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Journal Articles

A Method to Estimate Whole Blood Concentration of Voxelotor in People with Sickle Cell Disease Using High Performance Liquid Chromatography and Capillary Electrophoresis

Susanna Curtis, Elana M Friedman, Caterina P Minniti, Annie Ngyuen Dang, Mira P. Pochron, Julissa Morales, Andrew Crouch, Sean Campbell
Journal: Blood
Blood (2022) 140 (Supplement 1): 2572–2573.
https://doi.org/10.1182/blood-2022-170526
Published: 2022
Journal Articles

A Method to Measure Voxelotor Exposure in People with Sickle Cell Disease Using Capillary Zone Electrophoresis

Susanna A Curtis, Elana M Friedman, Caterina Minniti, Annie Ngyuen Dang, Mira Pochron, Merin Thomas, Jaime Luis Betancourt, Leena Vattappally, Andrew Crouch, Julissa Morales, Sean Campbell
Journal: Blood
Blood (2021) 138 (Supplement 1): 2025.
https://doi.org/10.1182/blood-2021-153676
Published: 2021
Journal Articles

Molecular and Phenotypic Profiling of Drug Product and Post-Infusion Samples from CRB-402, an Ongoing: Phase I Clinical Study of bb21217 a BCMA-Directed CAR T Cell Therapy

Olivia C Finney, Ashish Yeri, PhD, Pingping Mao, PhD, Chetanya Pandya, PhD, Eric Alonzo, PhD, Gregory Hopkins, BS, Sebastian Hymson, BS, Tiffany Hu, BS, Marianna Foos, MS, Sneha Bhadoriya, MS, Stephanie Hintzen, BS, Maple Gioia, MS, Alison Timm, MS, Monica Massaro, MPH, Ron Hause, PhD, Shari Kaiser, PhD, Nathan Martin, PhD, Melissa Alsina, MD, Nina Shah, MD, Noopur S. Raje, MD, Jesus G. Berdeja, MD, Shannon Grande, PhD, Hans Bitter, PhD, Fabio Petrocca, MD, Kevin M. Friedman, PhD, Dipen Sangurdekar, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 3–4.
https://doi.org/10.1182/blood-2020-142426
Published: 2020
Journal Articles

ROR1-Directed Chimeric Antigen Receptor T Cell Recognition of Self-Antigen Is Associated with Acute Toxicity, T Cell Dysfunction, and Poor Tumor Control.

James B Rottman, DVM, PhD DACVP, Kenneth Ganley, BS, Brenna Daly, BS, Holly M. Horton, PhD, Kevin M. Friedman, Molly Perkins, PhD, Shannon Grande, PhD, Claire J Rhodes, BS, Richard A. Morgan, PhD, Christopher J. Horvath, DVM, MS, DACVP
Journal: Blood
Blood (2017) 130 (Supplement 1): 4450.
https://doi.org/10.1182/blood.V130.Suppl_1.4450.4450
Published: 2017
Journal Articles

Gene Editing of TRAC Locus Utilizing Megatal Nucleases Increases Expression of Transgenic TCRs Delivered Via Lentiviral Vector-Mediated Gene Transfer

Michael S Magee, PhD, Iulia Diaconu, PhD, Mark Pogson, PhD, Ankit Gupta, PhD, Amy Jensen-Smith, PhD, Brian Collette, BS, Andrew Chavkin, MS, Eli Pasackow, BS, Aaron Edwards, MS, Kevin M. Friedman, Alexander Astrakhan, PhD, Michael T Certo, PhD, Jordan Jarjour, PhD, Richard A. Morgan, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1906.
https://doi.org/10.1182/blood.V130.Suppl_1.1906.1906
Published: 2017
Journal Articles

A Novel TGF-β 2 /Interleukin Receptor Signal Conversion Platform That Protects CAR/TCR T Cells from TGF-β 2 -Mediated Immune Suppression and Induces T Cell Supportive Signaling Networks

Benjamin Boyerinas, Sara M. Miller, Ryan C. Murray, John W. Evans, Geoffrey B. Parsons, Katherine J. Seidl, Kevin M. Friedman, Richard A. Morgan, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1911.
https://doi.org/10.1182/blood.V130.Suppl_1.1911.1911
Published: 2017
Journal Articles

Alemtuzumab-Cyclosporine Versus Tacrolimus-Methotrexate-Sirolimus for Graft-Versus-Host Disease Prophylaxis in Reduced Intensity Allogeneic Hematopoietic Stem Cell Transplantation from Unrelated Donors: Final Results of a Randomized Trial

Lauren M. Curtis, MD, Steven Z. Pavletic, MD, Rachel B. Salit, MD, Brian C Shaffer, MD, Seth M. Steinberg, PhD, Jennifer S. Wilder, RN, Filip Pirsl, Bazetta Blacklock-Schuver, RN, Jennifer Hsu, RN, Thomas E. Hughes, PharmD, David Stroncek, MD, Sharon Adams, Jennifer Hendricks, LCSW-C, Daniele N. Avila, CRNP, Jennifer Mann, CRNP, David C. Halverson, MD, Thea M. Friedman, PhD, Robert Korngold, PhD, Juan C. Gea-Banacloche, MD, Daniel H. Fowler, MD, Dennis L. Confer, MD, Frances T. Hakim, PhD, Ronald E. Gress, MD, Michael R. Bishop, MD
Journal: Blood
Blood (2015) 126 (23): 65.
https://doi.org/10.1182/blood.V126.23.65.65
Published: 2015
Journal Articles

A Novel and Highly Potent CAR T Cell Drug Product for Treatment of BCMA-Expressing Hematological Malignances

Alena A. Chekmasova, PhD, Holly M. Horton, PhD, Tracy E. Garrett, BA, John W. Evans, PhD, Johanna Griecci, BS, Amanda Hamel, BS, Howard J. Latimer, IV, BS, Stacie L. Seidel, MA, Byoung Y. Ryu, PhD, Michael Kuczewski, MS, Christopher J. Horvath, DVM, MS, DACVP, Kevin M. Friedman, PhD, Richard A. Morgan, PhD
Journal: Blood
Blood (2015) 126 (23): 3094.
https://doi.org/10.1182/blood.V126.23.3094.3094
Published: 2015
Journal Articles

Characterization of Lentiviral Vector Derived Anti-Bcma CAR T Cells Reveals Key Parameters for Robust Manufacturing of Cell-Based Gene Therapies for Multiple Myeloma

Graham Lilley, M.S., Alden Ladd, Daniel Cossette, Laura Viggiano, Gregory Hopkins, John W. Evans, PhD, Mingli Li, M.S., Howard J. Latimer, IV, BS, Sara M. Miller, Michael Kuczewski, MS, Wendy Bakeman, Kayla MacLeod, Kevin M. Friedman, PhD, Dawn A Maier, M.S., Michael Paglia, M.S., Richard A. Morgan, PhD, Mark D Angelino, PhD
Journal: Blood
Blood (2015) 126 (23): 3243.
https://doi.org/10.1182/blood.V126.23.3243.3243
Published: 2015
Journal Articles

Manufacturing an Enhanced CAR T Cell Product By Inhibition of the PI3K/Akt Pathway During T Cell Expansion Results in Improved In Vivo Efficacy of Anti-BCMA CAR T Cells

Molly R. Perkins, D.Phil., Shannon Grande, PhD, Amanda Hamel, BS, Holly M. Horton, PhD, Tracy E. Garrett, BA, Sara M. Miller, Howard J. Latimer, IV, BS, Christopher J. Horvath, DVM, MS, DACVP, Michael Kuczewski, MS, Kevin M. Friedman, PhD, Richard A. Morgan, PhD
Journal: Blood
Blood (2015) 126 (23): 1893.
https://doi.org/10.1182/blood.V126.23.1893.1893
Published: 2015
Journal Articles

Influence of Graft Versus-Host Disease Prophylaxis Regimen On T-Cell Repertoire Diversity Following Reduced-Intensity HLA-Matched Unrelated Donor Allogeneic Hematopoietic Stem Cell Transplantation.

Rachel B. Salit, MD, Frances T. Hakim, PhD, Michael R. Bishop, MD, Thea M. Friedman, PhD, Robert Korngold, PhD, Kira Goldgirsh, PhD, Sarfraz Memon, MD, Seth M. Steinberg, PhD, David Liewehr, MS, Daniel Peaceman, BS, Jennifer Wilder, RN, Kelly Bryant, RN, Daniel H. Fowler, MD, Juan Gea-Banacloche, MD, Ronald E. Gress, MD, Steven Z. Pavletic, MD
Journal: Blood
Blood (2012) 120 (21): 3054.
https://doi.org/10.1182/blood.V120.21.3054.3054
Published: 2012
Journal Articles

CBS9106 is a novel reversible oral CRM1 inhibitor with CRM1 degrading activity

Keiichi Sakakibara, Naoya Saito, Takuji Sato, Atsushi Suzuki, Yoko Hasegawa, Jonathan M. Friedman, Donald W. Kufe, Daniel D. VonHoff, Tadahiko Iwami, Takumi Kawabe
Journal: Blood
Blood (2011) 118 (14): 3922–3931.
https://doi.org/10.1182/blood-2011-01-333138
Published: 2011
Includes: Supplemental data
Journal Articles

Successful Implementation of GM-CSF Cellular Immunotherapy for the Treatment of Multiple Myeloma In a Mouse Model of Autologous Bone Marrow Transplantation

Jenny Zilberberg, PhD, Johann Stein, M.D., Thea M Friedman, PhD, Robert Korngold, PhD
Journal: Blood
Blood (2010) 116 (21): 4288.
https://doi.org/10.1182/blood.V116.21.4288.4288
Published: 2010
Journal Articles

Hemoglobin E (β26Glu→Lys) Exhibits Altered Nitrite Reactivity.

Camille J. Roche, Ph.D., Tatiana C. Balazs, Qiuying Chen, Ph.D., Juan C. Moreira, Joel M. Friedman, Ph.D., Rhoda Elison Hirsch, Ph.D.
Journal: Blood
Blood (2009) 114 (22): 2564.
https://doi.org/10.1182/blood.V114.22.2564.2564
Published: 2009
Journal Articles

Adoptive T Cell Therapy Using Educated T Cells Generated by the Sequential Stimulation with DC/Tumor Fusion Cells and Anti-CD3CD28

Jacalyn Rosenblatt, MD, Baldev Vasir, PhD, Zekui Wu, MD, Corrine Zarwan, MD, Richard Stone, MD, Adam Bissonnette, Thea M Friedman, PhD, Donna Neuberg, ScD, Natalya Rozenveyn, Brett Glotzbecker, MD, James D. Levine, MD, MS, Robin Joyce, MD, Vassiliki Boussiotis, MD, Dimitrios Tzachanis, MD, Dimitrios Spentzos, MD, Panagiotis Konstantinopoulos, MD, Donald Kufe, MD, David Avigan, MD
Journal: Blood
Blood (2008) 112 (11): 2913.
https://doi.org/10.1182/blood.V112.11.2913.2913
Published: 2008
Journal Articles

Vβ Spectratype-guided Separation of Graft-Versus-Host Disease and Graft-Versus-Leukemia Effects in a MHC-Matched miHA-Mismatched Mouse Model of Hematopoietic Stem Cell Transplantation

Stacey L Fanning, PhD, Stephanie A Berger, Kristin Vazzana, Loise N Gichuru, Robert Korngold, PhD, Thea M Friedman, PhD
Journal: Blood
Blood (2008) 112 (11): 3517.
https://doi.org/10.1182/blood.V112.11.3517.3517
Published: 2008
Journal Articles

Overlap between in vitro donor antihost and in vivo posttransplantation TCR Vβ use: a new paradigm for designer allogeneic blood and marrow transplantation

Thea M. Friedman, Kira Goldgirsh, Stephanie A. Berger, Jenny Zilberberg, Joanne Filicko-O'Hara, Neal Flomenberg, Michele Donato, Scott D. Rowley, Robert Korngold
Journal: Blood
Blood (2008) 112 (8): 3517–3525.
https://doi.org/10.1182/blood-2008-03-145391
Published: 2008
Journal Articles

A New Mouse Model of Multiple Myeloma: Engraftment of Primary Human Multiple Myeloma in SCID/Beige Mice.

Fabian D. Arditti, PhD, David Siegel, M.D., Thea M. Friedman, Ph.D., Robert Korngold
Journal: Blood
Blood (2007) 110 (11): 3532.
https://doi.org/10.1182/blood.V110.11.3532.3532
Published: 2007
Journal Articles

Vβ Spectratype Analysis of Tissue-Infiltrating T Cells Responding to Minor Histocompatibility Antigens Involved in Graft-Versus-Host Disease.

Jenny Zilberberg, Ph.D., Gichuru N. Loise, M.S, Thea M. Friedman, PhD
Journal: Blood
Blood (2007) 110 (11): 3244.
https://doi.org/10.1182/blood.V110.11.3244.3244
Published: 2007
Journal Articles

Spectratype Analysis of In Vitro Donor Anti-Host T Cell Repertoire Responses Predict Those of In Vivo Post-BMT.

Thea M. Friedman, PhD, Kira Goldgirsh, M.S., Jenny Zilberberg, Ph.D., Stephanie A. Berger, B.S., Joanne Filicko-O’Hara, M.D., Neal Flomenberg, M.D., Michele Donato, M.D., Scott D.D. Rowley, M.D., Robert Korngold, Ph.D.
Journal: Blood
Blood (2007) 110 (11): 2163.
https://doi.org/10.1182/blood.V110.11.2163.2163
Published: 2007