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Maria Armila Ruiz, B.S.
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Journal Articles

The LSD1 Inhibitor RN-1 Increases γ-Globin Expression in Baboons By Targeting an Early Event Responsible for γ-Globin Repression

Kestis Vaitkus, Vinzon Ibanez, B.S., Maria Armila Ruiz, B.S., Ramasamy Jagadeeswaran, PhD, Yogenthiran Saunthararajah, MD, James Douglas Engel, PhD, Joseph DeSimone, PhD, Angela Rivers, MD, Donald Lavelle, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1054.
https://doi.org/10.1182/blood-2018-99-113539
Published: 2018
Journal Articles

Oral Administration of the LSD1 Inhibitor OG-S1335 Increases Fetal Hemoglobin in Humanized Transgenic Sickle Cell Disease Mice and in Baboons

Angela Rivers, MD PhD, Kestis Vaitkus, Ramasamy Jagadeeswaran, PhD MSc, Vinzon Ibanez, B.S., Maria Armila Ruiz, B.S., Filippo Ciceri, PhD, Fernando Cavalcanti, PhD, Robert E. Molokie, MD, Donald Lavelle, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 356.
https://doi.org/10.1182/blood.V130.Suppl_1.356.356
Published: 2017
Journal Articles

RN-1, a Potent and Selective LSD1 Inhibitor, Induces High Levels of Fetal Hemoglobin (HbF) in Anemic Baboons ( P. anubis )

Angela Rivers, MD PhD, Kestis Vaitkus, Maria Armila Ruiz, B.S., Vinzon Ibanez, Tatiana Kouznetsova, M.S., Joseph DeSimone, PhD, Donald Lavelle, PhD
Journal: Blood
Blood (2014) 124 (21): 336.
https://doi.org/10.1182/blood.V124.21.336.336
Published: 2014
Journal Articles

The Tet Dioxygenase Co-Factor Ascorbic Acid Reduces DNA Methylation and Increases Expression of the γ-Globin Gene and Acts in a Combinatorial Manner with HbF-Inducing Drugs Targeting Repressive Epigenetic Modifications

Maria Armila Ruiz, B.S., Angela Rivers, MD PhD, Kestis Vaitkus, Vinzon Ibanez, Robert E. Molokie, MD, Joseph DeSimone, PhD, Donald Lavelle, PhD
Journal: Blood
Blood (2014) 124 (21): 334.
https://doi.org/10.1182/blood.V124.21.334.334
Published: 2014
Journal Articles

Dynamic Regulation of 5-Hydroxymethylcytosine At the γ-Globin Promoter During Erythroid Differentiation

Maria Armila Ruiz, B.S., Kestis Vaitkus, Aparna Vasanthakumar, PhD, Angela Rivers, MD, PhD, Tatiana Kouznetsova, M.S., Joseph DeSimone, PhD, Lucy A. Godley, MD, PhD, Donald Lavelle, Ph.D.
Journal: Blood
Blood (2012) 120 (21): 824.
https://doi.org/10.1182/blood.V120.21.824.824
Published: 2012
Journal Articles

Combinatorial Effect of Pharmacological Inhibitors of Lsd-1 and DNMT on γ-Globin Synthesis in Cultured Baboon Bone Marrow Erythroid Progenitors

Donald Lavelle, Ph.D., Kestis Vaitkus, Maria Armila Ruiz, B.S., Angela Rivers, MD, PhD, James D. Engel, PhD, Joseph DeSimone, PhD
Journal: Blood
Blood (2012) 120 (21): 249.
https://doi.org/10.1182/blood.V120.21.249.249
Published: 2012
Journal Articles

Quantitative Analysis of Tissue and Developmental Stage-Specific Differences in DNA Methylation throughout the β-Globin Gene Locus by DNA MassARRAY,

Maria Armila Ruiz, B.S., Kestutis Vaitkus, B.S., Tatiana Kouznetsova, B.S., Joseph DeSimone, PhD, Yogen Saunthararajah, MD, Donald Lavelle, Ph.D.
Journal: Blood
Blood (2011) 118 (21): 3196.
https://doi.org/10.1182/blood.V118.21.3196.3196
Published: 2011
Journal Articles

Oral Administration of Low-Dose Decitabine and Tetrahydrouridine In Combination Increases Fetal Hemoglobin to Therapeutic Levels In the Absence of Cytotoxicity and Reduces Inter-Individual Drug Bioavailability In Baboons

Donald Lavelle, Ph.D., Kestutis Vaitkus, B.S., Maria Armila Ruiz, B.S., Cassandra List, B.S., Tatiana Kouznetsova, B.S., Joseph DeSimone, PhD, Yogen Saunthararajah, MD
Journal: Blood
Blood (2011) 118 (21): 2147.
https://doi.org/10.1182/blood.V118.21.2147.2147
Published: 2011