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María Hernández-Sánchez, PhD
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Journal Articles

RPS15 and TP53 Co-Mutation Drives B Cell Malignancy through Altered Translation and MYC Activation in a Murine Model

Catherine Gutierrez, Tamara Ouspenskaia, PhD, Doris Fu, Peyton Waddicor, B.S., Anat Biran, PhD, Aviv Liani, Gregory Lazarian, PharmD, Elisa Ten Hacken, PhD, Elizabeth Witten, Fara Faye Regis, BS, Heather Joyal, Leah Billington, BA, Fabienne Lucas, MDPhD, Mei Zheng, Blake Tye, PhD, Maria Hernandez-Sanchez, PhD, Miguel Quijada Álamo, MSc, Shuqiang Li, PhD, Binyamin A. Knisbacher, PhD, Ziao Lin, BS, Aziz Al'Khafaji, PhD, Lili Wang, MDPhD, Kenneth J. Livak, PhD, Donna S. Neuberg, ScD, Florence Cymbalista, MD PhD, Gad Getz, PhD, Stirling Churchman, PhD, Ruben D. Carrasco, MD PhD, Sichen Shao, PhD, Aviv Regev, PhD, Catherine J. Wu, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 28–29.
https://doi.org/10.1182/blood-2020-138900
Published: 2020
Journal Articles

Clinical and Biological Impact of TP53 Alterations in Del(11q) Chronic Lymphocytic Leukemia

Claudia Pérez Carretero, MSc, BSc, Miguel Quijada Álamo, MSc, Maria Hernandez-Sanchez, PhD, Ana E. Rodriguez, PhD, Ana B Herrero, PhD, Jesus M Hernández-Sánchez, PhD, Marta Martín Izquierdo, MSc, Teresa González, PhD, Sandra Santos-Mínguez, Cristina Miguel-García, Araceli Rubio-Martínez, Alfonso García de Coca, MD PhD, Julio Dávila, Jose-Angel Hernandez, MD PhD, Rocio Benito, PhD, José Luis Ordóñez, PhD, Jesus Maria Hernández-Rivas, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 6–7.
https://doi.org/10.1182/blood-2020-141015
Published: 2020
Journal Articles

Biological Impact of Monoallelic and Biallelic BIRC3 Loss in Del(11q) Chronic Lymphocytic Leukemia Progression

Miguel Quijada Álamo, MSc, Maria Hernandez-Sanchez, PhD, Ana E. Rodriguez, PhD, Claudia Pérez Carretero, MSc, BSc, Marta Martín Izquierdo, MSc, Verónica Alonso Pérez, PhD, Ignacio García-Tuñón, PhD, Jose Maria Bastida, MDPhD, Maria Jesus Vidal, MD, Josefina Galende DEL Canto, MD, Carlos Aguilar, MD, José Antonio Queizán, MD, Isabel González-Gascón Y Marín, MD PhD, Jose-Angel Hernandez, MD PhD, Rocio Benito, PhD, José Luis Ordóñez, PhD, Jesus Maria Hernández-Rivas, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 4.
https://doi.org/10.1182/blood-2020-142658
Published: 2020
Journal Articles

Multiplexed CRISPR In Vivo Editing of CLL Loss-of-Function Lesions Models Transformation of Chronic Lymphocytic Leukemia into Richter's Syndrome

Elisa Ten Hacken, PhD, Tomasz Sewastianik, PhD, Robert A. Redd, MS, Geoffrey Fell, MS, Mohamed Uduman, PhD, Michaela Gruber, MD PhD, Shanye Yin, PhD, Kendell Clement, PhD, Erin Michelle Parry, MD PhD, Shuqiang Li, PhD, Maria Hernandez-Sanchez, PhD, Leah Billington, BA, Elizabeth Witten, Kaitlyn J Baranowski, Lili Wang, MDPhD, Luca Pinello, PhD, Kenneth J. Livak, PhD, Donna S. Neuberg, ScD, Ruben D. Carrasco, MD PhD, Catherine J. Wu, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 2–3.
https://doi.org/10.1182/blood-2020-137130
Published: 2020
Journal Articles

Interrogation of Individual CLL Loss-of-Function Lesions By CRISPR In Vivo Editing Reveals Common and Unique Pathway Alterations

Elisa Ten Hacken, PhD, Shanye Yin, PhD, Kendell Clement, PhD, Robert A. Redd, MS, Maria Hernandez-Sanchez, PhD, Shuqiang Li, PhD, Michaela Gruber, MD PhD, Heather Joyal, Geoffrey Fell, MS, Shu Wang, Jose Jacob, James Flynn, David Ruff, Keith W. Jones, Lili Wang, MD PhD, Donna S Neuberg, ScD, Luca Pinello, PhD, Kenneth J. Livak, PhD, Ruben D. Carrasco, MD PhD, Catherine J. Wu, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 684.
https://doi.org/10.1182/blood-2019-127673
Published: 2019
Journal Articles

MCL-1 and PKA/AMPK Axis Fuel Venetoclax Resistance in Lymphoid Cancers

Vivian M. Liu, MD, Romain Guièze, MD, Daniel Rosebrock, Alexis A Jourdain, PhD, María Hernández-Sánchez, PhD, Aina Zurita Martinez, Elisa Ten Hacken, PhD, Philip A. Thompson, MBBS, Julian Bryan Iorgulescu, MD PhD, Shuqiang Li, PhD, Matthew S. Davids, MD, Jennifer R. Brown, MD PhD, Ana Lako, Zoe B. Ciantra, Matthew A. Lawlor, William G. Wierda, MD PhD, Anthony G. Letai, MD PhD, Donna S Neuberg, ScD, Christopher J. Ott, PhD, Ignaty Leshchiner, PhD, Vamsi Mootha, MD, Gad Getz, PhD, Catherine J. Wu, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1284.
https://doi.org/10.1182/blood-2019-131336
Published: 2019
Journal Articles

Genetic Determinants of Venetoclax Resistance in Lymphoid Malignancies

Romain Guieze, MD, Vivian M Liu, Daniel Rosebrock, Alexis Jourdain, PhD, María Hernández-Sánchez, PhD, Aina zurita Martinez, Sun Jing, PhD, Kaitlyn J Baranowski, Philip A. Thompson, MBBS, Heo Jin-Mi, PhD, Zacchary Cartun, Ozan Aygun, PhD, Giulia Notarangelo, Dimitri Livitz, BS, Shuqiang Li, PhD, Matthew S. Davids, MD, Jennifer R. Brown, MD PhD, William G. Wierda, MD PhD, Anthony Letai, MD PhD, Donna S Neuberg, ScD, Wade Harper, PhD, Steven A. Carr, PhD, Federica Piccioni, PhD, Christopher J. Ott, PhD, Ignaty Leshchiner, PhD, Cory Johannessen, PhD, John G Doench, PhD, Vamsi Mootha, MD PhD, Gad Getz, PhD, Catherine J. Wu, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 893.
https://doi.org/10.1182/blood-2018-99-118604
Published: 2018
Journal Articles

CRISPR/Cas9-Generated Models Uncover Therapeutic Vulnerabilities of Del(11q) Chronic Lymphocytic Leukemia Cells to Dual BCR and PARP Inhibition

Miguel Quijada Álamo, BSc, MSc, María Hernández-Sánchez, PhD, José Luis Ordóñez, PhD, Verónica Alonso Pérez, PhD, Ana E. Rodriguez, PhD, Ignacio García-Tuñón, PhD, Ana B Herrero, PhD, Laura San-Segundo, Michaela Gruber, MD PhD, Juan Luis García, PhD, Rocio Benito, PhD, Catherine J. Wu, MD, Jesús-María Hernández-Rivas, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 948.
https://doi.org/10.1182/blood-2018-99-116080
Published: 2018