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Lakshmi Reddy Palam, PhD
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Journal Articles

Cooperativity between Flt3/Syk and Proteasome Inhibitors in Flt3mutant/Wildtype AML, By Acting on the Oxphos and Wnt Endpoints of Syk and p62SQSTM1 Pathways Prohibits Protective Autophagy; While Downregulation of NRF2, NQO1, Jun, and b-Catenin Bypasses Interfering RAS or WT1 Co-Mutations

Sravanti Rangaraju, MBBS, Silvia Marino, PhD, G. David Roodman, MD PhD, Larry D. Cripe, MD, Baskar Ramdas, PhD, Lakshmi Reddy Palam, PhD, Katie J Sargent, RN, Hamid Sayar, MD MSc, Heiko Konig, MD PhD, Reuben Kapur, PhD, H. Scott Boswell, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5051.
https://doi.org/10.1182/blood-2019-124384
Published: 2019
Journal Articles

Combined Heterozygous Loss of Tet2 and Dnmt3a Along with Expression of Flt3 ITD/WT results in Acute Myeloid Leukemia Which Responds to a Combination of FLT3 Inhibitor, APE1 Inhibitor and Decitabine

Baskar Ramdas, PhD, Lakshmi Reddy Palam, PhD, Raghuveer Singh Mali, PhD, Zhigang Cai, PhD, Ruchi Pandey, PhD, Reuben Kapur, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3754.
https://doi.org/10.1182/blood-2019-131172
Published: 2019
Journal Articles

Loss of Dnmt3a Dysregulates Hematopoietic Homeostasis and Myeloid Skewing Via the PI3Kinase Pathway: PI3Kα/β Inhibition Corrects Extramedullary Hematopoiesis and Myeloid Skewing Due to Loss of Dnmt3a

Lakshmi Reddy Palam, PhD, Baskar Ramdas, PhD, Katelyn Pickerell, Reuben Kapur, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 723.
https://doi.org/10.1182/blood-2019-131036
Published: 2019
Journal Articles

Identification of Beta-Catenin As a Novel Ubiquitin-Regulated Target of Combined Flβ3/Syk- and Proteasome Inhibitors for Interruption of LSC Signaling in Poor-Risk AML

Sravanti Rangaraju, MBBS, Silvia Marino, PhD, Daniela Nicoleta Petrusca, PhD, Larry D Cripe, MD, Katie J Sargent, RN, G. David Roodman, MD PhD, Hamid Sayar, MD MSc, Baskar Ramdas, PhD, Lakshmi Reddy Palam, PhD, Rajasubramaniam Shanmugam, PhD, Adriana Rogozea, Heiko Konig, MD PhD, Reuben Kapur, PhD, H. Scott Boswell, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3949.
https://doi.org/10.1182/blood-2018-99-111181
Published: 2018
Journal Articles

Temporal and Spatially Regulated Oncogenic KIT Expression and Loss of Dnmt3a Cooperate to Drive MPN Development: Role of PI3Kinase in Dnmt3a Loss Induced Hyperproliferation in Myeloid Cells

Lakshmi Reddy Palam, PhD, Baskar Ramdas, PhD, Sridhar reddy Srivatsan, MS, Sarath Chandra Janga, PhD, Axel Roers, PhD, Alexander Gerbaulet, Reuben Kapur, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3055.
https://doi.org/10.1182/blood-2018-99-118721
Published: 2018
Journal Articles

Downregulation of Morrbid in Tet2-Deficient Preleukemic Cells Overcomes Resistance to Inflammatory Stress and Mitigates Clonal Hematopoiesis

Zhigang Cai, PhD, Jonathan Kotzin, Baskar Ramdas, PhD, Sisi Chen, Sai Nelanuthala, Lakshmi Reddy Palam, PhD, Ruchi Pandey, Raghuveer Mali, PhD, Yan Liu, PhD, Mark R. Kelley, George Sandusky, DVM, PhD, Morvarid Mohseni, Adam Williams, Jorge Henao-Mejia, Reuben Kapur, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1288.
https://doi.org/10.1182/blood-2018-99-116703
Published: 2018
Journal Articles

PI3Kinase Inactivation through Combined Loss of Catalytic Subunits p110α, p110β and p110δ Derails Hematopoietic Homeostasis

Lakshmi Reddy Palam, PhD, Raghuveer Mali, PhD, Baskar Ramdas, PhD, Bart Vanhaesebroeck, PhD, Reuben Kapur, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3754.
https://doi.org/10.1182/blood.V130.Suppl_1.3754.3754
Published: 2017