hematopoietic Stem Cell Differentiation with a Selective JAK2 Antagonist.

Ifat Geron, MS, Charlene Barroga, PhD, Jason Gotlib, MD MS, Edward Kavalerchik, MD, Annelie Abrahamsson, MS, Daniel Goff, BS, Nicholas Cacalano, PhD, John Hood, PhD, Richard Soll, MD, Glenn Noronha, PhD, Ayalew Tefferi, MD, Irving L. Weissman, MD, Kenneth Kaushansky, MD PhD, Catriona Jamieson, MD, PhD

Blood (2006) 108 (11): 3616.

https://doi.org/10.1182/blood.V108.11.3616.3616

Published: 2006

Journal Articles

Thrombopoietin Promotes b1 Integrin-Mediated Adhesion in Hematopoietic Cells Via the Small GTPase Rap1.

Ian S. Hitchcock, PhD, Kenneth Kaushansky, MD

Blood (2006) 108 (11): 1393.

https://doi.org/10.1182/blood.V108.11.1393.1393

Published: 2006

Journal Articles

Endomitotic MKs Undergo Cortical Contraction during Anaphase but Do Not Complete Furrow Ingression.

Amy Geddis, MD, PhD, Norma Fox, Katherine Sear, Eugene Tkachenko, PhD, Kenneth Kaushansky, MD

Blood (2006) 108 (11): 1124.

https://doi.org/10.1182/blood.V108.11.1124.1124

Published: 2006

Journal Articles

PI3K/Akt/FOXO3a Pathway Contributes to Thrombopoietin-Induced Proliferation of Primary Megakaryocytes In Vitro and In Vivo Via Modulation of p27 Kip1 .

Takafumi Nakao, MD, Amy E Geddis, MD, Norma E. Fox, Kenneth Kaushansky, MD

Blood (2005) 106 (11): 202.

https://doi.org/10.1182/blood.V106.11.202.202

Published: 2005

Journal Articles

Thrombopoietin (TPO) Regulates HIF-1α Level through Generation of Mitochondrial Reactive Oxygen Species (ROS).

Kozue Yoshida, Keita Kirito, MD, Kenneth Kaushansky, MD, Norio Komatsu, MD

Blood (2005) 106 (11): 3145.

https://doi.org/10.1182/blood.V106.11.3145.3145

Published: 2005

Journal Articles

Thrombopoietin Enhances Expression of Vascular Endothelial Growth Factor (VEGF) in Primitive Hematopoietic Cells through Hif-1α.

Keita Kirito, MD, Norma Fox, Kenneth Kaushansky, MD

Blood (2004) 104 (11): 2170.

https://doi.org/10.1182/blood.V104.11.2170.2170

Published: 2004

Journal Articles

Aurora-B Kinase Translocates to the Midzone in Endomitotic Megakaryocytes.

Amy E. Geddis, MD, PhD, Kenneth Kaushansky, MD

Blood (2004) 104 (11): 1263.

https://doi.org/10.1182/blood.V104.11.1263.1263

Published: 2004

Journal Articles

Factors Affecting Thrombopoietin Production from Bone Marrow Stromal Cells.

Bryan J. McIntosh, BS, Norma E. Fox, MS, Kenneth Kaushansky, MD

Blood (2004) 104 (11): 1280.

https://doi.org/10.1182/blood.V104.11.1280.1280

Published: 2004

Journal Articles

The C-Mpl Receptor Expressed on Endothelial Cells Does Not Contribute Significantly to the Regulation of Circulating Thrombopoietin (TPO) Levels.

Amy E. Geddis, MD, PhD, Norma E. Fox, Kenneth Kaushansky, MD

Blood (2004) 104 (11): 739.

https://doi.org/10.1182/blood.V104.11.739.739

Published: 2004

NARROW

The JAK2V617F-Bearing Megakaryocytes Promote Hematopoietic Stem/Progenitor Cell Expansion through the Thrombopoietin/MPL Signaling

The JAK2 V617F -Bearing Vascular Niche Regulates Hematopoietic Stem/Progenitor Cell Regeneration Following Radiation Injury

JAK2 V617F -Mutant Vascular Niche Promotes JAK2 V617F Clonal Expansion in Myeloproliferative Neoplasms

JAK2 V617F -Mutant Megakaryocytes Contribute to Stem Cell Expansion in Myeloproliferative Neoplasms

A Novel Activating JAK2 Mutation, JAK2R564Q, Causes Familial Essential Thrombocytosis (fET) Via Mechanisms Distinct From JAK2V617F

Lineage Restricted JAK2V617F Expression and Its Role in Thrombosis and Hemostasis; The Potential Involvement of Endothelial JAK2V617F in Clotting Abnormalities

Functional Interaction Between c-MPL and Tensin2: A Novel and Potentially Important Pathway in Thrombopoietin Mediated Signaling.

Thrombopoietin-Mediated Ubiquitination and Degradation of C-Mpl

The Homodimeric Hematopoietic Cytokine Receptor C-Mpl Requires Cross Phosphorylation in Order to Signal Cell Proliferation

Erythropoietin Stimulates Thrombopoiesis in the Absence of C-Mpl Signaling

Selective Inhibition of JAK2 Driven Erythroid Differentiation of Polycythemia Vera Progenitors

Inhibition of JAK2 V617F-Induced Erythroid Skewing of Hematopoietic Stem Cell Differentiation with a Selective JAK2 Antagonist.

Thrombopoietin Promotes b1 Integrin-Mediated Adhesion in Hematopoietic Cells Via the Small GTPase Rap1.

Endomitotic MKs Undergo Cortical Contraction during Anaphase but Do Not Complete Furrow Ingression.

PI3K/Akt/FOXO3a Pathway Contributes to Thrombopoietin-Induced Proliferation of Primary Megakaryocytes In Vitro and In Vivo Via Modulation of p27 Kip1 .

Thrombopoietin (TPO) Regulates HIF-1α Level through Generation of Mitochondrial Reactive Oxygen Species (ROS).

Thrombopoietin Enhances Expression of Vascular Endothelial Growth Factor (VEGF) in Primitive Hematopoietic Cells through Hif-1α.

Aurora-B Kinase Translocates to the Midzone in Endomitotic Megakaryocytes.

Factors Affecting Thrombopoietin Production from Bone Marrow Stromal Cells.

The C-Mpl Receptor Expressed on Endothelial Cells Does Not Contribute Significantly to the Regulation of Circulating Thrombopoietin (TPO) Levels.

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American Society of Hematology

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American Society of Hematology

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