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Marcus Jaras, PhD
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Journal Articles

CDK8 Inhibitors Induce Transcriptional Reprogramming of AML Cells Associated with Differentiation

Milena Mazan, PhD, Marion Chapellier, PhD, Marcus Järås, PhD, Michal Mikula, MD PhD, Eliza Majewska, PhD, Katarzyna Wiklik, PhD, Michal Combik, PhD, Aniela Golas, PhD, Magdalena Masiejczyk, MSc, Elzbieta Fiedor, MSc, Federico Malusa, MSc, Przemyslaw Juszczynski, Prof., MD PhD, Magdalena Cybulska, DVM, Maciej Mikulski, PhD, Jerzy Ostrowski, Prof., MD PhD, Pawel Chrom, MD PhD, Krzysztof Brzózka, PhD, Tomasz Rzymski, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3774.
https://doi.org/10.1182/blood-2019-128073
Published: 2019
Journal Articles

Hepatic Leukemia Factor Is Critical for Hematopoietic Stem Cells and Promotes MLL-AF9 Acute Myeloid Leukemia

Aurelie Baudet, PhD, Karolina Paulina Komorowska, PhD, Hultmark Simon, MS, Marcus Järås, PhD, Marion Chapellier, PhD, Gunnar Juliusson, MD PhD, Mattias Magnusson, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2466.
https://doi.org/10.1182/blood-2019-122661
Published: 2019
Journal Articles

SEL120 - a First-in-Class CDK8/19 Inhibitor As a Novel Option for the Treatment of Acute Myeloid Leukemia and High-Risk Myelodysplastic Syndrome - Data from Preclinical Studies and Introduction to a Phase Ib Clinical Trial

Gautam M. Borthakur, MD, William B. Donnellan, MD, Scott R. Solomon, MD, Camille Abboud, MD, Aziz Nazha, MD, Milena Mazan, PhD, Michal Mikula, MD PhD, Eliza Majewska, PhD, Katarzyna Wiklik, PhD, Aniela Golas, PhD, Marcus Järås, PhD, Marion Chapellier, PhD, Anna Polak, PhD, Arkadiusz Bialas, PhD, Renata Windak, PhD, Jerzy Ostrowski, Prof., MD PhD, Przemyslaw Juszczynski, Prof., MD PhD, Pawel Chrom, MD PhD, Tomasz Rzymski, PhD, Krzysztof Brzózka, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2651.
https://doi.org/10.1182/blood-2019-127835
Published: 2019
Journal Articles

CDK8 Inhibitor SEL120-34A Has Therapeutic Efficacy in Murine and Human Acute Myeloid Leukemia Models

Marion Chapellier, PhD, Jun Chen, MD PhD, Carl Sandén, PhD, Milena Mazan, PhD, Eliza Majewska, Katarzyna Wiklik, PhD, Michal Combik, PhD, Magdalena Masiejczyk, MSc, Elzbieta Fiedor, Marta Obacz, Anna Polak, Arkadiusz Bialas, Paulina Chesy, Ewelina Gabor-Worwa, Przemyslaw Juszczynski, MD PhD, Krzysztof Brzózka, PhD, Tomasz Rzymski, PhD, Thoas Fioretos, MD PhD, Johan Flygare, MD PhD, Marcus Jaras, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1520.
https://doi.org/10.1182/blood-2018-99-111859
Published: 2018
Journal Articles

CXCR4 Has a CXCL12-Independent Essential Role in MLL-AF9 Driven Acute Myeloid Leukemia

Ramprasad Ramakrishnan, Pablo Peña-Martínez, Puneet Agarwal, PhD, Carl Högberg, PhD, Marion Chapellier, PhD, Mansi Shah, PhD, Björn Nilsson, MD PhD, Benjamin L. Ebert, MDPhD, Ravi Bhatia, MD, Marcus Järås, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 774.
https://doi.org/10.1182/blood-2018-99-116137
Published: 2018
Journal Articles

Interleukin 4 Induces Macrophage-Mediated Phagocytosis of Leukemia Cells

Pablo Peña-Martínez, Mia Eriksson, PhD, Ramprasad Ramakrishnan, Marion Chapellier, PhD, Carl Högberg, PhD, Caroline Jansson, David Gisselsson Nord, MD PhD, Marcus Järås, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2730.
https://doi.org/10.1182/blood-2018-99-110606
Published: 2018
Journal Articles

Modeling Chronic Myeloid Leukemia in Immunodeficient Mice Reveals an Inflammatory State with Expansion of Aberrant Mast Cells and Accumulation of Pre B Cells

Maria Askmyr, PhD, Helena Agerstam, PhD, Henrik Lilljebjörn, PhD, Nils Hansen, PhD, Christine Karlsson, PhD, Niklas Landberg, Carl Hogberg, PhD, Carin Lassen, Msc, Marianne Rissler, Johan Richter, MD PhD, Mats Ehinger, MD PhD, Marcus Jaras, PhD, Thoas Fioretos, MD PhD
Journal: Blood
Blood (2014) 124 (21): 3132.
https://doi.org/10.1182/blood.V124.21.3132.3132
Published: 2014
Journal Articles

Toll-like Receptor 1 Is a Candidate Therapeutic Target in Acute Myeloid Leukemia

Mia Eriksson, Pablo Peña, Marion Chapellier, PhD, Carl Högberg, PhD, Thoas Fioretos, MD PhD, Benjamin L Ebert, MD PhD, Marcus Järås, PhD
Journal: Blood
Blood (2014) 124 (21): 5782.
https://doi.org/10.1182/blood.V124.21.5782.5782
Published: 2014
Journal Articles

Interleukin-4 Is a Negative Regulator of Acute Myeloid Leukemia Cells

Pablo Enrique Peña Martínez, MSc, Marion Chapellier, PhD, Mia Eriksson, Ramprasad Ramakrishnan, MSc, Carl Högberg, PhD, Marcus Järås, PhD
Journal: Blood
Blood (2014) 124 (21): 2146.
https://doi.org/10.1182/blood.V124.21.2146.2146
Published: 2014
Journal Articles

Lenalidomide Induces Ubiquitination and Degradation of CSNK1A1 in MDS with Del(5q)

Emma C. Fink, Jan Krönke, MD, Slater N. Hurst, Namrata D. Udeshi, PhD, Tanya Svinkina, Rebekka K. Schneider, MD, Marie E. McConkey, PhD, Marcus Järås, PhD, Lars Bullinger, MD PhD, Steven A. Carr, PhD, Benjamin L. Ebert, MD DPhil
Journal: Blood
Blood (2014) 124 (21): 4.
https://doi.org/10.1182/blood.V124.21.4.4
Published: 2014
Journal Articles

Upregulation Of IL1RAP On Human Progenitor/Stem Cells Induces Features Of a Myeloproliferative Disorder In Mice

Nils Hansen, Kristian Reckzeh, PhD, Helena Agerstam, PhD, Maria Askmyr, PhD, Sandra Gordon, Marianne Rissler, Carl Högberg, PhD, Johan Richter, MD, PhD, Marcus Järås, PhD, Thoas Fioretos, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 1650.
https://doi.org/10.1182/blood.V122.21.1650.1650
Published: 2013
Journal Articles

Strong Therapeutic Effect Of Anti-IL1RAP Immunotherapy In a Xenograft Model Of Acute Myeloid Leukemia

Helena Agerstam, PhD, Maria Askmyr, PhD, Nils Hansen, Marianne Rissler, Gunnar Juliusson, MD, PhD, Johan Richter, MD, PhD, Mark Wunderlich, MS, Marcus Järås, PhD, James C. Mulloy, PhD, Thoas Fioretos, MD PhD
Journal: Blood
Blood (2013) 122 (21): 3954.
https://doi.org/10.1182/blood.V122.21.3954.3954
Published: 2013
Journal Articles

Critical Role Of Casein Kinase (Ck)1α Heterozygote Gene Inactivation In The Clonal Advantage Of Hematopoietic Stem Cells In Del(5q) MDS

Rebekka K. Schneider, MD, Dirk Heckl, PhD, Marcus Järås, PhD, Lisa Chu, McConkey Marie, PhD, Ann Mullally, MD, Benjamin L Ebert, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 98.
https://doi.org/10.1182/blood.V122.21.98.98
Published: 2013