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Journal Articles

Improved Anti-Leukemic Pre-Clinical Efficacy of a Protac Based MDM2 Degrader in a Large AML Cohort

Malathi Kandarpa, PhD, Luke F. Peterson, PhD, Harish Potu, PhD, Megha Ramappan, Yihong Liu, Avery Polk, Shaomeng Wang, PhD, Moshe Talpaz, MD

Blood (2019) 134 (Supplement_1): 2670.

https://doi.org/10.1182/blood-2019-131949

Published: 2019

Journal Articles

Superior Pre-Clinical Efficacy of Novel Protac Based BET Degrader in a Large Acute Myeloid Leukemia Cohort

Malathi Kandarpa, PhD, Luke F. Peterson, PhD, Harish Potu, PhD, Yihong Liu, Avery Polk, Shaomeng Wang, PhD, Moshe Talpaz, MD

Blood (2019) 134 (Supplement_1): 3936.

https://doi.org/10.1182/blood-2019-131759

Published: 2019

Journal Articles

Integrative Next Generation Sequencing of Myeloproliferative Neoplasms and Correlation of Genetic Variations to Disease Severity

Malathi Kandarpa, PhD, Kristen Pettit, MD, Yi-Mi Wu, PhD, Qing Li, MD, Robert Lonigro, Dan Robinson, PhD, Luke F. Peterson, PhD, Philip S Boonstra, PhD, Arul Chinnaiyan, MD, Moshe Talpaz, MD

Blood (2018) 132 (Supplement 1): 4324.

https://doi.org/10.1182/blood-2018-99-113418

Published: 2018

Journal Articles

Ets1 Enhances Context-Dependent Notch1 Activity in T-Cell Leukemia

Anna McCarter, BS, Ran Yan, Amparo Serna Alarcon, Catherine Chang, Erin Kim, Cher Sha, Yiran Liu, Qing Wang, PhD, Luke F. Peterson, PhD, Rork Kuick, Russell Ryan, MD, Moshe Talpaz, MD, Linda Samuelson, PhD, Michael Ostrowski, PhD, Mark Y Chiang, MD PhD

Blood (2018) 132 (Supplement 1): 2595.

https://doi.org/10.1182/blood-2018-99-111376

Published: 2018

Journal Articles

Targeting CDK6 and BCL2 Exploits the “MYB Addiction” of Ph+ Acute Lymphoblastic Leukemia

Marco De Dominici, MS, Angela Rachele Soliera, PhD, Patrizia Porazzi, PhD, Samanta A. Mariani, PhD, Sankar Addya, PhD, Luke F. Peterson, PhD, Orietta Spinelli, PhD, Alessandro Rambaldi, MD Prof, Giovanni Martinelli, MD, Ilaria Iacobucci, PhD, Anna Ferrari, PhD, Bruno Calabretta, MD PhD

Blood (2017) 130 (Supplement 1): 2490.

https://doi.org/10.1182/blood.V130.Suppl_1.2490.2490

Published: 2017

Journal Articles

Usp9x Silencing and Enzyme Inhibition Suppress Myeloma Cell Survival and in Vivo Tumor Growth.

Luke F. Peterson, PhD, Hanshi Sun, PhD, Yihong Liu, PhD, Malathi Kandarpa, PhD, Diane Giannola, Jessica Mercer, PhD, Hollis D. Showalter, Ph.D., Andrzej Jakubowiak, MD, PhD, Moshe Talpaz, MD, Nicholas J. Donato, PhD

Blood (2012) 120 (21): 2936.

https://doi.org/10.1182/blood.V120.21.2936.2936

Published: 2012

Journal Articles

Mechanism of Action of a Small Molecule Inhibitor That Targets Usp9x Deubiquitinase Activity in Multiple Myeloma and Mantle Cell Lymphoma

Luke F. Peterson, PhD, Hanshi Sun, PhD, Matthew Young, PhD, Hollis D. Showalter, Ph.D., Andrzej J Jakubowiak, MD, PhD, Moshe Talpaz, MD, Nicholas Donato, PhD

Blood (2011) 118 (21): 1415.

https://doi.org/10.1182/blood.V118.21.1415.1415

Published: 2011

Journal Articles

Deubiquitinase Usp9X Regulates Cell Survival and Metabolic Signal Transduction in Multiple Myeloma Cells

Luke F. Peterson, PhD, Hanshi Sun, PhD, Vaibhav Kapuria, Ph.D., Malathi Kandarpa, PhD, Moshe Talpaz, MD, Andrzej J Jakubowiak, MD, PhD, Nicholas Donato, PhD

Blood (2011) 118 (21): 1835.

https://doi.org/10.1182/blood.V118.21.1835.1835

Published: 2011

Journal Articles

Inhibition of Usp9x Deubiquitinase Activity by WP1130 Reduces Mcl-1 Levels and Induces Apoptosis In Cells From Patients with Plasma Cell Dyscrasia and Drug-Refractory Multiple Myeloma

Hanshi Sun, PhD, Vaibhav Kapuria, Ph.D., Luke F. Peterson, PhD, Diane Giannola, Kandarpa Malathi, Ph.D., Moshe Talpaz, MD, Andrzej J Jakubowiak, MD, PhD, Nicholas Donato, PhD

Blood (2010) 116 (21): 3005.

https://doi.org/10.1182/blood.V116.21.3005.3005

Published: 2010

Journal Articles

The Novel BCR-ABL1 V304D Mutation Induces Pan-Tyrosine Kinase Inhibitor Resistance by a Unique Kinase Lateral Escape Mechanism and Is Associated with Very Poor Prognosis In Patients (PTS) with Chronic Myeloid Leukemia (CML).

Sabrina Pricl, PhD, Don L Gibbons, MD, PhD, Paola Posocco, PhD, Erik Laurini, PhD, Maurizio Fermeglia, Hagop M. Kantarjian, MD, Moshe Talpaz, MD, Jorge Cortes, MD, Matthew Young, PhD, Hanshi Sun, PhD, Luke F. Peterson, PhD, Nicholas Donato, PhD, Alfonso Quintás-Cardama, MD

Blood (2010) 116 (21): 3402.

https://doi.org/10.1182/blood.V116.21.3402.3402

Published: 2010

Journal Articles

Cytogenetic and SNP Array Study of CML Patients In Complete Cytogenetic Remission.

Moshe Talpaz, MD, Luke F. Peterson, PhD, Emilija Mitrikeska, Peter Ouillette, Sami Malek, MD

Blood (2010) 116 (21): 3433.

https://doi.org/10.1182/blood.V116.21.3433.3433

Published: 2010

Journal Articles

Wnt-Pathway Directed Compound Targets Blast Crisis and Chronic Phase CML Leukemia Stem Progenitors.

Luke F Peterson, PhD, Anjanette J Turbiak, PhD, Diane M Giannola, BSc, Nicholas Donato, Hollis H.D. Showalter, PhD, Eric R Fearon, MD, PhD, Moshe Talpaz, MD

Blood (2009) 114 (22): 2168.

https://doi.org/10.1182/blood.V114.22.2168.2168

Published: 2009

Journal Articles

WP1130 Inhibits Signaling through BCR-ABL Ubiquitination and Cytoplasmic to Aggresome Trafficking to Induce Apoptosis of CML Cells.

Nicholas J Donato, Ph.D., Hanshi Sun, Ph.D., Vaibhav Kapuria, Luke F Peterson, PhD, Geoffrey Bartholomeusz, Ph.D., William G. Bornmann, Ph.D., Moshe Talpaz, M.D.

Blood (2009) 114 (22): 3303.

https://doi.org/10.1182/blood.V114.22.3303.3303

Published: 2009

Journal Articles

Inhibition of Cytokine Signaling through Activation of Jak2 Ubiquitination by WP1130.

Vaibhav Kapuria, Luke F Peterson, PhD, William Bornmann, Ph.D., Moshe Talpaz, MD, Nicholas J Donato

Blood (2009) 114 (22): 2907.

https://doi.org/10.1182/blood.V114.22.2907.2907

Published: 2009

Journal Articles

De-Ubiquitinase Inhibition by WP1130 Induces Formation of Aggresomes, Engages Autophagy and Activates Apoptosis in B-Cell Malignancies.

Vaibhav Kapuria, Luke F Peterson, PhD, Moshe Talpaz, MD, Nicholas J Donato

Blood (2009) 114 (22): 3769.

https://doi.org/10.1182/blood.V114.22.3769.3769

Published: 2009

Journal Articles

Degrasyn (a novel tyrophostin) Impacts BCR-ABL Protein Level and Is Cytotoxic to Chronic Myeloid Leukemia Early Progenitors

Luke F Peterson, PhD, Hanshi Sun, PhD, William Bornmann, PhD, Zhenghong Peng, PhD, David Maxwell, PhD, Nicholas Donato, Moshe Talpaz

Blood (2008) 112 (11): 3212.

https://doi.org/10.1182/blood.V112.11.3212.3212

Published: 2008

Journal Articles

Enhanced Cytotoxicity in Chronic Myeloid Leukemia Primitive Progenitors by the Combined Action of Imatinib and An HDM2-Inhibitor

Luke F Peterson, PhD, Shaomeng Wang, Moshe Talpaz

Blood (2008) 112 (11): 3213.

https://doi.org/10.1182/blood.V112.11.3213.3213

Published: 2008

Journal Articles

Cyclin-Dependent Kinases Phosphorylate AML1 (RUNX1) and Regulate AML1 Transactivation.

Joseph R. Biggs, PhD, Luke F. Peterson, PhD, Youhong Zhang, PhD, Andrew S. Kraft, MD, Dong-Er Zhang, PhD

Blood (2005) 106 (11): 2721.

https://doi.org/10.1182/blood.V106.11.2721.2721

Published: 2005

Journal Articles

A t(8;21) Fusion Protein Disrupts the Spindle Checkpoint and Promotes Aneuploidy.

Anita Boyapati, PhD, Luke F. Peterson, PhD, Ming Yan, PhD, Michelle M. Le Beau, PhD, Dong-Er Zhang, PhD

Blood (2005) 106 (11): 1345.

https://doi.org/10.1182/blood.V106.11.1345.1345

Published: 2005

Journal Articles

AML1-ETO9a, an Alternatively Spliced Form of AML1-ETO, Collaborates with AML1-ETO To Promote Leukemogenesis.

Ming Yan, PhD, Yang Wang, MD, PhD, Luke F. Peterson, PhD, Eiki Kanbe, MD, PhD, Anita Boyapati, PhD, Dong-Er Zhang, PhD

Blood (2005) 106 (11): 661.

https://doi.org/10.1182/blood.V106.11.661.661

Published: 2005

NARROW

Improved Anti-Leukemic Pre-Clinical Efficacy of a Protac Based MDM2 Degrader in a Large AML Cohort

Superior Pre-Clinical Efficacy of Novel Protac Based BET Degrader in a Large Acute Myeloid Leukemia Cohort

Integrative Next Generation Sequencing of Myeloproliferative Neoplasms and Correlation of Genetic Variations to Disease Severity

Ets1 Enhances Context-Dependent Notch1 Activity in T-Cell Leukemia

Targeting CDK6 and BCL2 Exploits the “MYB Addiction” of Ph+ Acute Lymphoblastic Leukemia

Usp9x Silencing and Enzyme Inhibition Suppress Myeloma Cell Survival and in Vivo Tumor Growth.

Mechanism of Action of a Small Molecule Inhibitor That Targets Usp9x Deubiquitinase Activity in Multiple Myeloma and Mantle Cell Lymphoma

Deubiquitinase Usp9X Regulates Cell Survival and Metabolic Signal Transduction in Multiple Myeloma Cells

Inhibition of Usp9x Deubiquitinase Activity by WP1130 Reduces Mcl-1 Levels and Induces Apoptosis In Cells From Patients with Plasma Cell Dyscrasia and Drug-Refractory Multiple Myeloma

The Novel BCR-ABL1 V304D Mutation Induces Pan-Tyrosine Kinase Inhibitor Resistance by a Unique Kinase Lateral Escape Mechanism and Is Associated with Very Poor Prognosis In Patients (PTS) with Chronic Myeloid Leukemia (CML).

Cytogenetic and SNP Array Study of CML Patients In Complete Cytogenetic Remission.

Wnt-Pathway Directed Compound Targets Blast Crisis and Chronic Phase CML Leukemia Stem Progenitors.

WP1130 Inhibits Signaling through BCR-ABL Ubiquitination and Cytoplasmic to Aggresome Trafficking to Induce Apoptosis of CML Cells.

Inhibition of Cytokine Signaling through Activation of Jak2 Ubiquitination by WP1130.

De-Ubiquitinase Inhibition by WP1130 Induces Formation of Aggresomes, Engages Autophagy and Activates Apoptosis in B-Cell Malignancies.

Degrasyn (a novel tyrophostin) Impacts BCR-ABL Protein Level and Is Cytotoxic to Chronic Myeloid Leukemia Early Progenitors

Enhanced Cytotoxicity in Chronic Myeloid Leukemia Primitive Progenitors by the Combined Action of Imatinib and An HDM2-Inhibitor

Cyclin-Dependent Kinases Phosphorylate AML1 (RUNX1) and Regulate AML1 Transactivation.

A t(8;21) Fusion Protein Disrupts the Spindle Checkpoint and Promotes Aneuploidy.

AML1-ETO9a, an Alternatively Spliced Form of AML1-ETO, Collaborates with AML1-ETO To Promote Leukemogenesis.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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