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Linda B. Couto, PhD
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Journal Articles

A Phase 1/2 Trial of Investigational Spk-8011 in Hemophilia a Demonstrates Durable Expression and Prevention of Bleeds

Katherine A. High, MD, Lindsey A. George, MD, M. Elaine Eyster, MD, Spencer K. Sullivan, MD, Margaret V. Ragni, MD MPH, Stacy E. Croteau, MD, Ben J. Samelson-Jones, MD PhD, Matthew Evans, MD, Marcelyne Joseney-Antoine, Amy Macdougall, BSN, Judith Kadosh, BSN RN, Alexa R. Runoski, MS, Cynthia Campbell-Baird, Kayla Douglas, Summer Tompkins, Howard Hait, Linda B. Couto, PhD, Ashlyn Eaton Bassiri, PhD, Leonard A. Valentino, MD, Marcus E. Carr, MD PhD, Daniel J Hui, PhD BS, Katie Wachtel, MS, Daniel Takefman, Federico Mingozzi, PhD, Xavier M. Anguela, PhD, Kathleen B Reape, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 487.
https://doi.org/10.1182/blood-2018-99-115495
Published: 2018
Journal Articles

Spk-9001: Adeno-Associated Virus Mediated Gene Transfer for Hemophilia B - 1 Year Follow up and Impact of Baseline Characteristics on Transgene-Derived Factor IX Activity and Persistence

Lindsey A. George, MD, Spencer K. Sullivan, MD, Adam Giermasz, MD, Ben J. Samelson-Jones, MD PhD, Jonathan M. Ducore, MD, Jerome M. Teitel, MD FRCPC, Adam Cuker, MD MS, Sylvia Von Mackensen, PhD, Suvankar Majumdar, MD, Catherine E. McGuinn, MD, Alexa R. Runoski, MS, Fraser Wright, PhD, Sue Dasen, MS, Kimberly Barber, Yifeng Chen, MD, Daniel J. Hui, PhD, Ruchi Patel, Yun Liu, PhD, Katie Wachtel, MS, Dan Takefman, Linda B. Couto, PhD, Kathleen Z. Reape, Marcus E. Carr, MD PhD, Xavier M. Anguela, PhD, Katherine A. High, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 601.
https://doi.org/10.1182/blood.V130.Suppl_1.601.601
Published: 2017
Journal Articles

Spk-8011: Preliminary Results from a Phase 1/2 Dose Escalation Trial of an Investigational AAV-Mediated Gene Therapy for Hemophilia a

Lindsey A. George, MD, Margaret V. Ragni, MD MPH, Ben J. Samelson-Jones, MD PhD, Adam Cuker, MD MS, Alexa R. Runoski, MS, Grace Cole, Fraser Wright, PhD, Yifeng Chen, MD, Daniel J Hui, PhD BS, Katie Wachtel, MS, Daniel Takefman, Linda B. Couto, PhD, Kathleen Z. Reape, Marcus E. Carr, MD PhD, Xavier M. Anguela, PhD, Katherine A. High, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 604.
https://doi.org/10.1182/blood.V130.Suppl_1.604.604
Published: 2017
Journal Articles

Spk-9001: Adeno-Associated Virus Mediated Gene Transfer for Hemophilia B Achieves Sustained Mean Factor IX Activity Levels of >30% without Immunosuppression

Lindsey A. George, MD, Spencer K. Sullivan, MD, Adam Giermasz, MD, PhD, Jonathan M. Ducore, Jerome M. Teitel, MD, Adam Cuker, MD MS, Lisa M. Sullivan, MD, Suvankar Majumdar, MD, Catherine E. McGuinn, MD, Aline M. Galvao, M.S., B.S.N.-R.N., Alvin Y. Luk, PhD, M.B.A., J. Fraser Wright, PhD, Yifeng Chen, MD, Daniel J. Hui, PhD, Katie Wachtel, M.S., Teresa Urich, B.S., Daniel Takefman, PhD, Linda B. Couto, PhD, Marcus E. Carr, MD, PhD, Xavier M. Anguela, PhD, Katherine A. High, MD
Journal: Blood
Blood (2016) 128 (22): 3.
https://doi.org/10.1182/blood.V128.22.3.3
Published: 2016